Internal medicine: open access最新文献_第2页

Growth Factors in Platelet Rich Plasma can Regenerate Pancreatic Beta Cells in Type 2 Diabetes 富血小板血浆中的生长因子可使2型糖尿病患者胰腺β细胞再生

Internal medicine: open access Pub Date : 2019-01-01 DOI: 10.35248/2165-8048.19.9.304

M. Younis

{"title":"Growth Factors in Platelet Rich Plasma can Regenerate Pancreatic Beta Cells in Type 2 Diabetes","authors":"M. Younis","doi":"10.35248/2165-8048.19.9.304","DOIUrl":"https://doi.org/10.35248/2165-8048.19.9.304","url":null,"abstract":"Introduction: 387 million people are considered to have diabetes all over the world, and the number is expected to increase miserably to 592 million by 2035. Alternative ways to create β-cells from endogenous sources should be found as a way for the evolution of treatment. This is to bypass the complication of tissue matching and surgical procedures. To date several rebuilding approaches have been developed to stimulate β-cells regeneration through the induction of the proliferation of remaining β-cells, neo-genesis; de novo islet formation from pancreatic progenitor cells, and trans-differentiation; converting non-β-cells within the pancreas to β-cells. Platelet Rich Plasma (PRP) contains various growth factors which can be used for tissue regeneration including pancreatic beta cells. Materials and methods: 2 groups of Type-2 diabetes patients had been monitored in a private clinic, number 40 each group, with 30 females and 50 males. The first group patients relieved oral hypoglycemic drugs as usual but injected by PRP weekly by subcutaneous injection of 3 ml, the second group received oral drugs only. Results: There were significant increases in c-peptide levels in patients with PRP injection with dpp4 inhibitors and metformin for 3 months with p-value less than 0.0001. In the second group patients on oral therapy only there were no significant change in c-peptide levels after 3 months of oral hypoglycemic drugs. Conclusion: As Growth factors (GFs) are considered as a natural biological mediators which control growth, differentiation, and have a role in the process of tissue reform and regeneration. The growth factors in platelet-rich plasma can induce beta cell regeneration and increase beta cell mass by stimulating β-cell neo-genesis and through ductal cell differentiation into β-cells which is detected by an increase in c-peptide levels which may add to Type-2 diabetes treatment.","PeriodicalId":92650,"journal":{"name":"Internal medicine: open access","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90134749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Multiple Brain Abscesses Caused by Streptococcus intermedius: Prognostic Index of Mortality 中间链球菌引起的多发性脑脓肿:死亡率的预后指标

Internal medicine: open access Pub Date : 2019-01-01 DOI: 10.35248/2165-8048.19.9.307

S. Moschonas, T. Katsikas, S. Drimis

引用次数: 0

Werner Syndrome: A Case Report of Two Brothers of Pangeria 沃纳综合征:Pangeria兄弟二例报告

Internal medicine: open access Pub Date : 2019-01-01 DOI: 10.35248/2165-8048.19.9.308

Sama Metwally, L. E. Ahwal, Khalid Zaghlol, N. Alwan, Raghda Gabar

{"title":"Werner Syndrome: A Case Report of Two Brothers of Pangeria","authors":"Sama Metwally, L. E. Ahwal, Khalid Zaghlol, N. Alwan, Raghda Gabar","doi":"10.35248/2165-8048.19.9.308","DOIUrl":"https://doi.org/10.35248/2165-8048.19.9.308","url":null,"abstract":"Werner syndrome is considered inherited premature ageing and genomic instability syndrome. It is an autosomal recessive disorder in which aging process is accelerated starting after puberty. It is also termed as Progeria adultorum. The hallmark features are short stature, senile facies, scleroderma like skin (dry atrophic skin, mottled darkness, telangiectasia, sclerodactyly, and gangrene), cataract, hypogonadism, contractures of skin over joint, premature atherosclerosis, loss of subcutaneous fat and ulcers over feet and leg. Treatment of painful ulcers is difficult with increased risk of malignancy (fibro sarcoma in 10% of patients). Death is usually occurring in the fourth to sixth decade due to myocardial infarction or malignancy. We reported 2 brothers of Pangeria of positive consanguinity parents the older is 40 years old, short stature, senile facies with bilateral hip joint replacement, chronic leg ulcer, bilateral cataract extraction and the younger is 35 years old, short stature, senile facies, infertile, previous cataract extraction with bone deformity. The later presented to us in outpatient clinic, Internal Medicine department, Tanta university Hospital, Egypt for preoperative assessment for cataract operation. We admit the patient to investigate him and to confirm our provisional diagnosis as regard Werner syndrome. As no definite treatment for this disorder and death usually occurs in the fourth to sixth decade, early diagnosis and follow up is beneficial and screening for malignancies and associated diseases should be performed regularly.","PeriodicalId":92650,"journal":{"name":"Internal medicine: open access","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86626413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Non-invasive Imaging Methods for Brown Adipose Tissue Detection and Function Evaluation. 褐色脂肪组织检测和功能评估的无创成像方法。

Internal medicine: open access Pub Date : 2018-01-01 Epub Date: 2019-01-07 DOI: 10.4172/2165-8048.1000299

Yaqi Zhang, Xiaofei Hu, Su Hu, Alessandro Scotti, Kejia Cai, Jian Wang, Xin Zhou, Ding Yang, Matteo Figini, Liang Pan, Junjie Shangguan, Jia Yang, Zhuoli Zhang

引用次数: 4