International journal of biomedical investigation最新文献

{"title":"Clinical Observation of Lichen Based Vitamin D3 (60000IU) Pill in Normal Healthy Peoples, Formulated by Ambrosiya Neo-Medicine Pvt. Ltd","authors":"Gourvendra Gangwar","doi":"10.31531/2581-4745.1000148","DOIUrl":"https://doi.org/10.31531/2581-4745.1000148","url":null,"abstract":"In the early 20th century in the United States, vitamin D fortification of food products was essential to the eradication of rickets. Since then, there has been a nearly 100-year period of building evidence connecting vitamin D insufficiency to a number of outcomes, which has coincided with growing public interest in and knowledge of the health advantages of vitamin D. Vitamin D supplements are now widely available in both developed and developing nations, and many of them are supplied to the general public in the form of unregulated formulations with minimal information about safe administration. Together, these factors have caused a shift in which incidences of vitamin D intoxication have dramatically increased across the globe. Vitamin D toxicity is characterised by serum 25-hydroxyvitamin D [25(OH)2D] values greater than 150 ng/ml (375 nmol/l) due to vitamin D overdose. Clinicians now have to manage an illness that might manifest as anything from asymptomatic problems to severe, life-threatening ones. A study of lichen-based vitamin D3 pills has been performed and analysed by different tests.","PeriodicalId":92528,"journal":{"name":"International journal of biomedical investigation","volume":"187 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139281589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation of Lichen Based Pill a Natural Source of Vitamin D3 with a High Absorption Rate by Ambrosiya Neo-Medicine Pvt. Ltd","authors":"Gourvendra Gangwar","doi":"10.31531/2581-4745.1000147","DOIUrl":"https://doi.org/10.31531/2581-4745.1000147","url":null,"abstract":"The physiological functioning of the human body depends on vitamin D as a source of minerals. Numerous ailments like bone health, cancer, heart issues, infectious diseases, and CNS are brought on by its shortage. The body's vitamin D insufficiency can be caused by a variety of things, including a person's diet, lifestyle, and geographic location. Blood levels of vitamin D can be maintained through a variety of means, including vitamin D supplements, vitamin D medications, and lifestyle changes. A pharmaceutical company with its main office in India called Ambrosiya Neo-Medicine Pvt. Ltd. has introduced a food-grade vitamin D pill based on lichen to address the global problem of vitamin D deficiency's consequences. In Dr. JAIN's Precision Diagnostic Centre, a comparison study of conventional vitamin D and lichen-based pills was done on ten patients who were vitamin D deficient. The results of the vitamin D level after 48-hours have shown that the lichen-based vitamin D is absorbed at a higher rate than regular vitamin D. We anticipate Ambrosiya’s supply of vitamin D supplements made from lichen, and it can make a big difference to the government's attempts to address the problem of vitamin D insufficiency in people everywhere.","PeriodicalId":92528,"journal":{"name":"International journal of biomedical investigation","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139281409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Narcissism and Masculinity/Feminity","authors":"P. Ribeiro, D. Moreira, A. Teixeira, A.V. Pereira, F. Almeida, Ivone Vale","doi":"10.31531/2581-4745.1000146","DOIUrl":"https://doi.org/10.31531/2581-4745.1000146","url":null,"abstract":"Why have we chosen this research question dedicated to Narcissistic Personality Disorders and Sexuality? This comes from vast clinical practice, in Psychiatry and Mental Health, which empirically highlights what appears to be a mature and cohesive mental structure within the individual’s psychic and sexual development with man and woman, each one well defined internally and externally what it is and feels, as well as its association with health or mental illness in terms of Personality Disorder being inevitable. At the heart of the importance of this study is an imbalance in their psychosexual development that is revealed latently or is manifested in the therapeutic approach of patients (mainly narcissistic and borderline), and there is already a history of studies on this topic. We defined a methodology whose study design, selection of participants, and sample size best reflected to our objectives, expecting to deepen the results and provide answers to the initial questions. These became clearer with the selection (inclusion/exclusion) of individuals for the Experimental and Control Groups, Clinical Interviews and Questionnaires over the years, which, in an objective way, reveals an unavoidable reality: the psychosexual development of the individual, in terms of Masculinity/Femininity, conditions and is conditioned by Personality Disorders in general, and Narcissistic and Borderline in particular. Soon it will be possible for us to objectify (qualify/quantify) the results that will be made available to the scientific community, for a better understanding of the Disease and Mental Health, with the final objective of its acceptance, consideration and therapeutic evolution.","PeriodicalId":92528,"journal":{"name":"International journal of biomedical investigation","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42033251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additive Benefits of Melatonin on Osteogenic Differentiation Rate and Osteogenic Potential Quantified by Alkaline Phosphatase - A Systematic Review","authors":"S. Narayan, Sankari Malaiappan","doi":"10.31531/2581-4745.1000144","DOIUrl":"https://doi.org/10.31531/2581-4745.1000144","url":null,"abstract":"Background: Periodontitis is a chronic inflammatory disease affecting the gingiva, Periodontal ligament, cementum and Alveolar bone. Treatment of such a disease is targeted at initial reduction of primary microbial burden followed by repair of existing periodontium and by regenerative procedures wherever required. Bone is a modified form of connective tissue with lifelong dynamic changes in its metabolism. Current advances in the field of regeneration suggest the use of agents which could alter, enhance, speed up or inducing bone formation at desired sites aiding in regenerative therapy and reducing reliance of external substitutes or grafts. Objective: To establish the additive effect of Melatonin on Osteoblast differentiation using Alkaline phosphatase as an indicator and the time required to record the same in-vitro. Data Sources: A search was executed in electronic database (i.e., PUBMED CENTRAL, COCHRANE, LILAC, EUROPEAN PMC, SCIENCEDIRECT, GOOGLE SCHOLAR) using following search terms alone and in combination by means of PUBMED search builder from January 1990 up to July 2020. Study Eligibility Criteria: Studies were stipulate if they met the following criteria: In vivo or In vitro studies comparing the additive effect of melatonin on Osteoblast differentiation rate using Alkaline phosphatase as an indicator were selected. Study Appraisal and Synthesis Methods: From a total of ten studies four studies claimed additive benefits of Melatonin in increasing Osteoblast differentiation rate or Osteogenic potential amongst Mesenchymal stem cells which was quantified using Alkaline Phosphatase. Results: The included article suggest without a doubt that Melatonin increases Osteoblast differentiation rate or Osteogenic potential among different Mesenchymal stem cells which was quantified using Alkaline Phosphatase, despite heterogeneity with regards to time duration, concentration and involved cell line. Conclusion: Although Melatonin was found to have a beneficial effect on osteoblast, myoblast, bone marrow stem cells of different origins, the present systematic review did not furnish concrete evidence to show the exact effect, concentration required, and time taken to visualize these clinical benefits.","PeriodicalId":92528,"journal":{"name":"International journal of biomedical investigation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49224207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study to Assess the Knowledge and Attitude Regarding Care After Coronary Angioplasty and its Importance Among Care Givers of Coronary Angioplasty Patients at Mamata Super Specialty Hospital, Khammam, Telangana, India","authors":"","doi":"10.31531/2581-4745.1000145","DOIUrl":"https://doi.org/10.31531/2581-4745.1000145","url":null,"abstract":"after coronary angioplasty and its importance among care givers of coronary angioplasty patients at Mamata super specialty hospital, Khammam, Telangana”. The objectives were to describe the socio demographic variables of care givers, to assess the levels of knowledge and attitude regarding care after coronary angioplasty and its importance among care givers, to find out the association between the levels of knowledge and attitude scores of care givers with their selected socio demographic variables, to develop and distribute an information booklet regarding care after coronary angioplasty and its importance. Methodology: The study was conducted with a survey research approach for a sample of 50 care givers of coronary angioplasty patients at Mamata super specialty hospital, Khammam, Telangana. Sample was selected by Nonprobability Convenience Sampling technique. The data was collected by Structured Interview schedule. The collected data is analyzed by using descriptive and inferential statistics. Results: The study results revealed that levels of knowledge of care givers regarding care after coronary angioplasty and its importance among 50, majority of care givers 33 (66%) had moderately adequate knowledge 14(28%) had inadequate knowledge and 3(6%) adequate knowledge. Regarding attitude scores among 50, Majority of care givers 28 (56%) had favorable attitude and 22(44%) had moderately favorable attitude. Conclusion: The study concluded that the majority of the care givers had moderately adequate knowledge and favorable attitude. So, it is indicated that there is a need to increase the knowledge of care givers regarding care after coronary angioplasty and its importance.","PeriodicalId":92528,"journal":{"name":"International journal of biomedical investigation","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136300254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lepidium Sativum Mucilage: From Characterization to Prebiotic Assessment","authors":"Archana., S. Choudhary","doi":"10.31531/2581-4745.1000143","DOIUrl":"https://doi.org/10.31531/2581-4745.1000143","url":null,"abstract":"Cress or garden cress (Lepidium sativum) has been widely reported for its numerous pharmacological activities. The cress seeds possess numbers of nutraceutical values from rubefacient, galactogogue, laxative to diuretic properties. In the current study mucilage is extracted from the seeds of Lepidium sativum by different methods and further purified exploiting the method of Munir et al. with slight modification. Chemical characterization confirmed the presence of carbohydrate, mucilage and polysaccharide. Proximate analysis confirmed the presence of crude fats, proteins, fibers and carbohydrates. FTIR analysis of Lepidium sativum mucilage shows presence of O-H, C-H and C=O functional group. We further investigated the prebiotic potential of Lepidium sativum L. seeds mucilage on different lactobacilli strains. The quantification of the total reducing sugar in the mucilage was attained by Ultraviolet-Visible Spectrophotometric method. The mucilage exhibited efficient resistance against α-amylase and artificial gastric juice hydrolysis compared to standard prebiotic inulin. The mucilage also exhibited efficient activity necessary for the augmentation of almost all strains of lactobacilli. In vitro studies also exhibited that lactobacilli amount was at par to standard prebiotics (p<0.05) in the medium supplemented with the mucilage. Further stability studies confirmed the stability of L. sativum mucilage over a period of six months making it a potential prebiotic nutrient supplement and pharmaceutical excipient.","PeriodicalId":92528,"journal":{"name":"International journal of biomedical investigation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48860492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study to Assess the Prevalence and Behaviour Regarding Covid -19 Among Public at Selected Rural and Urban Areas, Khammam, Telangana","authors":"Venaktesh E","doi":"10.31531/2581-4745.1000138","DOIUrl":"https://doi.org/10.31531/2581-4745.1000138","url":null,"abstract":"A comparative study to assess the prevalence and behaviour regarding Covid -19 among public at selected rural and urban areas, Khammam, Telangana. Th objectives were to assess the prevalence of Covid-19 among rural and urban public, to assess the behaviour regarding Covid-19 among rural and urban public. To develop and distribute an information booklet on appropriate behavior regarding Covid- 19 to rural and urban public. Methodology: A quantitative survey approach and Cross-sectional comparative descriptive design was used for this study. The study was conducted at rural public of Raghunadhapalem and urban public of Sambani nagar, it is one of the urban areas of Khammam, Telangana. The sample comprised of 200 (100 from Urban and 100 from Rural) and sample was selected by Non-Probability Convenience Sampling Technique. The data was collected by interview technique and tool use for the study was structured Interview schedule. Results: The results revealed that 200 (100 from urban and 100 from rural) Period prevalence was calculated according to the census available at sub centre on 30th August 2021.The period prevalence in urban public at Sambani nagar was 4.5 and in rural public at Raghunadhapalem was 4. The period prevalence was almost same at both the places. When it comes to appropriate behaviour for Covid-19 pandemic situation the urban public are following the preventive measures 100% when compared to the rural public which is only 43.3%. Conclusion: The study concludes that the period prevalence is almost same with slight difference in urban and rural public. When it comes to appropriate behaviour for Covid-19 pandemic situation the urban public are following the preventive measures when compared to the rural public. So the rural public need to be given more awareness programs regarding appropriate behavior to prevent spread of Covid-19.","PeriodicalId":92528,"journal":{"name":"International journal of biomedical investigation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48650248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dostarlimab “A Miracle Drug Against Cancer”: Current Knowledge and On-going Clinical Trials","authors":"Mohammed Asadullah Jahangir","doi":"10.31531/2581-4745.1000140","DOIUrl":"https://doi.org/10.31531/2581-4745.1000140","url":null,"abstract":"Cancer stands as one of the leading causes of death globally. Its socio-economic burden is increasing day by day. There is no defined treatment strategy for cancer. In most of the cases a combinatorial therapy approach is utilised which includes surgery, chemotherapy, immune therapy, radiation therapy etc. Immune checkpoints are a revolutionary discovery in cancer immunotherapy. Dostarlimab is an anti-programmed cell death protein-1 (PD-1) immunoglobulin G4 (IgG4) humanised monoclonal antibody (mAb), produced by recombinant DNA technology in mammalian Chinese hamster ovary (CHO) cells. PD-1 is an immune checkpoint receptor expressed by T-cells which has shown to suppress cancer-specific immune responses. In this article we provide the recent known information regarding dostarlimab along with currently undergoing 44 clinical trials globally with its title, conditions, interventions, and outcome measures.","PeriodicalId":92528,"journal":{"name":"International journal of biomedical investigation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49193597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Creatine Supplementation on the Muscular Inflammation and Muscle Atrophy in High-Fat High-Fructose Fed Obese Growing Rats","authors":"S. Oh","doi":"10.31531/2581-4745.1000139","DOIUrl":"https://doi.org/10.31531/2581-4745.1000139","url":null,"abstract":"Objective: This study aimed to investigate effects of creatine supplementation on high-fat high-fructose fed obese rats. Twenty-four six-week-old male Sprague-Dawley rats were randomly divided into three groups (n=8 each): control sedentary group (CD), high-fat high-fructose diet group (HD), and creatine-supplemented high-fat high-fructose diet group (CHD). Methodology: The CD group was supplemented with AIN-76G diet, and a high-fat high-fructose diet for HD and CHD groups was substituted with 5% corn oil fat to 35% lard. The CHD group was supplemented with 2% creatine. The total soleus muscle protein was extracted and prepared according to the procedure mentioned by Baghirova et al. for muscle cytokine assay and western blotting. Result: After eight weeks of the experimental period, weights of the soleus muscle in the HD and CHD groups were significantly lower than that in the CD group. In addition, levels of proinflammatory cytokines interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α in the HD groups were significantly higher than those in the CD group. In contrast, IL-1β, IL-6 concentrations in the CHD group were significantly lower than those in the HD group and irisin levels of HD and CHD group were significantly lower than those in the CD group. Moreover, levels of muscle protein degradation factors [Muscle RING-finger protein-1 (MuRF1) and atrogin-1] were significantly higher in the HD and CHD groups than those in the CD group. Conclusion: From these results, it was concluded that creatine supplementation attenuates the inflammation of skeletal muscle via pro-inflammatory cytokines; however, it has no significant role in preventing muscular atrophy in high-fat high-fructose fed obese rats.","PeriodicalId":92528,"journal":{"name":"International journal of biomedical investigation","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48473456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study to Assess the Knowledge and Attitude Regarding Intra Uterine Growth Retardation and its Prevention Among Antenatal Mothers in Rural and Urban Areas","authors":"Vanitha Chittaluri","doi":"10.31531/2581-4745.1000136","DOIUrl":"https://doi.org/10.31531/2581-4745.1000136","url":null,"abstract":"Intra Uterine Growth Retardation is an important cause of fetal and neonatal morbidity and mortality. The present study was undertaken to compare the knowledge and attitude regarding intra uterine growth retardation and its prevention among antenatal mothers in rural and urban areas Khammam, Telangana. The objectives of the study were to describe the levels of knowledge and attitude, to compare the levels of Knowledge and attitude in rural and urban areas, to find out the association between knowledge and attitude scores with their selected socio-demographic variables. A quantitative survey approach and comparative descriptive design was used for this study. The sample for current study is antenatal mothers who were residing at Raghunadhapalem rural area and Ballepalli urban area, Khammam. The sample size was 100((50 rural+50 urban) and the sample was selected by non-probability convenience sampling technique. Data was collected by using structure interview schedule. The Findings revealed that the knowledge means of antenatal mothers in rural and urban areas were 14.10 and 16.68 respectively. Standard deviations were 3.29 and 3.3 respectively. The ‘t’ calculated value was 3.89 which is significant at 0.05. The attitude means of antenatal mothers in rural and urban areas were 36.08 and 36.02 respectively. Standard deviations were 2.15 and 2.48 respectively. The ‘t’ calculated value was 0.12 which is significant at 0.05. The study concluded that the level of knowledge is low in rural area by comparing with urban area. There is an increased need for awareness program regarding intra uterine growth retardation and its prevention in selected setting in order to promote the health of the fetus and the mother.","PeriodicalId":92528,"journal":{"name":"International journal of biomedical investigation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48476621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}