International journal of neurodegenerative disorders最新文献

{"title":"Parkinson’s Disease, Diabetes, Functional Decline and Cognitive Impairment: A Comparative Study of Elderly Mexican Americans and Non-Hispanic Whites","authors":"P. L. Heller, D. Briones, J. Wilcox, J. D. Rosa","doi":"10.23937/2643-4539/1710008","DOIUrl":"https://doi.org/10.23937/2643-4539/1710008","url":null,"abstract":"Objective: Assess moderating effects of functional decline on the associations between late-life cognitive impairment (CImp) and diabetes and Parkinson’s disease (PD); including controls for Mexican-American ethnicity, education, life satisfaction, age, and sex. Methods: In-home interviews with 1,252 elderly Mexican-American (N = 799) and non-Hispanic white (N = 353) residents of El Paso County, Texas. CImp measured by MMSE, CLOXI and CLOXII; functional impairment (ADLimp) as impairment in 1-10 activities of daily living. Our hypothesis is that ethnicity will effect variance of diabetes, hence cognitive decline. Results: Logistic regression analyses--After controlling for effects of all above-cited variables, PD remains significantly associated with the three measures of CImp, including impairment in executive control function. Controlling for ADLimp does not extinguish the significant association between diabetes and CImp on any of the three measures. However, no significant degree of association between diabetes and CImp remains after other control variables (including Mexican-American ethnicity) have been added to the equation. Conclusions: 1) PD findings are statistically and clinically meaningful. After controlling for all other variables, the OR for respondents diagnosed with PD (compared to their non-diagnosed counterparts) is 1.42 for MMSE impairment (95% CI1.10-15.53); 4.12 for CLOXI impairment (95% CI 1.07-15.85); and 10.51 for CLOXII impairment (95% CI 2.55-43.41). 2) The connection between diabetes and CImp is problematic; our findings suggest that many of the earlierreported research findings linking diabetes with CImp may be an artifact of other intervening phenomena such as regional and ethnic differentials in prevalence rates for diabetes. 3) The relationship between CImp and ADLimp is strong and clinically meaningful; for each unit increase in ADLimp there is a corresponding 1.33 increase in odds for MMSE impairment (95% CI 1.15-1.55). For impairment on CLOX1 and CLOX2 the ORs are 1.22 (95% CI 1.05-1.42) and 1.21 (95% CI 1.03-1.42). 4) When coupled with other research findings, Mexican-American ethnicity may itself represent a risk factor for CImp. After controlling for effects all other variables, El Paso’s elderly Mexican Americans possess odds 2.46 times greater than those for NHWs in MMSE impairment (95% CI 1.42-4.25); 1.53 (95% CI 1.06-2.20) times greater for impairment in executive control function (CLOXI); and 2.35 times greater for impairment in ability to perform a simple copying task (1.35-4.09). 5) Our findings point to the importance of utilizing a number of different screening devices for assessment of cognitive function in order to increase the likelihood that results can be taken as valid, dependable, and clinically meaningful for elderly individuals a Hispanic ethnicity.","PeriodicalId":92384,"journal":{"name":"International journal of neurodegenerative disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49358780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of PSEN1 and PSEN2 Gene Variants and Clinical Findings with the Literature","authors":"Randa Nadide Cemre, Bora Elçin, A. Esra, Öz Özlem, Yener Görsev, Ulgenalp Ayfer","doi":"10.23937/IJND-2017/1710007","DOIUrl":"https://doi.org/10.23937/IJND-2017/1710007","url":null,"abstract":"• Page 1 of 8 • Citation: Randa NC, Bora E, Ataman E, Öz O, Yener G, et al. (2019) Identification of PSEN1 and PSEN2 Gene Variants and Clinical Findings with the Literature. Int J Neurodegener Dis 2:007 Accepted: April 09, 2019; Published: April 11, 2019 Copyright: © 2019 Randa NC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":92384,"journal":{"name":"International journal of neurodegenerative disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48610077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare and Hereditary Causes of Stroke-A Literature Review","authors":"C. Eyisi, I. Onwuekwe, Ig Eyisi, O. Ekenze","doi":"10.23937/ijnd-2017/1710005","DOIUrl":"https://doi.org/10.23937/ijnd-2017/1710005","url":null,"abstract":"• Page 1 of 6 • Citation: Eyisi CS, Onwuekwe IO, Eyisi IG, Ekenze O (2018) Rare and Hereditary Causes of Stroke-A Literature Review. Int J Neurodegener Dis 1:005 Accepted: November 17, 2018; Published: November 19, 2018 Copyright: © 2018 Eyisi CS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":92384,"journal":{"name":"International journal of neurodegenerative disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44034414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Clinicopathologic Case Report of a Female with Valosin-Containing Protein (VCP) Gene Mutation Related Disease","authors":"Surampalli Abhilasha, N. Angèle, D. Sandra, K. Manaswitha, Wang Annabel, C. Rudolph, Yin-Tsan Hong, R. Ana, P. Payal, W. John, Mozaffar Tahseen, E. KimonisVirginia","doi":"10.23937/ijnd-2017/1710006","DOIUrl":"https://doi.org/10.23937/ijnd-2017/1710006","url":null,"abstract":"• Page 1 of 5 • Citation: Surampalli A, Nalbandian A, Donkervoort S, Khare M, Wang AK, et al. (2018) A Clinicopathologic Case Report of a Female with Valosin-Containing Protein (VCP) Gene Mutation Related Disease. Int J Neurodegener Dis 1:006 Accepted: December 17, 2018; Published: December 19, 2018 Copyright: © 2018 Surampalli A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":92384,"journal":{"name":"International journal of neurodegenerative disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42537929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyotrophic Lateral Sclerosis (ALS) Linked to Intestinal Microbiota Dysbiosis & Systemic Microbial Infection in Human Patients: A Cross-Sectional Clinical Study","authors":"Steenblock David A, Ikrar Taruna, Antonio Andrew S San, Wardaningsih Elfi, Azizi Masoud J","doi":"10.23937/IJND-2017/1710003","DOIUrl":"https://doi.org/10.23937/IJND-2017/1710003","url":null,"abstract":"• Page 1 of 4 • Citation: Steenblock DA, Ikrar T, Antonio ASS, Wardaningsih E, Azizi MJ (2018) Amyotrophic Lateral Sclerosis (ALS) Linked to Intestinal Microbiota Dysbiosis & Systemic Microbial Infection in Human Patients: A Cross-Sectional Clinical Study. Int J Neurodegener Dis 1:003. Accepted: September 10, 2018; Published: September 12, 2018 Copyright: © 2018 Steenblock DA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":92384,"journal":{"name":"International journal of neurodegenerative disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42721871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Episodes of Full-Body Tremors: An Unexpected Adverse Effect during an Alzheimer's Disease Investigational Drug Study","authors":"T ApterJeffrey, A BillonesIvy, White Kaylee","doi":"10.23937/IJND-2017/1710004","DOIUrl":"https://doi.org/10.23937/IJND-2017/1710004","url":null,"abstract":"• Page 1 of 2 • Citation: Apter JT, Billones IA, White K (2018) Multiple Episodes of Full-Body Tremors: An Unexpected Adverse Effect during an Alzheimer’s Disease Investigational Drug Study. Int J Neurodegener Dis 1:004. Accepted: November 14, 2018; Published: November 16, 2018 Copyright: © 2018 Apter JT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":92384,"journal":{"name":"International journal of neurodegenerative disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46740912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epilepsy Increase in the Elderly: Role of not Evolutive Epileptogenic Brain Lesions (NEEBLs)","authors":"Chirchiglia Domenico","doi":"10.36959/459/598","DOIUrl":"https://doi.org/10.36959/459/598","url":null,"abstract":"Epilepsy in the elderly is a very debated case because much depends on the causes and associated pathologies. In particular, in the presence of comorbidity it is often difficult to find an effective and safe antiepileptic therapy that does not interfere with other drugs and therefore must be personalized. New-onset epilepsy in the elderly is caused by two types of cerebral lesions: The first concerns progressive, evolutive lesions, on which one can intervene, such as tumors or cerebrovascular pathologies, often acute.","PeriodicalId":92384,"journal":{"name":"International journal of neurodegenerative disorders","volume":"108 3‐4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72408091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near Infrared Spectroscopy alike Magnetic Resonance Imaging: Complementary Data in Rat Brain after Cocaine Treatment","authors":"Crespi Francesco, Formenti Francesca, Congestri Francesco","doi":"10.36959/459/597","DOIUrl":"https://doi.org/10.36959/459/597","url":null,"abstract":"Magnetic Resonance Imaging (MRI) and Near Infrared Spectroscopy (NIRS) are two major in vivo non invasive methodologies more and more applied in research. The first more than the second is largely used also in clinical domain. Both techniques are more or less related to the effectiveness of oxygen levels and/or functionality in blood and this can be exploited to monitor the influence of various factors and conditions upon the living tissue, in particular the brain. Here the complementarity of these two methodologies is challenged via comparison of the effect of cocaine treatment upon NIRS as well as MRI parameters monitored in vivo in rat brain. The aim of the study is to further support recent data obtained with our early introduced NIRS prototype to monitor hematic changes in CNS showing that NIRS is allowing evaluating rat blood brain barrier penetration of exogenous agents and demonstrating parallel alteration of brain metabolism following alcohol intake in rodents and man. Positive evidence will further confirm the utility of such prototype for real time translational rodent-man in vivo non invasive studies. The parallel MRI-NIRS data monitored confirm previous results obtained with these two non invasive methodologies and further support NIRS as a valuable tool for non invasive in vivo real time analysis of brain metabolism AND of drug treatments in the CNS.","PeriodicalId":92384,"journal":{"name":"International journal of neurodegenerative disorders","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90810994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dilemma of Raised Blood Levels of Folate and B12 in Autism","authors":"L. D","doi":"10.36959/459/596","DOIUrl":"https://doi.org/10.36959/459/596","url":null,"abstract":"","PeriodicalId":92384,"journal":{"name":"International journal of neurodegenerative disorders","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80307554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apolipoprotein E Fragmentation within Lewy Bodies of the Human Parkinson's Disease Brain.","authors":"Troy T Rohn,&nbsp;Jacob M Mack","doi":"10.23937/IJND-2017/1710002","DOIUrl":"https://doi.org/10.23937/IJND-2017/1710002","url":null,"abstract":"<p><p>Although harboring the Apolipoprotein E4 (APOE4) allele is a well-known risk factor in Alzheimer's disease (AD), whether a similar risk holds true for Parkinson's disease (PD) is currently not known. To investigate whether apoE pathology is present in PD, an immunohistochemical study was undertaken with fixed, human PD brain sections from the substantia nigra utilizing a recently characterized antibody that detects an amino-terminal fragment of apoE. This antibody, termed the apoE cleavage fragment p17 (nApoECFp17) antibody specifically detects an amino-terminal 17 kDa fragment of apoE without reacting with full-length forms of the protein. Application of this antibody revealed the presence of this fragment in Lewy bodies in all cases examined. Colocalization of nApoECFp17 with an antibody to alpha-synuclein (α-Syn), which served as a general marker for Lewy bodies, indicated the presence of this apoE fragment in 87.5% of all identified Lewy bodies. In addition, localization of nApoECFp17 was also evident within oligodendrocytes, the nucleus of melatonin-containing neurons, and blood vessels. Conversely, little staining was observed in the substantia nigra from Pick's disease or in the frontal cortex of dementia with Lewy bodies (DLB) cases, suggesting a specificity for nApoECFp17 immunoreactivity in PD. Collectively, these data have identified widespread evidence for apoE fragmentation in the human PD brain and documented for the first time the presence of apoE within Lewy bodies, the major pathological marker for this neurodegenerative disease.</p>","PeriodicalId":92384,"journal":{"name":"International journal of neurodegenerative disorders","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.23937/IJND-2017/1710002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36536815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}