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Diagnostic signatures from microarrays: a bioinformatics concept for personalized medicine 来自微阵列的诊断签名:个性化医疗的生物信息学概念
Biosilico Pub Date : 2003-05-02 Epub Date: 2004-02-25 DOI: 10.1016/S1478-5382(03)02329-1
Rainer Spang
{"title":"Diagnostic signatures from microarrays: a bioinformatics concept for personalized medicine","authors":"Rainer Spang","doi":"10.1016/S1478-5382(03)02329-1","DOIUrl":"10.1016/S1478-5382(03)02329-1","url":null,"abstract":"<div><p>Microarrays can be used as diagnostic clinical tools, providing a global overview of gene transcription in diseased tissues. Expression profiles can be easily obtained in a single assay and provide exhaustive information about molecular events that are often directly linked to the cause of a disease. However, the high complexity of the data are challenging. This article reviews recent efforts in bioinformatics and statistics to overcome this problem and make feasible the clinical analysis of gene expression profiles.</p></div>","PeriodicalId":9227,"journal":{"name":"Biosilico","volume":"1 2","pages":"Pages 64-68"},"PeriodicalIF":0.0,"publicationDate":"2003-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1478-5382(03)02329-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56572271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 47
Commercial norms and population genomics 商业规范和人口基因组学
Biosilico Pub Date : 2003-05-02 Epub Date: 2004-02-25 DOI: 10.1016/S1478-5382(03)02332-1
J.C. Louis (freelance writer)
{"title":"Commercial norms and population genomics","authors":"J.C. Louis (freelance writer)","doi":"10.1016/S1478-5382(03)02332-1","DOIUrl":"10.1016/S1478-5382(03)02332-1","url":null,"abstract":"","PeriodicalId":9227,"journal":{"name":"Biosilico","volume":"1 2","pages":"Pages 50-52"},"PeriodicalIF":0.0,"publicationDate":"2003-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1478-5382(03)02332-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78228975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutting edge approaches to drug design 药物设计的前沿方法
Biosilico Pub Date : 2003-05-02 Epub Date: 2004-02-25 DOI: 10.1016/S1478-5382(03)02335-7
Andreas Bender
{"title":"Cutting edge approaches to drug design","authors":"Andreas Bender","doi":"10.1016/S1478-5382(03)02335-7","DOIUrl":"10.1016/S1478-5382(03)02335-7","url":null,"abstract":"","PeriodicalId":9227,"journal":{"name":"Biosilico","volume":"1 2","pages":"Pages 53-54"},"PeriodicalIF":0.0,"publicationDate":"2003-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1478-5382(03)02335-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77147497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Informatics integration: the bedrock of NCE selection 信息学整合:NCE选择的基石
Biosilico Pub Date : 2003-03-01 Epub Date: 2004-02-25 DOI: 10.1016/S1478-5382(03)02231-5
Richard K. Scott
{"title":"Informatics integration: the bedrock of NCE selection","authors":"Richard K. Scott","doi":"10.1016/S1478-5382(03)02231-5","DOIUrl":"10.1016/S1478-5382(03)02231-5","url":null,"abstract":"<div><p>The life-science domain has been discussing the merits of data integration for several years. Approximately five years ago, knowledge management promised to solve many of the bottlenecks of the drug discovery pipeline. It was envisioned that companies would purchase off-the-shelf software solutions or hire consultants or informaticians to solve their informatics problems. However, knowledge management has not delivered all that it promised. Better investment in integration is required to deliver a system that significantly reduces the time-to-market and R&amp;D overheads, and increase the rate at which novel chemical entities (NCEs) progress through the pipeline. Such investments require strategic decisions that, if implemented successfully, deliver substantial benefits and act as the bedrock for NCE selection.</p></div>","PeriodicalId":9227,"journal":{"name":"Biosilico","volume":"1 1","pages":"Pages 14-17"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1478-5382(03)02231-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85895171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Adaptive evolution: E. coli's learning curve 适应性进化:大肠杆菌的学习曲线
Biosilico Pub Date : 2003-03-01 Epub Date: 2004-02-25 DOI: 10.1016/S1478-5382(03)02287-X
J.C. Louis (freelance writer)
{"title":"Adaptive evolution: E. coli's learning curve","authors":"J.C. Louis (freelance writer)","doi":"10.1016/S1478-5382(03)02287-X","DOIUrl":"10.1016/S1478-5382(03)02287-X","url":null,"abstract":"","PeriodicalId":9227,"journal":{"name":"Biosilico","volume":"1 1","pages":"Pages 9-10"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1478-5382(03)02287-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84534399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The rise of computational drug discovery? 计算机药物发现的兴起?
Biosilico Pub Date : 2003-03-01 Epub Date: 2004-02-25 DOI: 10.1016/S1478-5382(03)02264-9
Rolf Apweiler
{"title":"The rise of computational drug discovery?","authors":"Rolf Apweiler","doi":"10.1016/S1478-5382(03)02264-9","DOIUrl":"10.1016/S1478-5382(03)02264-9","url":null,"abstract":"","PeriodicalId":9227,"journal":{"name":"Biosilico","volume":"1 1","pages":"Pages 5-6"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1478-5382(03)02264-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78025930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Function prediction in BioPatents 生物专利中的功能预测
Biosilico Pub Date : 2003-03-01 Epub Date: 2004-02-25 DOI: 10.1016/S1478-5382(03)02220-0
Robert Harrison
{"title":"Function prediction in BioPatents","authors":"Robert Harrison","doi":"10.1016/S1478-5382(03)02220-0","DOIUrl":"10.1016/S1478-5382(03)02220-0","url":null,"abstract":"","PeriodicalId":9227,"journal":{"name":"Biosilico","volume":"1 1","pages":"Pages 12-13"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1478-5382(03)02220-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82145848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
From model organisms to organismal models: visualizing complex genomic datasets 从模式生物到有机体模型:可视化复杂的基因组数据集
Biosilico Pub Date : 2003-03-01 Epub Date: 2004-02-25 DOI: 10.1016/S1478-5382(03)02258-3
Christoph W. Sensen
{"title":"From model organisms to organismal models: visualizing complex genomic datasets","authors":"Christoph W. Sensen","doi":"10.1016/S1478-5382(03)02258-3","DOIUrl":"10.1016/S1478-5382(03)02258-3","url":null,"abstract":"<div><p>Genome research is rapidly expanding from the characterization of linear information (DNA and protein molecules) to information that contains spatial and temporal aspects (for example gene expression patterns and proteomics data). The analysis of these complex data sets poses new challenges for bioinformatics. A major challenge is the integration of highly diverse data types, ranging from gene functions and gene expression patterns over protein modifications to metabolic networks. New technologies need to be developed to integrate these data and build multi-dimensional models of cells, tissues, organs and entire organisms that reflect the results of functional genomics studies. The visualization of these models will be crucial for the success of genome research.</p></div>","PeriodicalId":9227,"journal":{"name":"Biosilico","volume":"1 1","pages":"Pages 23-26"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1478-5382(03)02258-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81266847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Challenges of structural genomics: bioinformatics 结构基因组学的挑战:生物信息学
Biosilico Pub Date : 2003-03-01 Epub Date: 2004-02-25 DOI: 10.1016/S1478-5382(03)02259-5
Adam Godzik , Jaume Canaves , Slawomir Grzechnik , Lukasz Jaroszewski , Andrew Morse , Jie Ouyang , Xianhong Wang , Bill West , John Wooley
{"title":"Challenges of structural genomics: bioinformatics","authors":"Adam Godzik ,&nbsp;Jaume Canaves ,&nbsp;Slawomir Grzechnik ,&nbsp;Lukasz Jaroszewski ,&nbsp;Andrew Morse ,&nbsp;Jie Ouyang ,&nbsp;Xianhong Wang ,&nbsp;Bill West ,&nbsp;John Wooley","doi":"10.1016/S1478-5382(03)02259-5","DOIUrl":"10.1016/S1478-5382(03)02259-5","url":null,"abstract":"<div><p>Structural genomics projects bring us many challenges, many of which were not anticipated when such initiatives were first planned and introduced. For instance, the huge amount of data generated within the project must be collected, displayed and analyzed to reap the benefits of this huge investment. Projects at the San Diego based Joint Center for Structural Genomics provide an example of how data can be managed within a structural genomics project, and how results can be presented on the web, as well as highlight some of the issues concerning data analysis.</p></div>","PeriodicalId":9227,"journal":{"name":"Biosilico","volume":"1 1","pages":"Pages 36-41"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1478-5382(03)02259-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79822187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
George Church discusses the quest for quality bioengineering George Church讨论了对高质量生物工程的追求
Biosilico Pub Date : 2003-03-01 Epub Date: 2004-02-25 DOI: 10.1016/S1478-5382(03)02266-2
J.C. Louis
{"title":"George Church discusses the quest for quality bioengineering","authors":"J.C. Louis","doi":"10.1016/S1478-5382(03)02266-2","DOIUrl":"10.1016/S1478-5382(03)02266-2","url":null,"abstract":"","PeriodicalId":9227,"journal":{"name":"Biosilico","volume":"1 1","pages":"Page 11"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1478-5382(03)02266-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87012464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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