BMJ Sexual & Reproductive Health最新文献

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Women's experiences of postpartum contraceptive services when elective caesarean section is the method of birth: a qualitative study. 选择剖腹产作为分娩方式的妇女对产后避孕服务的体验:一项定性研究。
IF 3.3 3区 医学
BMJ Sexual & Reproductive Health Pub Date : 2024-04-11 DOI: 10.1136/bmjsrh-2023-202046
Karin Lichtenstein Liljeblad, Helena Kopp Kallner, Jan Brynhildsen, Helena Kilander
{"title":"Women's experiences of postpartum contraceptive services when elective caesarean section is the method of birth: a qualitative study.","authors":"Karin Lichtenstein Liljeblad, Helena Kopp Kallner, Jan Brynhildsen, Helena Kilander","doi":"10.1136/bmjsrh-2023-202046","DOIUrl":"10.1136/bmjsrh-2023-202046","url":null,"abstract":"<p><strong>Background: </strong>The unmet need for postpartum contraception is a global challenge. Postpartum placement of an intrauterine device (IUD) within 48 hours of vaginal delivery is available in many settings worldwide, but is not routinely practised in Sweden. To improve contraceptive services and facilitate the informed choice of IUD placement at the time of a caesarean section (CS), we performed this study to identify and describe women's experiences of contraceptive services before, during and after an elective CS.</p><p><strong>Methods: </strong>A qualitative design and methodology was used. We interviewed 20 women aged 28-42 years who underwent elective CS in Sweden. Interviews were analysed using reflexive thematic analysis.</p><p><strong>Results: </strong>The three main themes found were (1) receptivity to contraceptive counselling in the context of CS, (2) communication and decision-making about postpartum contraception before CS and (3) lack of support and guidance to receive contraceptive services before and after CS. The participants described readiness and interest regarding postpartum contraception. They prefered counselling from around 25 weeks of gestation. Despite this finding, antenatal communication and contraceptive decision-making seemed rare. Participants reported a lack of support and guidance which necessitated a need by women to navigate the contraceptive services themselves in order to receive information about contraception before CS and to receive postpartum support.</p><p><strong>Conclusions: </strong>Antenatal contraceptive counselling including information about IUD placement during CS was appreciated and welcomed by women with elective CS as their birth method. Most of the women whom we interviewed would prefer to receive contraception counselling on postpartum use during the second half of their pregnancy.</p>","PeriodicalId":9219,"journal":{"name":"BMJ Sexual & Reproductive Health","volume":" ","pages":"107-113"},"PeriodicalIF":3.3,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11041589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139746147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient and public involvement in abortion research: reflections from the Shaping Abortion for Change (SACHA) Study. 堕胎研究中的患者和公众参与:塑造堕胎促进变革(SACHA)研究的反思。
IF 3.3 3区 医学
BMJ Sexual & Reproductive Health Pub Date : 2024-04-11 DOI: 10.1136/bmjsrh-2023-202018
Rebecca Blaylock, Maria Lewandowska, Charlotte Kelly, Becky Gunn, Rebecca Meiksin, Rachel H Scott, Melissa J Palmer, Kaye Wellings, Patricia A Lohr, Rebecca S French, The Sacha Study Team N/A
{"title":"Patient and public involvement in abortion research: reflections from the Shaping Abortion for Change (SACHA) Study.","authors":"Rebecca Blaylock, Maria Lewandowska, Charlotte Kelly, Becky Gunn, Rebecca Meiksin, Rachel H Scott, Melissa J Palmer, Kaye Wellings, Patricia A Lohr, Rebecca S French, The Sacha Study Team N/A","doi":"10.1136/bmjsrh-2023-202018","DOIUrl":"10.1136/bmjsrh-2023-202018","url":null,"abstract":"<p><p>Patient and public involvement (PPI) is limited within abortion-related research. Possible reasons for this include concerns about engaging with a stigmatised patient group who value confidentiality and may be reluctant to re-engage with services. Structural barriers, including limited funding for abortion-related research, also prevent researchers from creating meaningful PPI opportunities. Here, we describe lessons learnt on undertaking PPI as part of the Shaping Abortion for Change (SACHA) Study, which sought to create an evidence base to guide new directions in abortion care in Britain.Two approaches to PPI were used: involving patients and the public in the oversight of the research and its dissemination as lay advisors, and group meetings to obtain patients' views on interpretation of findings and recommendations. All participants observed the SACHA findings aligned with their own experiences of having an abortion in Britain. These priorities aligned closely with those identified in a separate expert stakeholder consultation undertaken as part of the SACHA Study. One additional priority which had not been identified during the research was identified by the PPI participants.We found abortion patients to be highly motivated to engage in the group meetings, and participation in them actively contributed to the destigmatisation of abortion by giving them a space to share their experiences. This may alleviate any ethical concerns about conducting research and PPI on abortion, including the assumption that revisiting an abortion experience will cause distress. We hope that our reflections are useful to others considering PPI in abortion-related research and service improvement.</p>","PeriodicalId":9219,"journal":{"name":"BMJ Sexual & Reproductive Health","volume":" ","pages":"142-145"},"PeriodicalIF":3.3,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11041545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139711519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opt-in versus universal codeine provision for medical abortion up to 10 weeks of gestation at British Pregnancy Advisory Service: a cross-sectional evaluation. 英国妊娠咨询服务机构为妊娠 10 周以内的药物流产提供可待因的选择性与普遍性:横断面评估。
IF 3.3 3区 医学
BMJ Sexual & Reproductive Health Pub Date : 2024-04-11 DOI: 10.1136/bmjsrh-2023-201893
Neda Taghinejadi, Hannah McCulloch, Michał Krassowski, Amelia McInnes-Dean, Katherine C Whitehouse, Patricia A Lohr
{"title":"Opt-in versus universal codeine provision for medical abortion up to 10 weeks of gestation at British Pregnancy Advisory Service: a cross-sectional evaluation.","authors":"Neda Taghinejadi, Hannah McCulloch, Michał Krassowski, Amelia McInnes-Dean, Katherine C Whitehouse, Patricia A Lohr","doi":"10.1136/bmjsrh-2023-201893","DOIUrl":"10.1136/bmjsrh-2023-201893","url":null,"abstract":"<p><strong>Objective: </strong>To assess patient experiences of pain management during medical abortion up to 10 weeks' gestation with opt-in versus universal codeine provision.</p><p><strong>Methods: </strong>We invited patients who underwent medical abortion up to 10 weeks of gestation to participate in an online, anonymous, English-language survey from November 2021 to March 2022. We performed ordinal regression analyses to compare satisfaction with pain management (5-point Likert scale) and maximum abortion pain score (11-point numerical rating scale) in the opt-in versus universal codeine provision groups.</p><p><strong>Results: </strong>Of 11 906 patients invited to participate, 1625 (13.6%) completed the survey. Participants reported a mean maximum pain score of 6.8±2.2. A total of 1149 participants (70.7%) reported using codeine for pain management during their abortion. Participants in the opt-in codeine provision group were significantly more likely to be satisfied with their pain management than those in the universal group (aOR 1.48, 95% CI 1.12 to 1.96, p<0.01). Maximum abortion pain scores were lower on average among the opt-in codeine provision group (OR 0.80, 95% CI 0.66 to 0.96, p=0.02); however, this association was not statistically significant in the model adjusted for covariates (aOR 0.85, 95% CI 0.70 to 1.03, p=0.09).</p><p><strong>Conclusion: </strong>Our findings suggest that patients have a better experience with pain management during medical abortion when able to opt-in to codeine provision following counselling versus receiving this medication routinely.</p>","PeriodicalId":9219,"journal":{"name":"BMJ Sexual & Reproductive Health","volume":" ","pages":"114-121"},"PeriodicalIF":3.3,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contraception prescribing in England during the COVID-19 pandemic. 新冠肺炎大流行期间英格兰的避孕处方。
IF 3.3 3区 医学
BMJ Sexual & Reproductive Health Pub Date : 2024-04-11 DOI: 10.1136/bmjsrh-2023-201856
Tanha Begum, Emer Cullen, Malcolm Moffat, Judith Rankin
{"title":"Contraception prescribing in England during the COVID-19 pandemic.","authors":"Tanha Begum, Emer Cullen, Malcolm Moffat, Judith Rankin","doi":"10.1136/bmjsrh-2023-201856","DOIUrl":"10.1136/bmjsrh-2023-201856","url":null,"abstract":"<p><strong>Background: </strong>National lockdowns in England due to COVID-19 resulted in rapid shifts in healthcare provision, including in primary care where most contraceptive prescriptions are issued. This study aimed to investigate contraception prescribing trends in primary care during the pandemic and the impact of socioeconomic deprivation.</p><p><strong>Methods: </strong>Prescribing data were accessed from the English Prescribing Dataset for the first year of the COVID-19 pandemic (1 March 2020-28 February 2021) and the year prior (1 March 2019-29 February 2020). Data were analysed by geographical region (London, Midlands and East of England, North of England, South of England) and contraceptive type (progestogen-only pill (POP), combined oral contraception (COC), emergency hormonal contraception (EHC) and contraceptive injections). Differences in prescribing rates were calculated using Poisson regression. Pearson correlation coefficients were calculated for the Index of Multiple Deprivation (IMD) scores for each Clinical Commissioning Group (CCG) in the North East and North Cumbria (NENC).</p><p><strong>Results: </strong>Contraception prescribing rates decreased overall during the COVID-19 pandemic in England (Poisson regression coefficient (β)=-0.035), with a statistically significant (p<0.01) decrease in all four regions. Prescriptions decreased for COC (β=-0.978), contraceptive injections (β=-0.161) and EHC (β=-0.2005), while POP (β=0.050) prescribing rates increased. There was a weak positive correlation between IMD and prescribing rates in NENC (p>0.05).</p><p><strong>Conclusions: </strong>Contraception provision was impacted by COVID-19 with an overall decrease in prescribing rates. The deprivation results suggest that this may not be a significant contributing factor to this decrease. Further research is recommended to better understand these changes, and to ensure that services respond appropriately to population needs.</p>","PeriodicalId":9219,"journal":{"name":"BMJ Sexual & Reproductive Health","volume":" ","pages":"76-82"},"PeriodicalIF":3.3,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49674452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors affecting female sexual well-being: a 5-year follow-up of a randomised clinical trial on post-abortion contraception. 影响女性性健康的因素:一项关于堕胎后避孕的随机临床试验的5年随访。
IF 3.3 3区 医学
BMJ Sexual & Reproductive Health Pub Date : 2024-04-11 DOI: 10.1136/bmjsrh-2023-201879
Janina Bosas, Elena Toffol, Elina Pohjoranta, Maarit J Mentula, Ritva Hurskainen, Satu Suhonen, Oskari Heikinheimo
{"title":"Factors affecting female sexual well-being: a 5-year follow-up of a randomised clinical trial on post-abortion contraception.","authors":"Janina Bosas, Elena Toffol, Elina Pohjoranta, Maarit J Mentula, Ritva Hurskainen, Satu Suhonen, Oskari Heikinheimo","doi":"10.1136/bmjsrh-2023-201879","DOIUrl":"10.1136/bmjsrh-2023-201879","url":null,"abstract":"<p><strong>Introduction: </strong>Sexual well-being is associated with general well-being. Several factors, such as overweight, infertility, anxiety and sex hormones, also play a role, but the effects of hormonal contraception remain a point of debate. We characterised the factors associated with sexual well-being in fertile-aged women following induced abortion.</p><p><strong>Methods: </strong>A 5-year follow-up of a nested, longitudinal, cohort study examining the effects of routine provision of intrauterine contraception as part of abortion care. Sexual well-being, anxiety and quality of life were assessed annually using validated questionnaires (McCoy Female Sexuality Questionnaire, State-Trait Anxiety Inventory and EuroQoL), along with data on general and reproductive health, and relationship status. Of the 742 women participating in the trial, 290 (39%) provided sufficient follow-up data and were included in this study.</p><p><strong>Results: </strong>Based on trajectories of McCoy scores across the 5-year follow-up, two groups were identified: those with stable and higher (n=223, 76.9%) and those with declining sexual well-being (n=67, 23.1%). Women in the group of declining sexual well-being had significantly higher levels of anxiety and lower quality of life at all time points. They also had chronic diseases more often and were less happy in their relationships. No differences were found in method of contraception when classified as hormonal versus non-hormonal, or long-acting versus short-acting reversible contraception.</p><p><strong>Conclusions: </strong>Lower anxiety and higher quality of life are associated with stable and higher sexual well-being. Method of contraception or relationship status are not associated with sexual well-being during long-term follow-up in fertile-aged women.</p>","PeriodicalId":9219,"journal":{"name":"BMJ Sexual & Reproductive Health","volume":" ","pages":"92-98"},"PeriodicalIF":3.3,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49674453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sexual and reproductive health clinical consultations: domestic abuse. 性与生殖健康临床咨询:家庭虐待。
IF 3.3 3区 医学
BMJ Sexual & Reproductive Health Pub Date : 2024-04-11 DOI: 10.1136/bmjsrh-2023-201993
Melissa Gardner, Jayne Kavanagh
{"title":"Sexual and reproductive health clinical consultations: domestic abuse.","authors":"Melissa Gardner, Jayne Kavanagh","doi":"10.1136/bmjsrh-2023-201993","DOIUrl":"10.1136/bmjsrh-2023-201993","url":null,"abstract":"","PeriodicalId":9219,"journal":{"name":"BMJ Sexual & Reproductive Health","volume":" ","pages":"139-141"},"PeriodicalIF":3.3,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140118830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlights from literature. 文献中的亮点。
IF 3.3 3区 医学
BMJ Sexual & Reproductive Health Pub Date : 2024-03-01 DOI: 10.1136/bmjsrh-2023-202105
{"title":"Highlights from literature.","authors":"","doi":"10.1136/bmjsrh-2023-202105","DOIUrl":"https://doi.org/10.1136/bmjsrh-2023-202105","url":null,"abstract":"","PeriodicalId":9219,"journal":{"name":"BMJ Sexual & Reproductive Health","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140012167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sexual well-being among young people in remote rural island communities in Scotland: a mixed methods study. 苏格兰偏远农村岛屿社区年轻人的性健康:一项混合方法研究。
IF 3.3 3区 医学
BMJ Sexual & Reproductive Health Pub Date : 2024-01-09 DOI: 10.1136/bmjsrh-2023-201822
Rebecah MacGilleEathain, Tamsin Smith, Isabel Steele
{"title":"Sexual well-being among young people in remote rural island communities in Scotland: a mixed methods study.","authors":"Rebecah MacGilleEathain, Tamsin Smith, Isabel Steele","doi":"10.1136/bmjsrh-2023-201822","DOIUrl":"10.1136/bmjsrh-2023-201822","url":null,"abstract":"<p><strong>Background: </strong>It has been identified that rural young people face barriers to accessing support for their sexual well-being such as availability and transport, knowing healthcare staff personally, and fear of being judged negatively within their community. These factors may contribute to widening health inequalities and expose young people living in rural areas to increased risk of poor sexual well-being. Little is known about the current needs of adolescents residing in remote rural island communities (RRICs).</p><p><strong>Methods: </strong>A cross sectional mixed methods study was conducted with 473 adolescents aged 13-18 across the islands of the Outer Hebrides of Scotland. Analysis included descriptive, inferential statistics and thematic analysis.</p><p><strong>Results: </strong>59% (n<i>=</i>279) of participants held the perception there was no support, or did not know if there was support, about condoms and contraception in their local area. 48% (n<i>=</i>227) said that free condoms were not easily available for local young people. 60% (n<i>=</i>283) said they would not use youth services if they were locally available. 59% (n<i>=</i>279) said they did not receive enough relationships, sexual health and parenthood (RSHP) education. Opinion differed significantly by gender, school year group, and sexual orientation. Qualitative analysis identified three key themes: (1) alone yet visible, (2) silence and disapproval, and (3) safe spaces, with an underpinning theme of island cultures.</p><p><strong>Conclusions: </strong>A need for further sexual well-being support that addresses the complexities and challenges for young people residing in RRICs is identified. The intersectionality of being LGBT+ and residing in this context may increase the experience of inequality in sexual well-being support.</p>","PeriodicalId":9219,"journal":{"name":"BMJ Sexual & Reproductive Health","volume":" ","pages":"7-12"},"PeriodicalIF":3.3,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10850708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9605147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Red blood cell capacity of modern menstrual products: considerations for assessing heavy menstrual bleeding. 现代月经产品的红细胞容量:评估大量月经出血的注意事项。
IF 3.3 3区 医学
BMJ Sexual & Reproductive Health Pub Date : 2024-01-09 DOI: 10.1136/bmjsrh-2023-201895
Emma DeLoughery, Alyssa C Colwill, Alison Edelman, Bethany Samuelson Bannow
{"title":"Red blood cell capacity of modern menstrual products: considerations for assessing heavy menstrual bleeding.","authors":"Emma DeLoughery, Alyssa C Colwill, Alison Edelman, Bethany Samuelson Bannow","doi":"10.1136/bmjsrh-2023-201895","DOIUrl":"10.1136/bmjsrh-2023-201895","url":null,"abstract":"<p><strong>Background: </strong>Heavy menstrual bleeding affects up to one third of menstruating individuals and has a negative impact on quality of life. The diagnosis of heavy menstrual bleeding is based primarily on history taking, which is highly dependent on traditional disposable menstrual products such as pads and tampons. Only tampons undergo industry-regulated testing for absorption capacity. As use of alternative menstrual products is increasing, there is a need to understand how the capacity of these products compare to that of standard products.</p><p><strong>Methods: </strong>A variety of commercially available menstrual products (tampons, pads, menstrual cups and discs, and period underwear) were tested in the laboratory to determine their maximal capacity to absorb or fill using expired human packed red blood cells. The volume of blood necessary for saturation or filling of the product was recorded.</p><p><strong>Results: </strong>Of the 21 individual menstrual hygiene products tested, a menstrual disc (Ziggy, Jiangsu, China) held the most blood of any product (80 mL). The perineal ice-activated cold pack and period underwear held the least (<3 mL each). Of the product categories tested, on average, menstrual discs had the greatest capacity (61 mL) and period underwear held the least (2 mL). Tampons, pads (heavy/ultra), and menstrual cups held similar amounts of blood (approximately 20-50 mL).</p><p><strong>Conclusion: </strong>This study found considerable variability in red blood cell volume capacity of menstrual products. This emphasises the importance of asking individuals about the type of menstrual products they use and how they use them. Further understanding of capacity of newer menstrual products can help clinicians better quantify menstrual blood loss, identify individuals who may benefit from additional evaluation, and monitor treatment.</p>","PeriodicalId":9219,"journal":{"name":"BMJ Sexual & Reproductive Health","volume":" ","pages":"21-26"},"PeriodicalIF":3.3,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10847380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9954092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reversal of medication abortion with progesterone: a systematic review. 黄体酮逆转药物流产:一项系统综述。
IF 3.3 3区 医学
BMJ Sexual & Reproductive Health Pub Date : 2024-01-09 DOI: 10.1136/bmjsrh-2023-201875
Bianca Maria Stifani, Antonella Francheska Lavelanet
{"title":"Reversal of medication abortion with progesterone: a systematic review.","authors":"Bianca Maria Stifani, Antonella Francheska Lavelanet","doi":"10.1136/bmjsrh-2023-201875","DOIUrl":"10.1136/bmjsrh-2023-201875","url":null,"abstract":"<p><strong>Background: </strong>We sought to determine whether there is evidence to recommend progesterone for individuals not wishing to complete a medication abortion after taking mifepristone.</p><p><strong>Methods: </strong>We undertook an updated systematic review including a primary search for studies in which individuals received progesterone to reverse the effects of mifepristone, and a secondary search for studies in which individuals received mifepristone alone. We searched PubMed, Embase, Cochrane, CINAHL and grey literature up to December 2022. We used the Joanna Briggs Institute critical appraisal tools for risk of bias assessment. We compared ongoing pregnancy rates among individuals treated with progesterone to those managed expectantly.</p><p><strong>Results: </strong>We did not find new studies in our secondary search. For the main search, we included three case series and one randomised controlled trial. Data were available for 561 individuals who received progesterone after mifepristone, of whom 271 (48%) had ongoing pregnancies. The quality of the evidence in the case series was low due to methodological and ethical issues. Enrollment in the randomised trial stopped early due to bleeding events in both arms. The ongoing pregnancy rate for individuals ≤7 weeks who received progesterone was 42% (95% CI 37-48) compared with 22% (95% CI 11-39) for mifepristone alone. At 7-8 weeks, the ongoing pregnancy rate was 62% (95% CI 52-71) in the progesterone group and 50% (95% CI 15- 85) in the mifepristone alone group.</p><p><strong>Conclusion: </strong>Based mostly on poor-quality data, it appears the ongoing pregnancy rate in individuals treated with progesterone after mifepristone is not significantly higher compared to that of individuals receiving mifepristone alone.</p>","PeriodicalId":9219,"journal":{"name":"BMJ Sexual & Reproductive Health","volume":" ","pages":"43-52"},"PeriodicalIF":3.3,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10850668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49674455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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