{"title":"PRP Versus Standard of Care for Venous leg Ulcers: A Systematic Review and Meta-Analysis of Prospective Comparative Studies.","authors":"Kaissar Yammine, Joe Ghanimeh, Sira Jil Agopian, Chahine Assi, Fady Hayek","doi":"10.1177/15347346221094424","DOIUrl":"10.1177/15347346221094424","url":null,"abstract":"<p><p>Venous leg ulcers (VLUs) are chronic and recalcitrant lower limb wounds that affect millions of patients annually, severely reducing their quality of life, and causing a significant burden on the health care system. Recently, Platelet rich plasma (PRP) has been used to improve healing of VLUs. This systematic review aimed at evaluating the effectiveness of PRP versus the standard of care commonly used to treat VLUs. Ten prospective studies (8 randomized) met the inclusion criteria comprising 451 patients with 527 VLUs. Results were as follows: a) the weighted Odds Ratio (OR) of the mean healing rate was 2.84 (95% CI = 1.160 to 5.056, I<sup>2</sup> = 41.4%, p = 0.0004), b) the mean healed ulcer areas were 79.2 ± 19% for the PRP group and 51.7 ± 36% for the control group (p = 0.007) in favor of the PRP group, and c) the weighted infection OR showed no significant difference between both groups. Additionally, negative correlations were found between healing rate <i>and</i> duration of VLUs and initial size of the ulcers. This meta-analysis demonstrated significant beneficial effects of PRP versus standard of care on healing rate, reduction in surface, and reduction in healing time of VLUs. Infection and other complications were similar to standard of care. Therefore, our analytical data would support the use of PRP as a safe and effective treatment for VLUs.</p>","PeriodicalId":92199,"journal":{"name":"Edinburgh medical and surgical journal","volume":"81 1","pages":"15347346221094424"},"PeriodicalIF":0.0,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83378045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A","authors":"J. Haynes","doi":"10.1515/9783111697888-026","DOIUrl":"https://doi.org/10.1515/9783111697888-026","url":null,"abstract":"The information society has generated new digital literacy which, because of its aspects and implications for education, training and the workplace, has coined the term digital competence. This articled deals with the problem of digital competence of citizens, understood as a key element for performing in the knowledge society, and putting the potential and opportunities offered by digital technology to its best use in different areas of professional and personal development of individuals. To this end, it addresses the issue of digital competence, the digital divide as an element that hinders development and proposes a set of recommendations that would facilitate the development of digital competence of citizens.","PeriodicalId":92199,"journal":{"name":"Edinburgh medical and surgical journal","volume":"20 1","pages":"333 - 334"},"PeriodicalIF":0.0,"publicationDate":"2021-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/9783111697888-026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49609005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"W","authors":"B. A. Orcutt","doi":"10.1515/9783111350486-021","DOIUrl":"https://doi.org/10.1515/9783111350486-021","url":null,"abstract":"FEVER, Dr Davis's scientific and popular view of, E. M. S. J. vi. 558. observations concerning it, E. M. S. J. vi. l262. Sir Gilbert Blane's observations on, E. M. S. J. ix. 194. Sir J. Fellowes's observations on, E. M. S. J. xii. 114. WALKER, (Dr JAMES), some Recount of the effect of antimoriial wine, E. P. L. ii. 2.54. WALKER, (Dr HENRY), on the varieties of ophthalmia, E. M. S. J. vii. 1. WALKER, (JOHN), case of petechia; sine febre cured by sulphuric acid, A. M. ii. 231. WALKER, (Mr JOHN), reply to Moore on vaccination, E. M. S. J. xxv. 383 WALKER, (Dr JOSHUA), on the use of cuprum ammoniacum, M. C. x. 2S8.","PeriodicalId":92199,"journal":{"name":"Edinburgh medical and surgical journal","volume":"20 1","pages":"319 - 329"},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/9783111350486-021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46597747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"S","authors":"R. Carlton","doi":"10.1515/9783110968545-092","DOIUrl":"https://doi.org/10.1515/9783110968545-092","url":null,"abstract":"All habitat suitability, use, movement, and landscape genetic analyses were conducted in R [1] across the whole of San Diego County. We created these initial models using relevant environmental variables for habitat use and movement for all focal species (Table S1) using an ecological neighborhood approach. To select the most appropriate scale for each variable, we used the smoothie package (v 1.0-1, [2]) to apply a Gaussian smooth to each variable at a variety of biologically-relevant spatial scales for each species based on movement and home range information for each species. We tested scales ranging from 30 m to 180 m for California mouse and woodrat, 30 m to 360 m for wrentit, 30 m to 2,160 m for mule deer, 30 m to 2,000 m for bobcat, and 30 m to 10,000 m for puma.","PeriodicalId":92199,"journal":{"name":"Edinburgh medical and surgical journal","volume":"20 1","pages":"264 - 293"},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/9783110968545-092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44998276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"D","authors":"M. Anni, Il Direttore","doi":"10.1515/9783111548050-015","DOIUrl":"https://doi.org/10.1515/9783111548050-015","url":null,"abstract":"This chapter of the historic context is organized in three sections that define the various suburban property types found in the study area. Each section provides a brief history of the suburban building type, criteria by which to assess its significance, and a list of character-defining elements (CDEs) to aid in its evaluation. The CDEs were developed from general research on the property types. They will be checked for consistency in the field and may need to be revised following intensive on-site survey as the project progresses. The evaluation criteria and CDEs are applicable to individual structures, as well as to entire neighborhoods.","PeriodicalId":92199,"journal":{"name":"Edinburgh medical and surgical journal","volume":"20 1","pages":"82 - 97"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/9783111548050-015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48647479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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{"title":"L","authors":"ogod Jo dltsre, Uun, oluetur€s ounJg Jord, flnolf ulisasau","doi":"10.1515/9783111697888-037","DOIUrl":"https://doi.org/10.1515/9783111697888-037","url":null,"abstract":"course ana termination, iVl. <J. x. 181. LACTUCA SYLVESTRIS, on its use in dropsy, M. C. xi. 37. VIROSA, Dr Gumprecht on, E. M. S. J. xii. 239. jLAGTUCARIUM, use of, in phthisis, E. JH. S. J. x. 491, L AENNEC, (31.), on rendering tlie motions in the thorax audible, E. M. S. J. xiv. 655. his treatise on diseases of the chest, E. M. S. J. xviii. 447. LAFISSE, (Citizen), eloge of Vicqd'Azyr, A. M. iv. 515. LA GUI discovered the property of coaks to excite galvanism, A. M. iii. 121. LAING, (Dr), case of ischuria renalis, E. M. S. J. x. 409. LAING, (Mr), case of painful subcutaneous tubercle extirpated by, E. M. S. J. xviii. 245. LAING, (Mr DAVID), takes out the larger share of the tibia, which is supplied by a callus, E. M. E. i. 192.","PeriodicalId":92199,"journal":{"name":"Edinburgh medical and surgical journal","volume":"20 1","pages":"179 - 192"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/9783111697888-037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48742356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"R","authors":"Mittelburgi grassantium","doi":"10.1515/9783111697888-020","DOIUrl":"https://doi.org/10.1515/9783111697888-020","url":null,"abstract":"","PeriodicalId":92199,"journal":{"name":"Edinburgh medical and surgical journal","volume":"20 1","pages":"356 - 357"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/9783111697888-020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46873232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"W","authors":"W. R. Bion","doi":"10.1515/9783111697888-024","DOIUrl":"https://doi.org/10.1515/9783111697888-024","url":null,"abstract":"Estamos gratos a Francesca Bion por nos permitir pu blicar a presente transcrição. Esta, belamente transmite os amplos po deres do pensamento reflexivo e especulativo de Bion, assim como, sua p eculiaridade de formular perguntas em vez de respondê-las. O que, a meu ver, não é possível veicular, satisfatoriamente, na modalidade escrita, é o andam ento das comunicações de Bion no seminário. Pelos padrões da linguagem co loquial e acadêmica de praxe, ele aqui fala de maneira bem lenta mas de um a forma que engendra incrível sensação de abertura, de curiosidade e vit alidade. Os que leram as obras de Bion por certo vão notar que ele diz neste seminário várias coisas que já dissera antes. É, no entanto, surpreendente que até essas idéias, com que estaríamos familiarizados (talvez ultrafamiliar izados), nos chegam neste seminário a partir de uma direção inesperada.","PeriodicalId":92199,"journal":{"name":"Edinburgh medical and surgical journal","volume":"20 1","pages":"362 - 363"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/9783111697888-024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46986613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Z","authors":"Zhifeng Ren","doi":"10.1515/9783111697888-048","DOIUrl":"https://doi.org/10.1515/9783111697888-048","url":null,"abstract":"EIGENSCHAFTEN • Die Siebdruckfarbserie Z ist Lösemittel basiert und wird zweikomponentig mit Härter verarbeitet. • Z ist gut verdruckbar, trocknet chemisch-physikalisch und zeigt ein glänzendes Oberflächenfinish. • Die Farbe wird besonders im technisch/industriellen Bereich eingesetzt, wenn hohe Beständigkeitsanforderungen zu erfüllen sind. • Ausgehärtete Drucke verfügen über hohe mechanische Festigkeit sowie gute chemische Beständigkeit gegenüber vielen organischen Lösemitteln, verdünnten Alkalien und Säuren, Ölen und Fetten. • Durch Einstellung mit schnellflüchtigen Verdünnern, z.B. ZVSP, lässt sich die Siebdruckfarbe Z auch mit einer Lackierspritzpistole applizieren. • Die Farbserie Z ist bindemittelbedingt (Epoxidharz) nicht witterungsbeständig. Sie ist für den Innenund kurzfristigen Außeneinsatz geeignet. Mögliche witterungsbeständige Alternativen wären die Farbserien ZM und ZMN. • Hinweis: Vorversuche zur Eignung dieser Farbe werden auf Grund der Vielfältigkeit der Substrate/ Bedruckstoffe dringend empfohlen. Auch die Effizienz einer ggf. erforderlichen Substratvorbehandlung durch Vorreinigung/Entfettung, Vorbehandlung durch Flamme, Corona, Plasma oder z.B. einer Nachbehandlung (Flammtrocknung) ist zu prüfen.","PeriodicalId":92199,"journal":{"name":"Edinburgh medical and surgical journal","volume":"20 1","pages":"331 - 332"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/9783111697888-048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42420915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"O","authors":"Nichtamtliche Lesefassung","doi":"10.1515/9783111548050-026","DOIUrl":"https://doi.org/10.1515/9783111548050-026","url":null,"abstract":": This paper analyzes Adélia, Joana, and Quiquina, black characters in the Lucas Procópio (1985) and Ópera dos mortos (1967) novels, by Autran Dourado. Although they are all black, there is a disparity between them. While the first is a mulatto who exchanges her freedom for sexual favors, freed by colonel Lucas Procópio – Isaltina’s husband – the others are portrayed as enslaved women living for sinhá Isaltina and boss Rosalina. For the social space occupied by these characters and the historical moment portrayed in the work analysis, this article is based on Gilberto Freyre (1933) and Roberto Reis (1987),","PeriodicalId":92199,"journal":{"name":"Edinburgh medical and surgical journal","volume":"20 1","pages":"353 - 353"},"PeriodicalIF":0.0,"publicationDate":"2020-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/9783111548050-026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46942664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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