BMJ : British Medical Journal最新文献

{"title":"Why the EU AI Act falls short on preserving what matters in health.","authors":"Nicole Gross, Hannah van Kolfschooten, Alice Beck","doi":"10.1136/bmj.r1332","DOIUrl":"https://doi.org/10.1136/bmj.r1332","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"389 ","pages":"r1332"},"PeriodicalIF":105.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can a digital NHS be equitable?","authors":"Jessica Morley, Eleanor Barry, Lucinda Hiam","doi":"10.1136/bmj.r1317","DOIUrl":"https://doi.org/10.1136/bmj.r1317","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"389 ","pages":"r1317"},"PeriodicalIF":105.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1 receptor agonists: MHRA to study possible side effects after acute pancreatitis cases.","authors":"Adrian O'Dowd","doi":"10.1136/bmj.r1344","DOIUrl":"https://doi.org/10.1136/bmj.r1344","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"389 ","pages":"r1344"},"PeriodicalIF":105.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencer breached UK advertising rules by promoting supplement to people with ADHD, watchdog rules.","authors":"Matthew Limb","doi":"10.1136/bmj.r1346","DOIUrl":"https://doi.org/10.1136/bmj.r1346","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"389 ","pages":"r1346"},"PeriodicalIF":105.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From genome to exposome: universal newborn genetic screening is the wrong focus if we want to improve population health.","authors":"Trevor Sheldon, John Wright","doi":"10.1136/bmj.r1349","DOIUrl":"https://doi.org/10.1136/bmj.r1349","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"389 ","pages":"r1349"},"PeriodicalIF":105.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prioritise UK medical graduates for NHS training places, doctors urge.","authors":"Elisabeth Mahase","doi":"10.1136/bmj.r1343","DOIUrl":"https://doi.org/10.1136/bmj.r1343","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"389 ","pages":"r1343"},"PeriodicalIF":105.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of intravaginal conjugated oestrogen on pessary continuation for pelvic organ prolapse: multicentre, randomised, double blind, placebo controlled trial.","authors":"Ying Zhou, Rusha Yin, Yuelun Zhang, Xuemei Wang, Fengbin Jin, Xiangjuan Li, Cheng Peng, Ping Wang, Haiyan Shen, Qiao Weng, Hongbin Xie, Hong Wang, Bengui Jiang, Kai Zhou, Nannan Liang, Yinghui He, Yingying Dai, Zheng Fang, Shuo Liang, Yiwei Zhang, Abraham Morse, Lan Zhu","doi":"10.1136/bmj-2025-084418","DOIUrl":"10.1136/bmj-2025-084418","url":null,"abstract":"<p><strong>Objective: </strong>To examine the effect of vaginal oestrogen cream on pessary continuation rates in pelvic organ prolapse.</p><p><strong>Design: </strong>Multicentre, randomised, double blind, placebo controlled trial.</p><p><strong>Setting: </strong>12 academic medical centres in China (May 2020-June 2023).</p><p><strong>Participants: </strong>Postmenopausal women with symptomatic pelvic organ prolapse ≥stage 2 and successfully fitted with ring pessaries were randomly assigned in a 1:1 ratio to receive oestrogen cream or placebo cream.</p><p><strong>Interventions: </strong>One gram of conjugated oestrogen cream (0.625 mg/g) or placebo cream was inserted vaginally every night for the first two weeks after successful pessary fitting followed by twice weekly for 12 months.</p><p><strong>Main outcome measures: </strong>The primary outcome was the pessary continuation rate with satisfaction, which was defined as the proportion of participants who continued using the pessary and reported a response of very much better or much better on the Patient Global Impression of Improvement questionnaire at 12 months. Secondary outcomes included self-reported pelvic floor symptoms and adverse events. All analyses were based on a modified intention-to-treat approach, including participants who had at least one visit.</p><p><strong>Results: </strong>Of 420 postmenopausal women randomised, 411 had at least one visit and were included in the modified intention-to-treat analysis (208 in the vaginal oestrogen group and 203 in the placebo group). The mean age of participants was 66 years. Pessary continuation rate with satisfaction did not differ significantly between the oestrogen group and the placebo group (181/208 (87.0%) <i>v</i> 176/203 (86.7%); risk difference 0.3%, 95% confidence interval -6.2% to 6.9%; P=0.92). Excessive discharge (34/208 (16.3%) <i>v</i> 52/203 (25.6%); -9.3%, -17.1% to -1.4%), vaginal erosion or ulcer (4/208 (1.9%) <i>v</i> 14/203 (6.9%); -5.0%, -8.9% to -1.0%), and vaginal bleeding (3/208 (1.4%) <i>v</i> 13/203 (6.4%); -5.0%, -8.7% to -1.2%) were less common in the vaginal oestrogen group.</p><p><strong>Conclusions: </strong>Oestrogen cream did not improve the continuation rate of ring pessary use with satisfaction. Use of oestrogen cream might be associated with a lower risk of common adverse events. The clinical decision to use vaginal oestrogen should take into account its benefits and risks and the patient's personal preferences.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov NCT04393194.</p>","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"389 ","pages":"e084418"},"PeriodicalIF":105.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wastewater surveillance tells a quiet story of polio's return.","authors":"Yemisi Bokinni","doi":"10.1136/bmj.r1153","DOIUrl":"https://doi.org/10.1136/bmj.r1153","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"389 ","pages":"r1153"},"PeriodicalIF":105.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sepsis: Diagnosis remains \"urgent and persistent safety risk,\" safety body warns.","authors":"Matthew Limb","doi":"10.1136/bmj.r1339","DOIUrl":"https://doi.org/10.1136/bmj.r1339","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"389 ","pages":"r1339"},"PeriodicalIF":105.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formula milk: Overpriced and misleading products are risking child health, say campaigners.","authors":"Gareth Iacobucci","doi":"10.1136/bmj.r1333","DOIUrl":"https://doi.org/10.1136/bmj.r1333","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"389 ","pages":"r1333"},"PeriodicalIF":105.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}