GMS infectious diseases最新文献_第6页

Antibiotic consumption and resistance of gram-negative pathogens (collateral damage). 抗生素消耗和革兰氏阴性病原体的耐药性（附带损害）。

GMS infectious diseases Pub Date : 2018-08-09 DOI: 10.3205/id000040

Milan Cižman, Tina Plankar Srovin

引用次数: 25

Medical treatment for urogenital tuberculosis (UGTB). 泌尿生殖系统结核病(UGTB)的医疗。

GMS infectious diseases Pub Date : 2018-08-09 eCollection Date: 2018-01-01 DOI: 10.3205/id000039

Christian Wejse

引用次数: 14

Clinical characteristics of a large cohort of patients with positive culture of Fusobacterium necrophorum. 一大群坏死梭杆菌培养阳性患者的临床特征。

GMS infectious diseases Pub Date : 2018-03-07 eCollection Date: 2018-01-01 DOI: 10.3205/id000038

Romana Klasinc, Kostiantyn Lupyr, Iris Zeller, Helga Paula, Athanasios Makristathis, Felix Tuchmann, Thomas Wrba, Ojan Assadian, Elisabeth Presterl

{"title":"Clinical characteristics of a large cohort of patients with positive culture of Fusobacterium necrophorum.","authors":"Romana Klasinc, Kostiantyn Lupyr, Iris Zeller, Helga Paula, Athanasios Makristathis, Felix Tuchmann, Thomas Wrba, Ojan Assadian, Elisabeth Presterl","doi":"10.3205/id000038","DOIUrl":"https://doi.org/10.3205/id000038","url":null,"abstract":"Background: Fusobacterium necrophorum is a rare pathogen, mostly affecting young adults, causing infections of the head and neck, typically described as the Lemierre's syndrome. Today this symptom complex has become increasingly rare and has almost turned to a 'forgotten disease'. Methods: We performed a retrospective, descriptive study to identify the clinical features of patients with positive culture of F. necrophorum. Additionally, the antibiotic susceptibility profile of the pathogens was analysed. Results: During a period of 22 years 36 patients with at least one isolate of F. necrophorum were identified. Mostly tonsillar and peritonsillar abscesses were found, 10 patients were identified with bacteraemia, but only 4 patients presented with symptoms like sore throat, fever and swollen cervical lymph nodes, which may suggest Lemierre's. Most of the isolates (33/35) showed sensitivity to all tested antibiotics. Conclusion: Appropriate techniques are needed to detect F. necropho rum, especially from throat swabs, in the microbiological laboratory. Current clinical and microbiological practice may lead to under-diagnosis of infections caused by F. necrophorum. Further research is needed to define the colonization rate and to optimize methods for detection as well as identification of virulence.","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":"6 ","pages":"Doc03"},"PeriodicalIF":0.0,"publicationDate":"2018-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36887900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Influenza vaccination coverage of health care workers: a cross-sectional study based on data from a Swiss gynaecological hospital. 卫生保健工作者的流感疫苗接种覆盖率:基于瑞士妇科医院数据的横断面研究。

GMS infectious diseases Pub Date : 2018-02-23 eCollection Date: 2018-01-01 DOI: 10.3205/id000037

Evelyn Dass von Perbandt, René Hornung, Mirjam Thanner

{"title":"Influenza vaccination coverage of health care workers: a cross-sectional study based on data from a Swiss gynaecological hospital.","authors":"Evelyn Dass von Perbandt, René Hornung, Mirjam Thanner","doi":"10.3205/id000037","DOIUrl":"https://doi.org/10.3205/id000037","url":null,"abstract":"Background: Pregnancy is a risk factor for severe influenza and related complications. The vaccination has been recommended in healthcare workers as a strategy for preventing influenza in risk patients. The aim of this study was to analyze the influenza vaccination rate of the department of obstetrics and gynaecology of the Cantonal hospital St. Gallen in Switzerland. Methods: A cross-sectional study was carried out to investigate the influenza vaccination rates of all staff members of the Department of obstetrics and gynaecology (n=259). The vaccination coverage was compared according to sociodemographic variables using Chi-squared test. Associations were determined using a logistic regression model. Possible reasons for and against vaccination coverage were then investigated. Results: 200 questionnaires were included (valid response rate 77%). 15% reported being vaccinated against influenza (n=29). Reasons to be vaccinated are the belief of protection of patients (82%), oneself (75%) or family (61%). Reasons not to get vaccinated, including beliefs regarding the vaccine is not important (49%) and its ineffectiveness (44%). In the logistic regression analysis, the vaccination coverage among doctors (61% vaccinated) and nurses/midwives (4% vaccinated) is different from the vaccination coverage among the non-medical staff reference category (16% vaccinated; p=0.004, p=0.027), after controlling for the effect of other variables sex (p=0.807), age (p=0.438) and full time employment (p=0.298). Discussion: This study showed that doctors have a higher vaccination rate compared to other job roles, whereas the nurses and midwives had very low vaccination rates, which indicate a significant public health communication gap that needs to be addressed.","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":"6 ","pages":"Doc02"},"PeriodicalIF":0.0,"publicationDate":"2018-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36886965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Anti-tubercular activity of a natural stilbene and its synthetic derivatives. 天然二苯乙烯及其合成衍生物的抗结核活性。

GMS infectious diseases Pub Date : 2018-02-01 eCollection Date: 2018-01-01 DOI: 10.3205/id000036

Claudia Reinheimer, Dominik Büttner, Eugen Proschak, Helge B Bode, Volkhard A J Kempf, Thomas A Wichelhaus

{"title":"Anti-tubercular activity of a natural stilbene and its synthetic derivatives.","authors":"Claudia Reinheimer, Dominik Büttner, Eugen Proschak, Helge B Bode, Volkhard A J Kempf, Thomas A Wichelhaus","doi":"10.3205/id000036","DOIUrl":"https://doi.org/10.3205/id000036","url":null,"abstract":"Objectives: Tuberculosis (TB) and multidrug- and extensively drug-resistant TB in particular are remaining a major global health challenge and efficient new drugs against TB are needed. This study evaluated the anti-tubercular activity of a natural stilbene and its synthetic derivatives against M. tuberculosis. Methods: Isopropylstilbene and its synthetic derivatives were analyzed for their anti-tubercular activity against M. tuberculosis ATCC 27294 as well as multidrug- and extensively drug-resistant M. tuberculosis clinical isolates by using MGIT 960 instrumentation and EpiCenter software equipped with TB eXiST module. Cytotoxic effects of drug candidates were determined by a MTT dye reduction assay using A549 adenocarcinomic human alveolar basal epithelial cells. Results: Growth of M. tuberculosis ATCC 27294 was suppressed by the natural isopropylstilbene HB64 as well as synthetic derivatives DB56 and DB55 at 25 µg/ml. Growth of clinical isolates MDR and XDR M. tuberculosis was suppressed by HB64 at 100 µg/ml as well as by synthetic derivatives DB56 and DB55 at 50 µg/ml and 25 µg/ml, respectively. No anti-tubercular activity was demonstrated for synthetic derivatives DB53, EB251, and RB57 at 100 µg/ml. Toxicity in terms of IC50 values of HB64, DB55 and DB56 were 7.92 µg/ml, 12.15 µg/ml and 16.01 µg/ml, respectively. Conclusions: Synthetical derivatives of stilbene might be effective candidates as anti-tubercular drugs. However, toxicity of these substances as determined by IC50 values might limit therapeutic success in vivo. Further investigations should address lowering the toxicity for parenteral administration by remodeling stilbene derivatives.","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":"6 ","pages":"Doc01"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36886967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Asymptomatic bacteriuria in recurrent UTI - to treat or not to treat. 复发性尿路感染无症状菌尿——治疗或不治疗。

GMS infectious diseases Pub Date : 2017-12-28 DOI: 10.3205/id000035

Tommaso Cai, Riccardo Bartoletti

{"title":"Asymptomatic bacteriuria in recurrent UTI - to treat or not to treat.","authors":"Tommaso Cai, Riccardo Bartoletti","doi":"10.3205/id000035","DOIUrl":"10.3205/id000035","url":null,"abstract":"Asymptomatic bacteriuria (ABU) is a common clinical condition that often leads to unnecessary antimicrobial use. The reduction of antibiotic overuse for ABU is consequently an important issue for antimicrobial stewardship to reduce the emergence of multidrug resistant strains. In the clinical setting we have an important issue that requires special attention: the role of ABU in women affected by recurrent urinary tract infections (rUTIs). In everyday clinical practice, young women affected by rUTI show after antibiotic treatment asymptomatic periods associated sometimes with or without bacteriuria. Although it is not recommended, the majority of women with ABU is treated with poor results and occasionally a selection of multidrug-resistant bacteria can be observed. Recent studies demonstrated that ABU should not be treated in young women affected by rUTI, because it may play even a protective role in preventing symptomatic episodes, particularly when Enterococcus faecalis has been isolated. Moreover, ABU treatment is associated with a higher occurrence of antibiotic-resistant bacteria, indicating that ABU treatment in women with rUTIs is even potentially dangerous.","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":"5 ","pages":"Doc09"},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36887898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Protease inhibitors for the treatment of hepatitis C virus infection. 蛋白酶抑制剂治疗丙型肝炎病毒感染。

GMS infectious diseases Pub Date : 2017-11-28 eCollection Date: 2017-01-01 DOI: 10.3205/id000034

Philipp de Leuw, Christoph Stephan

{"title":"Protease inhibitors for the treatment of hepatitis C virus infection.","authors":"Philipp de Leuw, Christoph Stephan","doi":"10.3205/id000034","DOIUrl":"10.3205/id000034","url":null,"abstract":"The hepatitis C virus (HCV) has affected an estimate of 80 million individuals worldwide and is a strain of public health. Around 25-30% of patients in Europe and the US infected with HIV are coinfected with HCV. Despite treatment modalities containing a NS3/4A protease inhibitor in combination with pegylated interferon and ribavirin prior to 2013 improved SVR rates, the amount of severe side effects was high. Nowadays, oral direct-acting antivirals (DAAs) combination therapy offers excellent treatment efficacy, safety and tolerability. This review focuses on current literature and clinical evidence and their impact regarding NS3/4A protease inhibitors. In addition, pitfalls in treatment from HIV- and HBV-coinfected patients will also be discussed. In the era of DAA treatment, the third-generation pan-genotypic NS3/4A protease inhibitors (mainly grazoprevir, glecaprevir and voxilaprevir) show a high antiviral activity and genetic resistance barrier with cure rates of over 95% when combined with an NS5A inhibitor, irrespectively of baseline resistance associated variants (RASs) being present. These new key components of DAA combination therapy are impressive options to eradicate HCV in the so called difficult-to-treat population (e.g. compensated cirrhosis, end-stage renal disease and patients who failed previous DAA treatment).","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":"5 ","pages":"Doc08"},"PeriodicalIF":0.0,"publicationDate":"2017-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36886963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal carriage of multidrug-resistant bacteria among healthcare professionals in Germany. 多药耐药细菌在德国卫生保健专业人员肠道运输。

GMS infectious diseases Pub Date : 2017-11-22 eCollection Date: 2017-01-01 DOI: 10.3205/id000033

Katalin Jozsa, Katja de With, Winfried Kern, Claudia Reinheimer, Volkhard A J Kempf, Cornelia Wichelhaus, Thomas A Wichelhaus

{"title":"Intestinal carriage of multidrug-resistant bacteria among healthcare professionals in Germany.","authors":"Katalin Jozsa, Katja de With, Winfried Kern, Claudia Reinheimer, Volkhard A J Kempf, Cornelia Wichelhaus, Thomas A Wichelhaus","doi":"10.3205/id000033","DOIUrl":"https://doi.org/10.3205/id000033","url":null,"abstract":"Healthcare professionals (HCP) might be at increased risk of acquisition of multidrug-resistant bacteria (MDRB), i.e., methillicin-resistant Staphy l oc occus aureus (MRSA), vancomycin-resistant enterococci (VRE), and multidrug-resistant gram-negative bacteria (MDRGN) and could be an unidentified source of MDRB transmission. The aim of this study was to determine the prevalence as well as risk factors of MDRB colonization among HCP. HCP (n=107) taking part in an antibiotic stewardship program, were voluntarily recruited to perform a rectal swab and to fill in a questionnaire to identify risk factors of MDRB carriage, i.e. being physician, gender, travel abroad within the previous 12 months, vegetarianism, regular consumption of raw meat, contact to domestic animals, household members with contact to livestock, work or fellowship abroad, as well as medical treatment abroad and antibiotic therapy within the previous 12 months. Selective solid media were used to determine the colonization rate with MRSA, VRE and MDRGN. MDRGN were further characterized by molecular analysis of underlying β-lactamases. None of the participants had an intestinal colonization with MRSA or VRE. 3.7% of the participants were colonized with extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae, predominantly bla CTX-M type. Neither additional flouroquinolone resistance nor carbapenem resistance was detected in any of these isolates. No risk factors were identified to have a significant impact of MDRB carriage among HCP. A colonization rate of 3.7% with ESBL-producing Enterobacteriaceae is of interest, but comparing it to previously published data with similar colonization rates in the healthy population in the same geographic area, it is probably less an occupational risk.","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":"5 ","pages":"Doc07"},"PeriodicalIF":0.0,"publicationDate":"2017-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36886960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Spectrum and antibiotic resistance of catheter-associated urinary tract infections. 导管相关性尿路感染的谱和抗生素耐药性。

GMS infectious diseases Pub Date : 2017-11-22 DOI: 10.3205/id000032

Béla Köves, András Magyar, Peter Tenke

{"title":"Spectrum and antibiotic resistance of catheter-associated urinary tract infections.","authors":"Béla Köves, András Magyar, Peter Tenke","doi":"10.3205/id000032","DOIUrl":"10.3205/id000032","url":null,"abstract":"Catheter associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections and are also considered among the most common complications associated with indwelling urinary catheters. Most catheter associated infections are derived from the patient's own perineal flora, however the presence of a catheter increases the chance of being colonised by cross transmission of nosocomial bacteria as well. Most episodes of short-term catheter-associated bacteriuria are asymptomatic and are caused by single organisms, while long-term catheterisation promotes multibacterial infections and colonization. With prolonged duration of catheterization bacteriuria is considered universal because of the formation of biofilms on the surface of the catheter. Chronic indwelling catheters are an important reservoir of different multiresistant gram-negative organisms, therefore they are frequently isolated from CAUTIs. Treatment of catheter associated asymptomatic bacteriuria is not recommended because it will only promote the emergence of resistant organisms without effectively clearing the urine of catheterised patients.","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":"5 ","pages":"Doc06"},"PeriodicalIF":0.0,"publicationDate":"2017-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3205/id000032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36886961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Invasion of HEp-2 cells by Shigella spp. isolated from acute pediatric diarrhea. 小儿急性腹泻分离的志贺氏菌对HEp-2细胞的侵袭。

GMS infectious diseases Pub Date : 2017-09-15 eCollection Date: 2017-01-01 DOI: 10.3205/id000031

Sajjad Omidi, Mohammad Mehdi Soltan Dallal, Abolfazle Davoodabadi, Ramin Mazaheri Nezhad Fard, Marayam Usefi, Ronak Bakhtiari

{"title":"Invasion of HEp-2 cells by Shigella spp. isolated from acute pediatric diarrhea.","authors":"Sajjad Omidi, Mohammad Mehdi Soltan Dallal, Abolfazle Davoodabadi, Ramin Mazaheri Nezhad Fard, Marayam Usefi, Ronak Bakhtiari","doi":"10.3205/id000031","DOIUrl":"https://doi.org/10.3205/id000031","url":null,"abstract":"Aim: Shigella infection is an important global health problem in developing countries where hygiene is poor and hence shigellosis is a main cause of diarrhoea-associated mortality and morbidity, particularly in children under the age of five. The bacterial entry into colon and rectal epithelial cells has been named 'bacterium-directed phagocytosis'. This term highlights that the bacteria actively stimulate their own uptake into non-professional phagocytes. The aim of this study was to demonstrate the invasion of HEp-2 cells by Shigella spp. isolated from acute pediatric diarrhea in Tehran, Iran. Methods: Three-hundred and ten non-duplicative diarrheal stool samples were collected from the children admitted to Children's Medical Center in Tehran, Iran. Samples were cultured and suspected colonies were identified by routine microbiological and biochemical tests. The invasion of the two isolated Shigella spp. to HEp-2 cells was studied. Results: Of 310 stool samples, 16 (5.2%) Shigella spp. were isolated, including seven (43.7%) S. sonnei and nine (56.3%) S. flexneri. Four (44.4%) S. sonnei and seven (42.8%) S. flexneri showed invasive phenotype to HEp-2. Conclusion: Shigella sonnei and S. flexneri are reported as the most prevalent Shigella spp. in nature which infect humans. Invasion of various cell lines gives the chance of survival to Shigella spp. This ability causes more virulent infections in the host. Despite costly and time consuming cell culture techniques, the current method described in this paper is reliable for detecting invasive behavior of Shigella spp. Results have also shown that not all the Shigella spp. are able to invade intestinal epithelial cells.","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":"5 ","pages":"Doc05"},"PeriodicalIF":0.0,"publicationDate":"2017-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36886962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2