GMS infectious diseases最新文献

{"title":"Current perspective of new anti-Wolbachial and direct-acting macrofilaricidal drugs as treatment strategies for human filariasis.","authors":"Alexandra Ehrens, Achim Hoerauf, Marc P Hübner","doi":"10.3205/id000079","DOIUrl":"10.3205/id000079","url":null,"abstract":"<p><p>Filarial diseases like lymphatic filariasis and onchocerciasis belong to the Neglected Tropical Diseases and remain a public health problem in endemic countries. Lymphatic filariasis and onchocerciasis can lead to stigmatizing pathologies and present a socio-economic burden for affected people and their endemic countries. Current treatment recommendations by the WHO include mass drug administration with ivermectin for the treatment of onchocerciasis and a combination of ivermectin, albendazole and diethylcarbamazine (DEC) for the treatment of lymphatic filariasis in areas that are not co-endemic for onchocerciasis or loiasis. Limitations of these treatment strategies are due to potential severe adverse events in onchocerciasis and loiasis patients following DEC or ivermectin treatment, respectively, the lack of a macrofilaricidal efficacy of those drugs and the risk of drug resistance development. Thus, to achieve the elimination of transmission of onchocerciasis and the elimination of lymphatic filariasis as a public health problem by 2030, the WHO defined in its roadmap that new alternative treatment strategies with macrofilaricidal compounds are required. Within a collaboration of the non-profit organizations Drugs for Neglected Diseases initiative (DND<i>i</i>), the Bill & Melinda Gates Foundation, and partners from academia and industry, several new promising macrofilaricidal drug candidates were identified, which will be discussed in this review.</p>","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":"10 1","pages":"Doc02"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41774425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial infections in patients with nipple piercings: a qualitative systematic review of case reports and case series","authors":"L. M. Acuña-Chávez, Christian A. Alva-Alayo, Giamfranco A. Aguilar-Villanueva, Kevin A. Zavala-Alvarado, Cristhian A. Alverca-Meza, M. M. Aguirre-Sánchez, Anyelo A. Amaya-Castro","doi":"10.3205/id000080","DOIUrl":"https://doi.org/10.3205/id000080","url":null,"abstract":"The main objective of this review is to identify the most frequently isolated bacteria in patients with infections related to nipple piercings in case reports and case series. In addition, the aim is to describe clinical manifestations and antecedents. There is a protocol of this review. The terms “bacterial infections”, “nipple piercing” and their synonyms were considered. Pubmed/Medline, Scopus, Embase, Web of Science core collection and Ovid/Medline databases were searched until November 15, 2021 without date or language restrictions. Two authors extracted the articles and three other authors performed the selection, first by title and abstract, and second by full-text revision. Discrepancies were resolved with yet two other authors. Quality was assessed using the Joanna Briggs checklists. Finally, data extraction was realized. A total of 1,531 articles were extracted, of which 20 articles were included, and one article was added by hand-searching. The final number of articles included was 21, all of them with acceptable quality of evidence. Twenty-seven patients were considered (23 women and 4 men), aged between 15–60 years old. The most frequent bacterial genus in case reports and case series was Staphylococcus (n=10), and the most frequent species was M. fortuitum (n=6), although etiology seems to be diverse. The breast was the main affected organ, and the most frequent findings were fluid collection, pain, erythema, granulation tissue and swelling. The suspicion of infection by this bacterial species could be taken into account when it is associated with nipple piercings; however, larger studies are required to give a conclusion based on the evidence.","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42194447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial burden of recurrent uncomplicated urinary tract infections","authors":"K. Naber, José Tirán-Saucedo, F. Wagenlehner","doi":"10.3205/id000078","DOIUrl":"https://doi.org/10.3205/id000078","url":null,"abstract":"Introduction: Urinary tract infections (UTI) are a leading cause of bacterial infections in women. Despite acute treatment, 30–50% of women who have a UTI will experience a recurrence within 6–12 months. In this review, the focus will be on the personal psychosocial impacts of recurrent UTI. Methods: A PubMed/MEDLINE literature search was carried out from 2000 to 2020 in order to identify any recent high-quality meta-analyses or systematic reviews on these topics. Results: One systematic review was found appropriate for this manuscript. Concerning impact on quality of life (QoL) and daily activities, a reduced quality of both intimate and social relationships, self-esteem, and capacity for work was found due to recurrent UTI. Social function was substantially more reduced than physical function. In one study, the greatest reduction overall was in mental role functioning, whereas in another study, mental health reductions were not substantially greater than those of physical health. About one third of women suffered from UTI very often or often after sexual intercourse, and more than half of the patients stated that sexual relations were negatively influenced by UTI. Data from the GESPRIT study suggest that prophylaxis for recurrent UTI is underutilized, because less than 40% of the study population were offered prophylaxis after experiencing three UTI per year, despite all surveyed participants being willing to undertake at least one of the prophylactic measures listed in the survey. Conclusions: Little data on the psychosocial impact of recurrent UTI are available. Therefore, future studies must also incorporate QoL assessments as key outcome measures.","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45993422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary tract infections in patients with renal insufficiency and dialysis - epidemiology, pathogenesis, clinical symptoms, diagnosis and treatment.","authors":"Jürgen E Scherberich, Reinhard Fünfstück, Kurt G Naber","doi":"10.3205/id000076","DOIUrl":"10.3205/id000076","url":null,"abstract":"<p><p>Epidemiological studies show an increasing number of patients worldwide suffering from chronic kidney diseases (CKD), which are associated with a risk for progression to end-stage kidney disease (ESKD). CKD patients stage 2-5, patients with regular chronic dialysis treatment (hemo- or peritoneal dialysis), and patients suffering from kidney allograft dysfunction are at high risk to develop infections, e.g. urinary tract infections (UTI) and/or sepsis (urosepsis). These groups show metabolic disturbance, chronic inflammation, and impaired immunocompetence. <i>Escherichia coli</i> is still the most common pathogen in UTI. A wide variety of other pathogens may be involved in UTI. Urological interventions, catheterization, as well as repeated courses of antibiotics contribute to an increased challenge of antimicrobial resistance. The diagnosis of UTI in CKD is based on standard clinical and laboratory criteria. Pyuria (≥10 leucocytes/µl) is more often observed in patients with oligoanuria and low bacterial colony counts. The treatment strategies for this population are based on the same principles as in patients with normal renal function. However, drugs cleared by the kidney or by dialysis membranes need dose adjustment. Antimicrobials with potential systemic toxicity and nephrotoxicity should be administered with caution.</p>","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":"9 ","pages":"Doc07"},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39879862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative in vitro activity of piperacillin-tazobactam and temocillin against third-generation cephalosporin-resistant, carbapenem-susceptible Escherichia coli and Klebsiella pneumoniae.","authors":"Michael Kresken,&nbsp;Yvonne Pfeifer,&nbsp;Guido Werner","doi":"10.3205/id000077","DOIUrl":"10.3205/id000077","url":null,"abstract":"<p><p>Carbapenems are considered the drugs of choice for first-line treatment of severe infections caused by carbapenem-susceptible, extended-spectrum β-lactamases (ESBL)-producing Enterobacterales, while piperacillin-tazobactam has been recommended as an alternative for treatment of non-severe infections. Temocillin is stable to ESBL and AmpC enzymes and may thus represent another treatment option. This study assessed the in vitro activity of piperacillin-tazobactam and temocillin against third-generation cephalosporin (3GC)-resistant <i>Esch</i> <i>erichia coli</i> and <i>Klebsiella pneumoniae</i>, as compared to 3GC-susceptible isolates of either species. One hundred and nine isolates from hospitalized patients with bloodstream and urinary tract infections were tested. All isolates were collected during the resistance surveillance study of the Paul-Ehrlich-Society for Chemotherapy in 2016/17. Minimum inhibitory concentrations (MICs) were determined by broth microdilution according to the standard ISO 20776-1 and interpreted using EUCAST clinical breakpoints (version 11.0). Seventy-nine isolates (<i>E. coli</i>, n=58; <i>K. pneumoniae</i>, n=21) were 3GC-resistant and 30 (<i>E. coli</i>, n=15; <i>K. pneumoniae</i>, n=15) were 3GC-susceptible. Susceptibility to piperacillin-tazobactam was detected in 93.3% of 3GC-susceptible isolates (for both <i>E. coli</i> and <i>K. pneumoniae</i>) and in 79.3% and 57.1% of the 3GC-resistant <i>E. coli</i> and <i>K. pneumoniae</i>, respectively. In contrast, 3GC-susceptible isolates were 100% susceptible to temocillin as were 94.8% and 90.5% of the 3GC-resistant <i>E. coli</i> and <i>K. pneumoniae</i>, respectively. In conclusion, temocillin demonstrated potent in vitro activity against carbapenem-susceptible, 3GC-resistant <i>E. coli</i> and <i>K. pneumoniae</i> from bloodstream and urinary tract infection samples, with susceptibility rates exceeding those of piperacillin-tazobactam.</p>","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":"9 ","pages":"Doc08"},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39879863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective audit of antibiotic use in a university general pediatrics department using hospital pharmacy dispensing data.","authors":"Leonie Egle,&nbsp;Katharina Sauter,&nbsp;Svenja Ockfen,&nbsp;Manfred Haber,&nbsp;Sören Becker,&nbsp;Gudrun Wagenpfeil,&nbsp;Michael Zemlin,&nbsp;Sascha Meyer,&nbsp;Arne Simon","doi":"10.3205/id000075","DOIUrl":"https://doi.org/10.3205/id000075","url":null,"abstract":"<p><p>Antibiotics are among the most frequently prescribed drugs in children's hospitals, which is why regular monitoring of antibiotic use in hospitals is of great importance. This retrospective audit (60 months, January 2014 - December 2018) analyzes the antibiotic consumption at a university inpatient department of general pediatrics including neonatal and pediatric intensive care based on pharmacy dispensing data in units of grams per 100 patient days and in Defined Daily Doses per 100 patient days. The results provide potential targets for Antibiotic Stewardship interventions. Conversely, this audit elicits methodological limitations of the method of antibiotic surveillance in pediatrics recommended by the Robert Koch Institute, Berlin.</p>","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":"9 ","pages":"Doc06"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39764061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare-associated urinary tract infections in urology.","authors":"José Medina-Polo,&nbsp;Kurt G Naber,&nbsp;Truls E Bjerklund Johansen","doi":"10.3205/id000074","DOIUrl":"https://doi.org/10.3205/id000074","url":null,"abstract":"<p><p>The purpose of the present review is to report the incidence and characteristics of healthcare-associated urinary tract infections (HAUTIs) in urology with their microbiological and resistance patterns. Urinary tract infections are the main type of healthcare-associated infection in patients hospitalized in a urology ward. Patients admitted to urology departments report a high prevalence of urinary tract catheterization, up to 75% during the hospitalization period, and up to 20% had a urinary catheter before admission. An endourological surgical procedure is another risk factor for HAUTIs. Other risk factors for HAUTIs are the presence of immunosuppression and previous urinary tract infections. In urological patients, Enterobacterales are the principal causative agent of HAUTIs, and <i>E. coli</i> is the most frequently isolated microorganism. However, there is also a high rate of microorganisms other than <i>E. coli</i> such as <i>Klebsiella</i> spp. and <i>Enterococcus</i> spp. Non-<i>E. coli</i> microorganisms show a higher prevalence in immunosuppressed patients and those with urinary catheters before admission. High resistance patterns are reported in patients with HAUTIs, and ESBL-producing bacteria are frequently described. Moreover, the isolation of multidrug-resistant microorganisms is more common in immunosuppressed patients, those with previous urinary tract infections, and urinary catheters into the upper urinary tract. Treatment must be tailored according to patient characteristics and patient profiles, bearing in mind the ORENUC classification for risk factors (no risk factors (O), recurrent urinary tract infections risk factors (R), extraurogenital risk factors (E), nephropathic disease (N), urological risk factors (U), permanent urinary catheter and non-resolvable urological risk factors (C)).</p>","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":"9 ","pages":"Doc05"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39430097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observational study over 8-year period evaluating microbiological characteristics and risk factor for isolation of multidrug-resistant organisms (MDRO) in patients with healthcare-associated infections (HAIs) hospitalized in a urology ward.","authors":"José Medina-Polo, Javier Gil-Moradillo, Alejandro González-Díaz, Pablo Abad-López, Rocío Santos-Pérez de la Blanca, Mario Hernández-Arroyo, Helena Peña-Vallejo, Julio Téigell-Tobar, Cristina Calzas-Montalvo, Prado Caro-González, Natalia Miranda-Utrera, Ángel Tejido-Sánchez","doi":"10.3205/id000073","DOIUrl":"10.3205/id000073","url":null,"abstract":"<p><p><b>Objective:</b> To analyze, in a urology ward, the prevalence and characteristics of healthcare-associated infections (HAIs) due to multidrug-resistant organisms (MDRO). <b>Methods:</b> We carried out an observational study from 2012 to 2019, evaluating MDRO among patients with HAIs, who were hospitalized in the urology ward. MDRO include <i>Pseudomonas</i> spp., resistant to at least three antibiotic groups, extended-spectrum beta-lactamase (ESBL) producing <i>Enterobacteriaceae</i> or those resistant to carbapenems, and <i>Enterococcus</i> spp. resistant to vancomycin. <b>Results:</b> Among patients with HAIs, MDRO were isolated in 100 out of 438 (22.8%) positive cultures. Univariate and multivariate analyses reported that prior urinary tract infection (UTI) [OR 2.45; 95% CI 1.14-5.36; p=0.021] and immunosuppression [OR 2.13; 95% CI 1.11-4.10; p=0.023] were risk factors for MDRO. A high prevalence of MRDO was found in patients with a catheter in the upper urinary tract; 27.6% for double J stent, 29.6% in those with a nephrostomy tube, and 50% in those with a percutaneous internal/external nephroureteral (PCNU) stent. MDRO were isolated in 28.4% of cultures with <i>Enterobacteriaceae</i> (23.8% and 44.7% in those with <i>E. coli</i> and <i>Klebsiella</i> spp.); 7% of <i>Enterobacteriaceae</i> showed resistance to carbapenems (1.3% and 10% for <i>E. coli</i> and <i>Klebsiella</i> spp., respectively). Three out of 80 <i>Enterococcus</i> spp. were vancomycin-resistant. The rate of <i>Pseudomonas aeruginosa</i> resistant to at least three antibiotic groups was 36.3%. <b>Conclusions:</b> The isolation of MDRO, in up to 25% of positive cultures in a urology ward, constitutes a challenge for the selection of antibiotics. MDRO are more common in immunosuppressed patients, those with previous UTIs, and those with a catheter in the upper urinary tract.</p>","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":"9 ","pages":"Doc04"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39430096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent uncomplicated urinary tract infections: definitions and risk factors.","authors":"Tommaso Cai","doi":"10.3205/id000072","DOIUrl":"https://doi.org/10.3205/id000072","url":null,"abstract":"<p><p><b>Introduction:</b> Recurrent uncomplicated urinary tract infections (UTI) have a high impact on patients' quality of life and high direct and indirect costs for public health. Therefore, optimal management should be of high priority. <b>Methods:</b> Current international guidelines were reviewed, and a systematic literature search was performed in Medline, Cochrane, and Embase. <b>Results:</b> Several risks factors have been identified and used in everyday clinical practice to plan the correct strategy for recurrence prevention. Among all factors, the most important are: sexual intercourse, spermicide use, having a new sex partner, having a mother with a history of UTI, having had UTI during childhood, and asymptomatic bacteriuria treatment. Moreover, other risk factors such as reduced fluid intake, habitual and post-coital delayed urination, wiping from back to front after defecation, douching and wearing occlusive underwear, as well as irregular bowel function should be taken into account. <b>Conclusions:</b> Recurrent UTI show a high impact on clinical practice. Risk factors are generally related to both virulence of pathogens and patient's behavior or condition. A recently developed nomogram can assist in identifying women at high risk of symptomatic recurrence that can be suitable candidates for a prophylactic strategy.</p>","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":"9 ","pages":"Doc03"},"PeriodicalIF":0.0,"publicationDate":"2021-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39082604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylaxis and treatment of influenza: options, antiviral susceptibility, and existing recommendations.","authors":"Susanne C Duwe,&nbsp;Barbara Schmidt,&nbsp;Barbara C Gärtner,&nbsp;Jörg Timm,&nbsp;Ortwin Adams,&nbsp;Helmut Fickenscher,&nbsp;Michaela Schmidtke","doi":"10.3205/id000071","DOIUrl":"https://doi.org/10.3205/id000071","url":null,"abstract":"<p><p>Influenza viruses of types A and B attack 5-10% of adults and 20-30% of children, thereby causing millions of acute respiratory infections in Germany annually. A significant number of these infections are associated with complications such as pneumonia and bacterial superinfections that need hospitalization and might lead to death. In addition to vaccines, drugs were developed that might support influenza prevention and that can be used to treat influenza patients. The timely application of anti-influenza drugs can inhibit virus replication, help reduce and shorten the symptoms, and prevent death as well as virus transmission. This review concisely describes the mechanism of action, the potential for prophylactic and therapeutic use, and the knowledge on resistance of anti-influenza drugs approved today. However, the main aim is to give an overview on the recommendations available in Germany for the proper use of these drugs. In doing so, the recommendations published in statements and guidelines of medical societies as well as the German influenza pandemic preparedness plan are summarized with the consideration of specific circumstances and groups of patients.</p>","PeriodicalId":91688,"journal":{"name":"GMS infectious diseases","volume":"9 ","pages":"Doc02"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39082603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}