Bone Abstracts最新文献

{"title":"The role of the RACK1-c-Src axis in regulation of osteoclast function","authors":"J. H. Park, Eutteum Jeong, Soo Young Lee","doi":"10.1530/boneabs.7.p24","DOIUrl":"https://doi.org/10.1530/boneabs.7.p24","url":null,"abstract":"","PeriodicalId":9160,"journal":{"name":"Bone Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74134368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-criteria decision analysis of the value of burosumab for the treatment of paediatric patients with X-linked hypophosphatemia in Portugal","authors":"Inês Alves, T. Francisco, H. Pinto, Sérgio Sousa, P. Connor, M. Amorim, Diogo Ramos, S. Azevedo, B. Vandewalle","doi":"10.1530/boneabs.7.p144","DOIUrl":"https://doi.org/10.1530/boneabs.7.p144","url":null,"abstract":"","PeriodicalId":9160,"journal":{"name":"Bone Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74296737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A playful type of intervention for infants with osteogenesis imperfecta","authors":"Rebecca Jones, D. Ford, C. Marr, A. Seasman, Claire Pickett, Metabolic Bone Team","doi":"10.1530/boneabs.7.p197","DOIUrl":"https://doi.org/10.1530/boneabs.7.p197","url":null,"abstract":"","PeriodicalId":9160,"journal":{"name":"Bone Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74319675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiographic evidence of zoledronic acid given during pregnancy - a case report","authors":"A. Peacock, A. Offiah, M. Balasubramanian, N. Bishop, P. Arundel","doi":"10.1530/boneabs.7.p10","DOIUrl":"https://doi.org/10.1530/boneabs.7.p10","url":null,"abstract":"","PeriodicalId":9160,"journal":{"name":"Bone Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73004941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FGF23-expressing osteocytes are confined to bone packets that completed primary mineralization in patients with chronic kidney disease on dialysis (CKD5D)","authors":"N. Fratzl-Zelman, R. Pereira, P. Roschger, I. Salusky, K. Klaushofer, K. Wesseling-Perry","doi":"10.1530/boneabs.7.p60","DOIUrl":"https://doi.org/10.1530/boneabs.7.p60","url":null,"abstract":"","PeriodicalId":9160,"journal":{"name":"Bone Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73589843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early life vitamin D depletion and mechanical loading determine methylation changes in the RXRA, Runx2 and osterix promoters in mice","authors":"Stephanie A Borg, N. Krstić, Harriet Buckley, E. Curtis, C. Cooper, K. Lillycrop, N. Harvey, T. Skerry, N. Bishop","doi":"10.1530/boneabs.7.oc4","DOIUrl":"https://doi.org/10.1530/boneabs.7.oc4","url":null,"abstract":"","PeriodicalId":9160,"journal":{"name":"Bone Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75394386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot-assisted exercises in children with cerebral palsy - a case study","authors":"A. Mikov, Dragana Vukliš, B. Borovac, M. Gnjatović, Jovica Tasevski, R. Krasnik","doi":"10.1530/boneabs.7.p206","DOIUrl":"https://doi.org/10.1530/boneabs.7.p206","url":null,"abstract":"","PeriodicalId":9160,"journal":{"name":"Bone Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74055814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D dependent rickets type 1 caused by CYP27B1 mutation","authors":"C. Kim","doi":"10.1530/boneabs.7.p111","DOIUrl":"https://doi.org/10.1530/boneabs.7.p111","url":null,"abstract":"","PeriodicalId":9160,"journal":{"name":"Bone Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78731697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum alkaline phosphatase with radiological rickets severity in children with X-linked hypophosphataemia on conventional therapy","authors":"S. Uday, N. Shaw, Z. Mughal, T. Randell, W. Högler, Rui Santos, R. Padidela","doi":"10.1530/boneabs.7.p97","DOIUrl":"https://doi.org/10.1530/boneabs.7.p97","url":null,"abstract":"","PeriodicalId":9160,"journal":{"name":"Bone Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75056235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference values of cortical thickness, bone width, and Bone Health Index in metacarpals of children from age 0 y, as determined with an extension of the fully automated BoneXpert bone age method","authors":"H. H. Thodberg, P. Thrane, David D Martin","doi":"10.1530/boneabs.7.p11","DOIUrl":"https://doi.org/10.1530/boneabs.7.p11","url":null,"abstract":"Introduction The BoneXpert method for automated bone age was introduced in 2009, covering the Greulich-Pyle bone age (BA GP) down to 2.5 years for boys and 2.0 years for girls. The method was recently extended down to newborns. BoneXpert also performs digital radiogrammetry of the cortical thickness (T), the bone width (W) and length (L) in metacarpals 2-4. From these, the method derives the cortical area: A = π·W·T (1 – T/W), the metacarpal index MCI = A / W2, and the Bone Health Index (BHI) BHI = A / (W1/3·L1/3). The aim of this study is to report reference curves for bone measurements for children starting at BA GP 0.08 years. Methods 410 healthy children born in Paris in 1955 were followed with hand X-rays at ages 1, 3, 6, 9, 12 and 18 months, and then annually until age 20 years. Reference curves were de ned versus BA GP determined automatically with BoneXpert, averaging over radius, ulna and 19 short bones. Results For males, T drops from 0.74 mm at BA GP 0.08 y to a minimum of 0.58 mm at BA GP 1 y, a reduction of 22%. Results (continued) In the same period, W increases by 38% from 3.2 to 4.4 mm, and A grows by 19%. Metacarpal length (L) increases 43% from 16.4 to 24 mm. MCI drops from 0.55 to 0.37 (33%) and BHI from 4.8 to 3.4 (29%). Females display a similar development, but their cortical thickness assumes its minimum already at BA GP 0.9 y. Discussion In the rst year of life, infants exhibit a dramatic recon guration of bone geometry: Bone width and length increase strongly and cortical thickness decreases by 21%. MCI and BHI decrease in this period. Further studies are needed to investigate if this decrease in cortical thickness is related to the observed increase in fracture-risk in children at age 1.0 years compared to newborns (Hedström 2010). This new method could be an alternative to DXA in infants because: 1) It is easier to record a hand X-ray 2) The new reference curves provide Z-scores 3) The reference curves are expressed versus bone age rather than chronological age. References Thodberg et al., A paediatric bone index derived by automated radiogrammetry. Osteoporos Int. 2010 Aug; 21(8): 1391–1400 Hedström et al., Epidemiology of fractures in children and adolescents. Acta Orthop. 2010 Feb;81(1):148-53","PeriodicalId":9160,"journal":{"name":"Bone Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85054326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}