Journal of kidney最新文献

筛选

英文中文

Cold Storage Exacerbates Renal and Mitochondrial Dysfunction Following Transplantation. 冷藏加重移植后肾脏和线粒体功能障碍。

Journal of kidney Pub Date : 2016-02-01 Epub Date: 2016-02-27

S Shrum, L A MacMillan-Crow, N Parajuli

引用次数: 0

Discovering Biomarkers within the Genomic Landscape of Renal Cell Carcinoma. 发现肾细胞癌基因组景观中的生物标志物。

Journal of kidney Pub Date : 2016-02-01 Epub Date: 2016-02-25 DOI: 10.4172/jok.1000115

Sankin A

引用次数: 0

Renal Mitochondrial Lipid Peroxidation during Sepsis. 脓毒症期间肾脏线粒体脂质过氧化。

Journal of kidney Pub Date : 2016-02-01 Epub Date: 2016-02-29 DOI: 10.4172/jok.1000116

P Singh, N Parajuli, P R Mayeux, L A MacMillan-Crow

{"title":"Renal Mitochondrial Lipid Peroxidation during Sepsis.","authors":"P Singh, N Parajuli, P R Mayeux, L A MacMillan-Crow","doi":"10.4172/jok.1000116","DOIUrl":"https://doi.org/10.4172/jok.1000116","url":null,"abstract":"<p><p>Sepsis can provoke kidney injury, which increases mortality. Human and animal studies have documented increased renal oxidative injury and mitochondrial damage during sepsis. However, few studies have attempted to dissect specific renal targets and/or types of oxidative injury using the cecal ligation and puncture (CLP) murine model of sepsis. The purpose of this short communication is to examine the extent of lipid peroxidation within renal mitochondria using CLP and blue native gel electrophoresis which separates intact mitochondrial respiratory complexes. Our results show that CLP induced increased 4-hydroxy-nonenal protein adduction (marker of lipid peroxidation) in renal homogenates and mitochondrial fractions. Blue native gel electrophoresis revealed that respiratory complex III was selectively targeted within mitochondrial fractions. This supports our prior report showing renal complex III inactivation following CLP. Future studies will identify specific renal proteins within complex III that are modified during sepsis to provide mechanistic insight on how mitochondrial respiration is inhibited during sepsis.</p>","PeriodicalId":91549,"journal":{"name":"Journal of kidney","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34336642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3