冷藏加重移植后肾脏和线粒体功能障碍。

Journal of kidney Pub Date : 2016-02-01 Epub Date: 2016-02-27
S Shrum, L A MacMillan-Crow, N Parajuli
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引用次数: 0

摘要

接受已故供体肾脏的患者在移植前需要冷藏,长期肾功能受损。众所周知,长期冷藏会导致肾脏损伤,包括我们自己的实验室在内的几个实验室已经证明了单独冷藏后肾脏线粒体损伤。然而,据我们所知,很少有研究评估短期(4小时)冷藏大鼠肾脏移植后与不冷藏移植(自体移植)相比的肾脏和线粒体功能。我们的数据显示,与单独的自体移植相比,冷藏加移植加重了肾脏和线粒体功能障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cold Storage Exacerbates Renal and Mitochondrial Dysfunction Following Transplantation.

Cold Storage Exacerbates Renal and Mitochondrial Dysfunction Following Transplantation.

Cold Storage Exacerbates Renal and Mitochondrial Dysfunction Following Transplantation.

Long-term renal function is compromised in patients receiving deceased donor kidneys which require cold storage exposure prior to transplantation. It is well established that extended cold storage induces renal damage and several labs, including our own, have demonstrated renal mitochondrial damage after cold storage alone. However, to our knowledge, few studies have assessed renal and mitochondrial function after transplantation of rat kidneys exposed to short-term (4 hr) cold storage compared to transplant without cold storage (autotransplantation). Our data reveal that cold storage plus transplantation exacerbated renal and mitochondrial dysfunction when compared to autotransplantation alone.

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