International journal of psychoanalytic self psychology最新文献

Chloride channel blocker IAA-94 increases myocardial infarction by reducing calcium retention capacity of the cardiac mitochondria. 氯化物通道阻滞剂IAA-94通过降低心脏线粒体的钙潴留能力来增加心肌梗塞。

International journal of psychoanalytic self psychology Pub Date : 2019-10-15 Epub Date: 2019-09-05 DOI: 10.1016/j.lfs.2019.116841

Devasena Ponnalagu, Ahmed Tafsirul Hussain, Rushi Thanawala, Jahnavi Meka, Piotr Bednarczyk, Yansheng Feng, Adam Szewczyk, Shubha GururajaRao, Jean C Bopassa, Mahmood Khan, Harpreet Singh

{"title":"Chloride channel blocker IAA-94 increases myocardial infarction by reducing calcium retention capacity of the cardiac mitochondria.","authors":"Devasena Ponnalagu, Ahmed Tafsirul Hussain, Rushi Thanawala, Jahnavi Meka, Piotr Bednarczyk, Yansheng Feng, Adam Szewczyk, Shubha GururajaRao, Jean C Bopassa, Mahmood Khan, Harpreet Singh","doi":"10.1016/j.lfs.2019.116841","DOIUrl":"10.1016/j.lfs.2019.116841","url":null,"abstract":"<p><p>Indanyloxyacetic acid-94 (IAA-94), an intracellular chloride channel blocker, is shown to ablate cardioprotection rendered by ischemic preconditioning (IPC), N (6)-2-(4-aminophenyl) ethyladenosine or the PKC activator phorbol 12-myristate 13-acetate and cyclosporin A (CsA) in both ex-vivo and in-vivo ischemia-reperfusion (IR) injury. Thus signifying the role of the IAA-94 sensitive chloride channels in mediating cardio-protection upon IR injury. Although IAA-94 sensitive chloride currents are recorded in cardiac mitoplast, there is still a lack of understanding of the mechanism by which IAA-94 increases myocardial infarction (MI) by IR injury. Mitochondria are the key arbitrators of cell life and death pathways. Both oxidative stress and calcium overload in the mitochondria, elicit pathways resulting in the opening of mitochondrial permeability transition pore (mPTP) leading to cell death. Therefore, in this study we explored the role of IAA-94 in MI and in maintaining calcium retention capacity (CRC) of cardiac mitochondria after IR. IAA-94 inhibited the CRC of the isolated cardiac mitochondria in a concentration-dependent manner as measured spectrofluorimetrically using calcium green-5 N. Interestingly, IAA-94 did not change the mitochondrial membrane potential. Further, CsA a blocker of mPTP opening could not override the effect of IAA-94. We also showed for the first time that IAA-94 perfusion after ischemic event augments MI by reducing the CRC of mitochondria. To conclude, our results demonstrate that the mechanism of IAA-94 mediated cardio-deleterious effects is via modulating the mitochondria CRC, thereby playing a role in mPTP opening. These findings highlight new pharmacological targets, which can mediate cardioprotection from IR injury.</p>","PeriodicalId":91515,"journal":{"name":"International journal of psychoanalytic self psychology","volume":"10 1","pages":"116841"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82042659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial Board Page EOV 编委会页EOV

International journal of psychoanalytic self psychology Pub Date : 2016-10-01 DOI: 10.1080/15551024.2016.1224662

引用次数: 0

From Self-Protection to Relational Protectiveness: The Modification of Defensive Structures 从自我保护到关系保护:防卫结构的修正

International journal of psychoanalytic self psychology Pub Date : 2016-09-02 DOI: 10.1080/15551024.2016.1213102

R. Geist

引用次数: 5

From Theory to Clinical Practice: Psychoanalytic Complexity Theory and the Lived Experience of Complexity 从理论到临床实践:精神分析复杂性理论与复杂性的生活经验

International journal of psychoanalytic self psychology Pub Date : 2016-09-02 DOI: 10.1080/15551024.2016.1213096

Margy Sperry

引用次数: 4

Thinking About Change: Discussion of Margy Sperry’s “From Theory to Clinical Practice: Psychoanalytic Complexity Theory and the Lived Experience of Complexity” 思考变化——论玛吉·斯佩里的《从理论到临床实践:精神分析复杂性理论与复杂性的生活体验》

International journal of psychoanalytic self psychology Pub Date : 2016-09-02 DOI: 10.1080/15551024.2016.1213099

Carol O. Mayhew

引用次数: 1

Racializing Kohut’s “Guilty Man” and “Tragic Man”: Serious Play in the Service of Inclusiveness 科胡特“有罪的人”和“悲剧的人”的种族化:为包容性服务的严肃游戏

International journal of psychoanalytic self psychology Pub Date : 2016-09-02 DOI: 10.1080/15551024.2016.1213093

L. Jacobs

引用次数: 0

The Self as a Process of Transformation 自我是一个转变的过程

International journal of psychoanalytic self psychology Pub Date : 2016-09-02 DOI: 10.1080/15551024.2016.1213103

S. Gerzi

引用次数: 0

The End of Comparative Psychoanalysis? Blurring the Boundaries Between Contemporary Theories 比较精神分析的终结?模糊当代理论之间的界限

International journal of psychoanalytic self psychology Pub Date : 2016-09-02 DOI: 10.1080/15551024.2016.1213091

J. G. Teicholz

引用次数: 6

A Novelist’s Sensibility in Chris Jaenicke’s The Search for a Relational Home: An Intersubjective View of Therapeutic Action 在克里斯·杰尼克的《寻找关系的家:治疗行为的主体间观》一书中，小说家的感性

International journal of psychoanalytic self psychology Pub Date : 2016-09-02 DOI: 10.1080/15551024.2016.1213104

Joye Weisel-Barth

{"title":"A Novelist’s Sensibility in Chris Jaenicke’s The Search for a Relational Home: An Intersubjective View of Therapeutic Action","authors":"Joye Weisel-Barth","doi":"10.1080/15551024.2016.1213104","DOIUrl":"https://doi.org/10.1080/15551024.2016.1213104","url":null,"abstract":"T he relational shift in psychoanalysis has given us wonderful and strange new ideas about the intersubjective processes that advance the development of mind and emotional balance in analysis. In accretion, these ideas imagine the relational processes by which we become most human. Identifying and exploring the complex functioning of empathy, mentalization, emotional resonance, and enactments in the therapeutic encounter have also stimulated new clinical strategies. Yes, these ideas have captivated the world of contemporary psychoanalysis. But—and here’s the big “but”—illustrating relational ideas in all their interactional nuances has been problematic. So often, after reading a fascinating theoretical offering, I have been disappointed with the accompanying clinical examples. They often seem to fall back on familiar one-person presentations, skimping on the analyst’s interactional contributions and failing to capture the nuts-and-bolts processes that create unpredictable and ineffable meetings of subjectivities. It is almost as though one needs a novelist’s sensibility, specificity, and skill to express adequately the complex intersubjective experience. Enter Chris Jaenicke in his newest book The Search for a Relational Home: An Intersubjective View of Therapeutic Action (2015). Jaenicke, an adherent of intersubjectivity systems theory, practices and writes in Berlin and writes, I will add, with a","PeriodicalId":91515,"journal":{"name":"International journal of psychoanalytic self psychology","volume":"11 1","pages":"398 - 402"},"PeriodicalIF":0.0,"publicationDate":"2016-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15551024.2016.1213104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60012661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opening Our Tent Flaps to Broaden the Reach of Psychoanalysis? Some Musings on Relational Psychoanalysis and Psychotherapy Integration: An Evolving Synergy, Edited by Jill Bresler and Karen Starr 打开我们的帐篷，拓宽精神分析的范围?关于关系精神分析和心理治疗整合的一些思考:一种不断发展的协同作用，由吉尔·布雷斯勒和卡伦·斯塔尔编辑

International journal of psychoanalytic self psychology Pub Date : 2016-07-02 DOI: 10.1080/15551024.2016.1178053

J. G. Teicholz

引用次数: 0