Bosnian journal of basic medical sciences最新文献_第8页

Skeletal muscle and fiber type-specific intramyocellular lipid accumulation in obese mice. 肥胖小鼠骨骼肌和纤维类型特异性细胞内脂质积累。

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2021-12-01 DOI: 10.17305/bjbms.2021.5876

Nejc Umek, Simon Horvat, Erika Cvetko

{"title":"Skeletal muscle and fiber type-specific intramyocellular lipid accumulation in obese mice.","authors":"Nejc Umek, Simon Horvat, Erika Cvetko","doi":"10.17305/bjbms.2021.5876","DOIUrl":"https://doi.org/10.17305/bjbms.2021.5876","url":null,"abstract":"In obesity, accumulation of lipid droplets in skeletal muscle fibers and a shift towards fast muscle fiber types can both contribute to insulin resistance. However, it is not yet clear how intramyocellular lipid accumulation and fiber type changes are associated. Therefore, we investigated to what extent the lipids accumulated in a fiber type-specific manner in the functionally similar fast-, intermediate- and slow-twitch gastrocnemius, plantaris, and soleus muscles, respectively, in high-fat diet-induced obese 54-week-old female C57BL/6JOlaHsd mice (n = 9) compared to control standard-diet-treated lean mice (n = 9). A high-fat diet was administered for 26 weeks. Fiber-type specific intramyocellular lipid content analysis and muscle fiber typing were performed using histochemical analysis of lipids with Sudan Black and immunohistochemical analysis of myosin heavy chains on serial sections of skeletal muscles. Compared to the lean mice, the lipid accumulation was most prominent in types 2a and 2x/d fibers (p < 0.05) of fast-twitch gastrocnemius and intermediate plantaris muscles in the obese mice, while in slow-twitch soleus muscle, there was no significant lipid accumulation in the obese animals. Furthermore, the slow-twitch soleus muscle of the obese mice with no significant change in muscle fiber diameters exhibited the most pronounced shift towards fast-type myosin heavy chain isoform expression (p < 0.05). In contrast, the fast-twitch and intermediate-twitch gastrocnemius and plantaris muscles, respectively, in which the muscle fiber diameters increased (p < 0.05), were more resistant toward myosin heavy chain expression changes. In conclusion, we demonstrated both muscle- and fiber-type specificity in intramyocellular lipid accumulation in obese mice, suggesting that in obesity, similar muscle fiber types in different muscles accumulate lipids differentially.","PeriodicalId":9147,"journal":{"name":"Bosnian journal of basic medical sciences","volume":"21 6","pages":"730-738"},"PeriodicalIF":3.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38989774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

How are central foveal and choroidal thickness affected in patients with mild COVID-19 infection? 轻度COVID-19感染患者的中央中央凹和脉络膜厚度如何受到影响?

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2021-12-01 DOI: 10.17305/bjbms.2021.5840

Müge Fırat, Sabiha Kobat

{"title":"How are central foveal and choroidal thickness affected in patients with mild COVID-19 infection?","authors":"Müge Fırat, Sabiha Kobat","doi":"10.17305/bjbms.2021.5840","DOIUrl":"10.17305/bjbms.2021.5840","url":null,"abstract":"The aim of this study was to evaluate the effects of COVID-19 on central foveal and choroidal thicknesses. Thirty-two patients with a positive SARS-CoV-2 PCR test who received outpatient treatment within the previous two months and 32 healthy controls were included in the study. Patients requiring hospitalization due to COVID-19 as well as the patients who received either intensive care support and/or antiplatelet therapy, smokers, or patients with systemic or ocular diseases were excluded from the study. After full ophthalmological examination, central foveal and choroidal thicknesses were evaluated by using optical coherence tomography. Statistical analysis of the study data demonstrated no significant difference between the groups in terms of age or gender (p>0.05). There was also no statistically significant difference between the groups in terms of central foveal thickness, central choroidal thickness, or nasal 500, nasal 1500, temporal 500, or temporal 500-micron distances (p>0.05 for all parameters). Choroidal and retinal thicknesses were not affected in patients with recent mild COVID 19 without comorbidities.","PeriodicalId":9147,"journal":{"name":"Bosnian journal of basic medical sciences","volume":"21 6","pages":"782-786"},"PeriodicalIF":3.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39115339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Integrated profiling identifies ITGB3BP as prognostic biomarker for hepatocellular carcinoma. 综合分析确定ITGB3BP作为肝细胞癌的预后生物标志物。

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2021-12-01 DOI: 10.17305/bjbms.2021.5690

Qiuli Liang, Chao Tan, Feifei Xiao, Fuqiang Yin, Meiliang Liu, Lei Lei, Liuyu Wu, Yu Yang, Hui Juan Jennifer Tan, Shun Liu, Xiaoyun Zeng

{"title":"Integrated profiling identifies ITGB3BP as prognostic biomarker for hepatocellular carcinoma.","authors":"Qiuli Liang, Chao Tan, Feifei Xiao, Fuqiang Yin, Meiliang Liu, Lei Lei, Liuyu Wu, Yu Yang, Hui Juan Jennifer Tan, Shun Liu, Xiaoyun Zeng","doi":"10.17305/bjbms.2021.5690","DOIUrl":"https://doi.org/10.17305/bjbms.2021.5690","url":null,"abstract":"Hepatocellular carcinoma (HCC) is a highly malignant tumor. In this study, we sought to identify a novel biomarker for HCC by analyzing transcriptome and clinical data. The R software was used to analyze the differentially expressed genes (DEGs) in the datasets GSE74656 and GSE84598 downloaded from the Gene Expression Omnibus database, followed by a functional annotation. A total of 138 shared DEGs were screened from two datasets. They were mainly enriched in the \"Metabolic pathways\" pathway (Padj = 8.21E-08) and involved in the carboxylic acid metabolic process (Padj = 0.0004). The top 10 hub genes were found by protein-protein interaction analysis and were upregulated in HCC tissues compared to normal tissues in The Cancer Genome Atlas database. Survival analysis distinguished 8 hub genes CENPE, SPDL1, Hyaluronan-mediated motility receptor, Rac GTPase activating protein 1, Thyroid hormone receptor interactor 13, cytoskeleton-associated protein (CKAP) 2, CKAP5, and Integrin subunit beta 3 binding protein (ITGB3BP) were considered as prognostic hub genes. Multivariate cox regression analysis indicated that all the prognostic hub genes were independent prognostic factors for HCC. Furthermore, the receiver operating characteristic curve revealed that the 8-hub genes model had better prediction performance for overall survival compared to the T stage (p = 0.008) and significantly improved the prediction value of the T stage (p = 0.002). The Human Protein Atlas showed that the protein expression of ITGB3BP was upregulated in HCC, so the expression of ITGB3BP was further verified in our cohort. The results showed that ITGB3BP was upregulated in HCC tissues and was significantly associated with lymph node metastasis.","PeriodicalId":9147,"journal":{"name":"Bosnian journal of basic medical sciences","volume":"21 6","pages":"712-723"},"PeriodicalIF":3.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38900835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Clinicopathological characteristics and survival in lung signet ring cell carcinoma: a population-based study. 肺印戒细胞癌的临床病理特征和生存率:一项基于人群的研究。

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2021-12-01 DOI: 10.17305/bjbms.2020.5454

Yunting Cai, Yan Xie, Yanli Xiong, Wei Guan, Yu Pu, Dong Wang, Mingfang Xu, Shenglan Meng

{"title":"Clinicopathological characteristics and survival in lung signet ring cell carcinoma: a population-based study.","authors":"Yunting Cai, Yan Xie, Yanli Xiong, Wei Guan, Yu Pu, Dong Wang, Mingfang Xu, Shenglan Meng","doi":"10.17305/bjbms.2020.5454","DOIUrl":"https://doi.org/10.17305/bjbms.2020.5454","url":null,"abstract":"Lung signet-ring cell carcinoma (LSRCC) is a very rare type of lung cancer, the clinical characteristics, and prognosis of which remain to be clarified. In order to explore the clinicopathological and survival-related factors associated with LSRCC, we performed a large population-based cohort analysis of data included in the Surveillance, Epidemiology, and End Results (SEER) registry from 2001 to 2015. A total of 752 LSRCC and 7518 lung mucinous adenocarcinoma (LMAC) patients were incorporated into our analysis, with respective mean ages of 63.8 and 67.5 years at the time of diagnosis. LSRCC patients were significantly more likely than LMAC patients to have distant-stage disease (72.1% vs. 45.8%, p < 0.0001), tumors of a high pathological grade (40.6% vs. 10.8%, p < 0.0001), have undergone chemotherapy (62.1% vs. 39.9%, p<0.0001), be male (52.7% vs. 48.5%, p = 0.03), and be < 40 years old (3.3% vs. 1.3%, p = 0.022), whereas they were less likely to have undergone surgical treatment (52.4% vs. 77.0%, p < 0.0001). LSRCC and LMAC patients exhibited median overall survival (OS) duration of 8 and 18 months (p < 0.0001), respectively, although these differences were not significant after adjusting for confounding variables. Independent factors associated with a favorable patient prognosis included a primary site in the middle or lower lung lobe, underwent surgery, and underwent chemotherapy. However, age ≥80 years, higher grade, distant summary stage disease, and T4 stage disease were linked to poor prognosis. Patient age, tumor grade, primary tumor site, summary stage, T stage, surgery, and chemotherapy were all significantly associated with LSRCC patient prognosis.","PeriodicalId":9147,"journal":{"name":"Bosnian journal of basic medical sciences","volume":"21 6","pages":"752-759"},"PeriodicalIF":3.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25375991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Construction and verification of prognostic nomogram for early-onset esophageal cancer. 早发性食管癌预后图的构建与验证。

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2021-12-01 DOI: 10.17305/bjbms.2021.5533

Xiaoxiao Liu, Wei Guo, Xiaobo Shi, Yue Ke, Yuxing Li, Shupei Pan, Yingying Jin, Yuchen Wang, Qinli Ruan, Hongbing Ma

{"title":"Construction and verification of prognostic nomogram for early-onset esophageal cancer.","authors":"Xiaoxiao Liu, Wei Guo, Xiaobo Shi, Yue Ke, Yuxing Li, Shupei Pan, Yingying Jin, Yuchen Wang, Qinli Ruan, Hongbing Ma","doi":"10.17305/bjbms.2021.5533","DOIUrl":"https://doi.org/10.17305/bjbms.2021.5533","url":null,"abstract":"This study aimed to build up nomogram models to evaluate overall survival (OS) and cancer-specific survival (CSS) in early-onset esophageal cancer (EOEC). Patients diagnosed with esophageal cancer (EC) from 2004 to 2015 were extracted from the Surveillance Epidemiology and End Results (SEER) database. Clinicopathological characteristics of younger versus older patients were compared, and survival analysis was performed in both groups. Independent related factors influencing the prognosis of EOEC were identified by univariate and multivariate Cox analysis, which were incorporated to construct a nomogram. The predictive capability of the nomogram was estimated by the concordance index (C-index), calibration plot, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA). A total of 534 younger and 17,243 older patients were available from the SEER database. Younger patients were randomly segmented into a training set (n = 266) and a validation set (n = 268). In terms of the training set, the C-index of the OS nomogram was 0.740 (95% CI: 0.707-0.773), and that of the CSS nomogram was 0.752 (95% CI: 0.719-0.785). In view of the validation set, the C-index of OS and CSS were 0.706 (95% CI: 0.671-0.741) and 0.723 (95% CI: 0.690-0.756), respectively. Calibration curves demonstrated the consistent degree of fit between actual and predicted values in nomogram models. From the perspective of DCA, the nomogram models were more beneficial than the tumor-node-metastasis (TNM) and the SEER stage for EOEC. In brief, the nomogram model can be considered as an individualized quantitative tool to predict the prognosis of EOEC patients to assist clinicians in making treatment decisions.","PeriodicalId":9147,"journal":{"name":"Bosnian journal of basic medical sciences","volume":"21 6","pages":"760-772"},"PeriodicalIF":3.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25564254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Efficacy of chemotherapeutics in classic and non-classic Kaposi sarcoma: A single-center retrospective real-world data. 经典和非经典卡波西肉瘤的化疗疗效:单中心回顾性真实世界数据。

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2021-12-01 DOI: 10.17305/bjbms.2020.5329

Sibel Oyucu Orhan, Ahmet Bilgehan Sahin, Erdem Cubukcu, Adem Deligonul, Birol Ocak, Bedrettin Orhan, Turkkan Evrensel

{"title":"Efficacy of chemotherapeutics in classic and non-classic Kaposi sarcoma: A single-center retrospective real-world data.","authors":"Sibel Oyucu Orhan, Ahmet Bilgehan Sahin, Erdem Cubukcu, Adem Deligonul, Birol Ocak, Bedrettin Orhan, Turkkan Evrensel","doi":"10.17305/bjbms.2020.5329","DOIUrl":"https://doi.org/10.17305/bjbms.2020.5329","url":null,"abstract":"Kaposi sarcoma is a rare disease and there is a gap in the literature about which chemotherapeutics should be applied, especially for the classical type. We aimed to present our institutional data on the demographic characteristics, treatment, and treatment efficacy in 16 Kaposi sarcoma (KS) patients treated with chemotherapy. We retrospectively analyzed the demographic and clinical characteristics, and the chemotherapeutic agents administered to the 16 KS patients diagnosed in our center and treated with chemotherapy, based on the medical records obtained. The median age, gender, type of KS, site of involvement, cytotoxic agents administered, progression-free survival (PFS), overall survival (OS), objective response rate (ORR), disease control rate (DCR), and safety profiles of the patients were evaluated. The median age at disease onset was 61.07 years (range, 39.4-85.8 years). Among the patients, 1 had immunosuppression-related KS, 4 had AIDS-related KS, and 11 had classical KS. In the first-line cytotoxic therapy, 7 patients received pegylated-liposomal doxorubicin (PLD), 6 patients received paclitaxel, 2 patients received oral etoposide, and 1 patient received the adriamycin, bleomycin, and vincristine regimen. In the Kaplan-Meier analysis, the PFS was 39.9 months (95% CI, 7.7-72.0). In the first-line setting, a significant difference in terms of PFS was observed between the PLD- and paclitaxel-treated groups (not reached vs. 12.8 months, p = 0.033). The OS was 66.1 months (95% CI, 30.2-102.0). The ORR of the 16 patients was 43.8%, and their DCR was 81.3%. No grade 3 or 4 toxicity was observed. This retrospective study showed that PLD seems better than paclitaxel in terms of PFS and response rates and it has shown to have a good safety profile in KS patients.","PeriodicalId":9147,"journal":{"name":"Bosnian journal of basic medical sciences","volume":"21 6","pages":"746-751"},"PeriodicalIF":3.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25375993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Reply to the letter regarding "Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis". 回复关于“慢性机械性刺激与口腔鳞状细胞癌:一项系统综述和荟萃分析”的信函。

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2021-12-01 DOI: 10.17305/bjbms.2021.6006

Archana A Gupta, Supriya Kheur, Saranya Varadarajan, Sameena Parveen, Harisha Dewan, Yaser Ali Alhazmi, A Thirumal Raj, Luca Testarelli, Shankargouda Patil

引用次数: 0

Letter regarding "Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis". 关于“慢性机械刺激和口腔鳞状细胞癌:系统回顾和荟萃分析”的信。

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2021-12-01 DOI: 10.17305/bjbms.2021.5939

Jian Xie, Lang Li

引用次数: 0

Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis. 慢性机械刺激与口腔鳞状细胞癌:一项系统综述和荟萃分析。

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2021-12-01 DOI: 10.17305/bjbms.2021.5577

Archana A Gupta, Supriya Kheur, Saranya Varadarajan, Sameena Parveen, Harisha Dewan, Yaser Ali Alhazmi, Thirumal A Raj, Luca Testarelli, Shankargouda Patil

{"title":"Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis.","authors":"Archana A Gupta, Supriya Kheur, Saranya Varadarajan, Sameena Parveen, Harisha Dewan, Yaser Ali Alhazmi, Thirumal A Raj, Luca Testarelli, Shankargouda Patil","doi":"10.17305/bjbms.2021.5577","DOIUrl":"https://doi.org/10.17305/bjbms.2021.5577","url":null,"abstract":"The objective of the present article was to qualitatively and quantitatively review the association between chronic mechanical irritation and oral squamous cell carcinoma (OSCC). PubMed, SCOPUS, and Web of Science databases were searched using the keyword combinations \"chronic trauma and oral squamous cell carcinoma; chronic irritation and oral squamous cell carcinoma; chronic irritation and oral cancer; and chronic trauma and oral cancer.\" Duplicates and irrelevant articles were excluded after the title and abstract screening. The full texts of the remaining articles were assessed using selection criteria. A total of 375 (PubMed-126; SCOPUS-152; WOS-97) articles were screened, and 343 duplicates and irrelevant articles were excluded from the study. Only 9 of the remaining 32 articles met the selection criteria and were included in the qualitative analysis. Buccal mucosa and tongue, being highly prone to chronic irritation through the dental prosthesis, were the common sites for OSCC. Edentulous subjects with ill-fitting dentures were at a high risk of developing chronic irritation associated-OSCC. According to the Joanna Briggs Institute of risk assessment, eight of the nine included studies had a low risk of bias. The quantitative analysis showed a significant association (p < 0.00001) between the chronic oral mucosal irritation and OSCC with an overall risk ratio of 2.56 at a confidence interval of 1.96-3.35. Chronic oral mucosa irritation has a significant association with OSCC, and the nature of association could be that of a potential co-factor (dependent risk factor) rather than an independent risk factor.","PeriodicalId":9147,"journal":{"name":"Bosnian journal of basic medical sciences","volume":"21 6","pages":"647-658"},"PeriodicalIF":3.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25564252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

The preoperative hemoglobin, albumin, lymphocyte and platelet (HALP) score is a useful predictor in patients with resectable esophageal squamous cell carcinoma. 术前血红蛋白、白蛋白、淋巴细胞和血小板（HALP）评分是可切除食管鳞状细胞癌患者的有效预测指标。

IF 3.1 4区医学

Bosnian journal of basic medical sciences Pub Date : 2021-12-01 DOI: 10.17305/bjbms.2021.5666

Ji-Feng Feng, Liang Wang, Xun Yang

{"title":"The preoperative hemoglobin, albumin, lymphocyte and platelet (HALP) score is a useful predictor in patients with resectable esophageal squamous cell carcinoma.","authors":"Ji-Feng Feng, Liang Wang, Xun Yang","doi":"10.17305/bjbms.2021.5666","DOIUrl":"10.17305/bjbms.2021.5666","url":null,"abstract":"The hemoglobin, albumin, lymphocyte and platelet (HALP) score has been confirmed as a prognostic factor in several types of cancers. The current study aimed to assess the prognostic value of preoperative HALP score, an inflammatory and nutritional based score, in predicting cancer-specific survival (CSS) in resectable patients undergoing curative resection for esophageal squamous cell carcinoma (ESCC). The clinical data of 355 consecutive patients with ESCC who underwent curative resection were retrospectively conducted and analyzed. The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value for preoperative HALP. The areas under the curve (AUC) for preoperative HALP and other variables were calculated and compared. Cox regression analyses and Kaplan-Meier methods were used to identify the factors associated with CSS. According to the ROC curve, the optimal cut-off value for preoperative HALP was 31.8. The 5-year CSS for preoperative HALP low (≤31.8) and high (>31.8) was 15.1% and 47.5%, respectively (p < 0.001). Preoperative HALP had reliable abilities to predict CSS in resectable ESCC patients in any stage or gender, according to the subgroup analysis based on the patients' cancer stage and gender. Multivariate analyses confirmed that preoperative HALP was an independent prognostic score regarding CSS in patients with resectable ESCC (p < 0.001). This study confirmed that the postoperative HALP score could be regarded as a potential independent prognostic factor for CSS in patients with resectable ESCC.","PeriodicalId":9147,"journal":{"name":"Bosnian journal of basic medical sciences","volume":"21 6","pages":"773-781"},"PeriodicalIF":3.1,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38900836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0