International journal of cancer research and molecular mechanisms最新文献

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Effect of MRP2 and MRP3 Polymorphisms on Anastrozole Glucuronidation and MRP2 and MRP3 Gene Expression in Normal Liver Samples. MRP2和MRP3基因多态性对正常肝脏阿那曲唑葡萄糖醛酸化及MRP2和MRP3基因表达的影响

International journal of cancer research and molecular mechanisms Pub Date : 2015-09-22 DOI: 10.16966/2381-3318.112

V. Edavana, R. Penney, A. Yao-Borengasser, Athena Starlard-Davenport, I. Dhakal, Susan A Kadlubar

{"title":"Effect of MRP2 and MRP3 Polymorphisms on Anastrozole Glucuronidation and MRP2 and MRP3 Gene Expression in Normal Liver Samples.","authors":"V. Edavana, R. Penney, A. Yao-Borengasser, Athena Starlard-Davenport, I. Dhakal, Susan A Kadlubar","doi":"10.16966/2381-3318.112","DOIUrl":"https://doi.org/10.16966/2381-3318.112","url":null,"abstract":"Anastrozole is an aromatase inhibitor (AI) used as adjuvant therapy for breast cancer. Anastrozole is subject to direct glucuronidation catalyzed by UDP-glucuronosyltransferase1A4 (UGT1A4). Interindividual variability in anastrozole glucuronidation may be affected by UGT1A4 SNPs. Interplay between drug metabolizing genes such as UGT1A4 and transporter genes may also be affected by genetic variability. Thus, we hypothesize that genetic variability in MRPs could influence anastrozole glucuronidation. The correlation between UGT1A4 and MRP2 or MRP3 transporter gene expressions and the correlation between MRP2 or MRP3 mRNA and anastrozole glucuronidation were analyzed in normal human liver samples. MRP2 and MRP3 mRNA levels were significantly correlated with UGT1A4 mRNA, with anastrozole glucuronidation and with each other (p<0.05). The data also demonstrated that MRP2 SNPs are positively correlated with MRP2 mRNA expression, while there was no association between MRP3 SNPs from this study and MRP3 expression. Significant correlations (p<0.05) between certain MRP2 SNPs (3972C>T, 2366C>T and -24C>T) and anastrozole glucuronidation were observed. There were no observed correlations between MRP3 SNPs and anastrozole glucuronidation. MRP2 polymorphisms have been identified as playing a role in the disposition of other drugs, and the data presented here indicate for the first time that MRP2 SNPs could influence anastrozole metabolism and contribute to interindividual variation in treatment responses.","PeriodicalId":91280,"journal":{"name":"International journal of cancer research and molecular mechanisms","volume":"1 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67392796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Cell Differentiation and Checkpoint 细胞分化和检查点

International journal of cancer research and molecular mechanisms Pub Date : 2015-07-02 DOI: 10.16966/2381-3318.107

S. Sancho, T. Ouchi

引用次数: 9

Treatment of Cancer 癌症的治疗

International journal of cancer research and molecular mechanisms Pub Date : 1900-01-01 DOI: 10.16966/2381-3318.150

Bojescu M

引用次数: 0

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