Clinical cancer drugs最新文献

{"title":"Meet Our Editorial Board Member","authors":"K. Sun","doi":"10.2174/2212697x0601190725112327","DOIUrl":"https://doi.org/10.2174/2212697x0601190725112327","url":null,"abstract":"","PeriodicalId":91228,"journal":{"name":"Clinical cancer drugs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/2212697x0601190725112327","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46102585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preface","authors":"G. Francia","doi":"10.2174/2212697x0601190725112228","DOIUrl":"https://doi.org/10.2174/2212697x0601190725112228","url":null,"abstract":"","PeriodicalId":91228,"journal":{"name":"Clinical cancer drugs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/2212697x0601190725112228","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47819903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coenzyme Q10 Attenuates Cisplatin-induced Nephrotoxicity Through Counteracting Oxidative Stress and Inflammation","authors":"Hala S. Bash and Ihsan S. Rabeea","doi":"10.2174/2212697X06666190701113043","DOIUrl":"https://doi.org/10.2174/2212697X06666190701113043","url":null,"abstract":"\u0000\u0000Cisplatin is an anticancer drug used in the management of solid tumors,\u0000however, dose-related nephrotoxicity is one of its major problems. Agents having antioxidants, antiinflammatory\u0000and/or antiapoptotic activities may thus represent potential therapeutic options to avoid\u0000cisplatin-induced nephrotoxicity. Among these agents, coenzyme Q10 has several pharmacological\u0000properties including antioxidant, anti-inflammatory and/or anti-apoptotic effects.\u0000\u0000\u0000\u0000 The current study aimed to examine whether coenzyme Q10 could attenuate cisplatininduced\u0000nephrotoxicity or not.\u0000\u0000\u0000\u000024 adult rats were randomly separated into three groups (8 rats per group). The first one\u0000was the control group, rats receiving vehicle (olive oil) intraperitoneally. The second group was Cisplatin\u0000treated group, rats were receiving 13 mg/kg of Cisplatin intraperitoneally as a single dose. The\u0000third group (Cisplatin + Coenzyme Q10), rats were receiving 13 mg/kg as a single intraperitoneal dose\u0000of Cisplatin and coenzyme Q10 daily for six consecutive days (10 mg/kg intraperitoneally).\u0000\u0000\u0000\u0000Cisplatin caused significant increases in serum creatinine and severe histological lesions.\u0000Cisplatin treated group also showed a significant elevation in renal malondialdehyde concentration as\u0000a marker of oxidative stress; renal tumor necrosis factor-alpha concentration as a marker of inflammation;\u0000and Kidney injury molecule -1 concentration. Coenzyme Q10 significantly attenuated cisplatininduced\u0000nephrotoxicity through lowering serum creatinine and improving nephrotoxicity histological\u0000scores. Coenzyme Q10 also significantly reduced the renal concentration of MDA, TNF-α and KIM-1\u0000relative to cisplatin treated group.\u0000\u0000\u0000\u0000Coenzyme Q10 has a potential nephroprotective effect against cisplatin-induced nephrotoxicity\u0000that was demonstrated by biochemical and histopathological analysis.\u0000","PeriodicalId":91228,"journal":{"name":"Clinical cancer drugs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/2212697X06666190701113043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45421928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Marine-based Meriolin (3-Pyrimidinylazaindole) Derivative (4ab) Targets PI3K/AKT /mTOR Pathway Inducing Cell Cycle Arrest and Apoptosis in Molt-4 Cells","authors":"G. Chashoo, Umed Singh, P. Singh, D. Mondhe, R. Vishwakarma","doi":"10.2174/2212697X06666190509094514","DOIUrl":"https://doi.org/10.2174/2212697X06666190509094514","url":null,"abstract":"\u0000\u0000Cyclin-dependent kinases play a central role in the control of cell division\u0000and therefore it is not surprising that cancer exhibits some features that disturb the normal controls\u0000over the cell cycle. Previous studies related to the development of 3-Pyrimidinylazaindole (Meriolin)\u0000derivatives as novel Cyclin dependent kinase inhibitors highlighted 4ab as the most potent inhibitor.\u0000\u0000\u0000\u0000The main objective of the current study was to understand the mode of cell death and the\u0000effect of 4ab on major cellular networking pathways in cancer.\u0000\u0000\u0000\u0000Preliminary apoptotic studies were carried out using flowcytometer and electron microscope.\u0000The effect on cellular signalling was studied via western blotting.\u0000\u0000\u0000\u00004ab was found to inhibit the enzymatic activity of CDK2. The inhibition of CDK2 activity\u0000was found to be associated with the down-regulation of P-cdc-25 and arrest of cells in G0-G1 phase of\u0000the cell cycle in lymphoblastic leukemia cells. Further, 4ab was found to affect AKT-mToR pathway\u0000by down-regulating the expression of major proteins including P-m-TOR (2448), P110α, P-AKT\u0000(S473) and P-p-70S6K.\u0000\u0000\u0000\u0000Current study shows that the potent anticancer potential of 4ab is mediated via cellular\u0000apoptosis, dysregulation of mitochondrial membrane potential and arrest of G1 phase in Molt-4 cells.\u0000Further, target-based studies showed the effect of 4ab on one of the major cellular signalling pathways\u0000deregulated in cancer.\u0000","PeriodicalId":91228,"journal":{"name":"Clinical cancer drugs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/2212697X06666190509094514","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44029831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head and Neck Cancer with Lung Metastases: Treatment Challenges","authors":"Selvamalar Vengathajalam and Norhafiza Mat Lazim","doi":"10.2174/2212697X06666190701113911","DOIUrl":"https://doi.org/10.2174/2212697X06666190701113911","url":null,"abstract":"Head and neck cancer has predilection of metastasising to the lung, bones or liver. The site of metastasis usually depends on the primary tumour location, the staging and the regional spread of the tumour. Patients with distant metastasis are predicted to have a poor prognosis with low survival rate. Oligometastasis is the term used for an intermediate biologic state of restricted metastatic capacity with limited number and sites of organ with metastasis. It is also defined by 5 or less than 5 metastatic lesion in a disease with a controlled primary tumour.In this case series, we have reported three cases of head and neck carcinomas that pose treatment dilemmas because of lung metastases. First case is a gentleman with laryngeal carcinoma with multiple small lung metastases where the treatment options of surgery versus chemoradiation was debated. The second case is a gentleman with low grade mucoepidermoid carcinoma of the parotid gland with suspicious lung spread of disease. Lastly is a patient with papillary thyroid carcinoma with florid lung metastases who completed chemoradiation.The presence of lung metastases does not necessarily mean that the prospect of surviving is poor for the patient. It is necessary to determine the best choice of treatment yielding the best quality of life to maximize the survival period for these patients.","PeriodicalId":91228,"journal":{"name":"Clinical cancer drugs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/2212697X06666190701113911","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47213867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Molecular Targets and Mechanisms Involved in the Invasion and Metastasis of Pancreatic Cancer","authors":"Ziyi Li, Weidong Li, Yu-xing Dong, Xueying Sun","doi":"10.2174/2212697X06666190328180331","DOIUrl":"https://doi.org/10.2174/2212697X06666190328180331","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancerrelated deaths and its morbidity and mortality are increasing. PDAC patients have a very poor prognosis because of aggressive features of PDAC cells, shortage of reliable diagnostic biomarkers and deficiency of effective therapeutics.The article aims to discuss the recent progress in the discovery of novel molecular targets and their related mechanisms in the invasion and metastasis of PDAC cells.Literatures based on Pubmed database were searched and those related to the molecular targets involved in the invasion and metastasis of PDAC were reviewed.The most promising discovery of molecular targets and phenomena include epithelialmesenchymal transition (EMT), cancer stem cells (CSCs), metastasis-related genes, hypoxiainducible factors (HIFs), non-coding RNAs (ncRNAs) and L1 cell adhesion molecule (L1CAM), which contribute to the vital biological behaviors of PDAC cells and tumor microenvironments.This review summarizes recent advances in novel molecular targets that regulate the invasion and metastasis of PDAC cells, and how they are targeted for developing diagnostic and therapeutic tools for combating PDAC. Further understanding the regulatory mechanisms of these molecular targets may help to discover biomarkers used for early diagnosis, predicting the prognosis and monitoring treatment response, and also to develop novel effective therapeutics.","PeriodicalId":91228,"journal":{"name":"Clinical cancer drugs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/2212697X06666190328180331","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48583357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Breast Cancer Stem Cells (BCSCs) with Liposomal Formulations","authors":"Sumayah Al-Mahmood","doi":"10.2174/2212697X06666190318150757","DOIUrl":"https://doi.org/10.2174/2212697X06666190318150757","url":null,"abstract":"\u0000\u0000Breast cancer stem cells (BCSCs) are a small proportion of cells that may be responsible\u0000for improving the resistance of cancer cells to the treatment and metastasis of breast cancer (MBC).\u0000Nanovehicles such as liposomes are extensively explored for diagnosis, treatment, and imaging of\u0000cancer. Targeted therapy with nanoparticles can be used to overcome the chemoresistance problem of\u0000cancer stem cells. Liposomes are lipid bilayer nanocarriers that have the ability to inhibit Pglycoprotein\u0000to overcome multidrug resistance that makes liposome ideal choice for using in BCSCs\u0000therapy. The main objective of this review is to describe novel liposomal formulations that are used in\u0000targeting BCSCs, which help in improving breast cancer treatment.\u0000","PeriodicalId":91228,"journal":{"name":"Clinical cancer drugs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/2212697X06666190318150757","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41837059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Fibrolytic Effect of Bauhinia purpurea L.","authors":"J. R. Dash, T. Sar, R. Buragohain, I. Samanta, R. Nanotkar","doi":"10.2174/2212697X06666190131155256","DOIUrl":"https://doi.org/10.2174/2212697X06666190131155256","url":null,"abstract":"\u0000\u0000Mammary gland tissue (left half) revealed the presence of excess proliferation\u0000of fibrous tissue with disorganization of alveolar structures and the right half showed extensive\u0000fibrous tissue proliferation of mammary gland following intramammary inoculation of 2000 c.f.u. of\u0000Staphylococcus aureus. However, oral dosing of Bauhinia variegata L. bark powder at 6 gm/kg for 7\u0000days and 3 gm/kg for another 7 days exhibited reduction of fibrous tissue in chronic mastitis.\u0000\u0000\u0000\u0000The fibrolytic effect of one week oral dosing of Bauhinia purpurea L. bark powder was\u0000studied in chronic mastitis with induced fibrosis as Bauhinia variegate L. is rarely available in plain\u0000land.\u0000\u0000\u0000\u0000Chronic mastitis with fibrosis was induced by intramammary inoculation of coagulase positive\u0000Staphylococcus aureus in group III and IV goats. Group I and III goats were injected with a single\u0000dose of ceftriaxone at 20 mg/kg intravenously, whereas group II and IV goats were orally administered\u0000Bauhinia purpurea L. bark powder at 6 g/kg for 7 days with a single dose of ceftriaxone at 20\u0000mg/kg intravenously.\u0000\u0000\u0000\u0000The t1/2β of ceftriaxone with Bauhinia purpurea L. stem bark powder in chronic mastitis increased\u0000significantly. Ceftizoxime was detected in plasma from 1 h to 48 h post dosing (pd) in group\u0000III and from 1 h to 96 h pd in group IV, respectively.\u0000\u0000\u0000\u0000Bark powder of Bauhinia purpurea L. at 6g/kg orally once daily increased the bioavailability\u0000of ceftriaxone and or ceftizoxime in milk due to its fibrolytic effect which was not reported earlier.\u0000Therefore, the Bauhinia purpurea L. bark powder having fibrolytic effect has the potential to reduce\u0000development of cancer.\u0000","PeriodicalId":91228,"journal":{"name":"Clinical cancer drugs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/2212697X06666190131155256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48036465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational Analysis of the Binding Site(s) of TNF β-TNFR1 Complex: Implications for Designing Novel Anticancer Agents","authors":"Trupti Khatal, G. Chaturbhuj","doi":"10.2174/2212697X06666181126111445","DOIUrl":"https://doi.org/10.2174/2212697X06666181126111445","url":null,"abstract":"","PeriodicalId":91228,"journal":{"name":"Clinical cancer drugs","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/2212697X06666181126111445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41773395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Lysozyme on Ehrlich Ascites Carcinoma Cells: The Possible Physiological Role of Lysozyme in the Prevention of Carcinogenesis","authors":"V. Gasparyan, H. Harutyunyan, M. V. Mikaelyan, G. Poghosyan","doi":"10.2174/2212697X06666190110120026","DOIUrl":"https://doi.org/10.2174/2212697X06666190110120026","url":null,"abstract":"","PeriodicalId":91228,"journal":{"name":"Clinical cancer drugs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/2212697X06666190110120026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42087674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}