Cardiovascular pharmacology: open access最新文献

Link between Vitamin D and Cardiovascular Diseases 维生素D与心血管疾病的关系

Cardiovascular pharmacology: open access Pub Date : 2019-01-01 DOI: 10.35248/2329-6607.19.8.251

K. Manju, Rathi Shikha, Jalwal Pawan

引用次数: 0

Compliance Amongst Warfarin Users Diagnosed Non-valvular Atrial Fibrillation are We Aware: Prospective Survey 我们意识到华法林使用者诊断为非瓣膜性心房颤动的依从性:前瞻性调查

Cardiovascular pharmacology: open access Pub Date : 2019-01-01 DOI: 10.35248/2329-6607.19.8.252

H. Mansour, Rafat Lubbad, Hasan Aboobaid, Khamis Issi

{"title":"Compliance Amongst Warfarin Users Diagnosed Non-valvular Atrial Fibrillation are We Aware: Prospective Survey","authors":"H. Mansour, Rafat Lubbad, Hasan Aboobaid, Khamis Issi","doi":"10.35248/2329-6607.19.8.252","DOIUrl":"https://doi.org/10.35248/2329-6607.19.8.252","url":null,"abstract":"Introduction: Vitamin k antagonists are the most commonly prescribed anticoagulation among non-valvular atrial fibrillation patients. It is indicated for stroke prevention in this group of patients. The aim of this study is to assess patient compliance among NVAF warfarin users. Method: The study designed as prospective study, conducted in the medical department in Indonesian and Shifa hospital- Palestine. We included patients undergoing oral anticoagulation with VKA diagnosed with NVAF with diabetes, cardiovascular disease aged between 20-85 years old, otherwise were excluded. The laboratory data include the INR, creatinine clearance, random blood sugar, systolic and diastolic blood pressure, liver chemistry extracted from patient file. Analysis: Continuous data are presented as the mean ± standard deviation, and the categoric variables were presented as percentage. To find the relationship between quantitative variables we used binary univariate analysis statistically significant results were considered at a two-tailed p-value <0.05. Data were analyzed using SPSS version 20 software. Finding: The total number was 100 patients, 50% males and the remain females. The results show that 43% of the patients know the risk of the drug while 39% know about the benefit. Only 58% of patients are within the therapeutic INR and 66% do not follow regular INR monitoring. There was 28% of patients are not in contact with any health care providers for drug monitoring. The results also show that 21% of patients do not follow their daily dose and 36% complain of hemorrhage. The results clarify that there exists a positive relationship between a creatinine, diastolic Bp, systolic Bp and INR Since p-value <0.05. Interpretation: The finding of this study shows that most of our patients' unaware warfarin, so we recommend construction of warfarin clinic for this group of patients for regular follow up with education program with qualified health care provider.","PeriodicalId":91222,"journal":{"name":"Cardiovascular pharmacology: open access","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72672746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frailty in Myocardial Infarction Patients: A Paradigm Shift 心肌梗死患者的虚弱:一种范式转变

Cardiovascular pharmacology: open access Pub Date : 2019-01-01 DOI: 10.35248/2329-6607.19.8.254

Mariam Hassan, H. Ibrahim, S. Ellahham

{"title":"Frailty in Myocardial Infarction Patients: A Paradigm Shift","authors":"Mariam Hassan, H. Ibrahim, S. Ellahham","doi":"10.35248/2329-6607.19.8.254","DOIUrl":"https://doi.org/10.35248/2329-6607.19.8.254","url":null,"abstract":"An insightful review of evidence-based literature unveils a drastically increasing incidence of myocardial infarction (MI). As the global population becomes older, the frequency of adverse coronary events escalates proportionally. The modifiable and non-modifiable risk factors that contribute toward the development of MI have been enumerated, and the aftereffects which may follow are known to be even more detrimental. Nevertheless, it is imperative to acknowledge that the management of MI patients does not only surround their cardiovascular health but is governed by many other seemingly superfluous concerns – some of which fall under the umbrella of frailty. A coalesce of frailty identification and appreciation of its subsequent role in prognostication and management is revolutionary. This further proves the need for considerable collaboration between geriatricians that meticulously deliberate the quintessential all-round care of the elderly as well as the cardiologists whose aim is to optimize cardiac function, survival and quality of life. Thus, the purpose of this mini-review is to ponder upon and adopt a validated assessment tool for the purposes of diagnosing frailty and prognostication amongst MI. This will allow for purposeful formulation of individualized management plans that could reduce the rates of mounting morbidities and all-cause mortality.","PeriodicalId":91222,"journal":{"name":"Cardiovascular pharmacology: open access","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83612803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

CYP-450 Epoxygenase Derived Epoxyeicosatrienoic Acid Contribute To Reversal of Heart Failure in Obesity-Induced Diabetic Cardiomyopathy via PGC-1 α Activation. cyp450环氧化酶衍生的环氧二碳三烯酸通过激活PGC-1 α参与肥胖诱导的糖尿病性心肌病心力衰竭的逆转

Cardiovascular pharmacology: open access Pub Date : 2018-01-01 Epub Date: 2018-02-08 DOI: 10.4172/2329-6607.1000233

S P Singh, J A McClung, L Bellner, J Cao, M Waldman, J Schragenheim, M Arad, E Hochhauser, J R Falck, J A Weingarten, S J Peterson, N G Abraham

{"title":"CYP-450 Epoxygenase Derived Epoxyeicosatrienoic Acid Contribute To Reversal of Heart Failure in Obesity-Induced Diabetic Cardiomyopathy via PGC-1 α Activation.","authors":"S P Singh, J A McClung, L Bellner, J Cao, M Waldman, J Schragenheim, M Arad, E Hochhauser, J R Falck, J A Weingarten, S J Peterson, N G Abraham","doi":"10.4172/2329-6607.1000233","DOIUrl":"https://doi.org/10.4172/2329-6607.1000233","url":null,"abstract":"We have previously shown that an Epoxyeicosatrienoic Acid (EET) -agonist has pleiotropic effects and reverses cardiomyopathy by decreasing inflammatory molecules and increasing antioxidant signaling. We hypothesized that administration of an EET agonist would increase Peroxisome proliferator-activated receptor-gamma coactivator (PGC-1α), which controls mitochondrial function and induction of HO-1 and negatively regulates the expression of the proinflammatory adipokines CCN3/NOV in cardiac and pericardial tissues. This pathway would be expected to further improve left ventricular (LV) systolic function as well as increase insulin receptor phosphorylation. Measurement of the effect of an EET agonist on oxygen consumption, fractional shortening, blood glucose levels, thermogenic and mitochondrial signaling proteins was performed. Control obese mice developed signs of metabolic syndrome including insulin resistance, hypertension, inflammation, LV dysfunction, and increased NOV expression in pericardial adipose tissue. EET agonist intervention decreased pericardial adipose tissue expression of NOV, while normalized FS, increased PGC-1α, HO-1 levels, insulin receptor phosphorylation and improved mitochondrial function, theses beneficial effect were reversed by deletion of PGC-1α. These studies demonstrate that an EET agonist increases insulin receptor phosphorylation, mitochondrial and thermogenic gene expression, decreased cardiac and pericardial tissue NOV levels, and ameliorates cardiomyopathy in an obese mouse model of the metabolic syndrome.","PeriodicalId":91222,"journal":{"name":"Cardiovascular pharmacology: open access","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2329-6607.1000233","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36054024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

The Probability of Inconstancy in Assessment of Cardiac Function Post-Myocardial Infarction in Mice 小鼠心肌梗死后心功能变化的概率分析

Cardiovascular pharmacology: open access Pub Date : 2016-09-09 DOI: 10.4172/2329-6607.1000195

Jiqiu Chen, N. Hammoudi, L. Bénard, D. Ceholski, Shihong Zhang, D. Lebeche, R. Hajjar

{"title":"The Probability of Inconstancy in Assessment of Cardiac Function Post-Myocardial Infarction in Mice","authors":"Jiqiu Chen, N. Hammoudi, L. Bénard, D. Ceholski, Shihong Zhang, D. Lebeche, R. Hajjar","doi":"10.4172/2329-6607.1000195","DOIUrl":"https://doi.org/10.4172/2329-6607.1000195","url":null,"abstract":"In the present study, we explore the inherent variability that leads to overlaps in cardiac functional parameters between control and post-myocardial infarction (MI) mice. Heart failure was induced by Left Coronary Artery (LCA) ligation in mice. Average Ejection Fraction (EF) measured by echocardiography was lower in MI mice compared to control, but exhibited higher Standard Deviation (SD) and Standard Error (SEM), notably in 2D mode. Fractional Shortening (FS) showed a higher degree of overlap between MI and control mice even though the mean values were significantly different. Hemodynamic measurements of EF resulted in greater SD, SEM, ± 95% confidence intervals, and effect size. In comparing echocardiography at different time points, EF and FS were consistent by mean, but had apparent fluctuation in individual tracks, which were more obvious in MI than control mice. Hemodynamic measurements showed more complexity in data collection in mice in vivo. MI size showed variability that correlated with severity of cardiac function. These studies show that there is inherent variability in functional cardiac parameters after induction of heart failure by MI in mice. Analysis of these parameters by traditional statistical methods is insufficient, and we propose a more robust statistical analysis for proper data interpretation.","PeriodicalId":91222,"journal":{"name":"Cardiovascular pharmacology: open access","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91378519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Recombinant Human Elastase Treatment of Cephalic Veins. 重组人弹性蛋白酶治疗头静脉。

Cardiovascular pharmacology: open access Pub Date : 2016-04-01 Epub Date: 2016-04-05 DOI: 10.4172/2329-6607.1000178

Marco D Wong, Karen Bingham, Emma Moss, J Donald Warn, Igor Smirnov, Kimberly S Bland, Barry Starcher, F Nicholas Franano, Steven K Burke

{"title":"Recombinant Human Elastase Treatment of Cephalic Veins.","authors":"Marco D Wong, Karen Bingham, Emma Moss, J Donald Warn, Igor Smirnov, Kimberly S Bland, Barry Starcher, F Nicholas Franano, Steven K Burke","doi":"10.4172/2329-6607.1000178","DOIUrl":"https://doi.org/10.4172/2329-6607.1000178","url":null,"abstract":"Background: Vessel injury at the time of Arteriovenous Fistula (AVF) creation may lead to neointimal hyperplasia that impairs AVF maturation. Vonapanitase, a recombinant human chymotrypsin-like elastase family member 1, is an investigational drug under development to improve AVF maturation and patency. The current studies were designed to document vonapanitase effects in human cephalic veins that are used in AVF creation.Methods: Human cephalic veins were mounted on a perfusion myograph. Vonapanitase 1.2, 4, 13.2, and 40 μg/ml or saline was applied drop wise on the vein followed by saline rinse. Vein segments were cut into rings for elastin content determination by desmosine radioimmunoassay and histology. Fluorescently-labelled vonapanitase was applied to veins and adventitial imaging was performed using laser scanning confocal microscopy. In vivo time course experiments were performed by treating rabbit jugular veins and harvesting 1 h and 4 h after vonapanitase treatment.Results / conclusion: Vonapanitase reduced desmosine content in a dose-related manner. Histology also confirmed a dose-related reduction in elastic fiber staining. Fluorescently-labelled vonapanitase persistently localized to elastic fibers in the vein adventitia. In vivo experiments showed a reduction in desmosine content in jugular veins from 1 h to 4 h following treatment. These data suggest that vonapanitase targets elastin in elastic fibers in a dose related manner and that elastase remains in the vessel wall and has catalytic activity for at least 1 h.","PeriodicalId":91222,"journal":{"name":"Cardiovascular pharmacology: open access","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2329-6607.1000178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34620778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Novel ASK Inhibitor AGI-1067 Inhibits TLR-4-Mediated Activation of ASK1 by Preventing Dissociation of Thioredoxin from ASK1. 一种新型ASK抑制剂AGI-1067通过阻止硫氧还蛋白从ASK1解离抑制tlr -4介导的ASK1活化。

Cardiovascular pharmacology: open access Pub Date : 2015-04-01 Epub Date: 2015-02-26 DOI: 10.4172/2329-6607.1000132

Shuhui Zheng, Lingli Long, Yonghao Li, Yuxia Xu, Zhang Jiqin, Weidong Ji, Wang Min

{"title":"A Novel ASK Inhibitor AGI-1067 Inhibits TLR-4-Mediated Activation of ASK1 by Preventing Dissociation of Thioredoxin from ASK1.","authors":"Shuhui Zheng, Lingli Long, Yonghao Li, Yuxia Xu, Zhang Jiqin, Weidong Ji, Wang Min","doi":"10.4172/2329-6607.1000132","DOIUrl":"10.4172/2329-6607.1000132","url":null,"abstract":"The cell type that normally limits the inflammatory and atherosclerotic process is the vascular endothelial cell (EC) that can be regulated by proinflammatory and various stresses. Toll-like receptor-4 (TLR4) plays an important role in the pathogenesis of atherosclerosis, in part, by activating apoptosis signal-regulating kinase 1 (ASK1) to initiate the activation of MAP kinases pathways and the expression of inflammatory genes. In the present study, we test the hypothesis that AGI-1067 acts as an anti-inflammatory agent by inhibiting the activation of ASK1 in human EC. Pretreatment of human aortic endothelial cells with AGI-1067 inhibits TLR4 ligand (LPS)-induced activation of ASK1 and the downstream p38 and c-Jun N-terminal kinase (JNK) MAP kinases. LPS dissociates two endogenous inhibitors thioredoxin-1 (Trx1) and 14-3-3 from ASK1, leading to ASK1 autoactivation. Interestingly, AGI-1067 inhibits the dissociation of Trx1, but not 14-3-3, from ASK1. However, inhibition of Trx1 dissociation from ASK1 by AGI-1067 is sufficient to suppress LPS-mediated phosphorylation of the transcription factors c-Jun and activating transcription factor 2, and inhibit LPS-induced inflammatory genes including vascular cell adhesion molecule 1, E-selectin, IL-6 and monocyte chemoattractant protein 1. Our findings suggest that AGI-1067 as a unique ASK1 inhibitor to inhibit TLR4-mediated ASK1 activation, contributing to its anti-inflammatory properties.","PeriodicalId":91222,"journal":{"name":"Cardiovascular pharmacology: open access","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2329-6607.1000132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34935879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The fractal-like complexity of heart rate variability beyond neurotransmitters and autonomic receptors: signaling intrinsic to sinoatrial node pacemaker cells. 超越神经递质和自主神经受体的心率变异性的分形样复杂性:窦房结起搏器细胞固有的信号。

Cardiovascular pharmacology: open access Pub Date : 2013-08-27 DOI: 10.4172/2329-6607.1000111

Y. Yaniv, A. Lyashkov, E. Lakatta

{"title":"The fractal-like complexity of heart rate variability beyond neurotransmitters and autonomic receptors: signaling intrinsic to sinoatrial node pacemaker cells.","authors":"Y. Yaniv, A. Lyashkov, E. Lakatta","doi":"10.4172/2329-6607.1000111","DOIUrl":"https://doi.org/10.4172/2329-6607.1000111","url":null,"abstract":"The heart rate and rhythm are controlled by complex chaotic neural, chemical and hormonal networks which are not strictly regular, but exhibit fluctuations across multiple time scales. A careful assessment of the heart rate variability (HRV) offers clues to this complexity. A reduction in HRV, specifically in advanced age, is associated with increase in morbidity and mortality. Mechanisms that induce this decrease, however, have not been fully elucidated. The classical literature characterizes changes in HRV as a result of changes in the balance of competing influences of the sympathetic and parasympathetic autonomic impulses delivered to the heart. It has now become clear, however, that the heart rate and HRV are also determined by intrinsic properties of the pacemaker cells that comprise sinoatrial node, and that these properties respond to autonomic receptor stimulation in a non-linear mode. That HRV is determined by both the intrinsic properties of pacemaker cells in the sinoatrial node and the competing influences of the two branches of the autonomic neural input to the cells requires an expansion of our perspective about mechanisms that govern HRV in the normal heart, and how HRV changes with aging in health and in heart diseases.","PeriodicalId":91222,"journal":{"name":"Cardiovascular pharmacology: open access","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86059175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28