Morgan H Kocher, Ronald K Hetzler, Cecilia M Shikuma, Iris F Kimura, Cris D Stickley, Rachel A Lindsey, Beau K Nakamoto, Dominic C Chow
{"title":"Autonomic Function is Associated with Fitness Level in HIV-Infected Individuals.","authors":"Morgan H Kocher, Ronald K Hetzler, Cecilia M Shikuma, Iris F Kimura, Cris D Stickley, Rachel A Lindsey, Beau K Nakamoto, Dominic C Chow","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular fitness can improve autonomic function (AF) in human immunodeficiency virus (HIV)-infected individuals.</p><p><strong>Methods: </strong>Cross-sectional study investigating relationship between AF and cardiovascular fitness in HIV+ individuals on antiretroviral therapy. Participants' (n=29) maximal oxygen consumption (VO<sub>2MAX</sub>) were assessed by graded exercise test and scaled allometrically, then divided into tertiles by fitness level (Unfit, Low-fit, and Moderately-fit). Heart rate variability (HRV) and the Autonomic Reflex Screen were used to assess AF.</p><p><strong>Results: </strong>Median VO<sub>2MAX</sub> were 104.9, 130.5, and 150.2 mL•kg<sup>-.67</sup>•min<sup>-1</sup> for Unfit (n=10), Low-fit (n=10), and Moderately-fit (n= 9) groups respectively (p<0.05). Positive correlations were found between VO<sub>2MAX</sub> and HRV (Spearman's rho range 0.383 to 0.553) were found. Quantitative Sudomotor Axon Reflex Test (QSART) Distal Leg volumes was lower in Unfit compared to Low-fit (<i>p</i>=0.007) and Moderately-fit groups (<i>p</i>=0.018). Unfit QSART total volumes was lower than Moderately-fit (<i>p</i>=0.014).</p><p><strong>Conclusion: </strong>A positive relationship existed between AF and fitness levels. HIV+ individuals could benefit from improved fitness.</p>","PeriodicalId":91102,"journal":{"name":"Jacobs journal of AIDS/HIV","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512303/pdf/nihms706284.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33938115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}