Autonomic Function is Associated with Fitness Level in HIV-Infected Individuals.

Jacobs journal of AIDS/HIV Pub Date : 2015-06-01

Morgan H Kocher, Ronald K Hetzler, Cecilia M Shikuma, Iris F Kimura, Cris D Stickley, Rachel A Lindsey, Beau K Nakamoto, Dominic C Chow

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Abstract

Background: Cardiovascular fitness can improve autonomic function (AF) in human immunodeficiency virus (HIV)-infected individuals.

Methods: Cross-sectional study investigating relationship between AF and cardiovascular fitness in HIV+ individuals on antiretroviral therapy. Participants' (n=29) maximal oxygen consumption (VO_2MAX) were assessed by graded exercise test and scaled allometrically, then divided into tertiles by fitness level (Unfit, Low-fit, and Moderately-fit). Heart rate variability (HRV) and the Autonomic Reflex Screen were used to assess AF.

Results: Median VO_2MAX were 104.9, 130.5, and 150.2 mL•kg^-.67•min^-1 for Unfit (n=10), Low-fit (n=10), and Moderately-fit (n= 9) groups respectively (p<0.05). Positive correlations were found between VO_2MAX and HRV (Spearman's rho range 0.383 to 0.553) were found. Quantitative Sudomotor Axon Reflex Test (QSART) Distal Leg volumes was lower in Unfit compared to Low-fit (p=0.007) and Moderately-fit groups (p=0.018). Unfit QSART total volumes was lower than Moderately-fit (p=0.014).

Conclusion: A positive relationship existed between AF and fitness levels. HIV+ individuals could benefit from improved fitness.

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自主神经功能与hiv感染者健康水平相关

背景:心血管健康可以改善人类免疫缺陷病毒(HIV)感染者的自主神经功能(AF)。方法:横断面研究HIV+患者接受抗逆转录病毒治疗后心房颤动与心血管健康的关系。参与者(n=29)的最大耗氧量(VO2MAX)通过分级运动试验和异速缩放来评估，然后按健身水平(不适合、低适合和中等适合)分为各组。使用心率变异性(HRV)和自主反射屏幕评估af。结果:中位VO2MAX为104.9,130.5和150.2 mL•kg-。不适合组(n=10)、低适合组(n=10)和中等适合组(n= 9)分别为67•min-1 (p2MAX和HRV (Spearman’s rho范围0.383 ~ 0.553)。与低配合组(p=0.007)和中等配合组(p=0.018)相比，不适合组远端腿部体积较低(p=0.007)。不适合QSART总容积低于适度拟合组(p=0.014)。结论:房颤与健康水平呈正相关。艾滋病毒携带者可以从健康状况的改善中受益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Jacobs journal of AIDS/HIV

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