International journal of medical nano research最新文献

Possible Effect of Nano Characterization of COVID-19 on Infection and Causing Disease COVID-19纳米表征对感染和致病的可能影响

International journal of medical nano research Pub Date : 2023-01-01 DOI: 10.23937/2378-3664.1410039

Sheng Wang

引用次数: 0

Therapeutic Application of Nanomaterials in the Management of Health Care: 'An Updated Review' 纳米材料在医疗保健管理中的治疗应用:“最新综述”

International journal of medical nano research Pub Date : 2022-12-31 DOI: 10.23937/2378-3664.1410037

M. Pooja, Irum Irum, Hussain Akhtar, B. Abu

引用次数: 0

Recent Trends in Nanoparticles Based Drug Delivery for Tuberculosis Treatment 纳米颗粒给药结核病治疗的最新趋势

International journal of medical nano research Pub Date : 2021-12-31 DOI: 10.23937/2378-3664.1410035

Pachouri Chandni, P. Bharat, Shroti Sandhya, S. Sandeep, P. Archna

{"title":"Recent Trends in Nanoparticles Based Drug Delivery for Tuberculosis Treatment","authors":"Pachouri Chandni, P. Bharat, Shroti Sandhya, S. Sandeep, P. Archna","doi":"10.23937/2378-3664.1410035","DOIUrl":"https://doi.org/10.23937/2378-3664.1410035","url":null,"abstract":"Current treatment therapeutic approach for tuberculosis is the administration of first line drugs in the form of tablets and capsules for 4-6 months however; this approach leads to sever adverse effect. Therefore, present study was designed to achieving local and sustained targeting of ant tuberculosis drugs in order to reduce dose n frequency. Nanoparticles (NPs) have been found to be potential targeted and controlled release drug delivery systems. Various drugs can be loaded in the NPs to achieve targeted delivery. Nanoparticles of antituberculosis drugs are generally prepared by using chitosan and PLGA polymer. Nanoparticles of Chitosan being biodegradable, biocompatible, less toxic and easy to prepare, are an effective and potential tool for drug delivery. The selection of a nanoencapsulation technique should consider drug property, nanoparticle quality, scale-up feasibility, manufacturing costs, personnel safety, environmental impact, waste disposal, and the like. In recent years, there have been a plethora of nanoengineering approaches for the development of poly (lactide-co-glycolide) (PLGA) nanoparticulate carrier systems. However, overlooking the multifaceted issues in the preparation and characterization of PLGA-based nanoparticles. Relevant information might be helpful to those who prepare and develop nanoparticles of ant tuberculosis drugs that meet their specific demands.","PeriodicalId":91094,"journal":{"name":"International journal of medical nano research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41749734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silver Nanoparticles Impregnated Nanocollagen as Scaffold for Soft Tissue Repair-Synthesis, Characterization, and In vitro Investigation 银纳米粒子浸渍纳米胶原作为软组织修复支架的合成、表征和体外研究

International journal of medical nano research Pub Date : 2021-07-09 DOI: 10.23937/2378-3664.1410034

S. V, K. S, I. R, R. S

{"title":"Silver Nanoparticles Impregnated Nanocollagen as Scaffold for Soft Tissue Repair-Synthesis, Characterization, and In vitro Investigation","authors":"S. V, K. S, I. R, R. S","doi":"10.23937/2378-3664.1410034","DOIUrl":"https://doi.org/10.23937/2378-3664.1410034","url":null,"abstract":"The regeneration of soft tissue is challenging task in the medicine due to infection at the wound site. Therefore, it requires a rapid regeneration scaffold for dermis and epidermis in the soft tissue. The silver nanoparticles (AgNPs) impregnated nanocollagen has been developed for soft tissue repair. The nano-collagen contained silver nanoparticles facilitates the rapid regeneration of wounded skin, when compared to collagen microfibers. Collagen was extracted from scales of Catla fish and made into nanocollagen using a standard ultrasonic processing method. The average diameter of collagen nanofibres after sonication process was evaluated to be 500 nm. The collagen fibres are aggregated due to hydrogen bonding between amino acids in the side chain. Size of silver nanoparticles to be impregnated into the nanocollegen varied from 180 to 210 nm. The nanocollagen with AgNPs, were characterized using UV-Vis spectroscopy, SDS PAGE, particle size analyzer, Transmission Electron Microscopy (TEM) and Fourier Transform Infrared spectroscopy (FTIR). The UV-Visible spectroscopy investigated the genesis of spherical shaped silver nanoparticles through surface plasmon band between 250 to 300 nm. The formation of silver nanoparticles was confirmed by wavelength of 300 nm under UV region. The silver nanoparticles have a good antibacterial action against wound pathogens. Nanocollagen with silver nanoparticles were subjected to MTT cytotoxicity assay under optimized concentration and in vitro wound healing assay was also performed on EA.hy926 cell lines, to evaluate efficacy of this nanomaterial scaffold for wound repair. This study confirmed that silver nanoparticles impregnated nanocollagen could be a potential wound repair biomedical scaffold.","PeriodicalId":91094,"journal":{"name":"International journal of medical nano research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46373032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

New Preparation Method of Reynolds' Stain for Transmission Electron Microscope for Liver Samples 肝脏透射电镜雷诺氏染色制备新方法

International journal of medical nano research Pub Date : 2021-07-09 DOI: 10.23937/2378-3664.1410033

L. Santhana Raj, MA Nur Dayana, SN Norzarila, C. Tan, MH Nur Afrina

引用次数: 2

Implantations and Applications of Brain Computer Interfaces as Medical Devices: A Short Review of Engineering Ethics 脑机接口作为医疗器械的植入与应用——工程伦理学综述

International journal of medical nano research Pub Date : 2021-03-28 DOI: 10.23937/2378-3664.1410032

Jawad Akram Jassim

{"title":"Implantations and Applications of Brain Computer Interfaces as Medical Devices: A Short Review of Engineering Ethics","authors":"Jawad Akram Jassim","doi":"10.23937/2378-3664.1410032","DOIUrl":"https://doi.org/10.23937/2378-3664.1410032","url":null,"abstract":"Nowadays, smart home devices have started to take a part in everything in our life, which mainly have been developed to consist from brain computer interface (BCI). In recent months, Neuralink BCI (1024-Electode) has been approved to be used by Food and Drug Administration (FDA) in the USA. That makes the ethical related studies have more attention to apply these devices and technologies in our daily life with more security. In this work, the ethical challenges of smart home systems that use BCI for personal monitoring, such as Neuralink Interfaces, have been reviewed, analysed and discussed regarding the fundamental principles in ‘Statement of Ethical Principles for the Engineering Profession’ of the UK. Firstly, a brief introduction of Neuralink BCI technology and important applications in daily life were discussed with related ethics issues. Then, proposed solutions and recommendations for every situation have been introduced and discussed as well. The main proposed ways to address that are establishing and introducing the related laws and rules, technology development of security and safety, and educate for acceptance culture in the society.","PeriodicalId":91094,"journal":{"name":"International journal of medical nano research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44167536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Origami-Induced Alignment of MNP Inside of DNA Nanotubes DNA纳米管内MNP的折纸诱导排列

International journal of medical nano research Pub Date : 2020-02-20 DOI: 10.23937/2378-3664/1410031

Rafati Adele, Zarrabi Ali, Gill Pooria

{"title":"Origami-Induced Alignment of MNP Inside of DNA Nanotubes","authors":"Rafati Adele, Zarrabi Ali, Gill Pooria","doi":"10.23937/2378-3664/1410031","DOIUrl":"https://doi.org/10.23937/2378-3664/1410031","url":null,"abstract":"Background: The advent of nanotubes in the nanotechnology world has led to significant advances in a number of biological and materials application, due to their structural properties such as the surface to volume ratio and potential to surface carrying or inside capsulation any materials. Among the various types of nanotubes, DNA nanotubes, due to their unique characteristics, such as precis controllability and programmability in shape/size/length/diameter and its biological origin compared to different types of nanomaterial, can be the suitable candidate for template patterning alignment and precise organization of nanoparticles at surface or into channel. These characteristics can be used in nanoelectronic devise or in the field of diagnostic nanobiosensores. Methods: Here, we report a new construction methodology for encapsulation of magnetic nanoparticles inside DNA nanotubes channel. Constructed-simultaneously encapsulation of magnetic nanoparticles into the large channel of this tubes leads to “pea-pod” particle alignment in nanotube channel. Results: Transmission electron microscopy and atomic force microscopy confirmed the fabrication of DNA nanotubes contained the magnetic nanoparticles inside the channel. Conclusion: These biohybrid nanomaterial would be proposed as the nanoarray platform in nanobiosensing devices.","PeriodicalId":91094,"journal":{"name":"International journal of medical nano research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42323196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Case for Viscoelastic Treatment of Excessive Girth in Treatment of the Presentation of a Spastic Colon: A Role for a Girth Injury Index? 粘弹性治疗过度围度治疗痉挛结肠的案例:围度损伤指数的作用?

International journal of medical nano research Pub Date : 2019-08-26 DOI: 10.23937/2378-3664.1410030

Williams Gareth R, Prior Timothy J, H. Geoffrey, Chuckle Barry L, Dave Chas N

引用次数: 0

A Supramolecular Indicator System for Detecting Urea Based on the Cellulose-Nanodiamond Composite Material and Urease 基于纤维素-纳米金刚石复合材料和脲酶的尿素检测超分子指示剂体系

International journal of medical nano research Pub Date : 2019-08-14 DOI: 10.23937/2378-3664.1410029

Posokhina Ekaterina, Ronzhin Nikita, Mogilnaya Olga, Baron Alexey, Bondarev Vladimir

{"title":"A Supramolecular Indicator System for Detecting Urea Based on the Cellulose-Nanodiamond Composite Material and Urease","authors":"Posokhina Ekaterina, Ronzhin Nikita, Mogilnaya Olga, Baron Alexey, Bondarev Vladimir","doi":"10.23937/2378-3664.1410029","DOIUrl":"https://doi.org/10.23937/2378-3664.1410029","url":null,"abstract":"A supramolecular indicator system (cellulose-nanodiamonds-urease) for reusable biochemical detection of urea has been fabricated using sequential immobilization of the components. Modified nanodiamonds (MNDs) were covalently immobilized onto DEAE cellulose granules via the nucleophilic addition reaction. At DEAE cellulose: MND ratio of 4:1 (w/w), up to 110 μg of nanoparticles bound onto 1 mg of the polymer during the addition reaction. Urease was immobilized by covalent conjugation onto the polymer-MND composite with the benzoquinone-activated surface. In comparative experiments, the enzyme was immobilized onto initial polymer granules via nonspecific adsorption and covalent conjugation. However, when these indicator systems were repeatedly used to detect the analyte, the enzyme was considerably inactivated, and that was evidenced by a decrease in the colored product yield. At the same time, the enzyme covalently bound onto the DEAE cellulose-MND composite showed higher functional efficacy and enabled more stable yields of the colored product in repeated urea assays. Comparative experiments with the indicator systems repeatedly used to detect urea at 37 °C demonstrated that the enzyme covalently conjugated onto the DEAE cellulose-MND composite showed greater thermo stability, and its activity was reduced at a much slower rate than the activity of the enzyme covalently bound to the polymer. The data obtained in the present study offer the prospect of designing a new type of reusable indicator assay systems (polymer carrier-nanodiamond-biomarker supramolecular systems) for biomedical analytical applications.","PeriodicalId":91094,"journal":{"name":"International journal of medical nano research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48398699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monitoring the Anticancer Effects of Two Different Gold Nanostructures Shapes towards Hep-2 Cells 监测两种不同形状的金纳米结构对Hep-2细胞的抗癌作用

International journal of medical nano research Pub Date : 2019-07-17 DOI: 10.23937/2378-3664.1410028

I SholqamyMaii, S Abd-ElHamidEhab, E. Mostafa, F MohamedAly, A El-SaidWaleed

{"title":"Monitoring the Anticancer Effects of Two Different Gold Nanostructures Shapes towards Hep-2 Cells","authors":"I SholqamyMaii, S Abd-ElHamidEhab, E. Mostafa, F MohamedAly, A El-SaidWaleed","doi":"10.23937/2378-3664.1410028","DOIUrl":"https://doi.org/10.23937/2378-3664.1410028","url":null,"abstract":"The change in cell size and alterations in the distribution of cells at different phases of the cell cycle are indicators of change in cell homeostasis. In this study, the HEp-2 cell line cells were treated for 24 hours by two shapes of Gold nanoparticles (GNPs): Gold nanospheres (GNSs) and Gold nanorods (GNRs). The cytotoxic effect of GNPs was evaluated by different methods. The MTT assay revealed that GNPs have a cytotoxic effect on HEp-2 cells and the GNRs are more toxic than GNSs. Image morphometric analysis showed a decrease in the mean values of Nuclear Area Factor (NAF) of HEp-2 cells treated with GNPs when compared to control cells. We found that cell size decreased in cells treated with GNPs and most of the cells were in S-phase and decreased at G2-phase of the cell cycle when compared to control cells. Also, it was noted that in cells treated with GNSs the apoptotic features increased with increasing concentration from pre IC50 to post IC50, contrary to cells treated with GNRs the apoptotic features decreased with increasing concentration from IC50 to post IC50. Cell size and cell cycle distribution changed after treatment by GNPs. The GNRs may be more toxic than GNSs.","PeriodicalId":91094,"journal":{"name":"International journal of medical nano research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48047981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2