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CRISPR/Cas9 Screenings Reveal the Role of STX1A and CDK1 in Cathepsin G Entering and Killing Colorectal Cancer Cells. CRISPR/Cas9筛选揭示STX1A和CDK1在组织蛋白酶G进入和杀死结直肠癌细胞中的作用
Interdisciplinary information sciences Pub Date : 2025-01-01 Epub Date: 2025-11-15 DOI: 10.4036/iis.2025.A.11
Yuxiang Wang, Valery Rozen, Trang Dinh, He Li, Yamu Li, Yiqing Zhao, Zhenghe Wang
{"title":"CRISPR/Cas9 Screenings Reveal the Role of STX1A and CDK1 in Cathepsin G Entering and Killing Colorectal Cancer Cells.","authors":"Yuxiang Wang, Valery Rozen, Trang Dinh, He Li, Yamu Li, Yiqing Zhao, Zhenghe Wang","doi":"10.4036/iis.2025.A.11","DOIUrl":"10.4036/iis.2025.A.11","url":null,"abstract":"<p><p>Neutrophils are the major populations of white blood cells and have been reported to facilitate cancer metastasis. Meanwhile, emerging evidence has recently suggested the anti-cancer role of neutrophils. Our previous study revealed that CB-839 and 5-FU-treated colorectal cancer (CRC) tumors recruited neutrophils and induced neutrophil extracellular traps (NETs). Cathepsin G (CTSG), which is released during NET formation, enters CRC cells through the receptor for advanced glycation end products (RAGE) and cleaves 14-3-3<i>ε</i> to promote apoptosis. However, the detailed mechanism underlying CTSG's anti-tumor function remains less studied. In this study, we report that CTSG enters CRC cells through RAGE-mediated endocytosis. Knocking out RAGE or inhibiting endocytosis blocks CTSG from entering CRC cells and attenuates CTSG-induced apoptosis. Furthermore, the clathrin coat assembly complex and SNARE proteins were enriched in an arrayed CRISPR/Cas9 screening targeting human membrane trafficking genes. Knocking out SNARE protein STX1A prevents the spread of CTSG in CRC cells and the induction of cleaved PARP. A pooled genome-wide CRISPR/Cas9 screening further identifies the role of CDK1 in the NET-induced killing of CRC cells. Inhibiting CDK1 protected CRC cells from killing by CTSG. Our study reveals novel mechanisms by which CTSG enters and kills CRC cells.</p>","PeriodicalId":91087,"journal":{"name":"Interdisciplinary information sciences","volume":"31 1","pages":"110-119"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13042082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Mathematical Consideration on the Relation of the Social Structure to the Infection Risk in a Community 社会结构与社区感染风险关系的数学思考
Interdisciplinary information sciences Pub Date : 2023-01-01 DOI: 10.4036/iis.2023.r.02
Elza Firdiani Sofia, H. Seno
{"title":"A Mathematical Consideration on the Relation of the Social Structure to the Infection Risk in a Community","authors":"Elza Firdiani Sofia, H. Seno","doi":"10.4036/iis.2023.r.02","DOIUrl":"https://doi.org/10.4036/iis.2023.r.02","url":null,"abstract":"","PeriodicalId":91087,"journal":{"name":"Interdisciplinary information sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70253944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measuring National Refugee Policies: Recent Trends and Implications for Future Development 衡量国家难民政策:近期趋势及其对未来发展的影响
Interdisciplinary information sciences Pub Date : 2023-01-01 DOI: 10.4036/iis.2022.r.05
Masaaki Higashijima, Yujin Woo
{"title":"Measuring National Refugee Policies: Recent Trends and Implications for Future Development","authors":"Masaaki Higashijima, Yujin Woo","doi":"10.4036/iis.2022.r.05","DOIUrl":"https://doi.org/10.4036/iis.2022.r.05","url":null,"abstract":"Refugee issues are among the most imminent and important problems facing mod-ern societies. This review essay systematically reviews recent social scientific literature that quantitatively measures national refugee policies. In so doing, we compare several recent and prominent cross-national data sets on this topic, namely those constructed by the International Migration Institute (IMI; 2015), Hatton (2016), Helbling et al. (2017), Blair, Grossman, and Weinstein (2021), and Savun (2021). We point to both the advantages and disadvantages of the respective data sets while providing suggestions on how to practically apply them and how to merge their scopes and perspectives in a more comprehensive manner in order to better fit researchers’ and practitioners’ scopes of interest. We conclude this article by suggesting future research agendas by highlighting the significance and feasibility of a compilation of a more extensive data set based on the existing ones.","PeriodicalId":91087,"journal":{"name":"Interdisciplinary information sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70253268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computational Complexity of Puzzles and Related Topics 谜题的计算复杂性和相关主题
Interdisciplinary information sciences Pub Date : 2023-01-01 DOI: 10.4036/iis.2022.r.06
Ryuhei Uehara
{"title":"Computational Complexity of Puzzles and Related Topics","authors":"Ryuhei Uehara","doi":"10.4036/iis.2022.r.06","DOIUrl":"https://doi.org/10.4036/iis.2022.r.06","url":null,"abstract":"","PeriodicalId":91087,"journal":{"name":"Interdisciplinary information sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70253277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Lecture Notes on the Singular Limit of Reaction-diffusion Systems 反应扩散系统的奇异极限讲义
Interdisciplinary information sciences Pub Date : 2023-01-01 DOI: 10.4036/iis.2023.a.01
D. Hilhorst, F. Salin, Victor P. Schneider, Yueyuan Gao
{"title":"Lecture Notes on the Singular Limit of Reaction-diffusion Systems","authors":"D. Hilhorst, F. Salin, Victor P. Schneider, Yueyuan Gao","doi":"10.4036/iis.2023.a.01","DOIUrl":"https://doi.org/10.4036/iis.2023.a.01","url":null,"abstract":"","PeriodicalId":91087,"journal":{"name":"Interdisciplinary information sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70253863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Singular limit of deterministic and stochastic reaction-diffusion systems 确定性和随机反应扩散系统的奇异极限
Interdisciplinary information sciences Pub Date : 2023-01-01 DOI: 10.4036/iis.2023.a.00
G. Akagi, Reika Fukuizumi, N. Yoshinaga
{"title":"Singular limit of deterministic and stochastic reaction-diffusion systems","authors":"G. Akagi, Reika Fukuizumi, N. Yoshinaga","doi":"10.4036/iis.2023.a.00","DOIUrl":"https://doi.org/10.4036/iis.2023.a.00","url":null,"abstract":"","PeriodicalId":91087,"journal":{"name":"Interdisciplinary information sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70253288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Qualitative Properties of Solutions of Degenerate Parabolic Equations via Energy Approaches 用能量法研究退化抛物方程解的定性性质
Interdisciplinary information sciences Pub Date : 2023-01-01 DOI: 10.4036/iis.2023.a.02
D. Andreucci, A. Tedeev
{"title":"Qualitative Properties of Solutions of Degenerate Parabolic Equations via Energy Approaches","authors":"D. Andreucci, A. Tedeev","doi":"10.4036/iis.2023.a.02","DOIUrl":"https://doi.org/10.4036/iis.2023.a.02","url":null,"abstract":"","PeriodicalId":91087,"journal":{"name":"Interdisciplinary information sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70253907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Non-QE Graphs on Six Vertices 六个顶点上的初等非QE图
Interdisciplinary information sciences Pub Date : 2022-07-27 DOI: 10.4036/iis.2023.R.01
N. Obata
{"title":"Primary Non-QE Graphs on Six Vertices","authors":"N. Obata","doi":"10.4036/iis.2023.R.01","DOIUrl":"https://doi.org/10.4036/iis.2023.R.01","url":null,"abstract":"A connected graph is called of non-QE class if it does not admit a quadratic embedding in a Euclidean space. A non-QE graph is called primary if it does not contain a non-QE graph as an isometrically embedded proper subgraph. The graphs on six vertices are completely classified into the classes of QE graphs, of non-QE graphs, and of primary non-QE graphs.","PeriodicalId":91087,"journal":{"name":"Interdisciplinary information sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44974860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
New Informatics Paradigm to Manage Quality and Value of Information 管理信息质量和价值的新信息学范式
Interdisciplinary information sciences Pub Date : 2022-01-01 DOI: 10.4036/iis.2022.a.00
S. Shioiri
{"title":"New Informatics Paradigm to Manage Quality and Value of Information","authors":"S. Shioiri","doi":"10.4036/iis.2022.a.00","DOIUrl":"https://doi.org/10.4036/iis.2022.a.00","url":null,"abstract":"","PeriodicalId":91087,"journal":{"name":"Interdisciplinary information sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70252840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epistemic Injustice as a Philosophical Conception for Considering Fairness and Diversity in Human-centered AI Principles 以人为本的人工智能原则中公平与多样性的哲学思考——认知不公正
Interdisciplinary information sciences Pub Date : 2022-01-01 DOI: 10.4036/iis.2022.a.01
M. Nihei
{"title":"Epistemic Injustice as a Philosophical Conception for Considering Fairness and Diversity in Human-centered AI Principles","authors":"M. Nihei","doi":"10.4036/iis.2022.a.01","DOIUrl":"https://doi.org/10.4036/iis.2022.a.01","url":null,"abstract":"","PeriodicalId":91087,"journal":{"name":"Interdisciplinary information sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70252881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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