Journal of clinical and experimental gastroenterology最新文献_第2页

Liver toxicity and DNA damage from exposure to the pesticide Mancozeb 接触农药代森锰锌引起的肝毒性和DNA损伤

Journal of clinical and experimental gastroenterology Pub Date : 2022-12-31 DOI: 10.46439/gastro.1.006

N. D. Uribe, M. F. Pezzini, Juliana Dall Agnol, N. Marroni, Sandy Benitez, D. Benedetti, J. Silva, C. Cerski, E. Dallegrave, Sandra Macedo, D. Joveleviths

{"title":"Liver toxicity and DNA damage from exposure to the pesticide Mancozeb","authors":"N. D. Uribe, M. F. Pezzini, Juliana Dall Agnol, N. Marroni, Sandy Benitez, D. Benedetti, J. Silva, C. Cerski, E. Dallegrave, Sandra Macedo, D. Joveleviths","doi":"10.46439/gastro.1.006","DOIUrl":"https://doi.org/10.46439/gastro.1.006","url":null,"abstract":"Introduction: Brazilian agriculture has developed to such an extent in the last 40 years that the country will become one of the world’s largest food suppliers in the future. Indeed, to keep up this production, agriculture makes intensive use of fertilizers and agricultural pesticides, helping Brazil become one of the main pesticide consumers worldwide. Ethylenebisdithiocarbamates are a group of fungicides that have been widely utilized around the world, and Mancozeb is one of their main representatives. Therefore, a pilot experimental model was created to evaluate the potential hepatotoxic effect of Mancozeb. Materials and Methods: An experimental study was performed with 27 male Wistar rats, divided into 3 groups of 9 rats. Control Group received saline solution, Intervention Group I received 250 mg/kg once a week and Intervention Group II received 500 mg/kg also once a week. The treatment was performed for 12 weeks. Anthropometric measurements were performed and the marker of biological exposure in urine was dosed, biochemical tests, evaluation micronucleus count and comet assay, oxidative stress markers and histological assessment of the liver were done. Results: The hepatotoxic effect of exposure to Mancozeb was confirmed by different tests: anthropometric measures, genotoxicity, and oxidative stress. Statistical significance was found when exposed groups were compared to the control. These results were supported by microscopic evaluation of the liver tissue, where histological changes were found such as inflammatory infiltrate and balloonization in the treated groups. Conclusion: Experimental model was effective to demonstrate the deleterious effect on the liver due to exposure to Mancozeb.","PeriodicalId":91025,"journal":{"name":"Journal of clinical and experimental gastroenterology","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81127853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A mini-review of the associations between hypertension and risk of gallstone disease 高血压与胆结石疾病风险之间关系的综述

Journal of clinical and experimental gastroenterology Pub Date : 2022-12-31 DOI: 10.46439/gastro.1.009

X. Wang, F. Hu, Yanmei Lou, Jing Xia, W. Yu, Min Zhang, F. Song, Qi Chen, Feng Rui, Chi Zhang, P. Cui, L. Kong, Pei Zhu, Guangcan Li, M. Mao, X. Shan

引用次数: 0

Gastric marginal zone B-cell lymphoma of MALT type – An updated histo- and molecular pathological summary 胃边缘带b细胞淋巴瘤MALT型-最新的组织和分子病理总结

Journal of clinical and experimental gastroenterology Pub Date : 2022-07-30 DOI: 10.46439/gastro.1.004

引用次数: 0

A comprehensive review of enteric duplication cysts, their pathophysiology, presentation, and treatment 全面检讨肠重复囊肿，他们的病理生理，表现和治疗

Journal of clinical and experimental gastroenterology Pub Date : 2022-07-30 DOI: 10.46439/gastro.1.001

引用次数: 1

Involvement of transient receptor potential in liver diseases 瞬时受体电位在肝脏疾病中的作用

Journal of clinical and experimental gastroenterology Pub Date : 2022-07-30 DOI: 10.46439/gastro.1.002

引用次数: 0

A rarely reported surgical problem: spontaneous scrotal enterocutaneous fistula 一个很少报道的外科问题:自发性阴囊肠皮瘘

Journal of clinical and experimental gastroenterology Pub Date : 2022-07-30 DOI: 10.46439/gastro.1.003

引用次数: 0

Ischemic colitis as a cause of severe hematochezia: A mini review. 缺血性结肠炎作为严重便血的一个原因:一个小回顾。

Journal of clinical and experimental gastroenterology Pub Date : 2022-01-01 DOI: 10.46439/gastro.1.005

Usah Khrucharoen, Dennis M Jensen

{"title":"Ischemic colitis as a cause of severe hematochezia: A mini review.","authors":"Usah Khrucharoen, Dennis M Jensen","doi":"10.46439/gastro.1.005","DOIUrl":"https://doi.org/10.46439/gastro.1.005","url":null,"abstract":"<p><p>Ischemic colitis (IC) is a common cause of severe lower gastrointestinal bleeding (LGIB) in the elderly. There are very few studies of patients with IC as a cause of severe LGIB in the literature. This article aims to review diagnosis, colonoscopic findings, medical treatment, and outcomes of patients with IC as a cause of severe hematochezia. The majority of IC patients with severe hematochezia can be successfully managed with medical treatment. Colonoscopic hemostasis with hemoclips is safe and feasible in treating major stigmata of recent hemorrhage in focal ischemic ulcers. Colon surgery is indicated in patients who fail medical treatment and/or have severe ongoing bleeding, clinical deterioration, or peritoneal signs. Overall, the morbidity rates in patients with IC range from 10% to 79%. Clinical outcomes in patients who need colon surgery for IC are worse than those treated with medical management. Patients who develop hematochezia from IC during hospitalization for other medical conditions have worse clinical outcomes than those with an outpatient start of bleeding. Further research is warranted for the prevention, early diagnosis, and treatment of patients with severe hematochezia from IC.</p>","PeriodicalId":91025,"journal":{"name":"Journal of clinical and experimental gastroenterology","volume":"1 1","pages":"22-26"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33460820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0