J. Sauter, S. K. Nayar, Paige D. Anders, Michael A. D'amico, K. Butnor, R. Wilcox
{"title":"Co-existence of Sarcina Organisms and Helicobacter pylori Gastritis/Duodenitis in Pediatric Siblings","authors":"J. Sauter, S. K. Nayar, Paige D. Anders, Michael A. D'amico, K. Butnor, R. Wilcox","doi":"10.17303/JCAP.2013.103","DOIUrl":"https://doi.org/10.17303/JCAP.2013.103","url":null,"abstract":"Sarcina are gram-positive anaerobic bacteria found to be associated with delayed gastric emptying and gastric outlet obstruction. We describe two cases of Sarcina co-existing with Helicobacter pylori organisms in pediatric siblings presenting within four months of each other with pyloric obstruction secondary to severe gastritis/duodenitis. The co-existence of Sarcina and Helicobacter pylori has not, to our knowledge, been previously reported. Its characteristic tetrad packeted morphology permits Sarcina to be readily identified on routine sections. Detection of these organisms in gastric biopsies should prompt consideration of gastric outlet obstruction and/or delayed gastric emptying as a possible etiologic factor.","PeriodicalId":90888,"journal":{"name":"Journal of clinical & anatomic pathology (JCAP)","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82143166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Three-Dimensional Tumor Cell Cultures and the Role of Tissue Biorepositories in Personalized Medicine","authors":"K. Valyi‐Nagy","doi":"10.17303/JCAP.2013.E101","DOIUrl":"https://doi.org/10.17303/JCAP.2013.E101","url":null,"abstract":"Tissue biorepositories have long been critically important for medical research by providing human tissues for scholarly investigations. In addition to this traditional research role, tissue banks are rapidly assuming new roles in the clinical side of medicine. In the modern era of personalized medicine, tissue biorepositories are increasingly expected to establish close collaborations with clinical and laboratory units and provide banked tissues for a variety of tests that in turn will guide clinical decision making tailored to the patient [1-4]. This new role of biorepositories requires the development of novel complex standard operating procedures (SOPs) for tissue collection, processing and storage that can provide tissues ideal for a variety of novel molecular and other tests [1,3,4].","PeriodicalId":90888,"journal":{"name":"Journal of clinical & anatomic pathology (JCAP)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79616708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recognizing the Limitations and Pitfalls of Cytology for Anaplastic Carcinoma within Hürthle Cell (Oncocytic) Carcinomas","authors":"T. Richardson, Shirley Yan, Elizabeth M. Kurian","doi":"10.17303/jcap.2015.2.102","DOIUrl":"https://doi.org/10.17303/jcap.2015.2.102","url":null,"abstract":"Fine needle aspiration is an initial method for diagnosis of enlarged thyroid nodules. Hurthle cell neoplasm is usually cytomorphologically distinct from undifferentiated/anaplastic thyroid carcinoma, except when there is marked atypia. Herein we contrast two cases, highlighting Hurthle cell atypia mimicking anaplastic change versus true anaplastic thyroid carcinoma. The first case is of a 44 year old female with a rapidly enlarging thyroid mass presenting with an outside fine needle aspiration diagnosis of anaplastic thyroid carcinoma; however the thyroidectomy found only a Hurthle cell follicular carcinoma with a component of cytologic atypia. The second case is from an 81 year old female with acute onset neck swelling. The cytologic evaluation was suspicious for a Hurthle cell neoplasm only, while the thyroidectomy showed Hurthle cell follicular carcinoma with anaplastic thyroid carcinoma. Hurthle cell neoplasm may have marked atypia, for which anaplastic thyroid carcinoma is important to exclude. Since fine needle aspirations have sampling limitations, subsequent surgical excision is essential in determining the correct diagnosis in cases of cytologic Hurthle cell neoplasm which may harbor anaplastic thyroid carcinoma.","PeriodicalId":90888,"journal":{"name":"Journal of clinical & anatomic pathology (JCAP)","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78764301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}