International journal of medicine and public health最新文献

{"title":"Detection of Colistin Resistance in Gram Negative Pathogens: A One Year Cross-sectional Study in a Tertiary Care Centre in Northeast India","authors":"Deepayan Biswas, W. Lyngdoh, Sheryl Lanong, C. Lyngdoh, P. Bhattacharya, N. Lyngdoh","doi":"10.5530/ijmedph.2022.4.32","DOIUrl":"https://doi.org/10.5530/ijmedph.2022.4.32","url":null,"abstract":"","PeriodicalId":90863,"journal":{"name":"International journal of medicine and public health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47220305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Let’s Understand Public Health: A Free-flow Writing from Novice Learners","authors":"Rounik Talukdar, Diplina Barman","doi":"10.5530/ijmedph.2022.4.27","DOIUrl":"https://doi.org/10.5530/ijmedph.2022.4.27","url":null,"abstract":"","PeriodicalId":90863,"journal":{"name":"International journal of medicine and public health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46109693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Respiratory Syncytial Viruses (RSV) Infection in Children”: A Scientometric Analysis of Global Publications during 2002-21","authors":"B. Gupta, M. Gore, Atul Gupta, Avadhesh Kumar Patel","doi":"10.5530/ijmedph.2021.4.29","DOIUrl":"https://doi.org/10.5530/ijmedph.2021.4.29","url":null,"abstract":"","PeriodicalId":90863,"journal":{"name":"International journal of medicine and public health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43891527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Vaccine Service Delivery Challenges: A Rapid Assessment of Private Health Facilities Providing COVID-19 Vaccination in Maharashtra, India, 2021","authors":"Aikant Bhatti, P. Raj, Rishabh Chopra, R. Gandhi, Jessica Mooney, Farzana Muhib, Manoj Mehta","doi":"10.5530/ijmedph.2022.4.31","DOIUrl":"https://doi.org/10.5530/ijmedph.2022.4.31","url":null,"abstract":"","PeriodicalId":90863,"journal":{"name":"International journal of medicine and public health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48103290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Ayurveda in School Health","authors":"S. Begum, Venkatakrishna Kv, Asha Sa","doi":"10.5530/ijmedph.2022.4.28","DOIUrl":"https://doi.org/10.5530/ijmedph.2022.4.28","url":null,"abstract":"Ayurveda is believed to be the oldest medical science of human civilization. Some of the contemporary concepts of today can be understood by the same age old principles and practices of Ayurveda. School health as a discipline is mainly seen as a part of or a similar stream of community medicine. However, the classical text of Ayurveda also describe certain principles of public health in its own parlances. Though the classical texts of Ayurveda describes many principles such as immunity, nutrition etc. School health is a new approach to health care which integrates at the community level of all factors requires for improving health status of population while it integrates promotive, preventing and curative services. The present document will focus on the concept of school health in brief with respect to Ayurveda.","PeriodicalId":90863,"journal":{"name":"International journal of medicine and public health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46316745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Has COVID-19 Made the Vulnerable Groups Even More Vulnerable? Exploring the Conditions of Diabetic Patients of Dhaka City Amidst COVID-19 Pandemic","authors":"Md. Shakhawat Hossain, Arifur Rahaman, Md Tanvir Hasan Sojib, Muhammad Awfa Islam, Yeasir Inzzamam Iftekhar, Maria Afroj, Mustain Karim Chowdhury","doi":"10.5530/ijmedph.2022.3.24","DOIUrl":"https://doi.org/10.5530/ijmedph.2022.3.24","url":null,"abstract":"SARS-CoV-2, commonly referred as COVID-19, has emerged as the most severe public health concern of the twenty - first century. Coronavirus usually is not very lethal to the persons who do not have any medical conditions, but it is fatal to people who have had past medical conditions that have often resulted in death. The objectives of this paper is to look at the effects of coronavirus on older diabetes patients, who are thought to be the ones who were affected the most by COVID-19. This research used a qualitative approach and was descriptive in nature. The researcher has purposefully chosen three areas in Dhaka city as the studies fixate: Shahbag, Khilgaon, and Rampura. Data was gathered using qualitative methods such as focus group discussion and key informant interviews. According to the study's findings, COVID-19 had a serious effect on older adults with diabetes. The number of patients at the hospital had significantly decreased. Despite the fact that hospitals were equipped to provide treatment and care, patients' mobility was limited. Many people preferred virtual consultation or telemedicine to face-to-face consultation and care. Doctors encouraged individuals to connect digitally, which is both safe and feasible in the face of the global pandemic. The expense of a diabetic patient rose, according to the majority of respondents. According to the findings, the pandemic is spurring new diabetes-care delivery methods. Many structural flaws were exposed as a result of Covid-19, paving the door for additional improvements in healthcare delivery in the study area.","PeriodicalId":90863,"journal":{"name":"International journal of medicine and public health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43015229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Wood Smoke Exposure and Associated Factors on Respiratory Parameters of Pygmies Involved in the Smoking of Game Meat in the Congo/Brazzaville","authors":"Simplice Innocent Moussouami, Yvon Rock Ghislain Alongo, Florent Nsompi, Mack Allah Mack, Bio Nigan Issiako, F. Mbemba","doi":"10.5530/ijmedph.2022.3.21","DOIUrl":"https://doi.org/10.5530/ijmedph.2022.3.21","url":null,"abstract":"2022 Phcog.Net. This is an open-access distributed under the terms of the Commons Attribution ABSTRACT Introduction: This study assesses the effects of pollutants generated by the burning of firewood by pygmies practicing the smoked meat trade. Materials and Methods: A total of 56 rural pygmies aged 36.92 ± 4.69 years old were divided into two groups, whose 29 exposed pygmies (practicing meat smoking) and 27 less exposed pygmies (not practicing this trade). Levels of PM2.5 pollutants and respiratory parameters were measured. A questionnaire including demographic data and another to identify symptoms of respiratory diseases were used. Epi info 7 software was used to perform the analyses. Results: This study indicates high concentrations of pollutants in the environment where this occupation is practiced. All spirometric parameters decreased in the exposed pygmies. The symptomatology was chronic cough, shortness of breath, wheezing and dyspnea that were higher in the exposed pygmy group. There was a strong association between the age of the subjects, the duration of exposure and the level of pollutants with certain symptoms. Conclusion: These results suggest that pygmies involved in smoking game meat inhale significant quantities of toxic particles. This pollution has health and environmental implications. Screening programmer are needed for this population.","PeriodicalId":90863,"journal":{"name":"International journal of medicine and public health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42623622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Epidemiological Survey Study to Enlist Vyadhi and its Classification WSR to Drought Affected Population","authors":"P. Chaudhary, V. Chate, Shreevathsa B.M","doi":"10.5530/ijmedph.2022.3.26","DOIUrl":"https://doi.org/10.5530/ijmedph.2022.3.26","url":null,"abstract":"Background: To achieve the two principal objectives, the concept of Trisu–tra and Bija Catustaya has been designed by A–ca–rya Caraka and A–ca–rya Susruta respectively, Vya–dhi is the one among them. Homeostasis of the components of life maintains health whereas the imbalance of same leads to disease. Ayurveda analyses Vya–dhi and its Vargikarana to facilitates easy understanding of Vya–dhi as well as shows the path for further treatment aspects. Without the knowledge of Vya–dhi Vargikarana, it is futile to achieve the Savikalpa Jña– na. Objectives: Evaluation of disaster affected diseases with Vya–dhi Vargikarana. Materials and Methods: For the survey study, the affected places of Drought disaster events were visited, observed and surveyed through face to face. To collect the data a modified general case proforma was prepared with the help of disaster management faculty. For each event sample of minimum 100 affected people have been incorporated to enlist the major diseases in order to classify them under Vya–dhi Vargikarana. Results: The following Vya–dhis observed under Drought disaster, population are more vulnerable to GI Diseases, RT Diseases, UT Diseases, Nutritional Deficiency, Skin Diseases, Sun stroke and Leucorrhoea. There is a more chance of getting following Vya–dhi Vargikarana in Drought viz., Nija, A–gantuja, Sa–kha–gata, Ko–sthagata, Marmagata, Pittaja, Dwandvaja, and Sannipa–taja are highly Significant with p = .001. Conclusion: Disaster directly impacts the health of the population. In the present study, major observed Vya–dhi has been enlisted. A–gantuja, Sa–riria–ka – Ma–nasika, Sa–kha–gata, Ko–sthagata and Sannipa–taja are the common Vargikarana.","PeriodicalId":90863,"journal":{"name":"International journal of medicine and public health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43532317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Stem Cell Therapy (SCT) to Covid-19: A Scientometric Assessment of Global Publications during 2020-21","authors":"B. Gupta, Mallikarjun Kappi, K. Ahmed","doi":"10.5530/ijmedph.2022.3.22","DOIUrl":"https://doi.org/10.5530/ijmedph.2022.3.22","url":null,"abstract":"Objectives: The study makes a bibliometric evaluation of global publications on \"Application of Stem Cell Therapy to Covid-19\" during 2020-22.","PeriodicalId":90863,"journal":{"name":"International journal of medicine and public health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48621025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROTACs: Opportunities and Challenges Ahead in the Field of Drug Discovery","authors":"A. Vadukoot","doi":"10.5530/ijmedph.2022.3.19","DOIUrl":"https://doi.org/10.5530/ijmedph.2022.3.19","url":null,"abstract":"Copyright © 2022 Phcog.Net. This is an openaccess article distributed under the terms of the Creative Commons Attribution 4.0 International license. Proteolysis Targeting Chimeras (PROTACs) are alternatives to traditional small molecule-based drug discovery techniques that focus on direct regulation of protein activity. Targeted protein degradation in cells by heterobifunctional small molecules has emerged as one of the most promising technologies for modulating a protein of interest (POI). PROTACs connect three chemical elements: POI ligand to an E3 ubiquitin ligase (E3) recruiting ligand with an optimal linker for conjugating these two ligands.1 PROTACs cause degradation via the ubiquitinproteasome system (UPS) through proximityinduced ubiquitination of the POI. PROTACs induce target protein degradation at low exposures due to their catalytic mode of action thus making them an attractive platform for cancer therapy and other diseases. The concept of PROTAC was developed by Raymond J. Desharies, Kathleen M. Sakamoto, Kyungbo Kim, and Craig M. Crews in 2001.2 Since then, significant progress has been made in developing multiple antitumor PROTACs over the last 20 years, with different subcellular localization.3 PROTACs due to their unique MOA achieve therapeutic efficacy at a very low dosing regimen compared to smallmolecule inhibitors (SMIs) which are used at higher concentrations. With PROTACs there lies a possibility to achieve tumor-specific degradation using ligands for tumor-specific E3 ligases and target “undruggable” proteins like transcription factors (TFs).4 Pharmaceutical companies have reported PROTACs targeting proteins related to various disease types. For example, PROTACs targeting B-cell lymphoma 6 (BCL6) were reported by AstraZeneca, Boehringer Ingelheim reported for focal adhesion kinase (FAK), Pfizer developed for Bruton’s tyrosine kinase (BTK), and Interleukin-1 receptor-associated kinase 4 (IRAK4) from GSK. More recently Arvinas, Inc., reported, ARV-110 an androgen (AR)-targeted PROTAC that exhibited satisfactory results in phase I clinical trial with high potency against both wild-type and mutants.5 As with any new technology, PROTACs have many challenges to overcome. There is an urgent need to establish new pharmacokinetics (PK) and pharmacodynamics (PD) evaluation system for PROTACs as the traditional methods cannot accurately measure their PK/PD properties due to their unique MOA.6 Developing an assay for effective screening for ligands that can be used in PROTACs for disrupting protein-protein interactions is a major challenge that needs to be addressed. A rational design for developing novel PROTACs is another major hurdle to address as there is limited knowledge on selectivity profiles, degradation mechanisms, and off-target effects in multiple diseases and cell types.7 There is an urgent need to explore the opportunities provided by PROTACs to address “undruggable targets’ as there has been only one reported example of","PeriodicalId":90863,"journal":{"name":"International journal of medicine and public health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48057282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}