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International journal of cancer research最新文献

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Inhibitory Effect of Lentils, Green Split and Yellow Peas (Sprouted and Non-sprouted) on Azoxymethane-induced Aberrant Crypt Foci in Fisher 344 Male Rats 小扁豆、绿裂豆和黄豆(发芽和未发芽)对偶氮甲烷诱导的Fisher 344雄性大鼠异常隐窝灶的抑制作用
International journal of cancer research Pub Date : 2014-01-01 DOI: 10.3923/IJCR.2014.27.36
K. Busambwa, R. L. Miller-Ceb, L. Aboagye, L. Dalrymple, J. Boateng, L. Shackelfor, L. Walker, M. Verghese
{"title":"Inhibitory Effect of Lentils, Green Split and Yellow Peas (Sprouted and Non-sprouted) on Azoxymethane-induced Aberrant Crypt Foci in Fisher 344 Male Rats","authors":"K. Busambwa, R. L. Miller-Ceb, L. Aboagye, L. Dalrymple, J. Boateng, L. Shackelfor, L. Walker, M. Verghese","doi":"10.3923/IJCR.2014.27.36","DOIUrl":"https://doi.org/10.3923/IJCR.2014.27.36","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"46 1","pages":"27-36"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74971485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Effect of Catha edulis on the Activities of Enzyme Markers of Carcinogenicity in Chemically-induced Hepatocellular Carcinoma in Rabbits 毛竹对兔化学诱导肝细胞癌致癌性酶标志物活性的影响
International journal of cancer research Pub Date : 2014-01-01 DOI: 10.3923/IJCR.2014.1.13
Haider Al-Mamary, Amina El-Shaiban, M. Al-Habori, A. Al-Meeri, A. Al-zubairi, M. Al-Mamary
{"title":"Effect of Catha edulis on the Activities of Enzyme Markers of Carcinogenicity in Chemically-induced Hepatocellular Carcinoma in Rabbits","authors":"Haider Al-Mamary, Amina El-Shaiban, M. Al-Habori, A. Al-Meeri, A. Al-zubairi, M. Al-Mamary","doi":"10.3923/IJCR.2014.1.13","DOIUrl":"https://doi.org/10.3923/IJCR.2014.1.13","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"51 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74738221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Role of Serum Osteopontin Level as a Diagnostic Biomarker for Early Hepatocellular Carcinoma 血清骨桥蛋白水平在早期肝细胞癌诊断中的作用
International journal of cancer research Pub Date : 2014-01-01 DOI: 10.3923/IJCR.2014.37.45
M. Abdelhami, E. DohaEl-Sayed, N. Omar
{"title":"Role of Serum Osteopontin Level as a Diagnostic Biomarker for Early Hepatocellular Carcinoma","authors":"M. Abdelhami, E. DohaEl-Sayed, N. Omar","doi":"10.3923/IJCR.2014.37.45","DOIUrl":"https://doi.org/10.3923/IJCR.2014.37.45","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"71 3 1","pages":"37-45"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77473578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Significance of Immunohistochemical Expression of Fascin and Caveolin-1 in Non Small Cell Lung Cancer 非小细胞肺癌中fastin和Caveolin-1免疫组化表达的意义
International journal of cancer research Pub Date : 2014-01-01 DOI: 10.3923/IJCR.2014.14.26
N. Osman, S. Hini, S. E. Elwany, Mohamed A. Ibrahie
{"title":"Significance of Immunohistochemical Expression of Fascin and Caveolin-1 in Non Small Cell Lung Cancer","authors":"N. Osman, S. Hini, S. E. Elwany, Mohamed A. Ibrahie","doi":"10.3923/IJCR.2014.14.26","DOIUrl":"https://doi.org/10.3923/IJCR.2014.14.26","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"74 1","pages":"14-26"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80609918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Apoptotic Effect of Wortmannolone on Cancer Cells through Potent ROS Induction. 沃曼诺酮通过活性氧诱导癌细胞凋亡的作用。
International journal of cancer research Pub Date : 2013-11-01
Ulyana Muñoz Acuña, Nighat Fatima, Safia Ahmed, Leng Chee Chang, Esperanza J Carcache de Blanco
{"title":"Apoptotic Effect of Wortmannolone on Cancer Cells through Potent ROS Induction.","authors":"Ulyana Muñoz Acuña,&nbsp;Nighat Fatima,&nbsp;Safia Ahmed,&nbsp;Leng Chee Chang,&nbsp;Esperanza J Carcache de Blanco","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nuclear factor κappa-B inhibitors isolated from natural sources that induce apoptosis are promising new agents with anticancer properties. Wortmannin and wortmannolone were isolated from endophytic fungus (<i>Penicillum polonicum</i>) and showed NF-κB inhibitory effects with inhibitory concentration (IC<sub>50</sub>) of 0.47 μM and 2.06 μM for wortmannin and wortmannolone, respectively. The activity was compared with rocaglamide (IC<sub>50</sub>=0.075 μM). The mechanism through which wortmannin and wortmannolone exhibited an attenuating effect on the NF-κB pathway was further evaluated in this study. Wortmannolone showed significant reactive oxygen species (ROS) inducing effects in HeLa cervical cells. The ROS inducing effect was concentration dependent, and the ROS generating activity was comparable with daunomycin, a potent chemotherapeutic agent. The findings suggested that the elevated formation of ROS was partially involved in the induction of apoptosis in treated cells. Potent cytotoxic and apoptotic effects were also displayed in MDA-MB-231 hormone independent breast cancer cells when treated with wortmannolone (IC<sub>50</sub>=3.79 nM). Thus, wortmannolone, a furanosteroid from an endophytic fungus, is a promising agent for further drug development.</p>","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"47 2","pages":"1185-1195"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318515/pdf/nihms-650873.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33364960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proliferative Inhibition and Apoptotic Mechanism on Human Non-small-cell Lung Cancer (A549 Cells) of a Novel Cucurbitacin from Wilbrandia ebracteata Cogn 新型葫芦素对人非小细胞肺癌(A549细胞)的增殖抑制及凋亡机制研究
International journal of cancer research Pub Date : 2013-02-01 DOI: 10.3923/IJCR.2013.54.68
I. T. Silva, M. R. Teixeira, K. L. Lang, T. R. Guimarães, S. E. Dudek, F. Durán, S. Ludwig, M. Caro, E. Schenkel, C. Simões
{"title":"Proliferative Inhibition and Apoptotic Mechanism on Human Non-small-cell Lung Cancer (A549 Cells) of a Novel Cucurbitacin from Wilbrandia ebracteata Cogn","authors":"I. T. Silva, M. R. Teixeira, K. L. Lang, T. R. Guimarães, S. E. Dudek, F. Durán, S. Ludwig, M. Caro, E. Schenkel, C. Simões","doi":"10.3923/IJCR.2013.54.68","DOIUrl":"https://doi.org/10.3923/IJCR.2013.54.68","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"17 1","pages":"54-68"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75538333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
The p.Pro47Ser Polymorphism of TP53: A Systematic Review TP53的p.Pro47Ser多态性:一个系统综述
International journal of cancer research Pub Date : 2013-01-01 DOI: 10.3923/IJCR.2013.1.8
N. Chandel, A. Chauhan, K. Guleria
{"title":"The p.Pro47Ser Polymorphism of TP53: A Systematic Review","authors":"N. Chandel, A. Chauhan, K. Guleria","doi":"10.3923/IJCR.2013.1.8","DOIUrl":"https://doi.org/10.3923/IJCR.2013.1.8","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"70 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88491638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Cytoprotective Effect and Antioxidant Properties of Silymarin on Cisplatin Induced Hepatotoxicity in Rats: A Biochemical and Histochemical Study 水飞蓟素对顺铂致大鼠肝毒性的细胞保护作用和抗氧化作用:生化和组织化学研究
International journal of cancer research Pub Date : 2013-01-01 DOI: 10.3923/IJCR.2013.9.23
N. S. Abouzeinab
{"title":"Cytoprotective Effect and Antioxidant Properties of Silymarin on Cisplatin Induced Hepatotoxicity in Rats: A Biochemical and Histochemical Study","authors":"N. S. Abouzeinab","doi":"10.3923/IJCR.2013.9.23","DOIUrl":"https://doi.org/10.3923/IJCR.2013.9.23","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"45 1","pages":"9-23"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87009216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Goyazensolide Induces Apoptosis in Cancer Cells in vitro and in vivo. 戈雅唑内酯诱导体外和体内癌细胞凋亡
International journal of cancer research Pub Date : 2013-01-01 DOI: 10.3923/ijcr.2013.36.53
Ulyana Muñoz Acuña, Qi Shen, Yulin Ren, Daniel D Lantvit, Jennifer A Wittwer, A Douglas Kinghorn, Steven M Swanson, Esperanza J Carcache de Blanco
{"title":"Goyazensolide Induces Apoptosis in Cancer Cells <i>in vitro</i> and <i>in vivo</i>.","authors":"Ulyana Muñoz Acuña, Qi Shen, Yulin Ren, Daniel D Lantvit, Jennifer A Wittwer, A Douglas Kinghorn, Steven M Swanson, Esperanza J Carcache de Blanco","doi":"10.3923/ijcr.2013.36.53","DOIUrl":"10.3923/ijcr.2013.36.53","url":null,"abstract":"<p><p>As part of the screening program for anticancer agents from natural sources, the sesquiterpene lactone goyazensolide (GZL) was identified as a potent NF-κB inhibitor. The hollow-fiber assay was used to evaluate the anti-tumor efficacy of GZL <i>in vivo</i>. The mechanistic effects of GZL were evaluated in the HT-29 colonic cell line to reveal the pathway through which GZL exerts its effects. NF-κB subunits p65 and p50 were inhibited, and the upstream mediator IκB kinase (IKKβ) was downregulated in a dose-dependent manner. Apoptosis was mediated by caspase-3, and cell cycle arrest was detected in G<sub>1</sub>-phase. Consequently, 96% of the cell population was in sub G<sub>1</sub>-phase after treatment with GZL (10 μM).The antitumor effect of GZL was observed at a dose of 12.5 mg/kg. Cell adhesion was affected as a result of NF-κB inhibition. GZL appears to selectively target the transcription factor NF-κB. In summary, GZL sensitizes HT-29 colon cancer cells to apoptosis and cell death in a dose-dependent manner both <i>in vivo</i> and <i>in vitro</i>, through NF-κB inhibition (IC<sub>50</sub> = 3.8 μM). Thus, it is a new potent lead compound for further development into a new effective chemotherapeutic agent.</p>","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"9 2","pages":"36-53"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303185/pdf/nihms-650875.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33003411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cortactin and EGFR Proteins Expression in Egyptian Patients with Non-small Cell Lung Carcinoma 埃及非小细胞肺癌患者表皮凝集素和EGFR蛋白的表达
International journal of cancer research Pub Date : 2013-01-01 DOI: 10.3923/IJCR.2013.24.35
A. I. Fawzy, M. Gayyed, N. Tawfik
{"title":"Cortactin and EGFR Proteins Expression in Egyptian Patients with Non-small Cell Lung Carcinoma","authors":"A. I. Fawzy, M. Gayyed, N. Tawfik","doi":"10.3923/IJCR.2013.24.35","DOIUrl":"https://doi.org/10.3923/IJCR.2013.24.35","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"46 1","pages":"24-35"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72534914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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