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Integrative cancer science and therapeutics最新文献

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APE1/Ref-1 with reducing activity induces mesenchymal-to-epithelial transition in TNF-α-stimulated breast cancer cells 具有还原活性的APE1/Ref-1在TNF-α刺激的乳腺癌细胞中诱导间质向上皮转化
Integrative cancer science and therapeutics Pub Date : 2022-01-01 DOI: 10.15761/icst.1000365
Sunga Choi, Ki Mo Kim, Euna Choi
{"title":"APE1/Ref-1 with reducing activity induces mesenchymal-to-epithelial transition in TNF-α-stimulated breast cancer cells","authors":"Sunga Choi, Ki Mo Kim, Euna Choi","doi":"10.15761/icst.1000365","DOIUrl":"https://doi.org/10.15761/icst.1000365","url":null,"abstract":"","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67478685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Exploiting mechanism-informed phenotypic screening for development of next-generation antimitotic phytochemicals 利用机制知情的表型筛选开发下一代抗有丝分裂植物化学物质
Integrative cancer science and therapeutics Pub Date : 2021-01-01 DOI: 10.15761/icst.1000350
Namrta Choudhry, Thaddeus David Allen, Vidhula R. Ahire, Jing Zhang, Dun Yang
{"title":"Exploiting mechanism-informed phenotypic screening for development of next-generation antimitotic phytochemicals","authors":"Namrta Choudhry, Thaddeus David Allen, Vidhula R. Ahire, Jing Zhang, Dun Yang","doi":"10.15761/icst.1000350","DOIUrl":"https://doi.org/10.15761/icst.1000350","url":null,"abstract":"in the CNS and therapeutic resistance which are repetitively seen at the time of microtubule-targeting, the use of these drugs is limited [1-4]. The new generation of mitotic drugs aims for the mitotic regulatory machinery which involves the motor proteins, mitotic kinesins, or the Aurora and polo-like kinases and complexes which are expressed only at the time of cell division [2]. Research efforts are intended towards developing superior antimitotic drugs that would not be only more specific in their action but would also lessen the burden of side effects on patients. Also, because cancer cells demonstrate vast phenotypic miscellany they are characteristically responsive to phenotypic screening which would assist in translating the molecular mechanism as a therapeutic approach in treating cancer with familiar cellular phenotypes following the theory of mechanism-informed phenotypic screening.","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67478144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Putative oncogenic viruses: Some data on Brazilian subjects 假定的致癌病毒:巴西受试者的一些数据
Integrative cancer science and therapeutics Pub Date : 2021-01-01 DOI: 10.15761/icst.1000358
Bernardo G Tenorio, Isadora S Bretas, Joao PRA Bernardes, Munnah NJ Mansour, Sarah MS Napoleao, Sheyla AS Rocha, Thatiane L Sampaio, Elisiario CV Leitao, Joaquim X Silva, Marcus VS Coimbra, Edson JM Bello, Elida CGM Kanzaki, I. Kanzaki
{"title":"Putative oncogenic viruses: Some data on Brazilian subjects","authors":"Bernardo G Tenorio, Isadora S Bretas, Joao PRA Bernardes, Munnah NJ Mansour, Sarah MS Napoleao, Sheyla AS Rocha, Thatiane L Sampaio, Elisiario CV Leitao, Joaquim X Silva, Marcus VS Coimbra, Edson JM Bello, Elida CGM Kanzaki, I. Kanzaki","doi":"10.15761/icst.1000358","DOIUrl":"https://doi.org/10.15761/icst.1000358","url":null,"abstract":"","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67478763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ataxia-telangiectasia 共济失调毛细血管扩张
Integrative cancer science and therapeutics Pub Date : 2021-01-01 DOI: 10.15761/icst.1000359
A. Ekladious
{"title":"Ataxia-telangiectasia","authors":"A. Ekladious","doi":"10.15761/icst.1000359","DOIUrl":"https://doi.org/10.15761/icst.1000359","url":null,"abstract":"proneness cancer-predisposing genes present in the population at frequencies affect cancer incidence which do not result in cancer with a high enough probability to give rise to \"cancer families.\" gene predisposing to be associated with the gene for debrizoquine metabolism autosomal recessive for A-T2 in the heterozygous (i.e., carrier) state, Homozygotes for A-T show a rare syndrome with a fascinating variety of aspects. Patients are deficient in immune response, show progressive neurological degeneration and defects in organ maturation, and are prone to develop cancer, particularly of the cells of the immune system Ref. Their cells show spontaneous chromosomal instabilities, and there are reports of hypersensitivity to the chromosome-breaking and/or lethal effect of ionizing radiation and certain chemicals such as bleomycin, neocarzinostatin, Adriamycin, and Hoechst 33342. A further addition to this list is phorbol ester (Shiloh, Boston, MA), a tumor that been cause endogenous","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67478811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of low doses of verapamil on the course of Kaposi's sarcoma 低剂量维拉帕米对卡波西肉瘤病程的影响
Integrative cancer science and therapeutics Pub Date : 2021-01-01 DOI: 10.15761/icst.1000362
Gridina Nina Yakivna
{"title":"The effect of low doses of verapamil on the course of Kaposi's sarcoma","authors":"Gridina Nina Yakivna","doi":"10.15761/icst.1000362","DOIUrl":"https://doi.org/10.15761/icst.1000362","url":null,"abstract":"","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67479077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial comments to the articles published in Volume 8 对第8卷发表的文章的评论
Integrative cancer science and therapeutics Pub Date : 2021-01-01 DOI: 10.15761/icst.1000363
H. Miyamoto
{"title":"Editorial comments to the articles published in Volume 8","authors":"H. Miyamoto","doi":"10.15761/icst.1000363","DOIUrl":"https://doi.org/10.15761/icst.1000363","url":null,"abstract":"","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67478623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular characterization of prevalence, serotypes, virulence factors, and antibiotic resistance of Streptococcus agalactiae in a maternity hospital, Iran 伊朗一家妇产医院无乳链球菌患病率、血清型、毒力因子和抗生素耐药性的分子特征
Integrative cancer science and therapeutics Pub Date : 2021-01-01 DOI: 10.15761/icst.1000356
Shokouh Sadat Aboutorabi, Z. Rasooli, H. Pakniat, Fahimeh Baloo
{"title":"Molecular characterization of prevalence, serotypes, virulence factors, and antibiotic resistance of Streptococcus agalactiae in a maternity hospital, Iran","authors":"Shokouh Sadat Aboutorabi, Z. Rasooli, H. Pakniat, Fahimeh Baloo","doi":"10.15761/icst.1000356","DOIUrl":"https://doi.org/10.15761/icst.1000356","url":null,"abstract":"","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67479013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Prospects for colorectal cancer prevention targeting intestinal microbiome 以肠道微生物组为靶点预防结直肠癌的研究前景
Integrative cancer science and therapeutics Pub Date : 2021-01-01 DOI: 10.15761/icst.1000351
T. Ohara
{"title":"Prospects for colorectal cancer prevention targeting intestinal microbiome","authors":"T. Ohara","doi":"10.15761/icst.1000351","DOIUrl":"https://doi.org/10.15761/icst.1000351","url":null,"abstract":"Received: January 03, 2021; Accepted: January 26, 2021; Published: January 29, 2021 It has been reported that a so-called clean colon procedure, in which all precancerous lesions, colorectal tubular adenomas / colorectal tubulovillous adenomas, are endoscopically resection treatment is extremely useful for preventing colorectal carcinogenesis and death from colorectal cancer [1-4]. The effectiveness of chemopreventive measures to take the antidiabetic drugs metformin and low-dose aspirin has also been reported [5-7]. Recently, there have been reports suggesting the involvement of intestinal microorganisms such as Fusobacterium nucleatum (F. nucleatum) in colorectal carcinogenesis [8-13], and there is a possibility that a strategy targeting intestinal microorganisms will be taken as future methods for preventing colorectal carcinogenesis. This review describes the prospects for new strategies on colorectal carcinogenesis prevention targeting intestinal microbiome such as F. nucleatum.","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67478281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytotherapy and oncology. A short review 植物疗法和肿瘤学。简短回顾
Integrative cancer science and therapeutics Pub Date : 2021-01-01 DOI: 10.15761/icst.1000353
A. Sannia
{"title":"Phytotherapy and oncology. A short review","authors":"A. Sannia","doi":"10.15761/icst.1000353","DOIUrl":"https://doi.org/10.15761/icst.1000353","url":null,"abstract":"","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67478372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compound cantharis revers chemotherapy resistance of TNBC via miR-520d/Beclin-1 signal axis 复方cantharis通过miR-520d/Beclin-1信号轴逆转TNBC化疗耐药
Integrative cancer science and therapeutics Pub Date : 2021-01-01 DOI: 10.15761/icst.1000354
Hong-chang Li, Huan Liu, Ya-feng Chen, Jie Li, Weiyan Liu, Ke-Bin Xu, D. Feng, Xia Sheng
{"title":"Compound cantharis revers chemotherapy resistance of TNBC via miR-520d/Beclin-1 signal axis","authors":"Hong-chang Li, Huan Liu, Ya-feng Chen, Jie Li, Weiyan Liu, Ke-Bin Xu, D. Feng, Xia Sheng","doi":"10.15761/icst.1000354","DOIUrl":"https://doi.org/10.15761/icst.1000354","url":null,"abstract":"","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67478572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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