{"title":"Administration of an Autogenous Vaccine in Patients with Chronic Bacterial Osteomyelitis","authors":"D. Vito, E. Jirillo, A. Ballini, G. Mastrorillo","doi":"10.13189/IID.2014.020103","DOIUrl":"https://doi.org/10.13189/IID.2014.020103","url":null,"abstract":"Since we face the problem of rapidly growing rates of antimicrobial resistance, autovaccination may provide a treatment alternative at least in those patients which suffer from treatment refractory infections. Interest is turning towards the therapy of infectious diseases by stimulation of the immune defence mechanisms. In fact there are reports of drug resistance in a wide range of bacterial diseases. In our experience, autovaccine immunization has the potential to treat chronic infections such as osteomyelitis unresponsive to antimicrobial therapy.","PeriodicalId":90849,"journal":{"name":"Immunology and infectious diseases","volume":"463 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77727306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dhelia M Williamson, Ruth Ann Marrie, Allison Ashley-Koch, Glen A Satten
{"title":"Interaction of <i>HLA-DRB1</i>*<i>1501</i> and <i>TNF-Alpha</i> in a Population-based Case-control Study of Multiple Sclerosis.","authors":"Dhelia M Williamson, Ruth Ann Marrie, Allison Ashley-Koch, Glen A Satten","doi":"10.13189/iid.2013.010102","DOIUrl":"10.13189/iid.2013.010102","url":null,"abstract":"<p><p>This study was conducted to determine whether single nucleotide polymorphisms (SNPs) in nine genes (human leukocyte antigen (<i>HLA</i>), T cell receptor beta (<i>TCA receptor β</i>), tumor necrosis factor α (<i>TNF α</i>), tumor necrosis factor β (<i>TNF β</i>), apolipoprotein E (<i>APOE</i>), interleukin 7 receptor alpha chain (<i>IL7RA</i>) interleukin 2 receptor alpha chain (<i>IL2RA</i>) myelin basic protein (<i>MBP</i>) and vitamin D receptor (<i>VDR</i>)) associated with multiple sclerosis (MS) could be replicated in a population-based sample, and to determine if these associations are modified by presence of <i>HLA DRB1</i>*<i>1501</i>. DNA was available from 722 individuals (223 with MS and 499 controls) who participated in a population-based case-control study. Cases and controls were matched on ancestry, age, gender and geographic area. <i>HLA DRB1</i>*<i>1501</i> risk allele (T) was confirmed in this population using a genotypic test, controlling for multiple comparisons. Examining the effect of each SNP in the presence or absence of the <i>HLA DRB1</i>*<i>1501</i> risk allele identified significant associations with <i>TNF α -1031</i> (rs1799964) among those without the HLA risk allele. No additional interactions were significant in a cases-only analysis. Our results indicate that an interaction between SNPs in TNF α and HLA DRB1*1501 may influence the risk of developing MS.</p>","PeriodicalId":90849,"journal":{"name":"Immunology and infectious diseases","volume":"1 1","pages":"10-17"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328031/pdf/nihms655953.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33104273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}