Biomaterials Research最新文献

{"title":"Biomaterial-based CRISPR/Cas9 delivery systems for tumor treatment","authors":"Mengmeng Li, Fenglei chen, Qian Yang, Qinglai Tang, Z. Xiao, Xinying Tong, Ying Zhang, Lanjie Lei, Shisheng Li","doi":"10.34133/bmr.0023","DOIUrl":"https://doi.org/10.34133/bmr.0023","url":null,"abstract":"","PeriodicalId":9079,"journal":{"name":"Biomaterials Research","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140376180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Size-dependent effect of indocyanine green nano-imaging agent for metastatic lymph node detection","authors":"Quoc-Viet Le, Sungtaek Kang, Jaeseong Lee, Hyeseon Park, Jeong Gil Sun, Jaiwoo Lee, G. Shim","doi":"10.34133/bmr.0022","DOIUrl":"https://doi.org/10.34133/bmr.0022","url":null,"abstract":"","PeriodicalId":9079,"journal":{"name":"Biomaterials Research","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140375253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accurately controlled tumor temperature with silica-coated gold nanorods for optimal immune checkpoint blockade therapy","authors":"W. Yun, Wonseok Yang, M. Shim, Sukyung Song, Jiwoong Choi, Jeongrae Kim, Jinseong Kim, Yujeong Moon, Seonghoon Jo, Dong-Kwon Lim, Kwangmeyung Kim","doi":"10.34133/bmr.0024","DOIUrl":"https://doi.org/10.34133/bmr.0024","url":null,"abstract":"","PeriodicalId":9079,"journal":{"name":"Biomaterials Research","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140374139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Standardized Rat Model to Study Transmucosal Osseointegrated Implants Peri-implantitis","authors":"Xingchen Liu, Shudan Deng, Xiyan Li, Haiwen Liu, Zhixin Li, You Wu, Pu Luo, Xin Zhong, R. Huang, Runheng Liu, Xiayi Wu, Baoxin Huang, Zetao Chen, Zhuofan Chen, Shoucheng Chen","doi":"10.34133/bmr.0021","DOIUrl":"https://doi.org/10.34133/bmr.0021","url":null,"abstract":"","PeriodicalId":9079,"journal":{"name":"Biomaterials Research","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140374212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable and near-infrared light-controllable fibrin hydrogels with antimicrobial and immunomodulating properties for infected wound healing","authors":"Guoqing Wei, Qing Zhang, Yongxian Jiang, Xiaolong Zhang, Yi Wang, Rong Ju","doi":"10.34133/bmr.0019","DOIUrl":"https://doi.org/10.34133/bmr.0019","url":null,"abstract":"","PeriodicalId":9079,"journal":{"name":"Biomaterials Research","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140224657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteogenic effect of magnesium oxychloride cement modified with phytic acid and loaded with strontium ranelate","authors":"Ting-jian Ma, Yijia Guan, Jinlun Feng, Yue Yang, Junying Chen, Wenjie Guo, Jianguo Liao, Yanru Zhang","doi":"10.1186/s40824-023-00474-8","DOIUrl":"https://doi.org/10.1186/s40824-023-00474-8","url":null,"abstract":"","PeriodicalId":9079,"journal":{"name":"Biomaterials Research","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138610175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in extracellular vesicle engineering and its applications to regenerative medicine","authors":"Won-Kyu Rhim, Jun Yong Kim, Seung Yeon Lee, Seung-Gyu Cha, Jeong Min Park, Hyeon Jeong Park, Chun Gwon Park, D. K. Han","doi":"10.1186/s40824-023-00468-6","DOIUrl":"https://doi.org/10.1186/s40824-023-00468-6","url":null,"abstract":"","PeriodicalId":9079,"journal":{"name":"Biomaterials Research","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138616459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fe-curcumin nanozyme-mediated immunosuppression and anti-inflammation in experimental autoimmune uveitis","authors":"Zhengxuan Jiang, Kun Liang, Xiang Gao, Fan Cao, Guangqi An, Si-qian Gui, Weiwei Tang, Liping Du, L. Tao, Xianwen Wang","doi":"10.1186/s40824-023-00451-1","DOIUrl":"https://doi.org/10.1186/s40824-023-00451-1","url":null,"abstract":"","PeriodicalId":9079,"journal":{"name":"Biomaterials Research","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138623421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoralen synergies with zinc implants to promote bone repair by regulating ZIP4 in rats with bone defect","authors":"Meijing Liu, Junlong Tan, Shuang Li, Chaoyang Sun, Xiangning Liu, Hongtao Yang, Xiaogang Wang","doi":"10.1186/s40824-023-00472-w","DOIUrl":"https://doi.org/10.1186/s40824-023-00472-w","url":null,"abstract":"","PeriodicalId":9079,"journal":{"name":"Biomaterials Research","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138612396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoarchitectured conjugates targeting angiogenesis: investigating heparin-taurocholate acid conjugates (LHT7) as an advanced anti-angiogenic therapy for brain tumor treatment.","authors":"Hyung Shik Kim,&nbsp;Jae Hak Seol,&nbsp;Hae Hyun Hwang,&nbsp;Dong Yun Lee","doi":"10.1186/s40824-023-00420-8","DOIUrl":"10.1186/s40824-023-00420-8","url":null,"abstract":"<p><strong>Background: </strong>Glioblastoma is a highly malignant brain tumor associated with poor prognosis. Conventional therapeutic approaches have limitations due to their toxic effects on normal tissue and the development of tumor cell resistance. This study aimed to explore alternative mechanisms for glioblastoma treatment by targeting angiogenesis.</p><p><strong>Methods: </strong>The study investigated the anti-angiogenic properties of heparin in glioblastoma treatment. To overcome the limitations of heparin, a heparin-taurocholate conjugate (LHT7) was synthesized by conjugating heparin to taurocholic acid. The study utilized the U87MG human glioblastoma cell line and human umbilical vein endothelial cells (HUVEC) as experimental models. Cell viability assays and sprouting assays were performed to assess the effects of LHT7. Additionally, phosphorylation of angiogenesis-related proteins, such as phospho-ERK and phospho-VEGFR2, was measured. The anti-angiogenic effects of LHT7 were further evaluated using a glioblastoma orthotopic mouse model.</p><p><strong>Results: </strong>Treatment with LHT7 resulted in a dose-dependent reduction in cell viability in U87MG human glioblastoma cells. The sprouting of HUVEC cells was significantly decreased upon LHT7 treatment. Furthermore, LHT7 treatment led to a decrease in the phosphorylation of angiogenesis-related proteins, including phospho-ERK and phospho-VEGFR2. In the glioblastoma orthotopic mouse model, LHT7 exhibited anti-angiogenic effects, supporting its potential as a therapeutic agent.</p><p><strong>Conclusions: </strong>The conjugation of heparin and taurocholic acid to create LHT7 offers several advantages over conventional therapeutic approaches for glioblastoma. LHT7 demonstrated anti-angiogenic properties, as evidenced by the reduction in cell viability and inhibition of endothelial cell sprouting. Moreover, LHT7 modulated the phosphorylation of angiogenesis-related proteins. These findings suggest that LHT7 holds promise as a medication for glioblastoma treatment, offering potential implications for improving patient outcomes.</p>","PeriodicalId":9079,"journal":{"name":"Biomaterials Research","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10310823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}