World journal of translational medicine最新文献

{"title":"Duodenal neuroendocrine tumor-tertiary care centre experience: A case report","authors":"U. Malladi, Suraj Kumar Chimata, R. K. Bhashyakarla, Sahitya Reddy Lingampally, Vikas Reddy Venkannagari, Zeeshan Ali Mohammed, Rahul Vijay Vargiya","doi":"10.5528/wjtm.v11.i1.1","DOIUrl":"https://doi.org/10.5528/wjtm.v11.i1.1","url":null,"abstract":"","PeriodicalId":90769,"journal":{"name":"World journal of translational medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45259254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation therapy for osteoarthritis: Mechanisms of action","authors":"Fábio Pericinoto Giolo, G. Santos, Victor Fontes Pacheco, S. Huber, K. Malange, B. Rodrigues, F. Bassora, Tomas Mosaner, G. Azzini, Lucas Leite Ribeiro, C. Parada, J. F. Lana","doi":"10.5528/wjtm.v10.i3.29","DOIUrl":"https://doi.org/10.5528/wjtm.v10.i3.29","url":null,"abstract":"Photobiomodulation (PBM) is a non-invasive therapeutic modality with demonstrated effects in many fields related to regenerative medicine. In the field of orthopedics, in particular, PBM at various wavelengths has demonstrated the capacity to trigger multiple biological effects associated with protective mechanisms in musculoskeletal tissues. The articles cited in this review show that devices operating close to or within the near infrared range at low intensities can provoke responses which favor the shift in the predominant catabolic microenvironment typically seen in degenerative joint diseases, especially osteoarthritis (OA). These responses include proliferation, differentiation and expression of proteins associated with stable cell cycles. Additionally, PBM can also modulate oxidative stress, inflammation and pain by exerting regulatory effects on immune cells and blocking the transmission of pain through sensory neuron fibers, without adverse events. Collectively, these effects are essential in order to control the progression of OA, which is in part attributed to exacerbated inflammation Giolo FP et al. PBM therapy for osteoarthritis: Mechanisms of action WJTM https://www.wjgnet.com 30 August 26, 2022 Volume 10 Issue 3 and degradative enzymatic reactions which gradually contribute to the destruction of joint tissues. PBM may offer medical experts ease of application, financial viability, efficacy and lack of serious adverse events. Therefore, it may prove to be a suitable ally in the management of mild to moderate degrees of OA. This review explores and discusses the principal biological mechanisms of PBM and how the produced effects may contribute to the amelioration of osteoarthritic progression. Literature was reviewed using PubMed and Google Scholar in order to find studies describing the mechanisms of PBM. The investigation included a combination of nomenclature such as: “photobiomodulation”, “phototherapy”, “laser therapy”, “PBM”, “osteoarthritis”, low level light therapy”, “inflammation” and “cartilage”. We considered only articles written in English, with access to the full text.","PeriodicalId":90769,"journal":{"name":"World journal of translational medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47329367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current progress and emerging technologies for generating extrapancreatic functional insulin-producing cells","authors":"Md. Aejaz Habeeb, S. Vishwakarma, Safwaan Habeeb, A. Khan","doi":"10.5528/wjtm.v10.i1.1","DOIUrl":"https://doi.org/10.5528/wjtm.v10.i1.1","url":null,"abstract":"","PeriodicalId":90769,"journal":{"name":"World journal of translational medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44102308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine intelligence for precision oncology","authors":"N. Yee","doi":"10.5528/WJTM.V9.I1.1","DOIUrl":"https://doi.org/10.5528/WJTM.V9.I1.1","url":null,"abstract":"","PeriodicalId":90769,"journal":{"name":"World journal of translational medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42939148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation and cardiovascular disease","authors":"C. Katsiari, D. Bogdanos, L. Sakkas","doi":"10.5528/WJTM.V8.I1.1","DOIUrl":"https://doi.org/10.5528/WJTM.V8.I1.1","url":null,"abstract":"Presentacion del programa Programa RES@CNIC 2019, dentro de la seccion Pathology of the Cardiovascular System","PeriodicalId":90769,"journal":{"name":"World journal of translational medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41355609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"More than boric acid: Increasing relevance of boron in medicine","authors":"E. Farfán-García, Emily L. Castillo-García, M. Soriano-Ursúa","doi":"10.5528/WJTM.V7.I1.1","DOIUrl":"https://doi.org/10.5528/WJTM.V7.I1.1","url":null,"abstract":"","PeriodicalId":90769,"journal":{"name":"World journal of translational medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47490509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene editing for corneal disease management.","authors":"Sudhanshu P Raikwar,&nbsp;Apoorva S Raikwar,&nbsp;Shyam S Chaurasia,&nbsp;Rajiv R Mohan","doi":"10.5528/wjtm.v5.i1.1","DOIUrl":"https://doi.org/10.5528/wjtm.v5.i1.1","url":null,"abstract":"<p><p>Gene editing has recently emerged as a promising technology to engineer genetic modifications precisely in the genome to achieve long-term relief from corneal disorders. Recent advances in the molecular biology leading to the development of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) and CRISPR-associated systems, zinc finger nucleases and transcription activator like effector nucleases have ushered in a new era for high throughput <i>in vitro</i> and <i>in vivo</i> genome engineering. Genome editing can be successfully used to decipher complex molecular mechanisms underlying disease pathophysiology, develop innovative next generation gene therapy, stem cell-based regenerative therapy, and personalized medicine for corneal and other ocular diseases. In this review we describe latest developments in the field of genome editing, current challenges, and future prospects for the development of personalized gene-based medicine for corneal diseases. The gene editing approach is expected to revolutionize current diagnostic and treatment practices for curing blindness.</p>","PeriodicalId":90769,"journal":{"name":"World journal of translational medicine","volume":"5 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2016-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9b/a6/nihms-1814087.PMC9221704.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40403060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contributions of neutrophils to the adaptive immune response in autoimmune disease","authors":"Kathryn M. Pietrosimone, Peng Liu","doi":"10.5528/wjtm.v4.i3.60","DOIUrl":"https://doi.org/10.5528/wjtm.v4.i3.60","url":null,"abstract":"Neutrophils are granulocytic cytotoxic leukocytes of the innate immune system that activate during acute inflammation. Neutrophils can also persist beyond the acute phase of inflammation to impact the adaptive immune response during chronic inflammation. In the context of the autoimmune disease, neutrophils modulating T and B cell functions by producing cytokines and chemokines, forming neutrophil extracellular traps, and acting as or priming antigen presentation cells. Thus, neutrophils are actively involved in chronic inflammation and tissue damage in autoimmune disease. Using rheumatoid arthritis as an example, this review focuses on functions of neutrophils in adaptive immunity and the therapeutic potential of these cells in the treatment of autoimmune disease and chronic inflammation.","PeriodicalId":90769,"journal":{"name":"World journal of translational medicine","volume":"4 1","pages":"60 - 68"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71037343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epithelial ovarian cancer: An overview.","authors":"Arpita Desai, Jingyao Xu, Kartik Aysola, Yunlong Qin, Chika Okoli, Ravipati Hariprasad, Ugorji Chinemerem, Candace Gates, Avinash Reddy, Omar Danner, Geary Franklin, Anachebe Ngozi, Guilherme Cantuaria, Karan Singh, William Grizzle, Charles Landen, Edward E Partridge, Valerie Montgomery Rice, E Shyam P Reddy, Veena N Rao","doi":"10.5528/wjtm.v3.i1.1","DOIUrl":"10.5528/wjtm.v3.i1.1","url":null,"abstract":"<p><p>Ovarian cancer is the second most common gynecological cancer and the leading cause of death in the United States. In this article we review the diagnosis and current management of epithelial ovarian cancer which accounts for over 95 percent of the ovarian malignancies. We will present various theories about the potential origin of ovarian malignancies. We will discuss the genetic anomalies and syndromes that may cause ovarian cancers with emphasis on Breast cancer type 1/2 mutations. The pathology and pathogenesis of ovarian carcinoma will also be presented. Lastly, we provide a comprehensive overview of treatment strategies and staging of ovarian cancer, conclusions and future directions.</p>","PeriodicalId":90769,"journal":{"name":"World journal of translational medicine","volume":"3 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2014-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267287/pdf/nihms631405.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32921525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular recognition of live <i>methicillin-resistant staphylococcus aureus</i> cells using DNA aptamers.","authors":"Diane Turek,&nbsp;Dimitri Van Simaeys,&nbsp;Judith Johnson,&nbsp;Ismail Ocsoy,&nbsp;Weihong Tan","doi":"10.5528/wjtm.v2.i3.67","DOIUrl":"https://doi.org/10.5528/wjtm.v2.i3.67","url":null,"abstract":"<p><strong>Aim: </strong>To generate DNA-aptamers binding to <i>Methicillin-resistant Staphylococcus aureus (MRSA)</i>.</p><p><strong>Methods: </strong>The Cell-Systematic Evolution of Ligands by Exponential Enrichment (SELEX) technology was used to run the selection against <i>MRSA</i> bacteria and develop target-specific aptamers. <i>MRSA</i> bacteria were targeted while <i>Enterococcus faecalis</i> bacteria were used for counter selection during that process. Binding assays to determine the right aptamer candidates as well as binding assays on clinical samples were performed through flow cytometry and analyzed using the FlowJo software. The characterization of the aptamers was done by determination of their <i>K_d</i> values and determined by analysis of flow data at different aptamer concentration using SigmaPlot. Finally, the recognition of the complex Gold-nanoparticle-aptamer to the bacteria cells was observed using transmission electron microscopy (TEM).</p><p><strong>Results: </strong>During the cell-SELEX selection process, 17 rounds were necessary to generate enrichment of the pool. While the selection was run using fixed cells, it was shown that the binding of the pools with live cells was giving similar results. After sequencing and analysis of the two last pools, four sequences were identified to be aptamer candidates. The characterization of those aptamers showed that based on their <i>K_d</i> values, DTMRSA4 presented the best binding with a <i>K_d</i> value of 94.61 ± 18.82 nmol/L. A total of ten clinical samples of <i>MRSA</i> , <i>S. aureus</i> and <i>Enterococcus faecalis</i> were obtained to test those aptamers and determine their binding on a panel of samples. DTMRSA1 and DTMRSA3 showed the best results regarding their specificity to <i>MRSA</i> , DTMRSA1 being the most specific of all. Finally, those aptamers were coupled with gold-nanoparticle and their binding to <i>MRSA</i> cells was visualized through TEM showing that adduction of nanoparticles on the aptamers did not change their binding property.</p><p><strong>Conclusion: </strong>A total of four aptamers that bind to MRSA were obtained with <i>K_d</i> values ranking from 94 to 200 nmol/L.</p>","PeriodicalId":90769,"journal":{"name":"World journal of translational medicine","volume":"2 3","pages":"67-74"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244701/pdf/nihms-609628.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32848489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}