Contributions of neutrophils to the adaptive immune response in autoimmune disease

Kathryn M. Pietrosimone, Peng Liu
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引用次数: 10

Abstract

Neutrophils are granulocytic cytotoxic leukocytes of the innate immune system that activate during acute inflammation. Neutrophils can also persist beyond the acute phase of inflammation to impact the adaptive immune response during chronic inflammation. In the context of the autoimmune disease, neutrophils modulating T and B cell functions by producing cytokines and chemokines, forming neutrophil extracellular traps, and acting as or priming antigen presentation cells. Thus, neutrophils are actively involved in chronic inflammation and tissue damage in autoimmune disease. Using rheumatoid arthritis as an example, this review focuses on functions of neutrophils in adaptive immunity and the therapeutic potential of these cells in the treatment of autoimmune disease and chronic inflammation.
中性粒细胞对自身免疫性疾病适应性免疫反应的贡献
中性粒细胞是先天免疫系统的粒细胞毒性白细胞,在急性炎症期间被激活。中性粒细胞也可以在炎症急性期后持续存在,影响慢性炎症期间的适应性免疫反应。在自身免疫性疾病中,中性粒细胞通过产生细胞因子和趋化因子、形成中性粒细胞胞外陷阱和充当或启动抗原呈递细胞来调节T细胞和B细胞的功能。因此,中性粒细胞积极参与自身免疫性疾病的慢性炎症和组织损伤。本文以类风湿性关节炎为例,就中性粒细胞在适应性免疫中的功能及其在自身免疫性疾病和慢性炎症中的治疗潜力进行综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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