microRNA diagnostics and therapeutics最新文献

Metabolic Reprogramming of Triple-Negative Breast Cancer: The Role of miRNAs 三阴性乳腺癌的代谢重编程:mirna的作用

microRNA diagnostics and therapeutics Pub Date : 2017-12-20 DOI: 10.1515/MICRNAT-2017-0001

A. Qattan

{"title":"Metabolic Reprogramming of Triple-Negative Breast Cancer: The Role of miRNAs","authors":"A. Qattan","doi":"10.1515/MICRNAT-2017-0001","DOIUrl":"https://doi.org/10.1515/MICRNAT-2017-0001","url":null,"abstract":"MicroRNAs (miRNAs) are well known to influence the expression of the genes that regulate critical cellular functions. Various reports have suggested that they play critical roles in breast cancer metabolism through the regulation of various metabolic pathways, including the metabolism of glucose, lipids, glycolysis and the mitochondrial tricarboxylic acid cycle (TCA). miRNAs regulate the metabolic process by targeting key molecules (enzymes, kinases transporters) or by modifying the expression of key transcription molecules. In addition, miRNAs can indirectly regulate mRNA translation by targeting chromatin-remodeling enzymes. Furthermore, miRNAs influence the expression of both oncogenes and tumor suppressors and have a major impact on PI3K/AKT, HIF, and MYC signal transduction, which contributes to the metabolic phenotype in human cancer. Although human epidermal growth factor and endocrine therapies have been effective in treating breast cancer, for locally advanced and distant metastases mortality remains high. Drug resistance and recurrence remain major hurdles for advanced breast cancer therapy. Given the critical influence of metabolic reprogramming in the progression of neoplasm, tumorigenesis and metastasis, research should focus on novel targets of metabolic enzymes to reverse drug resistance and improve overall survival rates. Blocking the miRNAs that contribute to metabolic reprogramming or the use of exogenous miRNAs as antisense oligonucleotides, may be an effective way to treat aggressive, chemo-resistant cancers. This review summarizes current knowledge on the mechanism of Research Article","PeriodicalId":90652,"journal":{"name":"microRNA diagnostics and therapeutics","volume":"3 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/MICRNAT-2017-0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42430720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Exosomic microRNAs as emerging key regulators of intercellular communication in the tumor microenvironment and beyond 外泌体microrna在肿瘤微环境及其他环境中作为细胞间通讯的关键调节因子

microRNA diagnostics and therapeutics Pub Date : 2016-01-21 DOI: 10.1515/MICRNAT-2016-0001

M. Murtadha, M. Fabbri

引用次数: 0

microRNA-based diagnostic and therapeutic opportunities in lung cancer 基于微rna的肺癌诊断和治疗的机会

microRNA diagnostics and therapeutics Pub Date : 2015-04-29 DOI: 10.2478/MICRNAT-2014-0006

Jianfei Zhao, Yan Cai, Xi Liu

引用次数: 0

MicroRNAs are central to osteogenesis: a review with a focus on cardiovascular calcification microrna是骨形成的核心:综述与心血管钙化的重点

microRNA diagnostics and therapeutics Pub Date : 2015-03-24 DOI: 10.2478/MICRNAT-2014-0005

S. Coffey, Gregory T. Jones

引用次数: 2

miRNA function and modulation in stem cells and cancer stem cells miRNA在干细胞和肿瘤干细胞中的功能和调控

microRNA diagnostics and therapeutics Pub Date : 2014-12-17 DOI: 10.2478/MICRNAT-2014-0004

A. Decastro, J. Direnzo

引用次数: 1

From life to death: microRNAs in the fine tuning of the heart 从生到死:心脏微调中的微rna

microRNA diagnostics and therapeutics Pub Date : 2014-12-12 DOI: 10.2478/MICRNAT-2014-0003

Sayantan Nath, S. Rizvi, Munish Kumar

{"title":"From life to death: microRNAs in the fine tuning of the heart","authors":"Sayantan Nath, S. Rizvi, Munish Kumar","doi":"10.2478/MICRNAT-2014-0003","DOIUrl":"https://doi.org/10.2478/MICRNAT-2014-0003","url":null,"abstract":"The heart is one of the most important vital organs, and any malfunctioning of the heart and its blood vessels may contribute to cardiovascular disorders. Diseases of the cardiovascular system represent the most common cause of human morbidity and mortality around the globe. Thus, there is always a need for innovative new therapies and diagnostics for cardiovascular disorders. In the past decades, a plethora of tiny, endogenous, single- stranded RNA sequences called microRNAs (miRNAs) has been studied meticulously in cardiovascular development and pathophysiology, providing a new dimension to the heart's biology. miRNAs posttranscriptional inhibit the gene expression of specific mRNA targets through Watson- Crick base pairing between the miRNA \"seed region\" and the 3' untranslated regions (UTRs) of target mRNAs. Better recognized as \"master switches\", miRNAs are emerging as vital regulators of mammalian cardiovascular development and disease and thus are helpful in understanding therapeutic targets and diagnostics for a variety of cardiovascular disorders. In this review, a detailed discussion of the roles of various microRNAs in cardiovascular development and pathophysiology with potential therapeutics is considered.","PeriodicalId":90652,"journal":{"name":"microRNA diagnostics and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/MICRNAT-2014-0003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69232901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating MicroRNAs as Biomarkers in Coronary Heart Disease and Heart Failure 循环microrna作为冠心病和心力衰竭的生物标志物

microRNA diagnostics and therapeutics Pub Date : 2014-09-12 DOI: 10.2478/MICRNAT-2014-0002

V. Cameron, A. Pilbrow

{"title":"Circulating MicroRNAs as Biomarkers in Coronary Heart Disease and Heart Failure","authors":"V. Cameron, A. Pilbrow","doi":"10.2478/MICRNAT-2014-0002","DOIUrl":"https://doi.org/10.2478/MICRNAT-2014-0002","url":null,"abstract":"MicroRNAs (miRNAs) are small non-coding, single-stranded RNAs (19-25 nucleotides long) that regulate expression of multiple target genes, predominantly by binding to the 3' untranslated region of messenger RNA (mRNA) transcripts, resulting either in translational inhibition or mRNA degradation. miRNAs are found in many bodily fluids, including plasma and serum, and are protected from degradation in the circulation through association with lipids, proteins, or microparticles, making them attractive disease biomarker candidates. Circulating levels of cardiac miRNAs (including miR-1, miR-133a, miR-208a, miR-208b, and miR-499) have been frequently reported as elevated in both coronary heart disease (CHD) and heart failure (HF) and have been proposed as candidate biomarkers that reflect the severity of myocardial injury. Subsequent large, array-based screening studies comparing patients and controls have identified altered expression of additional miRNAs, not just those of cardiac origin. However, among these studies there has been little consensus as to which miRNAs are top candidates for diagnosis or prognosis in either CHD or HF. The measurement of circulating miRNAs is further complicated by the timing of collection, especially after acute cardiac events while miRNA levels in blood may be rapidly changing; confounding influences from medications or contaminating blood cells at the time of sampling; and the need for standardization of normalization strategies. This review evaluates recent developments in the identification of circulating miRNAs as markers for diagnosis and prognosis in CHD and HF, and the methodological issues in measurement of circulating miRNAs. Research Article","PeriodicalId":90652,"journal":{"name":"microRNA diagnostics and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/MICRNAT-2014-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69232886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Can miRNA Biomarkers Be Utilized to Improve the Evaluation and Management of Pancreatic Cystic Lesions miRNA生物标志物能否用于改善胰腺囊性病变的评估和管理

microRNA diagnostics and therapeutics Pub Date : 2014-01-01 DOI: 10.2478/MICRNAT-2013-0003

Linda S. Lee, A. E. Szafranska-Schwarzbach, B. Andruss, D. Conwell

引用次数: 1

Diet-Derived MicroRNAs: Separating the Dream from Reality 饮食衍生的microrna:将梦想与现实分离

microRNA diagnostics and therapeutics Pub Date : 2014-01-01 DOI: 10.2478/MICRNAT-2014-0001

K. Cottrill, S. Y. Chan

引用次数: 14

In situ hybridization-based detection of microRNAs in human diseases 基于原位杂交技术检测人类疾病中的microrna

microRNA diagnostics and therapeutics Pub Date : 2014-01-01 DOI: 10.2478/MICRNAT-2013-0002

Xinna Zhang, Xiongbin Lu, G. Lopez-Berestein, A. Sood, G. Calin

引用次数: 12