Brain research. Developmental brain research最新文献

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Decrease of (+)-3-[125I]MK-801 binding to NMDA brain receptors revealed at puberty in rats treated neonatally with monosodium glutamate. 谷氨酸钠对大鼠青春期(+)-3-[125I]MK-801与NMDA脑受体结合的影响
Brain research. Developmental brain research Pub Date : 1996-01-01 DOI: 10.1016/0165-3806(96)00082-x
R. Otoya, A. Seltzer, A. Donoso
{"title":"Decrease of (+)-3-[125I]MK-801 binding to NMDA brain receptors revealed at puberty in rats treated neonatally with monosodium glutamate.","authors":"R. Otoya, A. Seltzer, A. Donoso","doi":"10.1016/0165-3806(96)00082-x","DOIUrl":"https://doi.org/10.1016/0165-3806(96)00082-x","url":null,"abstract":"","PeriodicalId":9057,"journal":{"name":"Brain research. Developmental brain research","volume":"226 1","pages":"149-56"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76094725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Expression of GAP-43 (neuromodulin) during the development of the rat adrenal gland. 大鼠肾上腺发育过程中神经调节素-43的表达。
N J Grant, F König, D Aunis, K Langley
{"title":"Expression of GAP-43 (neuromodulin) during the development of the rat adrenal gland.","authors":"N J Grant,&nbsp;F König,&nbsp;D Aunis,&nbsp;K Langley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The 'growth-associated protein', GAP-43 was originally considered to be a neuron-specific protein associated with plasticity. However, we have recently shown that GAP-43 is expressed by noradrenergic, but not by adrenergic chromaffin cells in the adult rat adrenal gland. In this study, we examine the expression of GAP-43 during embryonic and post-natal development of the adrenal gland using immunohistochemical techniques. In parallel, antibodies directed against two neuroendocrine markers, the catecholamine-synthesizing enzymes, tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) were employed to permit identification of the developing chromaffin cell phenotypes. At embryonic day 15.5, GAP-43 was predominately localized in sympathoadrenergic precursor cells in the extra-adrenal blastema, and also in nerve fibers within the adrenal gland. At later embryonic stages, GAP-43 was expressed by nearly all intra-adrenal chromoblasts. Two subsets of chromoblasts can be distinguished even at early stages. A strong GAP-43-positive immunoreaction was observed in those chromoblasts organized in a few large compact clusters which weakly expressed TH and did not express PNMT. A generally weaker GAP-43 immunoreaction was observed in a second type of intra-adrenal chromoblasts which were organized in small isolated groups and characterized by a PNMT-positive, and strong TH-positive immunoreactivity. GAP-43 immunoreactivity was still associated with many PNMT-positive adrenergic chromoblasts at birth, but decreased to undetectable levels during the first post-natal week. By the second post-natal week, GAP-43 was restricted, as in the adult, to noradrenergic chromaffin cells which expressed TH, but not PNMT, in addition to nerve fibers and their associated glial cells in the gland. An immunoblot analysis confirmed a decrease in GAP-43 protein during the post-natal period. In agreement with these observations, a three-fold decrease in GAP-43 mRNA in the adrenal gland was measured between late embryogenesis and the second post-natal week. During development, the spatiotemporal expression of GAP-43 suggests a possible role in the migration and aggregation of chromaffin cell precursors into the medullary region of the adrenal gland.</p>","PeriodicalId":9057,"journal":{"name":"Brain research. Developmental brain research","volume":"82 1-2","pages":"265-76"},"PeriodicalIF":0.0,"publicationDate":"1994-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18840822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transient expression of somatostatin immunoreactivity in the olfactory-forebrain region in the chick embryo. 鸡胚嗅前脑区生长抑素免疫反应性的瞬时表达。
Brain research. Developmental brain research Pub Date : 1994-01-01 DOI: 10.1016/S0921-8696(05)80983-1
S. Murakami, Yasumasa Arai
{"title":"Transient expression of somatostatin immunoreactivity in the olfactory-forebrain region in the chick embryo.","authors":"S. Murakami, Yasumasa Arai","doi":"10.1016/S0921-8696(05)80983-1","DOIUrl":"https://doi.org/10.1016/S0921-8696(05)80983-1","url":null,"abstract":"","PeriodicalId":9057,"journal":{"name":"Brain research. Developmental brain research","volume":"1997 1","pages":"277-85"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82487963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Spatial-temporal appearance of developing immunoreactive TRH neurons in the neuroepithelial wall of the diencephalon. 间脑神经上皮壁发育中的免疫反应性TRH神经元的时空外观。
Brain research. Developmental brain research Pub Date : 1991-01-01 DOI: 10.1016/0921-8696(91)90845-E
Y. Okamura, H. Kawano, S. Daikoku
{"title":"Spatial-temporal appearance of developing immunoreactive TRH neurons in the neuroepithelial wall of the diencephalon.","authors":"Y. Okamura, H. Kawano, S. Daikoku","doi":"10.1016/0921-8696(91)90845-E","DOIUrl":"https://doi.org/10.1016/0921-8696(91)90845-E","url":null,"abstract":"","PeriodicalId":9057,"journal":{"name":"Brain research. Developmental brain research","volume":"8 1","pages":"21-31"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90241888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Ontogeny of somatostatin in cerebral cortex of macaque monkey: an immunohistochemical study. 猕猴大脑皮层生长抑素的个体发生:免疫组织化学研究。
Brain research. Developmental brain research Pub Date : 1989-01-01 DOI: 10.1016/0921-8696(88)90294-0
A. Yamashita, M. Hayashi, K. Shimizu, K. Oshima
{"title":"Ontogeny of somatostatin in cerebral cortex of macaque monkey: an immunohistochemical study.","authors":"A. Yamashita, M. Hayashi, K. Shimizu, K. Oshima","doi":"10.1016/0921-8696(88)90294-0","DOIUrl":"https://doi.org/10.1016/0921-8696(88)90294-0","url":null,"abstract":"","PeriodicalId":9057,"journal":{"name":"Brain research. Developmental brain research","volume":"11 1","pages":"103-11"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83753963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 45
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