BMC Proceedings最新文献

{"title":"CellMigrationGym: a data-driven framework utilizing deep reinforcement learning to unravel mechanisms of cell migration.","authors":"Dali Wang, Jiawei Yang, Zi Wang, Yichi Xu, Zhirong Bao","doi":"10.1186/s12919-026-00365-5","DOIUrl":"10.1186/s12919-026-00365-5","url":null,"abstract":"<p><p>Cell migration is a fundamental phenomenon in biology that underlies normal development as well as cancer. Recently, a data-driven approach was introduced that uses deep reinforcement learning(DRL) and 3-D live images to study cell migration. This approach formulates the cell migration process as a sequential Markov decision process (MDP), so that hypotheses of the underlying mechanism of the observed migration can easily be incorporated as high-level regulatory rules and constraints for DRL. The application of the approach successfully uncovered a novel mechanism of cell migration in C. elegans embryogenesis that involves a modular organization of cells by using ubiquitous labels of cell nuclei and simple rules based on empirical statistics of the images. This success demonstrates new opportunities to use DRL to infer the biology of cell migration without prior knowledge. This paper presents an open framework, CellMigrationGym, to standardize the DRL approach to study cell migration. Built upon common packages (OpenAI Gym, PyBullet, and DRL libraries), CellMigrationGym provides powerful and flexible functions to investigate cell migration behavior. Through a case study, we demonstrate the critical functions of CellMigrationGym with technical details, such as 1) preparation and standardization of multiple observational data, 2) reward formulation and DRL model configuration appertaining to the hypotheses of migration mechanism (such as gradient-driven and collective cell behavior-driven mechanisms), 3) exploration of migration scenarios under hypothesized mechanisms, and 4) evaluation of neighboring cell's influence on the cell migration.</p>","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"20 Suppl 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12924247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146257385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Abstracts from the 6th Annual Conference of Emirates Society of Internal Medicine (ESIM) 2025.","authors":"","doi":"10.1186/s12919-026-00361-9","DOIUrl":"10.1186/s12919-026-00361-9","url":null,"abstract":"","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"20 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12908369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts from the Annual Pathology Conference of Victor Babeș Institute.","authors":"","doi":"10.1186/s12919-025-00359-9","DOIUrl":"10.1186/s12919-025-00359-9","url":null,"abstract":"","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"20 Suppl 5","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12865924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proceedings from the inaugural conference on the science of cancer health equity for Sexual and Gender Minority (SGM) communities.","authors":"Charles S Kamen, Milena E Insalaco, Richard Brown, Chasity Burrows Walters, Shine Chang, Viktor Clark, Jason Domogauer, Lauren V Ghazal, Kelly Haviland, Forrest Hosea, Nelson Sanchez, Matthew B Schabath, Zul Surani, Gwendolyn P Quinn","doi":"10.1186/s12919-026-00360-w","DOIUrl":"10.1186/s12919-026-00360-w","url":null,"abstract":"<p><strong>Purpose: </strong>Sexual and gender minority people (SGM) experience multiple cancer-related disparities, including higher rates of cancer risk factors, lower rates of cancer screening, higher lifetime risk of cancer, and unmet needs throughout cancer survivorship. Although many national organizations, including the National Cancer Institute (NCI) and the American Cancer Society (ACS), have emphasized the need for more cancer research among SGM communities, currently no consensus exists about the highest research priorities, promising research models, or mechanisms to support collaboration between geographically dispersed scientific teams.</p><p><strong>Methods: </strong>To address this gap, we convened a three-day conference to focus on the \"Science of Cancer Health Equity for SGM Communities.\" Held at the New York University (NYU) Langone Medical Center Campus in New York City from October 5-7, 2023, this conference brought together researchers, trainees, early-stage investigators, and community members. The conference aimed to: 1) examine the current span of evidence-based research on SGM cancer across the cancer control continuum; 2) establish SGM cancer research priorities; 3) promote the careers and research of trainees and early stage investigators, especially those from minoritized backgrounds; 4) develop a transdisciplinary network of professionals with a focus on mentorship and shared research methods; and 5) disseminate findings from this conference, including priorities for SGM cancer health equity research.</p><p><strong>Results: </strong>Response to the conference was overwhelmingly positive.</p><p><strong>Conclusion: </strong>The success of this inaugural conference indicated the need for additional efforts to advance SGM cancer research and expand on scientific priorities.</p>","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"20 Suppl 6","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12865925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and opportunities in combating viral hepatitis in India: insights from the Indian Hepatitis Summit 2025.","authors":"Vivekanandan Shanmugam, John Ward, Sujatha Vijayakumar, Giten Khwairakpam, Cary James, Lokesh Shanmugam, Vaishnavi Girija, Bharat Bhushan Rewari","doi":"10.1186/s12919-025-00358-w","DOIUrl":"10.1186/s12919-025-00358-w","url":null,"abstract":"<p><strong>Background: </strong>The world has committed to ending viral hepatitis as a public health threat as part of sustainable development goal 3.3. World Health Organization (WHO) has developed Global Health Sector Strategies (GHSS 2022-2030) to provide guidance to countries to end viral hepatitis by 2030. India instituted the national program for prevention and control of viral hepatitis (National Viral Hepatitis Control Program, NVHCP) in 2018 in alignment with the global perspective and strategic framework. The Chennai Liver Foundation conducted the first Indian Hepatitis Summit 2025 as a collective movement towards a hepatitis-free India.</p><p><strong>Methods: </strong>The summit was conducted on January 17-18, 2025, at Chennai. Healthcare professionals, policymakers, advocates, researchers, and civil society representatives gathered to share successes, discuss barriers, and address the urgent challenges of viral hepatitis and promote collaborative efforts to combat this silent epidemic in India.</p><p><strong>Results: </strong>The meeting was attended by 54 program faculty and 275 delegates from government agencies, national and international organizations, and public and private hospitals. The two-day agenda included 14 sessions, with 46 talks and four panel discussions. The summit gathered important lessons from global initiatives, surveyed the current landscape of viral hepatitis in India, shared the best practices from some parts of world including India, identified barriers to elimination initiatives, and discussed potential solutions to overcome these barriers. Discussions also included the developments in viral hepatitis screening, diagnosis, and treatment; the ways to tackle the stigma associated with the illness; and innovative measures to improve public health results. In collaboration with Indian Council of Medical Research (ICMR) and National Institute of Epidemiology (NIE), the Chennai Liver Foundation launched the Hepat App and a Hepatitis Online Course.</p><p><strong>Conclusion: </strong>The summit served as a platform to raise awareness about the importance of prevention, early diagnosis, and effective treatment options; and to delineate future directions for viral hepatitis elimination in India.</p>","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"20 Suppl 4","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12853636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146091966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening funding and integration for NTD elimination: insights from the 2025 Annual Meeting of National NTD Programme Managers in the WHO African Region.","authors":"Elizabeth Juma, Dorothy Achu, Abbie Barry, Abate Beshah, Ako A G Adjami, Amir B Kello, Augustin K Ebeja, Balla Jatta, Didier Bakajika, Dyesse Y Nduba, Dyuti Sen, Flora M Lekhanya-Mohatla, Honorat G M Zoure, Jorge Cano, Koku M Davi, Moussa S Sanfo, Namuchile Kaonga, Pauline Mwinzi, Santa-Mika Ndayiziga, Yves T M Barogui, Yuka Makino, Bridget Farham, Benido Impouma","doi":"10.1186/s12919-025-00357-x","DOIUrl":"10.1186/s12919-025-00357-x","url":null,"abstract":"<p><p>The 2025 Annual Meeting of National Neglected Tropical Disease (NTD) Programme Managers (2025 PMM) in the WHO African Region convened stakeholders in Lomé, Togo, under the theme \"Innovating for Acceleration: Pathway to NTD Elimination.\" A key focus was the changing funding environment and the necessity for enhanced integration of NTD services within health systems to guarantee sustainable advancement toward the 2030 elimination goals. The conference was convened in the context of substantial disruptions stemming from the USAID funding pause, which interrupted essential mass drug administration (MDA) programmes and epidemiological monitoring activities across multiple nations. Country experiences highlighted the fragility of external funding dependence and underscored the importance of domestic resource mobilization, decentralized implementation, and programmatic integration. Strategic discussions highlighted opportunities to incorporate NTD services into national health financing mechanisms, and routine health campaigns, alongside leveraging digital tools and partnerships. Participants emphasized the urgency of political commitment, sustained investments, and integrated service delivery models to build resilience and close equity gaps. The meeting further underscored the need for bold, country-led responses and multisectoral collaboration to advance NTD elimination efforts in a rapidly evolving global health financing environment.</p>","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"20 Suppl 3","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12833936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts from the 6th Annual Conference of Emirates Society of Internal Medicine (ESIM) 2025.","authors":"","doi":"10.1186/s12919-025-00352-2","DOIUrl":"10.1186/s12919-025-00352-2","url":null,"abstract":"","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"19 Suppl 32","pages":"38"},"PeriodicalIF":0.0,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12781233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meeting report of the eight annual Tri-Service Microbiome Consortium Symposium.","authors":"Melissa R Kardish, Richard T Agans, Robyn A Barbato, Stacey J Doherty, Michael S Goodson, J Philip Karl, Robert Kokoska, Zachary S Liechty, Neal D McNeal, Kenneth Racicot, J Jordan Steel, Charlie Sweet, Sara M Tuck, Dagmar H Leary","doi":"10.1186/s12919-025-00355-z","DOIUrl":"10.1186/s12919-025-00355-z","url":null,"abstract":"<p><p>The Tri-Service Microbiome Consortium (TSMC) was created to foster and enhance cooperation, collaboration, and communication of microbiome research among Department of Defense (DoD) researchers and their collaborators. The 8th Annual TSMC Symposium was held in Colorado Springs, CO on 25-26 September 2024 and featured oral and poster presentations and discussions centered on microbiome-related topics within four broad thematic areas: 1) Surveillance; 2) Health and Performance; 3) Enablers; and 4) Remediation. Collectively this meeting promoted sharing of methods, experiments, and findings across DoD affiliated microbiome research and promoted future and ongoing collaborations. This report summarizes the proceedings of the 8th Annual TSMC Symposium.</p>","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"20 Suppl 2","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12723844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145809052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bringing together clinical and physical sciences to deliver translational ageing research: the UK experience.","authors":"Lewis Steell, Chloe Hinchliffe, Rachel Cooper, Miles D Witham","doi":"10.1186/s12919-025-00354-0","DOIUrl":"10.1186/s12919-025-00354-0","url":null,"abstract":"","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"20 Suppl 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12720425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145803140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bringing evidence into public health policy 2024.","authors":"","doi":"10.1186/s12919-025-00353-1","DOIUrl":"10.1186/s12919-025-00353-1","url":null,"abstract":"","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"19 Suppl 33","pages":"37"},"PeriodicalIF":0.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12713244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}