BMC Proceedings最新文献

{"title":"Meeting Abstracts from the 5th National Big Data Health Science Conference.","authors":"","doi":"10.1186/s12919-024-00292-3","DOIUrl":"10.1186/s12919-024-00292-3","url":null,"abstract":"","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"18 Suppl 8","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11097451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into treatment of complex Crohn's perianal fistulas","authors":"Gregor Norčič, Nataša Smrekar, Srđan Marković, Goran Barišić, Gediminas Kiudelis, Henrikas Paužas, Tamás Molnár, Attila Szijarto, Z. Serclova, Tina Roblek, Viktor Uršič, I. White","doi":"10.1186/s12919-024-00291-4","DOIUrl":"https://doi.org/10.1186/s12919-024-00291-4","url":null,"abstract":"","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"22 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140658585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Proceedings of the 2023 International Maternal and Newborn Health Conference","authors":"","doi":"10.1186/s12919-024-00293-2","DOIUrl":"https://doi.org/10.1186/s12919-024-00293-2","url":null,"abstract":"","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140693074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proceedings of the 2023 International Maternal Newborn Health Conference.","authors":"","doi":"10.1186/s12919-024-00289-y","DOIUrl":"10.1186/s12919-024-00289-y","url":null,"abstract":"","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"18 Suppl 5","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10956174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proceedings of the 5^th Ibero-American Symposium on Sport and Physical Activity: Nutrition & Training (SIDANE) and 1^st International Conference on Nutrition Applied to Physical Activity and Sport.","authors":"","doi":"10.1186/s12919-024-00288-z","DOIUrl":"10.1186/s12919-024-00288-z","url":null,"abstract":"","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"18 Suppl 4","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10845380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139691174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking the pros and cons of randomized controlled trials and observational studies in the era of big data and advanced methods: a panel discussion.","authors":"Pamela Fernainy, Alan A Cohen, Eleanor Murray, Elena Losina, Francois Lamontagne, Nadia Sourial","doi":"10.1186/s12919-023-00285-8","DOIUrl":"10.1186/s12919-023-00285-8","url":null,"abstract":"<p><p>Randomized controlled trials (RCTs) have traditionally been considered the gold standard for medical evidence. However, in light of emerging methodologies in data science, many experts question the role of RCTs. Within this context, experts in the USA and Canada came together to debate whether the primacy of RCTs as the gold standard for medical evidence, still holds in light of recent methodological advances in data science and in the era of big data. The purpose of this manuscript, aims to raise awareness of the pros and cons of RCTs and observational studies in order to help guide clinicians, researchers, students, and decision-makers in making informed decisions on the quality of medical evidence to support their work. In particular, new and underappreciated advantages and disadvantages of both designs are contrasted. Innovations taking place in both of these research methodologies, which can blur the lines between the two, are also discussed. Finally, practical guidance for clinicians and future directions in assessing the quality of evidence is offered.</p>","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"18 Suppl 2","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10795211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139484406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmet needs in EGFR exon 20 insertion mutations in Central and Eastern Europe: reimbursement, diagnostic procedures, and treatment availability.","authors":"Maximilian J Hochmair, Mojca Unk, Jelena Spasic, Timur Cerić, Assia Konsoulova, Mircea Dediu, Krisztina Bogos, Alinta Hegmane, Kersti Oselin, Marko Stojiljkovic, Tina Roblek, Marko Jakopovic","doi":"10.1186/s12919-023-00287-6","DOIUrl":"10.1186/s12919-023-00287-6","url":null,"abstract":"<p><p>Lung cancer remains the leading cause of cancer-related deaths in Europe, with non-small cell lung cancer (NSCLC) accounting for approximately 85% of cases. NSCLC is a heterogeneous disease encompassing various oncogenic alterations. Among them, EGFR exon 20 insertion mutations, constituting 0.3-2.2% of NSCLC cases, rank as the third most common EGFR alteration after exon 19 deletions and the L858R point mutation in exon 21, also known as \"typical\" EGFR alterations. Recent advancements in understanding the molecular pathogenesis of NSCLC have led to significant breakthroughs in targeted therapies, revolutionizing treatment options for patients with specific genetic alterations.This article presents the outcomes of a Virtual Meeting conducted on the online platform (provided Within3©) from September 19 to October 30, 2022. The meeting focused on addressing the challenges in the diagnosis and treatment of NSCLC patients with EGFR exon 20 insertion mutations. The participants consisted of healthcare professionals from ten Central and Eastern European countries who shared their experiences and opinions on various aspects, including epidemiology, treatment options, and diagnostic approaches employed in their respective healthcare institutions. The discussions were facilitated through open-ended and multiple-choice questions.The primary objective of this article is to provide an overview of the identified challenges associated with the diagnosis and treatment of this heterogeneous disease, based on the assessments of the meeting participants. Among the major emerging challenges discussed, the reimbursement issues concerning next-generation sequencing (NGS), a recommended method in NSCLC molecular diagnosis, and the availability of approved targeted treatments to enhance patient outcomes were of paramount importance. Furthermore, fostering community awareness of lung cancer and promoting harmonized lung cancer care were identified as areas deserving greater attention. Notably, the rapidly evolving treatment landscape, particularly with NGS for NSCLC patients with genomic alterations like EGFR, ALK, RET, MET, NTRK, and ROS1, necessitates prioritizing the development of new drugs, even for the relatively smaller subgroup with exon 20 insertion mutations.</p>","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"18 Suppl 3","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10795200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139484419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial viewpoints of scientific publishing for early-career research scientists.","authors":"Pei-Chen Peng, Fadie T Coleman","doi":"10.1186/s12919-023-00286-7","DOIUrl":"10.1186/s12919-023-00286-7","url":null,"abstract":"<p><p>While the structure and composition of the scientific manuscript is well known within scientific communities, insider knowledge such as the tricks of the trade and editorial viewpoints of scientific publishing are often less known to early-career research scientists. This article focuses on the key aspects of scientific publishing, including tips for success geared towards senior postdocs and junior faculty. It also highlights important considerations for getting manuscripts published in an efficient and successful manner.</p>","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"18 Suppl 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10792771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publisher Correction: Harnessing a decade of research at the Research Institute for Bioscience and Biotechnology in Kathmandu, Nepal: Proceedings of the Fourth International Conference ICBB-2022.","authors":"Suvechhya Bastola, Remco Kort, Prajwal Rajbhandari","doi":"10.1186/s12919-023-00282-x","DOIUrl":"10.1186/s12919-023-00282-x","url":null,"abstract":"","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"18 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10775439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139401730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meeting Abstracts from the 5^th B Chromosome Conference.","authors":"","doi":"10.1186/s12919-023-00284-9","DOIUrl":"https://doi.org/10.1186/s12919-023-00284-9","url":null,"abstract":"","PeriodicalId":9046,"journal":{"name":"BMC Proceedings","volume":"17 Suppl 20","pages":"33"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138457692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}