Austin journal of biomedical engineering最新文献

Smart Bio-Polymeric Matrix for Accelerated Wound Healing and Tissue Regeneration 加速伤口愈合和组织再生的智能生物聚合物基质

Austin journal of biomedical engineering Pub Date : 2021-10-15 DOI: 10.26420/austinjbiomedeng.2021.1045

Dhasmana A, Singh L, M. S.

{"title":"Smart Bio-Polymeric Matrix for Accelerated Wound Healing and Tissue Regeneration","authors":"Dhasmana A, Singh L, M. S.","doi":"10.26420/austinjbiomedeng.2021.1045","DOIUrl":"https://doi.org/10.26420/austinjbiomedeng.2021.1045","url":null,"abstract":"Traditionally in Chinese medicine, animal sources and their by-products widely used for surgical and healing purposes. Eggshell Membrane (ESM) has been potentially used as grafting material for wound covering and healing due to its fibrous mesh enriched with collagen and glycoproteins. However, the fragile nature of ESM limits applicability for small and superficial wounds. Therefore, acellular matrix/scaffold fabricated from the allogeneic or xenogeneic tissues widely used as grafting material for the repairing and regeneration tissue. Here, we modified an acellular scaffold in different concentrations of ESM protein (ESMP)-5, 7.5 and 10%, and studied synergistic effect for intensifying the tissue healing and regeneration process. Modified Scaffolds (ESMP-AGDS) were evaluated for tissue regeneration by subjecting it through physicochemical and biological characterization i.e., biochemical assay, FTIR, FESEM, in vitro and in vivo analysis. The study revealed proper interaction between the ESMP and acellular matrix 3D interconnected pores structure (57.69±15.65 μm) with good porosity (60.56±9.78%) for better cell and nutrient diffusion. In vitro studies revealed good biodegradability and biocompatibility of modified scaffold with 3T3 mouse fibroblast cells. At the very least concentration of 5% ESMP, acellular matrix showed excellent proliferation and attachment of fibroblast with the progression of time. Similarly, in vivo study showed a full-thickness excisional wound in the albino mice model healed within 14 days along with hair follicles regenerated neo-skin tissue, without any immunogenicity and inflammation. Thus, the study confirmed ESMP and acellular matrix synergistic effect results in a cost-effective, biodegradable, biocompatible smart material potentially applicable for tissue regeneration.","PeriodicalId":90443,"journal":{"name":"Austin journal of biomedical engineering","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90439221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Novel Implications of Tissue Engineering in the Treatment and Management of Rotator Cuff Tendinopathy 组织工程在肩袖肌腱病治疗和管理中的新意义

Austin journal of biomedical engineering Pub Date : 2021-06-03 DOI: 10.26420/austinjbiomedeng.2021.1044

Sanchez Tc, Diaz Cg, T. George

{"title":"Novel Implications of Tissue Engineering in the Treatment and Management of Rotator Cuff Tendinopathy","authors":"Sanchez Tc, Diaz Cg, T. George","doi":"10.26420/austinjbiomedeng.2021.1044","DOIUrl":"https://doi.org/10.26420/austinjbiomedeng.2021.1044","url":null,"abstract":"Tendinopathy encompasses one of the most common and debilitating group of injuries in persons of all age. Current treatments range from rest and ice to more invasive mechanisms such as surgical repair or artificial tendon recreation. In recent years, there has been a push to study minimally invasive treatments to aid in the regeneration and repair of damaged tendons. These treatments are yet to show reproducible clinically significant improvement over placebo treatments. Years of research has been put into synthesizing different materials to create scaffolds including metals, bioactive glasses, natural and synthetic polymers. These scaffolds are constructed through one of a variety or complex processes from 3D printing to solvent leaching. These different mechanisms of creation and materials used allow the scaffolds to embody different properties including pore size, thermal stability, strength and pliability. This allows for the utilization of tissue engineering in a multitude of in vivo environments. Many different cell types are used to seed scaffolds including tenocytes, multipotent stem cells and induced pluripotent stem cells. Scaffolds show promise as a delivery system for drugs as well as cytokines and growth factors. Tissue engineering is a novel field of study that shows promise not only for tendon repair but the field of orthopedics as a whole. This paper focuses on systematic review of the principles of tissue engineering and the implications in tendinopathy.","PeriodicalId":90443,"journal":{"name":"Austin journal of biomedical engineering","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87994506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Tactile Sensing with Light Propagation in a Four-Layer Slab Waveguide for Breast Tumor Detection 四层平板波导光传播触觉检测乳腺肿瘤

Austin journal of biomedical engineering Pub Date : 2021-05-26 DOI: 10.26420/austinjbiomedeng.2021.1043

H. LeeJ.

引用次数: 0

Comparison of Kinetic Models for Dual-Tracer Receptor Concentration Imaging in Tumors. 肿瘤双示踪受体浓度成像动力学模型的比较。

Austin journal of biomedical engineering Pub Date : 2014-03-05

Nazanin Hamzei, Kimberley S Samkoe, Jonathan T Elliott, Robert W Holt, Jason R Gunn, Tayyaba Hasan, Brian W Pogue, Kenneth M Tichauer

{"title":"Comparison of Kinetic Models for Dual-Tracer Receptor Concentration Imaging in Tumors.","authors":"Nazanin Hamzei, Kimberley S Samkoe, Jonathan T Elliott, Robert W Holt, Jason R Gunn, Tayyaba Hasan, Brian W Pogue, Kenneth M Tichauer","doi":"","DOIUrl":"","url":null,"abstract":"Molecular differences between cancerous and healthy tissue have become key targets for novel therapeutics specific to tumor receptors. However, cancer cell receptor expression can vary within and amongst different tumors, making strategies that can quantify receptor concentration in vivo critical for the progression of targeted therapies. Recently a dual-tracer imaging approach capable of providing quantitative measures of receptor concentration in vivo was developed. It relies on the simultaneous injection and imaging of receptor-targeted tracer and an untargeted tracer (to account for non-specific uptake of the targeted tracer). Early implementations of this approach have been structured on existing \"reference tissue\" imaging methods that have not been optimized for or validated in dual-tracer imaging. Using simulations and mouse tumor model experimental data, the salient findings in this study were that all widely used reference tissue kinetic models can be used for dual-tracer imaging, with the linearized simplified reference tissue model offering a good balance of accuracy and computational efficiency. Moreover, an alternate version of the full two-compartment reference tissue model can be employed accurately by assuming that the K1s of the targeted and untargeted tracers are similar to avoid assuming an instantaneous equilibrium between bound and free states (made by all other models).","PeriodicalId":90443,"journal":{"name":"Austin journal of biomedical engineering","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235770/pdf/nihms-576410.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32829515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost-efficient and multi-functional systems for ultrasound measurement and imaging. 具有成本效益和多功能的超声测量和成像系统。

Austin journal of biomedical engineering Pub Date : 2014-01-01

Jayanth Kandukuri, Yuan Liu, Baohong Yuan

引用次数: 0

In Vitro Ultrasound Measurements of Powered and Unpowered Total Cavopulmonary Connection. 有动力和无动力全腔肺连接的体外超声测量。

Austin journal of biomedical engineering Pub Date : 2014-01-01

Bp Iliff, Aem Kerlo, J Chen, Md Rodefeld, Cj Goergen

{"title":"In Vitro Ultrasound Measurements of Powered and Unpowered Total Cavopulmonary Connection.","authors":"Bp Iliff, Aem Kerlo, J Chen, Md Rodefeld, Cj Goergen","doi":"","DOIUrl":"","url":null,"abstract":"Three-staged Fontan palliation is performed on children suffering from single ventricle congenital heart disease. The series of surgical procedures reroutes blood from the vena cavae directly to the pulmonary arteries, creating a total cavopulmonary connection (TCPC). A viscous impeller pump (VIP) is currently being developed as a cavopulmonary assist device that can modestly augment cavopulmonary flow, reduce systemic venous pressure, and improve ventricular preload. This study used ultrasound to visualize complex flow patterns in powered and unpowered in vitro mock Fontan circulations. The idealized TCPC was modeled with a silicone mold and blood analog made of water and glycerol that was seeded with 10-μm glass beads. B-mode, color Doppler, and pulsed-wave Doppler images were used to visualize complex flow patterns in the idealized TCPC with (1) no VIP, (2) static VIP, and powered VIP rotation rates of (3) 500 and (4) 2,000 rotations per minute (RPM). Pulsed-wave Doppler data showed higher mean velocities and greater variance in the outlets relative to the larger inlets. The maximum inlet velocity ± SD increased from 10.9 ± 3.53 cm/s with no VIP to 15.9 ± 1.03 when the VIP was rotating at 2,000 RPM. Likewise, the maximum outlet velocity increased from 14.9 ± 11.2 cm/s to 18.9 ± 7.25 cm/s at 2,000 RPM. The faster mean velocities with the VIP rotating suggest that the pump augments cavopulmonary flow. The results of this study suggest that measuring complex flow patterns with ultrasound in vivo could be used clinically to optimize VIP positioning and rotation rate during and after implantation.","PeriodicalId":90443,"journal":{"name":"Austin journal of biomedical engineering","volume":"1 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304092/pdf/nihms653413.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33003103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0