Austin Alzheimer's and Parkinson's disease最新文献

Basics of Alzheimer’s Disease and Dementia 阿尔茨海默病和痴呆症的基础知识

Austin Alzheimer's and Parkinson's disease Pub Date : 2023-04-03 DOI: 10.26420/austinalzheimersjparkinsonsdis.2023.1035

Goday Swapna, M. Mahitha, P. Teja Sree

引用次数: 3

Investigating the Involvement of Cytokines and Neurotrophic Factors in the Advanced Stages of Huntington’s Disease: A BACHD Study 研究细胞因子和神经营养因子在亨廷顿病晚期的参与:一项BACHD研究

Austin Alzheimer's and Parkinson's disease Pub Date : 2023-04-03 DOI: 10.26420/austinalzheimersjparkinsonsdis.2023.1034

P. A. Valadão, B. S. Oliveira, C. A. Machado, Heliana B. Fernandes, T. C. Machado, Kívia Santos Soares, A. L. Teixeira, C. Guatimosim, A. Miranda

引用次数: 2

Comparison of Subthalamic Nucleus and Globus Pallidus Deep Brain Stimulation in Parkinson’s Disease: A Systematic Review 丘脑下核和苍白球深部脑刺激治疗帕金森病的比较:系统综述

Austin Alzheimer's and Parkinson's disease Pub Date : 2021-09-16 DOI: 10.26420/austinalzheimersjparkinsonsdis.2021.1033

Azari H

{"title":"Comparison of Subthalamic Nucleus and Globus Pallidus Deep Brain Stimulation in Parkinson’s Disease: A Systematic Review","authors":"Azari H","doi":"10.26420/austinalzheimersjparkinsonsdis.2021.1033","DOIUrl":"https://doi.org/10.26420/austinalzheimersjparkinsonsdis.2021.1033","url":null,"abstract":"Background: Deep Brain Stimulation (DBS) is regarded as a viable therapeutic choice for Parkinson’s Disease (PD). The two most common sites for DBS are the Subthalamic Nucleus (STN) and Globus Pallidus (GPi). In this study, the clinical effectiveness of these two targets was compared. Methods: A systematic literature search in electronic databases were restricted to English language publications 2010 to 2021. Specified MeSH terms were searched in all databases. Studies that evaluated the Unified Parkinson’s Disease Rating Scale (UPDRS) III were selected by meeting the following criteria: (1) had at least three months follow-up period; (2) compared both GPi and STN DBS; (3) at least five participants in each group; (4) conducted after 2010. Study quality assessment was performed using the Modified Jadad Scale. Results: 3577 potentially relevant articles were identified 3569 were excluded based on title and abstract, duplicate and unsuitable article removal. Eight articles satisfied the inclusion criteria and were scrutinized (458 PD patients). Majority of studies reported no statistically significant between-group difference for improvements in UPDRS III scores. Conclusions: Although there were some results in terms of action tremor, rigidity, and urinary symptoms, which indicated that STN DBS might be a better choice or regarding the adverse effects, GPi seemed better; but it cannot be concluded that one target is superior. Other larger randomized clinical trials with longer follow-up periods and control groups are needed to decide which target is more efficient for stimulation and imposes fewer adverse effects on the patients.","PeriodicalId":90442,"journal":{"name":"Austin Alzheimer's and Parkinson's disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84311983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversible Parkinsonism due to Chronic Subdural Hematoma: A Case Report 慢性硬膜下血肿所致的可逆性帕金森病1例报告

Austin Alzheimer's and Parkinson's disease Pub Date : 2021-06-30 DOI: 10.26420/austinalzheimersjparkinsonsdis.2021.1032

Brahim Em, Mostarchid Me, H. Abderrahmane, K Inas, A. Ac, G Miloud

引用次数: 0

Comparing Differences in ADL Outcomes for the STOMP Intervention for Dementia in the Natural Home Environment Versus a Clinic Environment. 比较在自然家庭环境和临床环境中STOMP干预痴呆的ADL结果的差异。

Austin Alzheimer's and Parkinson's disease Pub Date : 2014-01-01 Epub Date: 2014-09-04

C A Ciro, J L Poole, B Skipper, L A Hershey

{"title":"Comparing Differences in ADL Outcomes for the STOMP Intervention for Dementia in the Natural Home Environment Versus a Clinic Environment.","authors":"C A Ciro, J L Poole, B Skipper, L A Hershey","doi":"","DOIUrl":"","url":null,"abstract":"Background: Few studies have examined structured rehabilitation techniques for improving activities of daily living in people with mild-moderate dementia. We sought to examine the advantages to delivering the Skill-building through Task-Oriented Motor Practice (STOMP) intervention in the home environment (versus the clinic), hypothesizing that ADL improvement would be significantly better, time to meeting goals would be faster and fewer displays of behavior would be noted.Methods: Compared results of two quasi-experimental studies of STOMP, one completed in the home, one completed previously in a clinic. Participants were English-speaking; community dwelling adults aged 50-90 diagnosed with mild-moderate dementia who could participate in an intensive rehabilitation program (5 days/week, 3 hours/day, for 2 weeks). Outcome measurements include examiner-observation of performance and proxy-report of performance and satisfaction with performance in patient-selected goals.Results: No differences existed in the sociodemographic characteristics between the home and clinic groups where the groups were primarily white, married, had > high school education and had mild-moderate dementia. Results from the home group indicate that participants made significant improvement in ADL which was generally retained at the 90 day follow-up. These results were not significantly different than the clinic group. No significant advantages were noted for the home group in terms of time to meeting goals or exhibition of fewer behaviors.Discussion: The STOMP intervention appeared to work equally as well in the home and in the clinic. Future studies should continue to examine the benefits of massed practice using high-dose regimens.","PeriodicalId":90442,"journal":{"name":"Austin Alzheimer's and Parkinson's disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333932/pdf/nihms847277.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34784122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cycle on Wheels: Is APP Key to the AppBp1 Pathway? 车轮上的循环:APP是AppBp1通路的关键吗?

Austin Alzheimer's and Parkinson's disease Pub Date : 2014-01-01

Y Chen, Rn Neve, H Zheng, Wts Griffin, Sw Barger, Re Mrak

引用次数: 0