{"title":"阿尔茨海默病和痴呆症的基础知识","authors":"Goday Swapna, M. Mahitha, P. Teja Sree","doi":"10.26420/austinalzheimersjparkinsonsdis.2023.1035","DOIUrl":null,"url":null,"abstract":"Alzheimer’s Disease (AD) is a disorder that causes degeneration of the cells in the brain and it is the main cause of dementia, which is characterized by a decline Independence in an individual’s daily activities. AD is considered a multifactorial disease. Two main hypotheses have been proposed as the cause of AD. The cholinergic hypothesis and the amyloid hypothesis. In addition, several risk factors have been implicated in this disease, including aging, genetic factors, head trauma, vascular disease, infections, and environmental factors. Currently, there are only two classes of drugs approved for the treatment of AD, including cholinesterase enzyme inhibitors and N-Methyl-D-Aspartic Acid (NMDA) antagonists, which are not associated with AD symptoms or disease. Prevent. Today, research is focused on understanding the pathology of AD by targeting multiple mechanisms such as alteration of AD course. This review describes the drugs currently available and future theories for the development of new treatments for AD, including Disease-Modifying Therapies (DMTs), chaperones, and natural products.","PeriodicalId":90442,"journal":{"name":"Austin Alzheimer's and Parkinson's disease","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Basics of Alzheimer’s Disease and Dementia\",\"authors\":\"Goday Swapna, M. Mahitha, P. Teja Sree\",\"doi\":\"10.26420/austinalzheimersjparkinsonsdis.2023.1035\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Alzheimer’s Disease (AD) is a disorder that causes degeneration of the cells in the brain and it is the main cause of dementia, which is characterized by a decline Independence in an individual’s daily activities. AD is considered a multifactorial disease. Two main hypotheses have been proposed as the cause of AD. The cholinergic hypothesis and the amyloid hypothesis. In addition, several risk factors have been implicated in this disease, including aging, genetic factors, head trauma, vascular disease, infections, and environmental factors. Currently, there are only two classes of drugs approved for the treatment of AD, including cholinesterase enzyme inhibitors and N-Methyl-D-Aspartic Acid (NMDA) antagonists, which are not associated with AD symptoms or disease. Prevent. Today, research is focused on understanding the pathology of AD by targeting multiple mechanisms such as alteration of AD course. This review describes the drugs currently available and future theories for the development of new treatments for AD, including Disease-Modifying Therapies (DMTs), chaperones, and natural products.\",\"PeriodicalId\":90442,\"journal\":{\"name\":\"Austin Alzheimer's and Parkinson's disease\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-04-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Austin Alzheimer's and Parkinson's disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26420/austinalzheimersjparkinsonsdis.2023.1035\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Austin Alzheimer's and Parkinson's disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26420/austinalzheimersjparkinsonsdis.2023.1035","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
摘要
阿尔茨海默病(AD)是一种导致大脑细胞退化的疾病,是痴呆症的主要原因,痴呆症的特征是个体日常活动的独立性下降。AD被认为是一种多因素疾病。关于阿尔茨海默病的病因,人们提出了两种主要假设。胆碱能假说和淀粉样蛋白假说。此外,一些危险因素也与此病有关,包括衰老、遗传因素、头部创伤、血管疾病、感染和环境因素。目前,只有两类药物被批准用于治疗阿尔茨海默病,包括胆碱酯酶抑制剂和n -甲基- d -天冬氨酸(NMDA)拮抗剂,它们与阿尔茨海默病的症状或疾病无关。预防。目前,研究的重点是通过AD病程改变等多种机制来了解AD的病理机制。本文综述了目前可用的药物和未来治疗AD的新方法,包括疾病修饰疗法(dmt)、伴侣和天然产物。
Alzheimer’s Disease (AD) is a disorder that causes degeneration of the cells in the brain and it is the main cause of dementia, which is characterized by a decline Independence in an individual’s daily activities. AD is considered a multifactorial disease. Two main hypotheses have been proposed as the cause of AD. The cholinergic hypothesis and the amyloid hypothesis. In addition, several risk factors have been implicated in this disease, including aging, genetic factors, head trauma, vascular disease, infections, and environmental factors. Currently, there are only two classes of drugs approved for the treatment of AD, including cholinesterase enzyme inhibitors and N-Methyl-D-Aspartic Acid (NMDA) antagonists, which are not associated with AD symptoms or disease. Prevent. Today, research is focused on understanding the pathology of AD by targeting multiple mechanisms such as alteration of AD course. This review describes the drugs currently available and future theories for the development of new treatments for AD, including Disease-Modifying Therapies (DMTs), chaperones, and natural products.