Translation (Austin, Tex.)最新文献_第5页

Text, genre and discourse shifts in translation 翻译中的文本、体裁和话语转换

Translation (Austin, Tex.) Pub Date : 2019-07-26 DOI: 10.4324/9780429266348-11

B. Hatim, J. Munday

引用次数: 0

Text register in translation 翻译中的文本寄存器

Translation (Austin, Tex.) Pub Date : 2019-07-26 DOI: 10.4324/9780429266348-24

B. Hatim, J. Munday

引用次数: 0

Text type in translation 翻译文本类型

Translation (Austin, Tex.) Pub Date : 2019-07-26 DOI: 10.4324/9780429266348-9

B. Hatim, J. Munday

引用次数: 0

Agents of power in translation 翻译中的权力代理人

Translation (Austin, Tex.) Pub Date : 2019-07-26 DOI: 10.4324/9780429266348-40

B. Hatim, J. Munday

引用次数: 0

Translation shifts 翻译变化

Translation (Austin, Tex.) Pub Date : 2019-07-26 DOI: 10.4324/9780429266348-32

B. Hatim, J. Munday

引用次数: 20

The analysis of meaning 意义分析

Translation (Austin, Tex.) Pub Date : 2019-07-26 DOI: 10.4324/9780429266348-33

B. Hatim, J. Munday

引用次数: 0

Translation strategies 翻译策略

Translation (Austin, Tex.) Pub Date : 2019-07-26 DOI: 10.4324/9780429266348-2

B. Hatim, J. Munday

引用次数: 0

Translation in the digital era 数字时代的翻译

Translation (Austin, Tex.) Pub Date : 2019-07-26 DOI: 10.4324/9780429266348-42

B. Hatim, J. Munday

引用次数: 1

A Staufen1-mediated decay pathway influences the local transcriptome in axons. staufen1介导的衰退通路影响轴突的局部转录组。

Translation (Austin, Tex.) Pub Date : 2017-12-12 eCollection Date: 2017-01-01 DOI: 10.1080/21690731.2017.1414016

Ju Youn Kim, Alessia Deglincerti, Samie R Jaffrey

{"title":"A Staufen1-mediated decay pathway influences the local transcriptome in axons.","authors":"Ju Youn Kim, Alessia Deglincerti, Samie R Jaffrey","doi":"10.1080/21690731.2017.1414016","DOIUrl":"https://doi.org/10.1080/21690731.2017.1414016","url":null,"abstract":"Local translation is critical for diverse aspects of neuronal function, including mediating responses of elongating axons to guidance cues and other signaling molecules. A major determinant of the protein synthetic capacity of axons and growth cones is the specific set of mRNAs that are trafficked to these sites. However, recently it has become clear that the axonal transcriptome can also be shaped by local RNA degradation mechanisms, such as nonsense-mediated decay. Here we show that Staufen1-mediated decay can also occur within axons and mediate degradation of specific axonal transcripts. We show that Staufen1 and Upf1, which function together in Staufen1-mediated decay, are localized in growth cones. Selective depletion of Staufen1 from neurons results in a complex pattern of transcriptional alterations, with a subset of transcripts showing increased expression and increased RNA half-life consistent with their regulation by Staufen1-mediated decay. Additionally, we show certain transcripts, such as Rac1, are regulated by Staufen1 within axons and growth cones. The functional significance of Staufen1 in growth cones is supported by morphological alterations in growth cones following Staufen1 knockdown. Together these data point to Staufen1-mediated decay as a novel mechanism to control mRNA expression levels in axons and growth cones through local RNA degradation.","PeriodicalId":90376,"journal":{"name":"Translation (Austin, Tex.)","volume":"5 2","pages":"e1414016"},"PeriodicalIF":0.0,"publicationDate":"2017-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21690731.2017.1414016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35810037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Regulation of gene expression by translation factor eIF5A: Hypusine-modified eIF5A enhances nonsense-mediated mRNA decay in human cells. 翻译因子eIF5A对基因表达的调控:hypusine修饰的eIF5A增强人细胞中无义介导的mRNA衰变。

Translation (Austin, Tex.) Pub Date : 2017-08-14 eCollection Date: 2017-01-01 DOI: 10.1080/21690731.2017.1366294

Mainul Hoque, Ji Yeon Park, Yun-Juan Chang, Augusto D Luchessi, Tavane D Cambiaghi, Raghavendra Shamanna, Hartmut M Hanauske-Abel, Bart Holland, Tsafi Pe'ery, Bin Tian, Michael B Mathews

{"title":"Regulation of gene expression by translation factor eIF5A: Hypusine-modified eIF5A enhances nonsense-mediated mRNA decay in human cells.","authors":"Mainul Hoque, Ji Yeon Park, Yun-Juan Chang, Augusto D Luchessi, Tavane D Cambiaghi, Raghavendra Shamanna, Hartmut M Hanauske-Abel, Bart Holland, Tsafi Pe'ery, Bin Tian, Michael B Mathews","doi":"10.1080/21690731.2017.1366294","DOIUrl":"https://doi.org/10.1080/21690731.2017.1366294","url":null,"abstract":"Nonsense-mediated mRNA decay (NMD) couples protein synthesis to mRNA turnover. It eliminates defective transcripts and controls the abundance of certain normal mRNAs. Our study establishes a connection between NMD and the translation factor eIF5A (eukaryotic initiation factor 5A) in human cells. eIF5A modulates the synthesis of groups of proteins (the eIF5A regulon), and undergoes a distinctive two-step post-translational modification (hypusination) catalyzed by deoxyhypusine synthase and deoxyhypusine hydroxylase. We show that expression of NMD-susceptible constructs was increased by depletion of the major eIF5A isoform, eIF5A1. NMD was also attenuated when hypusination was inhibited by RNA interference with either of the two eIF5A modifying enzymes, or by treatment with the drugs ciclopirox or deferiprone which inhibit deoxyhypusine hydroxylase. Transcriptome analysis by RNA-Seq identified human genes whose expression is coordinately regulated by eIF5A1, its modifying enzymes, and the pivotal NMD factor, Upf1. Transcripts encoding components of the translation system were highly represented, including some encoding ribosomal proteins controlled by alternative splicing coupled to NMD (AS-NMD). Our findings extend and strengthen the association of eIF5A with NMD, previously inferred in yeast, and show that hypusination is important for this function of human eIF5A. In addition, they advance drug-mediated NMD suppression as a therapeutic opportunity for nonsense-associated diseases. We propose that regulation of mRNA stability contributes to eIF5A's role in selective gene expression.","PeriodicalId":90376,"journal":{"name":"Translation (Austin, Tex.)","volume":"5 2","pages":"e1366294"},"PeriodicalIF":0.0,"publicationDate":"2017-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21690731.2017.1366294","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35511023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18