Transfusion alternatives in transfusion medicine : TATM最新文献_第10页

The hemoglobin-nitric oxide axis: implications for transfusion therapeutics 血红蛋白-一氧化氮轴:输血治疗的意义

Transfusion alternatives in transfusion medicine : TATM Pub Date : 2007-12-01 DOI: 10.1111/J.1778-428X.2007.00084.X

J. R. Lancaster, A. Hutchings, J. Kerby, R. Patel

引用次数: 6

Oxidation of hemoglobin: mechanisms of control in vitro and in vivo 血红蛋白氧化:体内和体外控制机制

Transfusion alternatives in transfusion medicine : TATM Pub Date : 2007-12-01 DOI: 10.1111/J.1778-428X.2007.00081.X

P. Buehler, A. Alayash

{"title":"Oxidation of hemoglobin: mechanisms of control in vitro and in vivo","authors":"P. Buehler, A. Alayash","doi":"10.1111/J.1778-428X.2007.00081.X","DOIUrl":"https://doi.org/10.1111/J.1778-428X.2007.00081.X","url":null,"abstract":"SUMMARY \u0000 \u0000 \u0000Hemoglobin (Hb) within red blood cells (RBC) is protected from oxidative processes by enzymatic and small molecule antioxidants as well as the RBC membrane that provides a physical barrier against oxidation. When Hb is introduced into the circulation as a result of hemolysis or following infusion of Hb-based oxygen carriers (HBOCs; ‘blood substitutes’), the control of oxidative processes becomes dependent on plasma oxidative status. In vitro studies clearly demonstrate that Hb and HBOCs undergo oxidative modification at the site of heme iron and at multiple amino acid sites as a result of autoxidation, nitrosylation and peroxidation. Recent findings from in vitro studies provide a strong basis for understanding of potential toxicity in vivo. The antioxidative status of both plasma and tissue becomes an important factor in the control of Hb and HBOC oxidation and nitrosylation in the circulation. Several studies that performed ex vivo and in vivo have demonstrated a critical role for plasma antioxidants such as ascorbic acid and uric acid in maintaining Hb and HBOCs in functional non-oxidized states. In the present review we discuss mechanisms of Hb and HBOC autoxidation, nitrosylation and peroxidation in vitro and in vivo. Additionally, we explore the role(s) of plasma antioxidants in maintaining functional HBOC status that may potentially be exploited as part of protective strategies against Hb and HBOC oxidative toxicity.","PeriodicalId":90375,"journal":{"name":"Transfusion alternatives in transfusion medicine : TATM","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/J.1778-428X.2007.00081.X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63389026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Solution to the problems of acellular hemoglobins by encapsulation and the intrinsic issues of hemoglobin vesicles as a molecular assembly 通过包封解决脱细胞血红蛋白的问题和血红蛋白囊泡作为分子集合的内在问题

Transfusion alternatives in transfusion medicine : TATM Pub Date : 2007-12-01 DOI: 10.1111/J.1778-428X.2007.00089.X

H. Sakai, K. Sou, E. Tsuchida

{"title":"Solution to the problems of acellular hemoglobins by encapsulation and the intrinsic issues of hemoglobin vesicles as a molecular assembly","authors":"H. Sakai, K. Sou, E. Tsuchida","doi":"10.1111/J.1778-428X.2007.00089.X","DOIUrl":"https://doi.org/10.1111/J.1778-428X.2007.00089.X","url":null,"abstract":"SUMMARY \u0000 \u0000 \u0000Hemoglobin vesicles (HbV), or liposome-encapsulated hemoglobins, are developed as artificial oxygen carriers for the use as a transfusion alternative. The safety and efficacy of HbV have been clarified in detail: HbV can overcome the side effects of hemoglobin (Hb) molecules (stroma-free, and intra- or intermolecularly crosslinked) such as vasoconstriction, hypertension and possible vascular damage induced by direct contact of the vascular surface with Hb. On the other hand, intrinsic issues related to the suspension of HbV as a molecular assembly have to be considered: blood compatibility, structural and dispersion stabilities of the vesicles, and the requirement of prompt degradation in the reticuloendothelial system. Having overcome these issues, the results make us confident in advancing further development of HbV. Easy manipulation of physicochemical parameters of HbV provides possibilities for various clinical applications in addition to their use as a transfusion alternative.","PeriodicalId":90375,"journal":{"name":"Transfusion alternatives in transfusion medicine : TATM","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/J.1778-428X.2007.00089.X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63389258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Perfluorocarbons as gas transporters for O2, NO, CO and volatile anesthetics 全氟碳化合物作为O2、NO、CO和挥发性麻醉剂的气体转运体

Transfusion alternatives in transfusion medicine : TATM Pub Date : 2007-12-01 DOI: 10.1111/J.1778-428X.2007.00085.X

P. Cabrales, B. Y. S. Vázquez, A. C. Negrete, M. Intaglietta

引用次数: 13

Blood viscosity modulates tissue perfusion: sometimes and somewhere. 血液粘度调节组织灌注:有时和某处。

Transfusion alternatives in transfusion medicine : TATM Pub Date : 2007-12-01 DOI: 10.1111/J.1778-428X.2007.00080.X

C. Lenz, A. Rebel, K. Waschke, R. Koehler, Thomas Frietsch

{"title":"Blood viscosity modulates tissue perfusion: sometimes and somewhere.","authors":"C. Lenz, A. Rebel, K. Waschke, R. Koehler, Thomas Frietsch","doi":"10.1111/J.1778-428X.2007.00080.X","DOIUrl":"https://doi.org/10.1111/J.1778-428X.2007.00080.X","url":null,"abstract":"Each organ possesses specific properties for controlling microvascular perfusion. Such specificity provides an opportunity to design transfusion fluids that target thrombo-embolic or vasospasm-induced ischemia in a particular organ or that optimize overall perfusion from systemic shock. The role of viscosity in the design of these fluids might be underestimated, because viscosity is rarely monitored or considered in critical care decisions. Studies linking viscosity-dependent changes of microvascular perfusion to outcome-relevant data suggest that whole blood viscosity is negligible as a determinant of microvascular perfusion under physiological conditions when autoregulation is effective. Because autoregulation is driven to maintain oxygen supply constant, the organism will compensate for changes in blood viscosity to sustain oxygen delivery. In contrast, under pathological conditions in the brain and elsewhere, increases of overall viscosity should be avoided - including all the situations where vascular autoregulatory mechanisms are inoperative due to ischemia, structural damage or physiologic dysfunction. As latter conditions are not to identify with high certainty, the risks that accompany therapeutic correction of blood viscosity are outweighing the benefits. The ability to bedside monitor blood viscosity and to link changes in viscosity to outcome parameters in various clinical conditions would provide more solid foundation for evidence-based clinical management.","PeriodicalId":90375,"journal":{"name":"Transfusion alternatives in transfusion medicine : TATM","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81312792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45

Resuscitation from hemorrhagic shock: recovery of oxygen carrying capacity or perfusion? Efficacy of new plasma expanders 失血性休克复苏:恢复携氧能力还是恢复灌注?新型等离子体膨胀器的功效

Transfusion alternatives in transfusion medicine : TATM Pub Date : 2007-12-01 DOI: 10.1111/J.1778-428X.2007.00086.X

A. Tsai, P. Cabrales, S. Acharya, M. Intaglietta

{"title":"Resuscitation from hemorrhagic shock: recovery of oxygen carrying capacity or perfusion? Efficacy of new plasma expanders","authors":"A. Tsai, P. Cabrales, S. Acharya, M. Intaglietta","doi":"10.1111/J.1778-428X.2007.00086.X","DOIUrl":"https://doi.org/10.1111/J.1778-428X.2007.00086.X","url":null,"abstract":"SUMMARY \u0000 \u0000 \u0000Potential shortages and perceived issues with the biosafety of blood have strengthened interest in the search for alternatives to blood. Currently available plasma expanders are effective in recovering pressure by volume expansion but are not safely deployed beyond the transfusion trigger. Conventional reasoning indicates that this limitation relates to oxygen carrying capacity reaching the threshold where it no longer can satisfy the metabolic demand of the organism; however, recent findings show that this limitation is also determined by other physical factors such as their viscosity and colloidal osmotic pressure. These fluid transport properties have a strong influence on the maintenance of microvascular perfusion and function in conditions of extreme hemodilution that obtain when resuscitation is continued beyond the transfusion trigger with plasma expanders. This realization leads to the possibility of developing new plasma expanders whose physical properties enhance microvascular function compensating for the decreased intrinsic oxygen carrying capacity in extreme hemodilution via enhanced microvascular perfusion. This review presents experimental, systemic and microvascular findings obtained using polyethylene glycol conjugated albumin solutions in extreme hemodilution and shock resuscitation in the hamster window chamber model, concluding that plasma expanders of this type can be effectively used beyond the transfusion trigger.","PeriodicalId":90375,"journal":{"name":"Transfusion alternatives in transfusion medicine : TATM","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/J.1778-428X.2007.00086.X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63389131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Novel strategies for transporting cellular hemoglobin-based oxygen carriers in the systemic circulation 在体循环中运输细胞血红蛋白氧载体的新策略

Transfusion alternatives in transfusion medicine : TATM Pub Date : 2007-12-01 DOI: 10.1111/J.1778-428X.2007.00082.X

D. Harris, A. Palmer

引用次数: 5

Blood transfusion: challenges and limitations 输血:挑战与限制

Transfusion alternatives in transfusion medicine : TATM Pub Date : 2007-09-01 DOI: 10.1111/J.1778-428X.2007.00062.X

S. Knowles

引用次数: 8

Evaluation of anemia in the elective surgical patient 择期手术患者贫血的评价

Transfusion alternatives in transfusion medicine : TATM Pub Date : 2007-09-01 DOI: 10.1111/J.1778-428X.2007.00063.X

L. Goodnough

引用次数: 1

Hydroxyethyl starch solutions and their effect on the microcirculation and tissue oxygenation 羟乙基淀粉溶液及其对微循环和组织氧合的影响

Transfusion alternatives in transfusion medicine : TATM Pub Date : 2007-09-01 DOI: 10.1111/J.1778-428X.2007.00076.X

K. Yuruk, E. Almac, C. Ince

引用次数: 10