SOJ immunology最新文献_第2页

T Lymphocytes Response to Caecal Coccidiosis in Broilers Infected with Exo and Endogenous Stages of Eimeria Tenella 外源性和内源性柔嫩艾美耳球虫感染肉鸡盲肠球虫病的T淋巴细胞应答

SOJ immunology Pub Date : 2018-01-22 DOI: 10.15226/2372-0948/6/1/00166

Kaze Paul Davou, I. Lawal, Ajanusi Joseph, S. Lawal, Karaye Gp, M. Patrobas, B. Markus, F. Ayinzat, D. Christopher, K. Karaye

引用次数: 3

Vaccination with Melanoma Cells Infected with Recombinant Newcastle Disease Virus Suppresses Tumor Metastasis 重组新城疫病毒感染黑色素瘤细胞免疫抑制肿瘤转移

SOJ immunology Pub Date : 2018-01-04 DOI: 10.15226/2372-0948/6/1/00165

ShigefumiKishida, T. Nakaya, KatsuroHagiwara

{"title":"Vaccination with Melanoma Cells Infected with Recombinant Newcastle Disease Virus Suppresses Tumor Metastasis","authors":"ShigefumiKishida, T. Nakaya, KatsuroHagiwara","doi":"10.15226/2372-0948/6/1/00165","DOIUrl":"https://doi.org/10.15226/2372-0948/6/1/00165","url":null,"abstract":"Newcastle Disease Virus (NDV) is an RNA virus, which infects several tumor cells and shows cellular toxicity towards them. The antitumor activity of NDV has been reported in several tumors. In this study, we evaluated the antitumor effect of a NDV-infected melanoma cell vaccine on lung metastasis based on tumor-specific immune responses in a mouse model. B16 mouse melanoma cells were infected with the GFP-expressing recombinant NDV (rNDV) to prepare the vaccine (rNDV-BV). C57BL/6 mice were then immunized twice with rNDV-BV and intravenously inoculated with B16 cells, and the number of metastasis dots in the lungs was evaluated 21 days later. The mice were divided into three groups: pre-inoculation (mice were vaccinated before inoculation with B16 cells), post-inoculation (mice were vaccinated after inoculation with B16 cells), and control (mice were inoculated with DMEM) groups. To evaluate the immune responses, the mouse splenocytes were monitored for lymphocyte subsets and dendritic cells, and IFN-γ and IL-10gene expression after metastasis was measured. The mice receiving rNDV-BV showed prolonged survival and a lower number of metastasis dots. Furthermore, lung metastasis was significantly decreased upon post-metastasis vaccination with rNDV-BV. In pre-inoculation group, cytokine responses against tumor antigens were also significantly affected: IFN-γ levels were increased, but IL-10 levels were decreased. The vaccination also increased the T cell population along with the number of CD8+ dendritic cells during early metastasis. These results indicated that rNDV-BV induced an IFN-γ response against the tumor antigen and suppressed metastasis in the mouse model. Keywords: Autologous-tumor Vaccine; Newcastle Disease Virus; Melanoma Lung Metastasis Mouse Model; Cell-Mediated Immunity; IFN-γ; Abbreviations: NDV: Newcastle Disease Virus; rNDV: Recombinant Newcastle Disease Virus; rNDV-BV: Recombinant Newcastle Disease Virus to Prepare the Vaccine; B16: B16 Mouse Melanoma Cell; IFN: Interferon; IL: Interleukin.","PeriodicalId":90344,"journal":{"name":"SOJ immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81519904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Declining Maternally-Derived Measles Antibodies in Infants and Nursing Mothers in Nigeria: A Review 尼日利亚婴儿和哺乳母亲的母源性麻疹抗体下降:综述

SOJ immunology Pub Date : 2018-01-02 DOI: 10.15226/2372-0948/6/1/00164

Taiwo Mo, A. Ho, Adebayo Os, Sakariyau Ao, Akindele Oo, Adegoke Oo

{"title":"Declining Maternally-Derived Measles Antibodies in Infants and Nursing Mothers in Nigeria: A Review","authors":"Taiwo Mo, A. Ho, Adebayo Os, Sakariyau Ao, Akindele Oo, Adegoke Oo","doi":"10.15226/2372-0948/6/1/00164","DOIUrl":"https://doi.org/10.15226/2372-0948/6/1/00164","url":null,"abstract":"Measles, also reffered to as rubeolais an endemic respiratory disease caused by a virus. It is a highly contagious infection which typically begins with a mild to moderate fever, often accompanied by a persistent cough, runny nose, conjunctivitis and sore throat. Today, despite the availability of a safe, effective and relatively inexpensive vaccine for more than 40 years, measles still kills more than any other vaccines preventable disease among children. In Pregnant women, IgG immunoglobulin antibody is produced and crosses the placenta to developing fetus’ blood circulation; thereby conferring primary protection against infections in the early life of newborns. The presence or absence of Maternal Measles Antibody (MMA) in infants is therefore a factor to be considered in immunization of infants against measles. In Nigeria, the recommended age for routine measles vaccination for infants is at 9 month of age. However, it has been severely reported that the present-day civilized mothers are more measles vaccine-immuned contrary to been natural measles virus-immuned and as such, produce low titer anti-measles virus antibody which consequently decays or clears from their respective infants earlier than 9 months of age when measles vaccine is routinely administered. Early immunization against measles may potentially minimize the duration of the period between the loss of maternal antibodies transferred via the placenta and the administration of the recommended measles vaccination for infants, hence the need for the re-evaluation of the measles immunization schedule. Keywords: Vaccination; Maternal Measles Antibody; Infant, Virus;","PeriodicalId":90344,"journal":{"name":"SOJ immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75532210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A T cell equation as a conceptual model of T cell responses for maximizing the efficacy of cancer immunotherapy. 一个T细胞方程作为T细胞反应的概念模型，以最大化癌症免疫治疗的疗效。

SOJ immunology Pub Date : 2017-01-01 Epub Date: 2017-02-25 DOI: 10.15226/2372-0948/5/1/00155

Haidong Dong, Yiyi Yan, Roxana S Dronca, Svetomir N Markovic

引用次数: 0

The Inflammatory Cytokine IL-21 is Expressed by Splenic Neutrophils in Response to Transplantation of Allogeneic Cells. 异基因细胞移植后脾中性粒细胞表达炎性细胞因子IL-21的研究。

SOJ immunology Pub Date : 2016-06-08 DOI: 10.15226/2372-0948/4/1/00144

J. Thompson, Debra L. Hardin, Judy F Glass, J. Dziba, J. Campion, Stephen P. A. Brown

{"title":"The Inflammatory Cytokine IL-21 is Expressed by Splenic Neutrophils in Response to Transplantation of Allogeneic Cells.","authors":"J. Thompson, Debra L. Hardin, Judy F Glass, J. Dziba, J. Campion, Stephen P. A. Brown","doi":"10.15226/2372-0948/4/1/00144","DOIUrl":"https://doi.org/10.15226/2372-0948/4/1/00144","url":null,"abstract":"We have previously reported that GR-1 neutrophil/monocytes rose dramatically in the spleen, peaked by day 7 and declined through day 14. This period corresponded to the peak of acute Graft-Versus-Host Disease (aGVHD) in BALB/c mice transplanted with allogeneic donor cells. We now asked: what cytokines did these splenic neutrophil/monocytes express on day 7 and 14 post transplant? BALB/c mice were transplanted with allogeneic B6 or syngeneic BALB/c donor cells. Long term survival was recorded through day 31. Other groups were sacrificed on days 3, 5, 7, 14, 21 and 31 days post transplant to record the total number of cells in the spleens and their phenotypes. Neutrophils were isolated from the spleens of mice transplanted with B6 and BALB/c cells on days 7 and 14. Daily body weight demonstrated a transient drop in the syngeneic transplants on day 2 but a much greater drop with its nadir at day 7 and never fully recovering through 31 days. CD8/CD4 T lymphocytes peaked in the spleen on day 5 and were followed on day 7 by GR-I cells in all of the allogeneic transplants. In syngeneic transplants this early rise in lymphocytes did not occur and GR-1 cells peaked on day 14. Highly purified neutrophils were isolated in two separate experiments from the spleens on days 7 and 14 post transplant. In both experiments day 7 allogeneic neutrophils expressed significantly elevated levels of Interleukin-21 (IL-21) mRNA whereas the day 7 and 14 syngeneic cells expressed lower but significant levels of TNFα. Intracellular IL-21 was demonstrated in the allogeneic neutrophils on day 7 before and after in vitro stimulation. In conclusion Purified neutrophils isolated from the spleen on day 7, the early peak of allogeneic transplantation a GVHD, express high levels of IL-21 message and intracellular IL-21.","PeriodicalId":90344,"journal":{"name":"SOJ immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88764394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Estrogen Receptor Alpha Binding to ERE is Required for Full Tlr7- and Tlr9-Induced Inflammation. 雌激素受体α与ERE结合是Tlr7-和tlr9诱导炎症的必要条件。

SOJ immunology Pub Date : 2014-01-20 DOI: 10.15226/soji.2014.00107

Melissa A Cunningham, Jena R Wirth, Osama Naga, Jackie Eudaly, Gary S Gilkeson

引用次数: 19