Journal of surgery and science最新文献

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Outcomes of Hybrid Video Assisted Thoracoscopic Surgery for Pulmonary Metastasectomy. 混合视频辅助胸腔镜手术治疗肺转移瘤的疗效。
Journal of surgery and science Pub Date : 2014-12-01
Ali Raza, Kazuaki Takabe, Luke G Wolfe, C Gregory Lockhart, Roger H Kim
{"title":"Outcomes of Hybrid Video Assisted Thoracoscopic Surgery for Pulmonary Metastasectomy.","authors":"Ali Raza,&nbsp;Kazuaki Takabe,&nbsp;Luke G Wolfe,&nbsp;C Gregory Lockhart,&nbsp;Roger H Kim","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary metastasectomy is an acceptable treatment option in various metastatic lesions. The role of minimally invasive surgery for metastasectomy remains controversial. We report on a recently described hybrid video-assisted thoracoscopic surgery (hVATS) technique in the community hospital setting.</p><p><strong>Methods: </strong>Using a retrospective study design, data on 61 patients undergoing 67 resections between April 2000 and January 2008 was collected at a single institution. Patient demographics, pathology, and clinical outcome data were recorded. Kaplan Meier estimates and multivariate Cox regression were used to assess survival and prognostic factors, respectively.</p><p><strong>Results: </strong>Mean patient age was 61.7 years. The majority of lesions were solitary, unilateral, and genitourinary or gastrointestinal in origin (69%). R0 resection was achieved in 97% of cases with the most common operation being lobectomy. Mean length of stay was 4.4 days. Mean follow-up was 39.7 months and 5-year overall survival was 63.2% for the cohort; median survival was not reached. The number of lesions (univariate only) and tumor size over 4 cm influenced overall survival.</p><p><strong>Conclusions: </strong>Hybrid VATS is a safe and feasible technique in the community medical center setting and warrants additional investigation as an alternative strategy in the management of pulmonary metastases.</p>","PeriodicalId":90243,"journal":{"name":"Journal of surgery and science","volume":"2 1","pages":"18-24"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332393/pdf/nihms656981.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33074530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of HER-2 in Breast Cancer. HER-2在乳腺癌中的作用。
Journal of surgery and science Pub Date : 2014-12-01
Takashi Ishikawa, Yasushi Ichikawa, Daisuke Shimizu, Takeshi Sasaki, Mikiko Tanabe, Takashi Chishima, Kazuaki Takabe, Itaru Endo
{"title":"The role of HER-2 in Breast Cancer.","authors":"Takashi Ishikawa,&nbsp;Yasushi Ichikawa,&nbsp;Daisuke Shimizu,&nbsp;Takeshi Sasaki,&nbsp;Mikiko Tanabe,&nbsp;Takashi Chishima,&nbsp;Kazuaki Takabe,&nbsp;Itaru Endo","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":90243,"journal":{"name":"Journal of surgery and science","volume":"2 1","pages":"4-9"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323095/pdf/nihms-656982.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33052348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Pathological Response to Anthracycline is Associated with Topoisomerase IIα Gene Amplification in the HER2 Breast Cancer Subset. HER2乳腺癌亚群对蒽环类药物的病理反应与拓扑异构酶i α基因扩增相关
Journal of surgery and science Pub Date : 2014-12-01
Takashi Ishikawa, Takeshi Sasaki, Mikiko Tanabe, Kazutaka Narui, Kumiko Kida, Kazuhiro Shimada, Daisuke Shimizu, Akimitsu Yamada, Satoshi Morita, Mari S Oba, Kae Kawachi, Akinori Nozawa, Yasushi Ichikawa, Kazuaki Takabe, Itaru Endo
{"title":"The Pathological Response to Anthracycline is Associated with Topoisomerase IIα Gene Amplification in the HER2 Breast Cancer Subset.","authors":"Takashi Ishikawa,&nbsp;Takeshi Sasaki,&nbsp;Mikiko Tanabe,&nbsp;Kazutaka Narui,&nbsp;Kumiko Kida,&nbsp;Kazuhiro Shimada,&nbsp;Daisuke Shimizu,&nbsp;Akimitsu Yamada,&nbsp;Satoshi Morita,&nbsp;Mari S Oba,&nbsp;Kae Kawachi,&nbsp;Akinori Nozawa,&nbsp;Yasushi Ichikawa,&nbsp;Kazuaki Takabe,&nbsp;Itaru Endo","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>HER2-positive breast cancer sensitivity to anthracyclines is enhanced when topoisomerase IIα (TOP2A) is co-amplified under both adjuvant and metastatic settings. However, the relationship between anthracycline sensitivity and TOP2A amplification in HER2-positive breast cancers in neoadjuvant settings is not known.</p><p><strong>Methods: </strong>The TOP2A gene status was examined by FISH in biopsies from 18 patients who received anthracycline and cyclophosphamide before surgery.</p><p><strong>Results: </strong>The TOP2A gene was amplified in 6/17 patients and was significantly associated with pathological response to the chemotherapy regimen.</p><p><strong>Conclusions: </strong>TOP2A amplification could predict anthracycline-sensitivity. Thus, the HER2/TOP2A co-amplified subtype may be effectively treated by anthracycline-containing regimens alone.</p>","PeriodicalId":90243,"journal":{"name":"Journal of surgery and science","volume":"2 1","pages":"10-12"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309011/pdf/nihms656984.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33346255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges in the Treatment of Triple Negative and HER2-Overexpressing Breast Cancer. 三阴性和her2过表达乳腺癌治疗的挑战。
Journal of surgery and science Pub Date : 2013-12-01
L Alexis Hoeferlin, Charles E Chalfant, Margaret A Park
{"title":"Challenges in the Treatment of Triple Negative and HER2-Overexpressing Breast Cancer.","authors":"L Alexis Hoeferlin,&nbsp;Charles E Chalfant,&nbsp;Margaret A Park","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>While the 5-year survival rate of breast cancer is at an all-time high of 90%, this disease remains the second most common cause of cancer-related death, surpassed only by lung cancer in the US. The reasons for this discrepancy stem from cancer subtypes which become resistant to current therapies. These subtypes: \"Triple negative\" and ErbB2-overexpressing, are discussed in this review.</p>","PeriodicalId":90243,"journal":{"name":"Journal of surgery and science","volume":"1 1","pages":"3-7"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012677/pdf/nihms-576637.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32334575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intestinal Co-infection of Tuberculosis and CMV can Cause Massive Lower GI Bleeding in a Patient with HIV. 结核病和巨细胞病毒的肠道联合感染可导致HIV患者大量下消化道出血。
Journal of surgery and science Pub Date : 2013-12-01
Masayuki Nagahashi, Tomoyoshi Aoyagi, Akimitsu Yamada, Omar M Rashid, Barbara J Adams, Kazuaki Takabe
{"title":"Intestinal Co-infection of Tuberculosis and CMV can Cause Massive Lower GI Bleeding in a Patient with HIV.","authors":"Masayuki Nagahashi,&nbsp;Tomoyoshi Aoyagi,&nbsp;Akimitsu Yamada,&nbsp;Omar M Rashid,&nbsp;Barbara J Adams,&nbsp;Kazuaki Takabe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tuberculosis (TB) and HIV are considered pandemic by the World Health Organization (WHO). It has been reported that HIV infection is one of the major risk factors for the development of TB, increasing the incidence by up to 1,000 times, but it often has an atypical presentation. The incidence of extrapulmonary TB is increasing, largely among HIV patients. The diagnosis of intestinal TB is a challenge because of its chronic and nonspecific presentation which often mimics other diseases, and requires a high clinical suspicion to timely diagnose. Massive lower gastrointestinal bleeding due to intestinal TB was once an uncommon complication of TB, but recent reports indicate an increased incidence especially in developing countries. We suspect that co-infection with cytomegalovirus colitis contributes to the massive hemorrhage from intestinal TB. Surgical intervention is the recommended management for intestinal TB complicated by lower gastrointestinal bleeding. Accordingly, it is important for HIV patients to be screened and treated for TB to prevent this complication. Although the diagnosis is a challenge, it is important to consider intestinal TB as a cause of gastrointestinal bleeding in the HIV positive patients.</p>","PeriodicalId":90243,"journal":{"name":"Journal of surgery and science","volume":"1 1","pages":"12-15"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109321/pdf/nihms-554923.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32539655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Welcome to the Journal of Surgery and Science! 欢迎来到外科与科学杂志!
Journal of surgery and science Pub Date : 2013-12-01
Kazuaki Takabe
{"title":"Welcome to the <i>Journal of Surgery and Science!</i>","authors":"Kazuaki Takabe","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":90243,"journal":{"name":"Journal of surgery and science","volume":"1 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225642/pdf/nihms554920.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32810705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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