{"title":"HER2乳腺癌亚群对蒽环类药物的病理反应与拓扑异构酶i α基因扩增相关","authors":"Takashi Ishikawa, Takeshi Sasaki, Mikiko Tanabe, Kazutaka Narui, Kumiko Kida, Kazuhiro Shimada, Daisuke Shimizu, Akimitsu Yamada, Satoshi Morita, Mari S Oba, Kae Kawachi, Akinori Nozawa, Yasushi Ichikawa, Kazuaki Takabe, Itaru Endo","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>HER2-positive breast cancer sensitivity to anthracyclines is enhanced when topoisomerase IIα (TOP2A) is co-amplified under both adjuvant and metastatic settings. However, the relationship between anthracycline sensitivity and TOP2A amplification in HER2-positive breast cancers in neoadjuvant settings is not known.</p><p><strong>Methods: </strong>The TOP2A gene status was examined by FISH in biopsies from 18 patients who received anthracycline and cyclophosphamide before surgery.</p><p><strong>Results: </strong>The TOP2A gene was amplified in 6/17 patients and was significantly associated with pathological response to the chemotherapy regimen.</p><p><strong>Conclusions: </strong>TOP2A amplification could predict anthracycline-sensitivity. Thus, the HER2/TOP2A co-amplified subtype may be effectively treated by anthracycline-containing regimens alone.</p>","PeriodicalId":90243,"journal":{"name":"Journal of surgery and science","volume":"2 1","pages":"10-12"},"PeriodicalIF":0.0000,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309011/pdf/nihms656984.pdf","citationCount":"0","resultStr":"{\"title\":\"The Pathological Response to Anthracycline is Associated with Topoisomerase IIα Gene Amplification in the HER2 Breast Cancer Subset.\",\"authors\":\"Takashi Ishikawa, Takeshi Sasaki, Mikiko Tanabe, Kazutaka Narui, Kumiko Kida, Kazuhiro Shimada, Daisuke Shimizu, Akimitsu Yamada, Satoshi Morita, Mari S Oba, Kae Kawachi, Akinori Nozawa, Yasushi Ichikawa, Kazuaki Takabe, Itaru Endo\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>HER2-positive breast cancer sensitivity to anthracyclines is enhanced when topoisomerase IIα (TOP2A) is co-amplified under both adjuvant and metastatic settings. However, the relationship between anthracycline sensitivity and TOP2A amplification in HER2-positive breast cancers in neoadjuvant settings is not known.</p><p><strong>Methods: </strong>The TOP2A gene status was examined by FISH in biopsies from 18 patients who received anthracycline and cyclophosphamide before surgery.</p><p><strong>Results: </strong>The TOP2A gene was amplified in 6/17 patients and was significantly associated with pathological response to the chemotherapy regimen.</p><p><strong>Conclusions: </strong>TOP2A amplification could predict anthracycline-sensitivity. Thus, the HER2/TOP2A co-amplified subtype may be effectively treated by anthracycline-containing regimens alone.</p>\",\"PeriodicalId\":90243,\"journal\":{\"name\":\"Journal of surgery and science\",\"volume\":\"2 1\",\"pages\":\"10-12\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309011/pdf/nihms656984.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of surgery and science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of surgery and science","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Pathological Response to Anthracycline is Associated with Topoisomerase IIα Gene Amplification in the HER2 Breast Cancer Subset.
Background: HER2-positive breast cancer sensitivity to anthracyclines is enhanced when topoisomerase IIα (TOP2A) is co-amplified under both adjuvant and metastatic settings. However, the relationship between anthracycline sensitivity and TOP2A amplification in HER2-positive breast cancers in neoadjuvant settings is not known.
Methods: The TOP2A gene status was examined by FISH in biopsies from 18 patients who received anthracycline and cyclophosphamide before surgery.
Results: The TOP2A gene was amplified in 6/17 patients and was significantly associated with pathological response to the chemotherapy regimen.
Conclusions: TOP2A amplification could predict anthracycline-sensitivity. Thus, the HER2/TOP2A co-amplified subtype may be effectively treated by anthracycline-containing regimens alone.
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