{"title":"YKL-40 as a biomarker in various inflammatory diseases: A review","authors":"Nina Blazevic, Nina Blazevic, Dunja Rogic, Stipe Pelajic, Marijana Miler, Goran Glavcic, Valentina Ratkajec, Nikolina Vrkljan, Dejan Bakula, Davor Hrabar, Tajana Pavic","doi":"10.11613/bm.2024.010502","DOIUrl":"https://doi.org/10.11613/bm.2024.010502","url":null,"abstract":"Highlights\u0000YKL-40 is a biomarker for inflammatory diseases’ diagnosis and prediction\u0000YKL-40 concentration increases with age and has variations in healthy population\u0000YKL-40 is convincing in pancreatic/liver disease, arthritis, bronchitis, and sepsis\u0000YKL-40 is debatable in cardiovascular/neurological/renal disease, diabetes, asthma\u0000Future larger studies and age-stratified reference intervals of YKL-40 are needed","PeriodicalId":9021,"journal":{"name":"Biochemia Medica","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138741621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biochemia MedicaPub Date : 2023-12-19DOI: 10.11613/bm.2024.011001
Natividad Rico Ríos, Natividad Rico Ríos, Alison Bransfield, Caroline M Joyce, Mary R Cahill, Michelle O’Shaughnessy, Seán J. Costelloe
{"title":"Challenges of providing biochemistry results in a patient with Evans syndrome","authors":"Natividad Rico Ríos, Natividad Rico Ríos, Alison Bransfield, Caroline M Joyce, Mary R Cahill, Michelle O’Shaughnessy, Seán J. Costelloe","doi":"10.11613/bm.2024.011001","DOIUrl":"https://doi.org/10.11613/bm.2024.011001","url":null,"abstract":"Highlights\u0000A case report of <i>in vivo</i> hemolysis in patient with Evans syndrome is described\u0000Hemolysis disrupts biochemistry analysis, yielding unreliable results\u0000A laboratory designed algorithm ensures results with interpretative comments\u0000Close communication between the laboratory and the clinical team is essential","PeriodicalId":9021,"journal":{"name":"Biochemia Medica","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138741562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Determination of cystatin C reference interval for children in Croatia","authors":"Vlasta Cigula Kurajica, Vlasta Cigula Kurajica, Željka Vogrinc, Ana Turčić, Slobodan Galić","doi":"10.11613/bm.2024.010702","DOIUrl":"https://doi.org/10.11613/bm.2024.010702","url":null,"abstract":"Graphical abstract\u0000<img alt=\"bm-34-1-010702-g1.tif\" src=\"bm-34-1-010702-g1.tif\"/>","PeriodicalId":9021,"journal":{"name":"Biochemia Medica","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138741614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biochemia MedicaPub Date : 2023-12-19DOI: 10.11613/bm.2024.010703
Ivana Baršić Lapić, Ivana Baršić Lapić, Lara Milevoj Kopčinović, Nedjeljka Ruljančić, Nedjeljka Ruljančić, Marija Grdić Rajković, Maja Kuštro
{"title":"Point of care testing in Croatia: a survey of the Working group for point of care testing of the Croatian society of medical biochemistry and laboratory medicine","authors":"Ivana Baršić Lapić, Ivana Baršić Lapić, Lara Milevoj Kopčinović, Nedjeljka Ruljančić, Nedjeljka Ruljančić, Marija Grdić Rajković, Maja Kuštro","doi":"10.11613/bm.2024.010703","DOIUrl":"https://doi.org/10.11613/bm.2024.010703","url":null,"abstract":"Graphical abstract\u0000<img alt=\"bm-34-1-010703-g1.tif\" src=\"bm-34-1-010703-g1.tif\"/>","PeriodicalId":9021,"journal":{"name":"Biochemia Medica","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138741619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biochemia MedicaPub Date : 2023-12-19DOI: 10.11613/bm.2024.010802
Tugba Barlas, Tugba Barlas, Mehmet Muhittin Yalcin, Zakir Osmanov, Ozlem Gulbahar, Alev Eroglu Altinova, Mujde Akturk, Mehmet Ayhan Karakoc, Ilhan Yetkin, Fusun Balos Toruner
{"title":"Detecting the interferences in adrenocorticotropic hormone measurement - three cases reinforcing the efficiency of the complementary clinical and laboratory audit","authors":"Tugba Barlas, Tugba Barlas, Mehmet Muhittin Yalcin, Zakir Osmanov, Ozlem Gulbahar, Alev Eroglu Altinova, Mujde Akturk, Mehmet Ayhan Karakoc, Ilhan Yetkin, Fusun Balos Toruner","doi":"10.11613/bm.2024.010802","DOIUrl":"https://doi.org/10.11613/bm.2024.010802","url":null,"abstract":"Highlights\u0000Comparing test results to clinical data enhances the identification of interferences\u0000Misinterpretation of ACTH as a result of interference may lead to unnecessary testing\u0000Despite the interference, ACTH concentration can be in the reference interval","PeriodicalId":9021,"journal":{"name":"Biochemia Medica","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138741618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biochemia MedicaPub Date : 2023-12-19DOI: 10.11613/bm.2024.010803
Luka Švitek, Luka Švitek, Barbara Grubišić, Barbara Grubišić, Ema Schonberger, Ema Schonberger, Mihaela Zlosa, Mihaela Zlosa, Dario Sabadi, Dario Sabadi, Dario Sabadi, Dubravka Lišnjić, Dubravka Lišnjić, Silvija Canecki-Varžić, Silvija Canecki-Varžić, Ines Bilić-Ćurčić, Ines Bilić-Ćurčić, Sanja Mandić, Sanja Mandić, Sanja Mandić
{"title":"Syndrome of inappropriate antidiuretic hormone secretion as an adverse reaction of ciprofloxacin: a case report and literature review","authors":"Luka Švitek, Luka Švitek, Barbara Grubišić, Barbara Grubišić, Ema Schonberger, Ema Schonberger, Mihaela Zlosa, Mihaela Zlosa, Dario Sabadi, Dario Sabadi, Dario Sabadi, Dubravka Lišnjić, Dubravka Lišnjić, Silvija Canecki-Varžić, Silvija Canecki-Varžić, Ines Bilić-Ćurčić, Ines Bilić-Ćurčić, Sanja Mandić, Sanja Mandić, Sanja Mandić","doi":"10.11613/bm.2024.010803","DOIUrl":"https://doi.org/10.11613/bm.2024.010803","url":null,"abstract":"Highlights\u0000Euvolemic patient with mild hyponatremia during ciprofloxacin treatment was evaluated\u0000No diuretic use; hypothyroidism and hypocortisolism were excluded as causes\u0000Our findings highlight ciprofloxacin's potential role in inducing Syndrome of inappropriate antidiuretic hormone secretion","PeriodicalId":9021,"journal":{"name":"Biochemia Medica","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138741615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biochemia MedicaPub Date : 2023-12-19DOI: 10.11613/bm.2024.010701
Dražan Butorac, Ivana Ćelap, Ivana Ćelap, Sanja Kačkov Maslać, Tomislav Miletić, Andrea Hulina Tomašković, Petra Turčić, Dubravka Rašić, Ivana Stojanović, Marija Grdić Rajković, Marija Grdić Rajković
{"title":"Paraoxonase and arylesterase activity of paraoxonase 1 and oxidative stress parameters in cervical intraepithelial neoplasia","authors":"Dražan Butorac, Ivana Ćelap, Ivana Ćelap, Sanja Kačkov Maslać, Tomislav Miletić, Andrea Hulina Tomašković, Petra Turčić, Dubravka Rašić, Ivana Stojanović, Marija Grdić Rajković, Marija Grdić Rajković","doi":"10.11613/bm.2024.010701","DOIUrl":"https://doi.org/10.11613/bm.2024.010701","url":null,"abstract":"Graphical abstract\u0000<img alt=\"bm-34-1-010701-g1.tif\" src=\"bm-34-1-010701-g1.tif\"/>","PeriodicalId":9021,"journal":{"name":"Biochemia Medica","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138741627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Potential biomarkers and therapeutic targets for obsessive compulsive disorder: Evidences from clinical studies","authors":"Aarushi Sultania, Shashank Venkatesan, Dhruv Rishb Batra, Keerthna Rajesh, Rahul Vashishth, Sudesh Ravi, Faraz Ahmad, Faraz Ahmad","doi":"10.11613/bm.2024.010503","DOIUrl":"https://doi.org/10.11613/bm.2024.010503","url":null,"abstract":"Highlights\u0000The study proposes a set of potential biomarkers for obsessive compulsive disorder\u0000Methods to assess their concentrations in biological samples are critically analyzed\u0000Links between the disorder, diabetes and circadian disruptions are assessed\u0000The implications of biomarkers as therapeutic biotargets are discussed","PeriodicalId":9021,"journal":{"name":"Biochemia Medica","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138742040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biochemia MedicaPub Date : 2023-10-15Epub Date: 2023-08-05DOI: 10.11613/BM.2023.030502
Điđi Delalić, Tanja Brežni, Ingrid Prkačin
{"title":"Diagnostic value and utility of commonly used biomarkers of cardiac and renal function in cardiorenal syndromes: a narrative review.","authors":"Điđi Delalić, Tanja Brežni, Ingrid Prkačin","doi":"10.11613/BM.2023.030502","DOIUrl":"10.11613/BM.2023.030502","url":null,"abstract":"<p><p>Cardiorenal syndrome (CRS), first defined in 2004 as a consequence of the interactions between the kidneys and other circulatory departments leading to acute heart failure, has since been recognized as a complex clinical entity that is hard to define, diagnose and classify. The framework for the classification of CRS according to pathophysiologic background was laid out in 2008, dividing CRS into five distinct phenotypes. However, determining the timing of individual organ injuries and making a diagnosis of either renal or cardiac failure remains an elusive task. In clinical practice, the diagnosis and phenotyping of CRS is mostly based on using laboratory biomarkers in order to directly or indirectly estimate the degree of end-organ functional decline. Therefore, a well-educated clinician should be aware of the effects that the reduction of renal and cardiac function has on the diagnostic and predictive value and properties of the most commonly used biomarkers (<i>e.g.</i> troponins, N-terminal pro-brain natriuretic peptide, serum creatinine <i>etc</i>). They should also be acquainted, on a basic level, with emerging biomarkers that are specific to either the degree of glomerular integrity (cystatin C) or tubular injury (neutrophil gelatinase-associated lipocalin). This narrative review aims to provide a scoping overview of the different roles that biomarkers play in both the diagnosis of CRS and the prognosis of the disease in patients who have been diagnosed with it, along with highlighting the most important pitfalls in their interpretation in the context of impaired renal and/or cardiac function.</p>","PeriodicalId":9021,"journal":{"name":"Biochemia Medica","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9954832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic challenges of diabetic kidney disease.","authors":"Marijana Vučić Lovrenčić, Sandra Božičević, Lea Smirčić Duvnjak","doi":"10.11613/BM.2023.030501","DOIUrl":"10.11613/BM.2023.030501","url":null,"abstract":"<p><p>Diabetic kidney disease (DKD) is one of the most common microvascular complications of both type 1 and type 2 diabetes and the most common cause of the end-stage renal disease (ESRD). It has been evidenced that targeted interventions at an early stage of DKD can efficiently prevent or delay the progression of kidney failure and improve patient outcomes. Therefore, regular screening for DKD has become one of the fundamental principles of diabetes care. Long-established biomarkers such as serum-creatinine-based estimates of glomerular filtration rate and albuminuria are currently the cornerstone of diagnosis and risk stratification in routine clinical practice. However, their immanent biological limitations and analytical variations may influence the clinical interpretation of the results. Recently proposed new predictive equations without the variable of race, together with the evidence on better accuracy of combined serum creatinine and cystatin C equations, and both race- and sex-free cystatin C-based equation, have enabled an improvement in the detection of DKD, but also require the harmonization of the recommended laboratory tests, wider availability of cystatin C testing and specific approach in various populations. Considering the complex pathophysiology of DKD, particularly in type 2 diabetes, a panel of biomarkers is needed to classify patients in terms of the rate of disease progression and/or response to specific interventions. With a personalized approach to diagnosis and treatment, in the future, it will be possible to respond to DKD better and enable improved outcomes for numerous patients worldwide.</p>","PeriodicalId":9021,"journal":{"name":"Biochemia Medica","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9949076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}