Journal of coupled systems and multiscale dynamics最新文献_第4页

Evaluation of aerodynamic characteristics of a coupled fluid-structure system using generalized Bernoulli's principle: An application to vocal folds vibration. 利用广义伯努利原理评估流固耦合系统的空气动力特性：声带振动的应用

Journal of coupled systems and multiscale dynamics Pub Date : 2016-12-01 DOI: 10.1166/jcsmd.2016.1114

Lucy T Zhang, Jubiao Yang

{"title":"Evaluation of aerodynamic characteristics of a coupled fluid-structure system using generalized Bernoulli's principle: An application to vocal folds vibration.","authors":"Lucy T Zhang, Jubiao Yang","doi":"10.1166/jcsmd.2016.1114","DOIUrl":"10.1166/jcsmd.2016.1114","url":null,"abstract":"In this work we explore the aerodynamics flow characteristics of a coupled fluid-structure interaction system using a generalized Bernoulli equation derived directly from the Cauchy momentum equations. Unlike the conventional Bernoulli equation where incompressible, inviscid, and steady flow conditions are assumed, this generalized Bernoulli equation includes the contributions from compressibility, viscous, and unsteadiness, which could be essential in defining aerodynamic characteristics. The application of the derived Bernoulli's principle is on a fully-coupled fluid-structure interaction simulation of the vocal folds vibration. The coupled system is simulated using the immersed finite element method where compressible Navier-Stokes equations are used to describe the air and an elastic pliable structure to describe the vocal fold. The vibration of the vocal fold works to open and close the glottal flow. The aerodynamics flow characteristics are evaluated using the derived Bernoulli's principles for a vibration cycle in a carefully partitioned control volume based on the moving structure. The results agree very well to experimental observations, which validate the strategy and its use in other types of flow characteristics that involve coupled fluid-structure interactions.","PeriodicalId":90211,"journal":{"name":"Journal of coupled systems and multiscale dynamics","volume":"4 4","pages":"241-250"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841236/pdf/nihms920661.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35903290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Connecting within and between-hosts dynamics in the influenza infection-staged epidemiological models with behavior change. 与行为改变的流感感染阶段流行病学模型中宿主内部和宿主之间的动态联系。

Journal of coupled systems and multiscale dynamics Pub Date : 2015-09-01 DOI: 10.1166/jcsmd.2015.1082

Kasia A Pawelek, Cristian Salmeron, Sara Del Valle

{"title":"Connecting within and between-hosts dynamics in the influenza infection-staged epidemiological models with behavior change.","authors":"Kasia A Pawelek, Cristian Salmeron, Sara Del Valle","doi":"10.1166/jcsmd.2015.1082","DOIUrl":"https://doi.org/10.1166/jcsmd.2015.1082","url":null,"abstract":"Influenza viruses are a major public health problem worldwide. Although influenza has been extensively researched, there are still many aspects that are not fully understood such as the effects of within and between-hosts dynamics and their impact on behavior change. Here, we develop mathematical models with multiple infection stages and estimate parameters based on within-host data to investigate the impact of behavior change on influenza dynamics. We divide the infected population into three and four groups based on the age of the infection, which corresponds to viral load shedding. We consider within-host data on viral shedding to estimate the length and force of infection of the different infectivity stages. Our results show that behavior changes, due to exogenous events (e.g., media coverage) and disease symptoms, are effective in delaying and lowering an epidemic peak. We show that the dynamics of viral shedding and symptoms, during the infection, are key features when considering epidemic prevention strategies. This study improves our understanding of the spread of influenza virus infection in the population and provides information about the impact of emergent behavior and its connection to the within and between-hosts dynamics.","PeriodicalId":90211,"journal":{"name":"Journal of coupled systems and multiscale dynamics","volume":"3 3","pages":"233-243"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654582/pdf/nihms875236.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35494891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Algebraic Statistical Model for Biochemical Network Dynamics Inference. 生化网络动力学推断的代数统计模型。

Journal of coupled systems and multiscale dynamics Pub Date : 2013-12-01 DOI: 10.1166/jcsmd.2013.1032

Daniel F Linder, Grzegorz A Rempala

{"title":"Algebraic Statistical Model for Biochemical Network Dynamics Inference.","authors":"Daniel F Linder, Grzegorz A Rempala","doi":"10.1166/jcsmd.2013.1032","DOIUrl":"10.1166/jcsmd.2013.1032","url":null,"abstract":"With modern molecular quantification methods, like, for instance, high throughput sequencing, biologists may perform multiple complex experiments and collect longitudinal data on RNA and DNA concentrations. Such data may be then used to infer cellular level interactions between the molecular entities of interest. One method which formalizes such inference is the stoichiometric algebraic statistical model (SASM) of [2] which allows to analyze the so-called conic (or single source) networks. Despite its intuitive appeal, up until now the SASM has been only heuristically studied on few simple examples. The current paper provides a more formal mathematical treatment of the SASM, expanding the original model to a wider class of reaction systems decomposable into multiple conic subnetworks. In particular, it is proved here that on such networks the SASM enjoys the so-called sparsistency property, that is, it asymptotically (with the number of observed network trajectories) discards the false interactions by setting their reaction rates to zero. For illustration, we apply the extended SASM to in silico data from a generic decomposable network as well as to biological data from an experimental search for a possible transcription factor for the heat shock protein 70 (Hsp70) in the zebrafish retina.","PeriodicalId":90211,"journal":{"name":"Journal of coupled systems and multiscale dynamics","volume":"1 4","pages":"468-475"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267476/pdf/nihms571761.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32922773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting mechanism of biphasic growth factor action on tumor growth using a multi-species model with feedback control. 利用带反馈控制的多物种模型预测双相生长因子对肿瘤生长的作用机制

Journal of coupled systems and multiscale dynamics Pub Date : 2013-12-01 DOI: 10.1166/jcsmd.2013.1028

Anna Konstorum, Stephanie A Sprowl, Marian L Waterman, Arthur D Lander, John S Lowengrub

引用次数: 0

Mathematical modeling approaches in the study of glaucoma disparities among people of African and European descents. 研究非洲裔和欧洲裔青光眼差异的数学建模方法。

Journal of coupled systems and multiscale dynamics Pub Date : 2013-04-01 DOI: 10.1166/jcsmd.2013.1004

Giovanna Guidoboni, Alon Harris, Julia C Arciero, Brent A Siesky, Annahita Amireskandari, Austin L Gerber, Andrew H Huck, Nathaniel J Kim, Simone Cassani, Lucia Carichino

{"title":"Mathematical modeling approaches in the study of glaucoma disparities among people of African and European descents.","authors":"Giovanna Guidoboni, Alon Harris, Julia C Arciero, Brent A Siesky, Annahita Amireskandari, Austin L Gerber, Andrew H Huck, Nathaniel J Kim, Simone Cassani, Lucia Carichino","doi":"10.1166/jcsmd.2013.1004","DOIUrl":"10.1166/jcsmd.2013.1004","url":null,"abstract":"Open angle glaucoma (OAG) is a severe ocular disease characterized by progressive and irreversible vision loss. While elevated intraocular pressure (IOP) is a well-established risk factor for OAG, the progression of OAG in many cases, despite IOP treatment, suggests that other risk factors must play significant roles in the development of the disease. For example, various structural properties of the eye, ocular blood flow properties, and systemic conditions have been identified as risk factors for OAG. Ethnicity has also been indicated as a relevant factor that affects the incidence and prevalence of OAG; in fact, OAG is the leading cause of blindness among people of African descent. Numerous clinical studies have been designed to examine the possible correlation and causation between OAG and these factors; however, these studies are met with the challenge of isolating the individual role of multiple interconnected factors. Over the last decade, various mathematical modeling approaches have been implemented in combination with clinical studies in order to provide a mechanical and hemodynamical description of the eye in relation to the entire human body and to assess the contribution of single risk factors to the development of OAG. This review provides a summary of the clinical evidence of ocular structural differences, ocular vascular differences and systemic vascular differences among people of African and European descent, describes the mathematical approaches that have been proposed to study ocular mechanics and hemodynamics while discussing how they could be used to investigate the relevance to OAG of racial disparities, and outlines possible new directions of research.","PeriodicalId":90211,"journal":{"name":"Journal of coupled systems and multiscale dynamics","volume":"1 1","pages":"1-21"},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912249/pdf/nihms540430.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32093861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0