ISRN nephrology最新文献_第2页

Prevalence of chronic kidney disease and its related risk factors in elderly of southern iran: a population-based study. 伊朗南部老年人慢性肾病患病率及其相关危险因素:一项基于人群的研究

ISRN nephrology Pub Date : 2013-07-07 eCollection Date: 2013-01-01 DOI: 10.5402/2013/427230

Leila Malekmakan, Parviz Khajehdehi, Maryam Pakfetrat, Alireza Malekmakan, Hamideh Mahdaviazad, Jamshid Roozbeh

引用次数: 17

Vitamin e is a nephroprotectant agent in male but not in female in a model of Cisplatin-induced nephrotoxicity. 在顺铂诱导的肾毒性模型中，维生素e在男性中是一种肾保护剂，但在女性中不是。

ISRN nephrology Pub Date : 2013-06-23 eCollection Date: 2013-01-01 DOI: 10.5402/2013/280395

Sima Jilanchi, Mehdi Nematbakhsh, Mehrnoosh Bahadorani, Ardeshir Talebi, Fatemeh Eshraghi-Jazi, Azam Mansouri, Farzaneh Ashrafi

{"title":"Vitamin e is a nephroprotectant agent in male but not in female in a model of Cisplatin-induced nephrotoxicity.","authors":"Sima Jilanchi, Mehdi Nematbakhsh, Mehrnoosh Bahadorani, Ardeshir Talebi, Fatemeh Eshraghi-Jazi, Azam Mansouri, Farzaneh Ashrafi","doi":"10.5402/2013/280395","DOIUrl":"https://doi.org/10.5402/2013/280395","url":null,"abstract":"Background. The role of gender for nephroprotectant agent such as vitamin E in cisplatin- (CP-) induced nephrotoxicity has not been documented yet. Methods. One group from each gender of Wistar rats received a single dose of CP (7 mg/kg; i.p) and was treated with vitamin E (1 g/kg/day) for 7 days, and they were compared with similar gender in the control group. Results. The serum levels of blood urea nitrogen (BUN) and creatinine (Cr) in male animals treated with CP was not different from the control group, but it was significantly different in the female rats (P < 0.05). The CP-induced damage intensity in male kidney tissue was not significantly different between the CP-treated and control groups, but this was not the case in female, indicating that the tissue damage in female is significantly different from the control group (P < 0.05). No significant difference in serum levels of magnesium (Mg), nitrite, malondialdehyde (MDA), and lactate dehydrogenase (LDH) was seen between the genders. Kidney weight and body weight changes were statistically significant in both genders (P < 0.05). Significant difference was observed in uterus weight between the two groups of female (P < 0.05). Conclusion. Vitamin E may prevent CP-induced nephrotoxicity in male, but possibly it has not such nephroprotectant effect in female. ","PeriodicalId":90192,"journal":{"name":"ISRN nephrology","volume":"2013 ","pages":"280395"},"PeriodicalIF":0.0,"publicationDate":"2013-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2013/280395","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32449120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Lack of influence of serum magnesium levels on overall mortality and cardiovascular outcomes in patients with advanced chronic kidney disease. 血清镁水平对晚期慢性肾病患者的总死亡率和心血管结局缺乏影响

ISRN nephrology Pub Date : 2013-06-19 eCollection Date: 2013-01-01 DOI: 10.5402/2013/191786

Olimpia Ortega, Isabel Rodriguez, Gabriela Cobo, Julie Hinostroza, Paloma Gallar, Carmen Mon, Milagros Ortiz, Juan Carlos Herrero, Cristina Di Gioia, Aniana Oliet, Ana Vigil

{"title":"Lack of influence of serum magnesium levels on overall mortality and cardiovascular outcomes in patients with advanced chronic kidney disease.","authors":"Olimpia Ortega, Isabel Rodriguez, Gabriela Cobo, Julie Hinostroza, Paloma Gallar, Carmen Mon, Milagros Ortiz, Juan Carlos Herrero, Cristina Di Gioia, Aniana Oliet, Ana Vigil","doi":"10.5402/2013/191786","DOIUrl":"https://doi.org/10.5402/2013/191786","url":null,"abstract":"Background. Low serum magnesium has been associated with an increased cardiovascular risk in the general population and in dialysis patients. Our aim was to analyze the influence of serum magnesium on overall mortality and cardiovascular outcomes in patients with advanced CKD not yet on dialysis. Methods. Seventy patients with CKD stages 4 and 5 were included. After a single measurement of s-magnesium, patients were followed a mean of 11 months. Primary end-point was death of any cause, and secondary end-point was the occurrence of fatal or nonfatal CV events. Results. Basal s-magnesium was within normal range (2.1 ± 0.3 mg/dL), was lower in men (P = 0.008) and in diabetic patients (P = 0.02), and was not different (P = 0.2) between patients with and without cardiopathy. Magnesium did not correlate with PTH, calcium, phosphate, albumin, inflammatory parameters (CRP), and cardiac (NT-proBNP) biomarkers but correlated inversely (r = -0.23; P = 0.052) with the daily dose of loop diuretics. In univariate and multivariate Cox proportional hazard models, magnesium was not an independent predictor for overall mortality or CV events. Conclusions. Our results do not support that serum magnesium can be an independent predictor for overall mortality or future cardiovascular events among patients with advanced CKD not yet on dialysis. ","PeriodicalId":90192,"journal":{"name":"ISRN nephrology","volume":"2013 ","pages":"191786"},"PeriodicalIF":0.0,"publicationDate":"2013-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32449118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Urine bag as a modern day matula. 尿袋作为现代马甲。

ISRN nephrology Pub Date : 2013-05-23 eCollection Date: 2013-01-01 DOI: 10.5402/2013/215690

Stalin Viswanathan

引用次数: 15

Decrease rate of the renal diameter in chronic hemodialysis patients. 慢性血液透析患者肾直径减小率。

ISRN nephrology Pub Date : 2013-05-22 eCollection Date: 2013-01-01 DOI: 10.5402/2013/521949

Teiichiro Aoyagi, Masaaki Tachibana, Shinji Naganuma

{"title":"Decrease rate of the renal diameter in chronic hemodialysis patients.","authors":"Teiichiro Aoyagi, Masaaki Tachibana, Shinji Naganuma","doi":"10.5402/2013/521949","DOIUrl":"https://doi.org/10.5402/2013/521949","url":null,"abstract":"We here present the results of ultrasonographic (US) evaluations on the alteration of renal diameter of chronic HD patients. Of 109 outpatient HD patients who had neither severe acquired cystic disease of the kidney nor hereditary polycystic kidney disease, we performed US two or three times to measure their maximum renal diameter (mean of both kidneys), and the yearly alteration rate was calculated. The average interval of the two measurements was 35.9 months, and the average HD duration from the HD induction to the first measurement was 29.5 months. The average decrease rate of renal diameter was 4.34 ± 0.4 (SE) mm/year. No statistical difference was seen on the decrease rate in relation to gender, age and original disease (among three groups, glomerulonephritis and IgA nephropathy, diabetes, and others including hypertension). However, the decrease rate was large when the first measurement was close to the induction of hemodialysis, suggesting that the alteration rate reduced according to the hemodialysis vintage (5.3 ± 0.8 mm/year, first measurement not more than 10 months after induction of HD and 1.5 ± 1.6 mm/year, first measurement more than 80 months after induction of HD). Renal diameter decreased approximately 4.3 mm each year, and the decrease rate slowed as the length of time on dialysis increased. ","PeriodicalId":90192,"journal":{"name":"ISRN nephrology","volume":"2013 ","pages":"521949"},"PeriodicalIF":0.0,"publicationDate":"2013-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32456973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current understanding of guanylin peptides actions. 目前对观音肽作用的认识。

ISRN nephrology Pub Date : 2013-04-17 eCollection Date: 2013-01-01 DOI: 10.5402/2013/813648

Aleksandra Sindic

{"title":"Current understanding of guanylin peptides actions.","authors":"Aleksandra Sindic","doi":"10.5402/2013/813648","DOIUrl":"https://doi.org/10.5402/2013/813648","url":null,"abstract":"Guanylin peptides (GPs) family includes guanylin (GN), uroguanylin (UGN), lymphoguanylin, and recently discovered renoguanylin. This growing family is proposed to be intestinal natriuretic peptides. After ingestion of a salty meal, GN and UGN are secreted into the intestinal lumen, where they inhibit sodium absorption and induce anion and water secretion. At the same conditions, those hormones stimulate renal electrolyte excretion by inducing natriuresis, kaliuresis, and diuresis and therefore prevent hypernatremia and hypervolemia after salty meals. In the intestine, a well-known receptor for GPs is guanylate cyclase C (GC-C) whose activation increases intracellular concentration of cGMP. However, in the kidney of GC-C-deficient mice, effects of GPs are unaltered, which could be by new cGMP-independent signaling pathway (G-protein-coupled receptor). This is not unusual as atrial natriuretic peptide also activates two different types of receptors: guanylate cylcase A and clearance receptor which is also G-protein coupled receptor. Physiological role of GPs in other organs (liver, pancreas, lung, sweat glands, and male reproductive system) needs to be discovered. However, it is known that they are involved in pathological conditions like cystic fibrosis, asthma, intestinal tumors, kidney and heart failure, obesity, and metabolic syndrome. ","PeriodicalId":90192,"journal":{"name":"ISRN nephrology","volume":"2013 ","pages":"813648"},"PeriodicalIF":0.0,"publicationDate":"2013-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32456976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Diabetes insipidus: a challenging diagnosis with new drug therapies. 尿崩症:一个具有挑战性的诊断与新的药物治疗。

ISRN nephrology Pub Date : 2013-03-24 eCollection Date: 2013-01-01 DOI: 10.5402/2013/797620

Chadi Saifan, Rabih Nasr, Suchita Mehta, Pranab Sharma Acharya, Isera Perrera, Giovanni Faddoul, Nikhil Nalluri, Mayurakhan Kesavan, Yorg Azzi, Suzanne El-Sayegh

{"title":"Diabetes insipidus: a challenging diagnosis with new drug therapies.","authors":"Chadi Saifan, Rabih Nasr, Suchita Mehta, Pranab Sharma Acharya, Isera Perrera, Giovanni Faddoul, Nikhil Nalluri, Mayurakhan Kesavan, Yorg Azzi, Suzanne El-Sayegh","doi":"10.5402/2013/797620","DOIUrl":"https://doi.org/10.5402/2013/797620","url":null,"abstract":"Diabetes Insipidus (DI) is either due to deficient secretion of arginine vasopressin (central) or to tubular unresponsiveness (nephrogenic). Drug induced DI is a well-known entity with an extensive list of medications. Polyuria is generally defined as urine output exceeding 3 liters per day in adults. It is crucial to identify the cause of diabetes insipidus and to implement therapy as early as possible to prevent the electrolyte disturbances and the associated mortality and morbidity. It is very rare to have an idiosyncratic effect after a short use of a medication, and physicians should be aware of such a complication to avoid volume depletion. The diagnosis of diabetes insipidus is very challenging because it relies on laboratory values, urine output, and the physical examination of the patient. A high clinical suspicion of diabetes insipidus should be enough to initiate treatment. The complications related to DI are mostly related to the electrolyte imbalance that can affect the normal physiology of different organ systems. ","PeriodicalId":90192,"journal":{"name":"ISRN nephrology","volume":"2013 ","pages":"797620"},"PeriodicalIF":0.0,"publicationDate":"2013-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2013/797620","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32464818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

ISRN nephrology Pub Date : 2013-03-11 eCollection Date: 2013-01-01 DOI: 10.5402/2013/612675

Mehdi Nematbakhsh, Zahra Pezeshki

{"title":"Sex-Related Difference in Nitric Oxide Metabolites Levels after Nephroprotectant Supplementation Administration against Cisplatin-Induced Nephrotoxicity in Wistar Rat Model: The Role of Vitamin E, Erythropoietin, or N-Acetylcysteine.","authors":"Mehdi Nematbakhsh, Zahra Pezeshki","doi":"10.5402/2013/612675","DOIUrl":"https://doi.org/10.5402/2013/612675","url":null,"abstract":"Background. Nitric oxide (NO) concentration in serum is altered by cisplatin (CP), and NO influences CP-induced nephrotoxicity. The effect of nephroprotectant agent supplementation (vitamin E, human recombinant erythropoietin (EPO), or n-acetylcysteine (NAC)) on the NO metabolites levels after CP administration in the two genders was determined. Methods. Sixty-four adult Wistar rats were randomly divided into 10 groups. Male and female rats in different groups received vehicle (saline), CP (7 mg/kg) alone, CP plus EPO (100 IU/kg), CP plus vitamin E (250 mg/kg), and CP plus NAC (600 mg/kg). CP was administrated as a single dose, but the supplementations were given for a period of 7 days. Results. In male rats, the serum levels of total NO metabolites (NO x ) and nitrite were increased significantly (P < 0.05) by CP. However, vitamin E significantly reduced the serum levels of these metabolites, which was increased by administration of CP (P < 0.05), and such findings were not observed for female rats. The EPO or NAC did not influence NO metabolites neither in male rats nor in female rats. Conclusion. Although vitamin E, EPO, and NAC are reported to be nephroprotectant agents against CP-induced nephrotoxicity, only vitamin E could reduce the level of all NO metabolites only in male rats. ","PeriodicalId":90192,"journal":{"name":"ISRN nephrology","volume":"2013 ","pages":"612675"},"PeriodicalIF":0.0,"publicationDate":"2013-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32456974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Glomerular disease in patients with infectious processes developing antineutrophil cytoplasmic antibodies. 肾小球疾病患者感染过程中产生抗中性粒细胞细胞质抗体。

ISRN nephrology Pub Date : 2013-02-19 eCollection Date: 2013-01-01 DOI: 10.5402/2013/324315

Konstantin N Konstantinov, Suzanne N Emil, Marc Barry, Susan Kellie, Antonios H Tzamaloukas

{"title":"Glomerular disease in patients with infectious processes developing antineutrophil cytoplasmic antibodies.","authors":"Konstantin N Konstantinov, Suzanne N Emil, Marc Barry, Susan Kellie, Antonios H Tzamaloukas","doi":"10.5402/2013/324315","DOIUrl":"10.5402/2013/324315","url":null,"abstract":"To identify differences in treatment and outcome of various types of glomerulonephritis developing in the course of infections triggering antineutrophil cytoplasmic antibody (ANCA) formation, we analyzed published reports of 50 patients. Immunosuppressives were added to antibiotics in 22 of 23 patients with pauci-immune glomerulonephritis. Improvement was noted in 85% of 20 patients with information on outcomes. Death rate was 13%. Corticosteroids were added to antibiotics in about 50% of 19 patients with postinfectious glomerulonephritis. Improvement rate was 74%, and death rate was 26%. Two patients with mixed histological features were analyzed under both pauci-immune and post-infectious glomerulonephritis categories. In 9 patients with other renal histology, treatment consisted of antibiotics alone (7 patients), antibiotics plus immunosuppressives (1 patient), or immunosuppressives alone (1 patient). Improvement rate was 67%, permanent renal failure rate was 22%, and death rate was 11%. One patient with antiglomerular basement disease glomerulonephritis required maintenance hemodialysis. Glomerulonephritis developing in patients who became ANCA-positive during the course of an infection is associated with significant mortality. The histological type of the glomerulonephritis guides the choice of treatment. Pauci-immune glomerulonephritis is usually treated with addition of immunosuppressives to antibiotics. ","PeriodicalId":90192,"journal":{"name":"ISRN nephrology","volume":"2013 ","pages":"324315"},"PeriodicalIF":0.0,"publicationDate":"2013-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32451606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Serum NGAL in Critically Ill Children in ICU from a Single Center in Egypt. 埃及单一中心ICU重症患儿血清NGAL分析

ISRN nephrology Pub Date : 2013-02-03 eCollection Date: 2013-01-01 DOI: 10.5402/2013/140905

Doaa Mohammed Youssef, Asmaa Mohammed Esh, Ebthag Helmy Hassan, Tahia Mohammed Ahmed

{"title":"Serum NGAL in Critically Ill Children in ICU from a Single Center in Egypt.","authors":"Doaa Mohammed Youssef, Asmaa Mohammed Esh, Ebthag Helmy Hassan, Tahia Mohammed Ahmed","doi":"10.5402/2013/140905","DOIUrl":"https://doi.org/10.5402/2013/140905","url":null,"abstract":"Introduction. The mortality and morbidity associated with acute kidney injury (AKI), unfortunately, remain unacceptably high. We aimed to detect the extent of serum neutrophil gelatinase-associated lipocalin (NGAL) to early detect AKI in critically ill children. Subjects and Methods. This is a case control study. It included 75 subjects that include 15 as controls and 60 critically ill children. Patients were further subdivided according to RIFLE criteria into two other categories: patients who developed AKI and patients who did not develop AKI. Serum NGAL assayed on admission and after 3 days. Results. There was significant increase in the level of NGAL among patients group when compared with control group. Also, 21.7% of children admitted to PICU developed AKI from which 8.3% needed dialysis. The receiver operating characteristic curve of NGAL at day 0 revealed AUC of 0.63 with 95% CI of 0.50-0.77. At a cutoff value of 89.5 ng/mL, the sensitivity of NGAL was 84.6%, while specifcity was 59.6%, positive predictive value was 36.7%, negative predictive value was 68.4%, and accuracy was 93.3% in diagnosis of AKI. Conclusion. We found that NGAL acts as a sensitive marker rather than a specific one for AKI. At the same time, it presents as a negative predictive value more valuable than being a positive predictive value in detecting AKI. ","PeriodicalId":90192,"journal":{"name":"ISRN nephrology","volume":"2013 ","pages":"140905"},"PeriodicalIF":0.0,"publicationDate":"2013-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32449117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6