Grief matters最新文献_第8页

Claustrophilie

Grief matters Pub Date : 2019-07-28 DOI: 10.3917/grief.192.0011

Olivier Cayla

引用次数: 0

Preserved functional networks in a hydrocephalic mouse 脑积水小鼠保存的功能网络

Grief matters Pub Date : 2019-06-10 DOI: 10.19185/MATTERS.201905000001

F. Mandino, Ling Yun Yeow, J. Gigg, M. Olivo, J. Grandjean

{"title":"Preserved functional networks in a hydrocephalic mouse","authors":"F. Mandino, Ling Yun Yeow, J. Gigg, M. Olivo, J. Grandjean","doi":"10.19185/MATTERS.201905000001","DOIUrl":"https://doi.org/10.19185/MATTERS.201905000001","url":null,"abstract":"Hydrocephalus is a brain condition characterized by enlarged ventricles, due to an excess of cerebrospinal fluid. Although it is known to affect cognition, development, gait, and mood, the impact of hydrocephalus on large-scale functional brain organization is poorly documented. Here, we present results on a single spontaneous occurrence of severe hydrocephalus observed in a 3xTgAD mouse, compared to a control cohort of 3xTgAD littermates. Resting-state functional magnetic resonance imaging analysis, carried out under light anesthesia, revealed the remarkable presence of functional connectivity (FC) resembling the common mouse resting-state networks (RSNs). Four main components were identified in the hydrocephalic mouse, attributable to the Default Mode network, Salience network, and sensorimotor networks. Characteristic features of the RSNs in the hydrocephalic mouse were found to be well preserved, both in spatial distribution and in FC magnitude, despite the severity of the pathology. This is the first documented case of resting-state fMRI conducted on a mouse affected by severe hydrocephalus. The surprising presence of resting-state networks was found to be comparable to littermate controls, highlighting a remarkable functional resilience in the hydrocephalic brain.","PeriodicalId":90172,"journal":{"name":"Grief matters","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86540619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Functional characterization of salvador and warts in planarians 涡虫中萨尔瓦多和疣的功能特征

Grief matters Pub Date : 2019-06-07 DOI: 10.19185/MATTERS.201905000004

N. Sousa, E. Pascual-Carreras, E. Saló, T. Adell

{"title":"Functional characterization of salvador and warts in planarians","authors":"N. Sousa, E. Pascual-Carreras, E. Saló, T. Adell","doi":"10.19185/MATTERS.201905000004","DOIUrl":"https://doi.org/10.19185/MATTERS.201905000004","url":null,"abstract":"In the last years, the Hippo signaling has emerged as an essential pathway to control tissue and organ homeostasis, and its deregulation leads to tumoral transformation in all animals studied. However, the underlying cellular and molecular mechanism of this transformation are still not clear. The core of the Hippo pathway includes a kinase cassette composed by the kinases Hippo, Salvador, Mats, and Warts that in turn phosphorylates the nuclear effector of the pathway, Yorkie, targeting it to proteasomal degradation. Recently, the functional study of hippo, in planarians, flatworms that continuously change their size and renew their tissues according to nutrients, allowed demonstrating that the underlying mechanism of cellular transformation was not an increase in cell proliferation but inducing cell cycle arrest and promoting cell dedifferentiation. However, the functional study of yorkie did not allow to relate it with the Hippo function. Here, we show that inhibition of salvador and warts phenocopies the defects observed in hippo RNAi planarians. Since Warts is responsible for phosphorylating yorkie, this data suggests that not only the kinase cassette of the Hippo pathway is functionally conserved but also the nuclear effector.","PeriodicalId":90172,"journal":{"name":"Grief matters","volume":"371 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80483129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The curious incident of the hermit crab and the gastropod 寄居蟹和腹足动物的奇怪事件

Grief matters Pub Date : 2019-06-03 DOI: 10.19185/matters.201905000006

D. Gorman, A. Turra, M. Denadai

引用次数: 0

Molecular detection of Trypanosoma cruzi from formalin fixed placentas and fetuses of Wistar rats Wistar大鼠福尔马林固定胎盘和胎儿克氏锥虫的分子检测

Grief matters Pub Date : 2019-06-03 DOI: 10.19185/MATTERS.201905000002

C. Costa, L. M. Pereira, José Clóvis do Prado Júnior, Ana Amélia Carraro Abrahão

{"title":"Molecular detection of Trypanosoma cruzi from formalin fixed placentas and fetuses of Wistar rats","authors":"C. Costa, L. M. Pereira, José Clóvis do Prado Júnior, Ana Amélia Carraro Abrahão","doi":"10.19185/MATTERS.201905000002","DOIUrl":"https://doi.org/10.19185/MATTERS.201905000002","url":null,"abstract":"Chagas disease is a tropical disease, endemic of the Americas and caused by the protozoan Trypanosoma cruzi. The classic transmission route of T. cruzi is based on the contact with feces from Triatominae insects containing trypomastigotes forms of the parasite. T. cruzi is also spread by oral and congenital forms, besides blood donation and organ transplant transmission. The parasite has a tropism to several organs and tissues, including heart, brain, digestive tract, muscles, placenta, and fetuses. The determination of parasite burden in organs is an important parameter for scientific assays related to parasite control and epidemiology. Among the procedures to detect and quantify T. cruzi, PCR demonstrates high sensitivity and specificity. In this study, we developed a simple and fast method to detect T. cruzi from fixed placentas and fetuses of Wistar rats. T. cruzi was detected only in tissues from infected animals, with different parasite burdens. Once the histology usually demonstrates some limitations such as low sensitivity and specificity to detect T. cruzi in fetuses, our methodology will be useful for fixed fetal tissues from organ banks. The detection of T. cruzi from gestational tissues will contribute to the elucidation of mechanisms related to congenital Chagas disease.","PeriodicalId":90172,"journal":{"name":"Grief matters","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87515999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retour sur l’affaire DSK et l’évolution dilemmique du droit pénal contemporain 回顾卡恩案和当代刑法的困境演变

Grief matters Pub Date : 2019-05-28 DOI: 10.3917/grief.191.0019

Olivier Cayla

引用次数: 0

À mort papa ! 致死爸爸!

Grief matters Pub Date : 2019-05-28 DOI: 10.3917/grief.191.0011

Rainer Maria Kiesow

引用次数: 0

Les curieuses leçons d’anthropologie de Maurice Godelier 莫里斯·戈德利埃的人类学课

Grief matters Pub Date : 2019-05-28 DOI: 10.3917/grief.191.0013

E. Désveaux