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Homeobox Gene Deregulation: Impact on the Hallmarks of Cancer. 同形盒基因解除管制:对癌症特征的影响。
Cancer hallmarks Pub Date : 2013-09-01 DOI: 10.1166/ch.2013.1007
Dhwani Haria, Honami Naora
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引用次数: 47
A Brief Review of the Biophysical Hallmarks of Metastatic Cancer Cells. 转移癌细胞的生物物理特征综述。
Cancer hallmarks Pub Date : 2013-08-01 DOI: 10.1166/ch.2013.1010
Weijia Zhang, Kazuharu Kai, Naoto T Ueno, Lidong Qin
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引用次数: 19
Epithelial-mesenchymal Transition---A Hallmark of Breast Cancer Metastasis. 上皮-间质转化——乳腺癌转移的标志。
Cancer hallmarks Pub Date : 2013-03-01 DOI: 10.1166/ch.2013.1004
Yifan Wang, Binhua P Zhou
{"title":"Epithelial-mesenchymal Transition---A Hallmark of Breast Cancer Metastasis.","authors":"Yifan Wang,&nbsp;Binhua P Zhou","doi":"10.1166/ch.2013.1004","DOIUrl":"https://doi.org/10.1166/ch.2013.1004","url":null,"abstract":"<p><p>Epithelial-mesenchymal transition (EMT) is a highly conserved cellular program that converts polarized, immotile epithelial cells to migratory mesenchymal cells. In addition, EMT was initially recognized as a key step for morphogenesis during embryonic development. Emerging evidences indicate that this important developmental program promotes metastasis, drug resistance, and tumor recurrence, features that are associated with a poor clinical outcome for patients with breast cancer. Therefore, better understanding of regulation and signaling pathways in EMT is essential to develop novel targeted therapeutics. In this review, we present updated developments underlying EMT in tumor progression and metastasis, and discuss the challenges remaining in breast cancer research.</p>","PeriodicalId":90133,"journal":{"name":"Cancer hallmarks","volume":"1 1","pages":"38-49"},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944831/pdf/nihms-483395.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40294645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 138
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