Applied & translational genomics最新文献_第2页

A systems approach to personalised nutrition: Report on the Keystone Symposium “Human Nutrition, Environment and Health” 个性化营养的系统方法:“人类营养、环境与健康”基石研讨会报告

Applied & translational genomics Pub Date : 2016-09-01 Epub Date: 2016-08-04 DOI: 10.1016/j.atg.2016.08.001

Michael Maher , Amy M. Pooler , James Kaput, Martin Kussmann

引用次数: 7

Omics challenges and unmet translational needs 组学挑战和未满足的翻译需求

Applied & translational genomics Pub Date : 2016-09-01 Epub Date: 2016-08-18 DOI: 10.1016/j.atg.2016.08.002

Carol Isaacson Barash

引用次数: 3

Metabolic modeling with Big Data and the gut microbiome 利用大数据和肠道微生物组进行代谢建模

Applied & translational genomics Pub Date : 2016-09-01 Epub Date: 2016-02-05 DOI: 10.1016/j.atg.2016.02.001

Jaeyun Sung , Vanessa Hale , Annette C. Merkel , Pan-Jun Kim , Nicholas Chia

引用次数: 24

Standardization and quality management in next-generation sequencing 新一代测序的标准化与质量管理

Applied & translational genomics Pub Date : 2016-09-01 Epub Date: 2016-07-01 DOI: 10.1016/j.atg.2016.06.001

Christoph Endrullat, Jörn Glökler, Philipp Franke, Marcus Frohme

{"title":"Standardization and quality management in next-generation sequencing","authors":"Christoph Endrullat, Jörn Glökler, Philipp Franke, Marcus Frohme","doi":"10.1016/j.atg.2016.06.001","DOIUrl":"https://doi.org/10.1016/j.atg.2016.06.001","url":null,"abstract":"<div><p>DNA sequencing continues to evolve quickly even after >30years. Many new platforms suddenly appeared and former established systems have vanished in almost the same manner. Since establishment of next-generation sequencing devices, this progress gains momentum due to the continually growing demand for higher throughput, lower costs and better quality of data. In consequence of this rapid development, standardized procedures and data formats as well as comprehensive quality management considerations are still scarce. Here, we listed and summarized current standardization efforts and quality management initiatives from companies, organizations and societies in form of published studies and ongoing projects. These comprise on the one hand quality documentation issues like technical notes, accreditation checklists and guidelines for validation of sequencing workflows. On the other hand, general standard proposals and quality metrics are developed and applied to the sequencing workflow steps with the main focus on upstream processes. Finally, certain standard developments for downstream pipeline data handling, processing and storage are discussed in brief. These standardization approaches represent a first basis for continuing work in order to prospectively implement next-generation sequencing in important areas such as clinical diagnostics, where reliable results and fast processing is crucial. Additionally, these efforts will exert a decisive influence on traceability and reproducibility of sequence data.</p></div>","PeriodicalId":90104,"journal":{"name":"Applied & translational genomics","volume":"10 ","pages":"Pages 2-9"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.atg.2016.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91726544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 155

A systems approach to personalised nutrition: Report on the Keystone Symposium “Human Nutrition, Environment and Health” 个性化营养的系统方法:“人类营养、环境与健康”基石研讨会报告

Applied & translational genomics Pub Date : 2016-08-04 DOI: 10.1016/j.atg.2016.08.001

M. Maher, A. Pooler, J. Kaput, M. Kussmann

引用次数: 8

Standardization and quality management in next-generation sequencing 新一代测序的标准化与质量管理

Applied & translational genomics Pub Date : 2016-07-01 DOI: 10.1016/j.atg.2016.06.001

C. Endrullat, J. Glökler, Philipp Franke, M. Frohme

引用次数: 160

Tau protein as a biomarker for asphyxia: A possible forensic tool? Tau蛋白作为窒息的生物标志物:一种可能的法医工具?

Applied & translational genomics Pub Date : 2016-06-01 Epub Date: 2016-03-03 DOI: 10.1016/j.atg.2016.03.001

Mohamed Salama , Wael M.Y. Mohamed

引用次数: 7

Translating translational medicine into global health equity: What is needed? 将转化医学转化为全球卫生公平:需要什么?

Applied & translational genomics Pub Date : 2016-06-01 Epub Date: 2016-03-10 DOI: 10.1016/j.atg.2016.03.004

Carol Isaacson Barash

{"title":"Translating translational medicine into global health equity: What is needed?","authors":"Carol Isaacson Barash","doi":"10.1016/j.atg.2016.03.004","DOIUrl":"10.1016/j.atg.2016.03.004","url":null,"abstract":"<div><p>While genomics, and other omics, research is rapidly advancing in the US and Europe, progress has been slower in less resourced countries. The imbalance has given rise to concern about whether the benefits of these advances, namely new and better tests, treatments, risk identification, and prevention strategies, will be shared and available to those living in less resourced reaches of the globe. In effort to give voice to researchers, an informal survey about barriers to advancing translational medicine was administered to attendees of the 11th Asia Pacific Conference on Human Genetics, 2015, Hanoi. The overall goal of the survey was to identify unmet needs and rank their importance. Most attendees completed the survey. Not surprisingly funding is indicated as a major need. Respondents reported that lack of bioinformatics and computational tools, trained data scientists and access to datasets is creating a significant lag behind better resourced regions. Results are intended to inform efforts to create a regional consensus statement of need. Such a regional statement could help funding organizations and policy makers seeking to promote global genomics benefit sharing.</p></div>","PeriodicalId":90104,"journal":{"name":"Applied & translational genomics","volume":"9 ","pages":"Pages 37-39"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.atg.2016.03.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34620341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pharmacogenomics for infectious diseases in sub-Saharan Africa: Successes and opportunities 撒哈拉以南非洲传染病药物基因组学:成功与机遇

Applied & translational genomics Pub Date : 2016-06-01 Epub Date: 2016-05-07 DOI: 10.1016/j.atg.2016.04.001

Mamoonah Chaudhry, Marco Alessandrini, Michael S. Pepper

引用次数: 8

Limited resources of genome sequencing in developing countries: Challenges and solutions 发展中国家有限的基因组测序资源:挑战和解决办法

Applied & translational genomics Pub Date : 2016-06-01 Epub Date: 2016-03-10 DOI: 10.1016/j.atg.2016.03.003

Mohamed Helmy , Mohamed Awad , Kareem A. Mosa

{"title":"Limited resources of genome sequencing in developing countries: Challenges and solutions","authors":"Mohamed Helmy , Mohamed Awad , Kareem A. Mosa","doi":"10.1016/j.atg.2016.03.003","DOIUrl":"10.1016/j.atg.2016.03.003","url":null,"abstract":"<div><p>The differences between countries in national income, growth, human development and many other factors are used to classify countries into developed and developing countries. There are several classification systems that use different sets of measures and criteria. The most common classifications are the United Nations (UN) and the World Bank (WB) systems. The UN classification system uses the UN Human Development Index (HDI), an indicator that uses statistic of life expectancy, education, and income per capita for countries' classification. While the WB system uses gross national income (GNI) per capita that is calculated using the World Bank Atlas method. According to the UN and WB classification systems, there are 151 and 134 developing countries, respectively, with 89% overlap between the two systems. Developing countries have limited human development, and limited expenditure in education and research, among several other limitations. The biggest challenge facing genomic researchers and clinicians is limited resources. As a result, genomic tools, specifically genome sequencing technologies, which are rapidly becoming indispensable, are not widely available. In this report, we explore the current status of sequencing technologies in developing countries, describe the associated challenges and emphasize potential solutions.</p></div>","PeriodicalId":90104,"journal":{"name":"Applied & translational genomics","volume":"9 ","pages":"Pages 15-19"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.atg.2016.03.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34619080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 98