Journal of neuroscience and neuroengineering最新文献_第3页

Assessment of Prefrontal Cortex Activity in Amyotrophic Lateral Sclerosis Patients with Functional Near Infrared Spectroscopy 用功能性近红外光谱评价肌萎缩侧索硬化症患者前额皮质活动

Journal of neuroscience and neuroengineering Pub Date : 2014-02-01 DOI: 10.1166/JNSNE.2014.1095

H. Ayaz, P. Shewokis, L. Scull, D. Libon, Sara J Feldman, Joel S. Eppig, B. Onaral, T. Heiman-Patterson

{"title":"Assessment of Prefrontal Cortex Activity in Amyotrophic Lateral Sclerosis Patients with Functional Near Infrared Spectroscopy","authors":"H. Ayaz, P. Shewokis, L. Scull, D. Libon, Sara J Feldman, Joel S. Eppig, B. Onaral, T. Heiman-Patterson","doi":"10.1166/JNSNE.2014.1095","DOIUrl":"https://doi.org/10.1166/JNSNE.2014.1095","url":null,"abstract":"Cognitive impairment in amyotrophic lateral sclerosis (ALS) is associated with cortical changes beyond the motor cortex. The overall goal of this project is to determine if task induced hemodynamic changes detected by functional near infrared (fNIR) spectroscopy from the anterior prefrontal cortex (PFC) has discriminant validity across ALS (n = 17) patients and matching healthy (n = 17) controls. The experimental protocol was composed of the King-Devick Test, the Number Interference Test and a Continuous Performance Test targeting a range of cognitive domains including sustained attention and executive function. Results indicate that fNIR measures provided significant differences between ALS and healthy controls in all three tasks providing an additional metric for the assessment of cognitive decline. Although this is a pilot study, given the safe, wearable and realworld validity of fNIR, these results may set the foundation for the use of fNIR as a clinical tool in monitoring progression of neurocognitive decline in a simple, less invasive and objective manner than allowed by current imaging technology.","PeriodicalId":89986,"journal":{"name":"Journal of neuroscience and neuroengineering","volume":"3 1","pages":"41-51"},"PeriodicalIF":0.0,"publicationDate":"2014-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64643374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Maternal Behavior: A Novel Experimental Approach and Detailed Statistical Analysis 母性行为:一种新的实验方法和详细的统计分析

Journal of neuroscience and neuroengineering Pub Date : 2014-02-01 DOI: 10.1166/JNSNE.2014.1096

K. K. Tanaeva, Y. Dobryakova, V. Dubynin

引用次数: 3

Glioblastoma development in mouse brain: general reduction of OCTs and mislocalization of OCT3 transporter and subsequent uptake of ASP⁺ substrate to the nuclei. 小鼠脑胶质母细胞瘤的发展:OCTs的普遍减少和OCT3转运体的错误定位以及随后ASP+底物向细胞核的摄取。

Journal of neuroscience and neuroengineering Pub Date : 2014-02-01 DOI: 10.1166/jnsne.2014.1091

Lilia Y Kucheryavykh, Kimberleve Rolón-Reyes, Yuriy V Kucheryavykh, Serguei Skatchkov, Misty J Eaton, Priscila Sanabria, William D Wessinger, Mikhail Inyushin

{"title":"Glioblastoma development in mouse brain: general reduction of OCTs and mislocalization of OCT3 transporter and subsequent uptake of ASP+ substrate to the nuclei.","authors":"Lilia Y Kucheryavykh, Kimberleve Rolón-Reyes, Yuriy V Kucheryavykh, Serguei Skatchkov, Misty J Eaton, Priscila Sanabria, William D Wessinger, Mikhail Inyushin","doi":"10.1166/jnsne.2014.1091","DOIUrl":"https://doi.org/10.1166/jnsne.2014.1091","url":null,"abstract":"Organic cation transporters (OCTs) were first found and then isolated from cultured glioma cells. When glioma cells are implanted into brain the fate of OCTs varies with time after implantation and transporter type. Here we report that OCT1, OCT2 and OCT3 immunofluorescence is significantly reduced over time in implanted GL261 glioma cells, during tumor development in the brain. By day 21 after glioma implantation, OCT1, OCT2 and OCT3 immunofluorescence was reduced more than 10-fold in the cytoplasm of glioma cells, while OCT3 immunofluorescence became concentrated in the nucleus. The well-known fluorescent substrate for OCT transporters, 4-(4-(dimethylamino)-styryl)-N-methylpyridinium iodide (ASP+), previously shown to accumulate in glioma-cell cytoplasm in in vivo slices, began to accumulate in the nucleus of these cells, but not in cytoplasm, after 21 days post-implantation. Considering this mislocalization phenomenon, and other literature on similar nuclear mislocalization of different transporters, receptors and channels in glioma cells, we suggest that it is one of the \"omens\" preceding the motility and aggressivity changes in glioma behavior.","PeriodicalId":89986,"journal":{"name":"Journal of neuroscience and neuroengineering","volume":"3 1","pages":"3-9"},"PeriodicalIF":0.0,"publicationDate":"2014-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143131/pdf/nihms610395.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32620979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

BACE1 Silencing Using siRNA Shows Immediate, Dynamic Changes in Spontaneous Electrical Activity of Cultured Neurons 使用siRNA沉默BACE1显示出培养神经元自发电活动的即时动态变化

Journal of neuroscience and neuroengineering Pub Date : 2013-12-01 DOI: 10.1166/JNSNE.2013.1084

Arati Sridharan, J. Muthuswamy

引用次数: 2

Peripheral Neural Devices: State-of-the-Art 外周神经装置:最先进的

Journal of neuroscience and neuroengineering Pub Date : 2013-12-01 DOI: 10.1166/JNSNE.2013.1087

S. Alwarappan, Mahaswetha Das, S. Mohapatra, Chen-zhong Li

引用次数: 0

Multi-Variate Gait Data Analysis: Comparison Between Healthy Adults of Different Age Groups 多变量步态数据分析:不同年龄组健康成年人的比较

Journal of neuroscience and neuroengineering Pub Date : 2013-12-01 DOI: 10.1166/JNSNE.2013.1082

C. Pradhan, M. Wuehr, Maximilian Neuhaeusser, Sabrina Huth, T. Brandt, K. Jahn, R. Schniepp

引用次数: 4

Overlapping Brain Activity as Reflected by the Spatial Differentiation of Functional Magnetic Resonance Imaging, Electroencephalography and Magnetoencephalography Data 功能磁共振、脑电图和脑磁图数据空间分异反映的重叠脑活动

Journal of neuroscience and neuroengineering Pub Date : 2013-12-01 DOI: 10.1166/JNSNE.2013.1086

K. Strelnikov, P. Barone, Cnrs Cerco

{"title":"Overlapping Brain Activity as Reflected by the Spatial Differentiation of Functional Magnetic Resonance Imaging, Electroencephalography and Magnetoencephalography Data","authors":"K. Strelnikov, P. Barone, Cnrs Cerco","doi":"10.1166/JNSNE.2013.1086","DOIUrl":"https://doi.org/10.1166/JNSNE.2013.1086","url":null,"abstract":"In classical neuroimaging, the activity of each voxel is considered separately. However, it was recently demonstrated that there are significant stimulation-specific differences between adjacent voxels at the group level. With this approach, the activity of adjacent voxels in the same condition is compared, and the direction of the highest increase of activity in the neighbourhood of each voxel is established as a gradient vector per voxel. Using this vector approach, we compared fMRI, EEG and MEG spatial differential activity during different tasks to see what amount of fMRI differential activity corresponds to the electromagnetic differential activity. Distributed source reconstruction was used to obtain 3-dimensional models of electric and magnetic activity in EEG and MEG prior to vector analysis. Using independent datasets, we illustrated that the mean overlap of the fMRI differential activity with EEG and MEG is 79%. In addition, about 93% of divergence (spatial sources) in fMRI corresponded to the EEG and MEG divergences. These results correspond to the spatial sum of the peak activities in EEG and MEG and, further, suggest a link between the spatial and temporal properties of brain activity. We propose a novel model of activity flows in the brain to explain this link.","PeriodicalId":89986,"journal":{"name":"Journal of neuroscience and neuroengineering","volume":"2 1","pages":"550-561"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64643189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Targeted Delivery of 4-Aminopyridine Into the Rat Brain by Minicontainers from Carbon-Nanodiamonds Composite 碳纳米金刚石复合材料微型容器将4-氨基吡啶靶向递送至大鼠大脑

Journal of neuroscience and neuroengineering Pub Date : 2013-12-01 DOI: 10.1166/JNSNE.2013.1088

A. Volnova, S. Gordeev, D. Lenkov

引用次数: 8

Multiparametric Magnetic Resonance Imaging of Radiation Induced Brain Injury in Preclinical Animal Models 临床前动物模型辐射性脑损伤的多参数磁共振成像研究

Journal of neuroscience and neuroengineering Pub Date : 2013-12-01 DOI: 10.1166/JNSNE.2013.1089

Silun Wang, Xiaodong Zhang

引用次数: 0

Assessing White Matter Integrity in Experimental Spinal Cord Injury Using Diffusion Tensor Imaging 利用弥散张量成像评估实验性脊髓损伤中的白质完整性

Journal of neuroscience and neuroengineering Pub Date : 2013-10-01 DOI: 10.1166/JNSNE.2013.1074

Tsang-Wei Tu, J. Frank

引用次数: 9