Journal of neurological disorders最新文献

{"title":"Patterns and Correlates of Physical Symptoms among People with Peripheral Neuropathy.","authors":"Miyong T Kim, Nicole Murry, Jacklyn Hecht, Tara Hutson, Tonychris Nnaka, Tiffany Ewere, Elizabeth Heitkemper, Emily T Hebert, Kavita Radhakrishnan, Alexa Stuifbergen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>As the population ages and more people are affected by multiple chronic conditions, the prevalence of Peripheral Neuropathy (PN) has also rapidly increased. This swift rise in PN leaves clinicians and patients challenged by a lack of consistent diagnosis and treatment guidelines.</p><p><strong>Purpose: </strong>To assist those affected by PN, it is imperative to understand the breadth of symptoms, experiences, and factors related to the quality of life. The primary aims of this study are to (1) characterize the symptoms of PN in a nationwide sample; (2) discern differences in symptom clusters, given perceived causes of PN; and (3) identify significant physiological symptoms related to the quality of life for people with PN.</p><p><strong>Methods: </strong>An online survey of people in online PN support groups. Participants were recruited primarily <i>via</i> an open request sent to recipients of web-based communications from nationally recognized online PN support groups. Inclusion criteria were as follows: Self-reported diagnosis of PN, ability to read English or Spanish, residence in the U.S., and age ≥ 18 years.</p><p><strong>Results: </strong>A total of 608 individuals with PN were included in the analysis. This sample represents 49 U.S. states and the District of Colombia; 221 were male and 387 female. Their disease severity and etiology were similar to previously reported information on this population, with 53.3% of respondents suffering from PN without a known cause. Among known causes, diabetes was the most common (19.6%), followed by chemotherapy (6.9%) and autoimmune diseases (3.6%). Factors affecting the quality of life among people with PN included lower extremity mobility, upper extremity mobility, sleep disturbance, depressive symptoms, and patient activation.</p>","PeriodicalId":89983,"journal":{"name":"Journal of neurological disorders","volume":"10 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10812380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139572321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Quantum Theory of Entanglement and Alzheimer's","authors":"S. Goradia","doi":"10.4172/2329-6895-C6-041","DOIUrl":"https://doi.org/10.4172/2329-6895-C6-041","url":null,"abstract":"S anguivi is a semi-domestic indigenous vegetable very valuable in many African countries with potential to become a cultivated market vegetable in Nigeria. Uptake of Solanum anguivi cause hypoglycemic effect, hypertension e.t.c. The effect of Saponin from Solanum anguivi on heart function of an alloxan-induced diabetic rat was investigated in this Study. Twenty four (24) rats of average weight 120g were randomly divided into six (6) groups A-F. Group A (control) rats were given 2.0ml of distilled water, Group B (Diabetic control), Group C to F were diabetic rats which were administered 20mg/ kg, 40mg/kg and 80mg/kg Saponin from Solanum anguivi respectively for 14 days. The results showed that there was a significant reduction in plasma glucose in the diabetic rat to almost the level in the Control. The result also shows that there were a significant reduction in Aspartate Aminotransferase AST and Alanine aminotransferase ALT activities in serum and heart compared with the control (p<0.05). This study shows that Solanum anguivi fruit has an anti-diabetic effect on alloxan induced diabetic rat.","PeriodicalId":89983,"journal":{"name":"Journal of neurological disorders","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70267602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classical Music and Childhood Music Intervention on Moderate Alzheimer's Patients: Case Study","authors":"T. Chen","doi":"10.4172/2329-6895.1000406","DOIUrl":"https://doi.org/10.4172/2329-6895.1000406","url":null,"abstract":"Alzheimer’s Disease (AD) has become a major worldwide health crisis with increasing prevalence among the aging population. People with early stage Alzheimer’s will continue to experience symptoms that progressively worsen as time goes on. Pharmacotherapy has shown its limited effectiveness in slowing down the development of symptoms, but non-pharma therapies such as music therapy have shown promise in assisting Alzheimer’s patients to improve their quality of life. The goal of this study is to assess the effects of two genres of music interventions on an Alzheimer’s patient’s selective cognitive measures such as relational communication, the verbal and nonverbal aspects of how messages from the patient are conveyed. This paper presents the case of a 73-year-old patient with moderate Alzheimer’s living at Memory Care Center at Fox Trail, Princeton, NJ. Music interventions were applied to slow the development of additional symptoms. His successful response to certain types of music inspired the author to continue Alzheimer’s treatment using music interventions, and as a systematic controlled treatment for this condition. The different response after the periods of treatment using different types of music genres in a five-year period (2014-2019) may suggest the modality of certain genres of music interventions on this patient. The Individualized Music Therapy Assessment Profile (IMTAP) will be used to measure the patient’s cognitive response. This study may lay the groundwork for future research on selective genres of music intervention in non-drug therapy for Alzheimer’s patients, specifically music therapy.","PeriodicalId":89983,"journal":{"name":"Journal of neurological disorders","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49550656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study to assess the noise stress-induced changes on cognition in Wistar albino rats","authors":"pArchana Ap","doi":"10.4172/2329-6895-C11-055","DOIUrl":"https://doi.org/10.4172/2329-6895-C11-055","url":null,"abstract":"Purpose: Epilepsy Action Australia (EAA) sought to understand the attitudes toward and lived experiences of adults and parents of children living with epilepsy of cannabinoid-based therapies in an ever-changing climate of public opinion, government legislation and clinical trials in Australia. Method: Two studies were undertaken with the first informing the second study. A nationwide online survey was conducted assessing demographics, clinical factors, including diagnosis and seizure types and experiences with and opinions towards cannabis use in epilepsy. The second study (PELICAN) focused on experiences of 61 families of children with epilepsy under the age of 16 years who desired, were currently or had previously administered cannabinoid-based therapies to their children to manage seizures. Semi-structured interviews were conducted; samples collected with subsequent laboratory analysis. Any compound capable of activating the cannabinoid receptor and/or and They a wide variety of while some exert psychoactive effects, including euphoria","PeriodicalId":89983,"journal":{"name":"Journal of neurological disorders","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70267526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addition of Low Molecular Weight Heparin to Antiplatelet in Patients with Stroke Ineligible for Thrombolysis: Can it Improve Outcome?","authors":"Hassan A. Soliman, Yasser Hamed Mustafa, A. Salem, A. Yousry, Mohamed El-Refaey","doi":"10.4172/2329-6895.1000402","DOIUrl":"https://doi.org/10.4172/2329-6895.1000402","url":null,"abstract":"Objective: Stroke is one of the most frequent causes of death and disability, urgent thrombolytic therapy can save thousands of lives and disabilities but unfortunately not all patients are eligible for thrombolysis. Dual antiplatelet are superior to anticoagulants in management of stroke and the use of full dose anticoagulants alone or in combination with aspirin is still debatable and carry the risk of hemorrhagic complications. Aim of study: We aimed to compare the use double antiplatelet (oral Aspirin plus Clopidogrel) versus oral aspirin plus subcutaneous low dose enoxaparin in treatment of progressing stroke ineligible for thrombolysis. Methods: The study was carried out on fifty-six patients presented with progressing stroke from February 2017 to the end January of 2019. Patients eligible for thrombolytic therapy (recombinant tissue plasminogen activator (r-TPA), TIA, Hemorrhagic stroke and stroke with stationary course were excluded from the study. The included patients were randomly divided into two groups, group (A) were treated with double antiplatelet aspirin 81 mg plus Clopidogrel 75 mg preceded by the loading dose of both and group (B) were treated with aspirin plus subcutaneous enoxaparin 40 mg (Clexane) once daily for 3 days. After 3 days, both groups continued on double antiplatelet aspirin 81 mg plus Clopidogrel 75 mg. Results: We found that, at time of discharge 59.3% of group A showed progression in neurological symptoms and remaining 40.7% showed improvement in neurological symptoms while in group B only 13.8% of patients showed progression and remaining 86.2% showed improvement at this time. After one month, 55.56% of group A and 89.66% of group B of patients showed improvement and after 3 months, 66.67% of group A and 89.66% of group B showed improvement with significant difference of the outcome between both groups Conclusion: We concluded that aspirin plus enoxaparin 40 mg could be superior to aspirin plus Clopidogrel in the early treatment of stroke.","PeriodicalId":89983,"journal":{"name":"Journal of neurological disorders","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70265074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgG4-related disease mimicking cholangiocarcinoma","authors":"E. Hf","doi":"10.4172/2329-6895-C9-050","DOIUrl":"https://doi.org/10.4172/2329-6895-C9-050","url":null,"abstract":"","PeriodicalId":89983,"journal":{"name":"Journal of neurological disorders","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70267658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The etiologic profile of shoulder pain after stroke","authors":"pNataliia O Melnykp","doi":"10.4172/2329-6895-C9-048","DOIUrl":"https://doi.org/10.4172/2329-6895-C9-048","url":null,"abstract":"","PeriodicalId":89983,"journal":{"name":"Journal of neurological disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47389003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous levetiracetam versus phenytoin in the management of status epilepticus in adults: A systematic review of randomized-controlled trials","authors":"pSanad Esmailp","doi":"10.4172/2329-6895-C11-056","DOIUrl":"https://doi.org/10.4172/2329-6895-C11-056","url":null,"abstract":"","PeriodicalId":89983,"journal":{"name":"Journal of neurological disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45505847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging in post treatment glioma: The concepts of pseudo progression & pseudo response","authors":"pMitusha Vermap","doi":"10.4172/2329-6895-C7-042","DOIUrl":"https://doi.org/10.4172/2329-6895-C7-042","url":null,"abstract":"","PeriodicalId":89983,"journal":{"name":"Journal of neurological disorders","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70267625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epilepsy wellness: Beyond diagnosis, beyond therapy","authors":"pRamon Bautistap","doi":"10.4172/2329-6895-C5-036","DOIUrl":"https://doi.org/10.4172/2329-6895-C5-036","url":null,"abstract":"","PeriodicalId":89983,"journal":{"name":"Journal of neurological disorders","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70267320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}